In possible scenarios on the origin of life, protocells represent the precursors of the first living cells. To study such hypothetical protocells, giant vesicles are being widely used as a simple model. Lipid vesicles can undergo complex morphological changes enabling self‐reproduction such as growth, fission, and extra‐ and intravesicular budding. These properties of vesicular systems may in some way reflect the mechanism of reproduction used by protocells. Moreover, remarkable similarities exist between the morphological changes observed in giant vesicles and bacterial (...) L‐form cells, which represent bacteria that have lost their rigid cell wall, but retain the ability to reproduce. L‐forms feature a dismantled cellular structure and are unable to carry out classical binary fission. We propose that the striking similarities in morphological transitions of L‐forms and giant lipid vesicles may provide insights into primitive reproductive mechanisms and contribute to a better understanding of the origin and evolution of mechanisms of cell reproduction.Editor's suggested further reading in BioEssays Synthesizing artificial cells from giant unilamellar vesicles: State‐of‐the art in the development of microfluidic technology Abstract. (shrink)

Previous research in Explainable Artificial Intelligence (XAI) suggests that a main aim of explainability approaches is to satisfy specific interests, goals, expectations, needs, and demands regarding artificial systems (we call these “stakeholders' desiderata”) in a variety of contexts. However, the literature on XAI is vast, spreads out across multiple largely disconnected disciplines, and it often remains unclear how explainability approaches are supposed to achieve the goal of satisfying stakeholders' desiderata. This paper discusses the main classes of stakeholders calling for explainability (...) of artificial systems and reviews their desiderata. We provide a model that explicitly spells out the main concepts and relations necessary to consider and investigate when evaluating, adjusting, choosing, and developing explainability approaches that aim to satisfy stakeholders' desiderata. This model can serve researchers from the variety of different disciplines involved in XAI as a common ground. It emphasizes where there is interdisciplinary potential in the evaluation and the development of explainability approaches. (shrink)

Assertions are speech acts by means of which we express beliefs. As such they are at the heart of our linguistic and social practices. Recent research has focused extensively on the question whether the speech act of assertion is governed by norms, and if so, under what conditions it is acceptable to make an assertion. Standard theories propose, for instance, that one should only assert that p if one knows that p (the knowledge account), or that one should only assert (...) that p if p is true (the truth account). In a series of four experiments, this question is addressed empirically. Contrary to previous findings, knowledge turns out to be a poor predictor of assertability, and the norm of assertion is not factive either. The studies here presented provide empirical evidence in favour of the view that a speaker is warranted to assert that p only if her belief that p is justified. (shrink)

In der 1970 gegr ndeten Reihe erscheinen Arbeiten, die philosophiehistorische Studien mit einem systematischen Ansatz oder systematische Studien mit philosophiehistorischen Rekonstruktionen verbinden. Neben deutschsprachigen werden auch englischsprachige Monographien ver ffentlicht. Gr ndungsherausgeber sind: Erhard Scheibe (Herausgeber bis 1991), G nther Patzig (bis 1999) und Wolfgang Wieland (bis 2003). Von 1990 bis 2007 wurde die Reihe von J rgen Mittelstra mitherausgegeben.

Though ancient Pyrrhonian skepticism is apparently based on disagreement, this aspect of skepticism has been widely neglected in contemporary discussion on skepticism. The paper provides a rational reconstruction of the skeptical argument from disagreement that can be found in the books of Sextus Empiricus. It is argued that this argument forms a genuine skeptical paradox that has no fully satisfactory resolution. All attempts to resolve it make knowledge or justified belief either intuitively too easy or impossible.

We present an argument against physicalism in two steps: 1) Physics reduces the world to a mathematical structure; 2) The notion of 'structure' only makes sense when carried by something and interpreted by something else. Physicalism does not allow such a carrier and interpreter at a fundamental level, hence it must be wrong. An extended notion of Mind is presented as the fundamental 'hardware' which is necessary by the argument. In particular, qualia correspond to the 'monitor component' of mind. Some (...) ideas are presented on how to extend this mind-matter relation to a more elaborate picture: (1) A system of two complementary reductionisms (one physical, the other mental) may hint toward a deeper reality in which mind and the physical world are closely entangled. (2) A division of mind into a conscious 'monitor' and an unconscious 'processor' is suggested using the analogy of dreams. Finally, the problem of Solipsism and the existence of 'minds other than my own' is discussed. (shrink)

This paper presents a series of studies (total N=579) which demonstrate that folk judgments concerning the reasonableness of decisions and actions depend strongly on whether they engender positive or negative consequences. A particular decision is deemed more reasonable in retrospect when it produces beneficial consequences than when it produces harmful consequences, even if the situation in which the decision was taken and the epistemic circumstances of the agent are held fixed across conditions. This finding is worrisome for the law, where (...) the reasonable person standard plays a prominent role. The legal concept of reasonableness is outcome-insensitive: whether the defendant acted in a reasonable fashion or not depends exclusively on her context of action, no matter how things play out. Folk judgments of reasonableness are thus inconsistent with the legal concept of reasonableness. Problematically, in common law jurisdictions, the decision whether a defendant’s behavior was reasonable or not is frequently (though not necessarily) delegated to a lay jury. (shrink)

According to Anscombe, acting intentionally entails knowledge in ac- tion. This thesis has been near-universally rejected due to a well-known counter- example by Davidson: a man intending to make ten legible carbon copies might not believe with confidence, and hence not know, that he will succeed. If he does, however, his action surely counts as intentional. Damaging as it seems, an even more powerful objection can be levelled against Anscombe: while act- ing, there is as yet no fact of the (...) matter as to whether the agent will succeed. Since his belief that he will is not yet true while his action is in progress, he can- not possibly know that he is indeed bringing about the intended goal. Knowl- edge in action is not only unnecessary for intentional action, it seems, but–at least as regards success-bound types of action–impossible to attain in the first place. -/- In this paper I argue that traditional strategies to counter these objections are unsatisfactory and propose a new account of knowledge in action which has two core features: (i) It invokes an externalist conception of justification which not only meets Davidson’s challenge, but also casts doubts on the tacit internalist premise on which his example relies. (ii) Drawing on recent work about by John MacFarlane, the proposed account conceives of claims to in action as assessment-sensitive so as to overcome the factivity objection. From a retrospective point of evaluation, previous claims about future events and actions can not only be deemed as having been true, but also as having been known. (shrink)

The concept of a good life is usually assumed by philosophers to be equivalent to that of well-being, or perhaps of a morally good life, and hence has received little attention as a potentially distinct subject matter. In a series of experiments participants were presented with vignettes involving socially sanctioned wrongdoing toward outgroup members. Findings indicated that, for a large majority, judgments of bad character strongly reduce ascriptions of the good life, while having no impact at all on ascriptions of (...) happiness or well-being. Taken together with earlier findings these results suggest that the lay concept of a good life is clearly distinct from those of happiness, well-being, or morality, likely encompassing both morality and well-being, and perhaps other values as well: whatever matters in a person’s life. Importantly, morality appears not to play a fundamental role in either happiness or well-being among the folk. (shrink)

It is a common intuition that at least in some cases disagreement has skeptical consequences: the participants are not justified in persisting in their beliefs. I will argue that the currently popular non-dialectical and individualistic accounts of justification, such as evidentialism and reliabilism, cannot explain this intuition and defend the dialectical conception of justification that can explain it. I will also argue that this sort of justification is a necessary condition of knowledge by relying on Craig's genealogy of the concept (...) of knowledge. I will then respond to the accusation that the dialectical conception leads to radical skepticism. My response is partly concessive. It does lead to skepticism in areas where controversy prevails, such as philosophy, politics and religion, but this sort of skepticism is quite intuitive. Finally, I deal with the objection that my defense of skepticism about philosophy is self-refuting. (shrink)

In an important and widely discussed series of studies, Jonathan Phillips and colleagues have suggested that the ordinary concept of happiness has a substantial moral component. For in- stance, two persons who enjoy the same extent of positive emotions and are equally satisfied with their lives are judged as happy to different degrees if one is less moral than the other. Considering that the relation between morality and happiness or self-interest has been one of the central questions of moral philosophy (...) since at least Plato, such a result would be of considerable philosophical interest. On closer examination of the original research and new studies, we suggest that the data point to a different conclusion: in the dominant folk understanding of happiness, morality has no fundamental role. Findings seeming to indicate a moralized concept are better explained, we suggest, by folk theories on which extreme moral turpitude indicates that an individual suffers from psychological dysfunction. (shrink)

Das Buch weist in exemplarischen Fallstudien von der Antike bis zur Gegenwart die zentrale Rolle von Bildern für Prozesse der Vergemeinschaftung auf. Gegen Ende des 20. Jahrhunderts setzt in der akademischen Diskussion eine verstärkte Rückwendung zum Konzept der Gemeinschaft ein.

This interview deals with the major themes in the work of Ruth Millikan. Her most fundamental idea is that the intentionality of inner and outer representations can be understood in analogy to biological functions. Another innovative feature is the view that thought and language stand parallel to each other. Thirdly, the basic ideas concerning the ontology and the epistemology of concepts are explained. Millikan aims at clarifying her position by contrasting it with Dretske, Fodor, Sellars, and Brandom. Finally, the interview (...) addresses topics that pose problems for her account as well as questions she does not treat in her work. (shrink)

How can we ever find out whether our psychological processes are reliable? According to many reliabilists—e.g. Alston, Goldman, Papineau, and Van Cleve —there is no problem: We just use our psychological processes and then arrive at the belief that these very same processes are reliable. If our psychological processes are actually reliable, we can arrive in this way at a justified belief. And, indeed, we can even come to know that they are reliable.

To solve the ancient Pyrrhonian problematic, it is not enough to show that knowledge and justified belief are possible. They must be shown to be actual. It is argued that the attempts by the main advocates of reliabilism, William Alston, Alvin Goldman, and Ernest Sosa, fail to solve the problematic because they fall under the Agrippan modes of circularity and hypothesis. There is also another sort of response implicit in their discussion. It is not to try to solve the problematic, (...) but to accept the Pyrrhonian moral and to settle for appearances. Finally, a version of Pyrrhonism is given, and it is suggested that reliabilism be understood as a case of this sort of Pyrrhonism. (shrink)

Recently the functional model of reduction has become something like the standard model of reduction in philosophy of mind. In this paper, I argue that the functional model fails as an account of reduction due to problems related to three key concepts: functionalization, realization and causation. I further argue that if we try to revise the model in order to make it more coherent and scientifically plausible, the result is merely a simplified version of what in philosophy of science is (...) known as mechanistic explanation. Hence, instead of analyzing reduction in philosophy of mind in terms of functional reduction, it should be analyzed in terms of mechanistic explanation. (shrink)

Japanese rank among the least likely to intervene to help a stranger in a non-emergency situation while Americans rank among the most likely. Across four studies, we demonstrate that Japanese are less likely to offer help to strangers because their decisions rely more heavily on the assessment of the needs of others. Accordingly, when there is uncertainty about the need for help, Japanese are less likely to intervene than Americans because without an understanding of the needs of recipient, the impact (...) of intervention may also be harmful. When the situation is unambiguous, Japanese and Americans are equally likely to help. This divergence in readiness to help strangers elaborates the understanding of why people in Japanese contexts are more likely than those in United States contexts to attend to the situation and to avoid uncertain situations. It also illuminates cultural differences in models of agency—implicit understandings of when and why a person should act to aid another. (shrink)

Legislation and ethical guidelines around the globe call for effective human oversight of AI-based systems in high-risk contexts – that is oversight that reliably reduces the risks otherwise associated with the use of AI-based systems. Such risks may relate to the imperfect accuracy of systems (e.g., inaccurate classifications) or to ethical concerns (e.g., unfairness of outputs). Given the significant role that human oversight is expected to play in the operation of AI-based systems, it is crucial to better understand the conditions (...) for effective human oversight. We argue that the reliable detection of errors (as an umbrella term for inaccuracies and unfairness) is crucial for effective human oversight. We then propose that Signal Detection Theory (SDT) offers a promising framework for better understanding what affects people’s sensitivity (i.e., how well they are able to detect errors) and response bias (i.e., the tendency to report errors given a perceived evidence of an error) in detecting errors. Whereas an SDT perspective on the detection of inaccuracies is straightforward, we demonstrate its broader applicability by detailing the specifics for an SDT perspective on unfairness detection, including the need to choose a standard for (un)fairness. Additionally, we illustrate that an SDT perspective helps to better understand the conditions for effective error detection by showing examples of task-, system-, and person-related factors that may affect the sensitivity and response bias of humans tasked with detecting unfairness associated with the use of AI-based systems. Finally, we discuss future research directions for an SDT perspective on error detection. (shrink)

Fogelin’s neo-Pyrrhonism is skepticism about epistemology and philosophy more generally. Philosophical reflection on ordinary epistemic practices leads us to deny the possibility of knowledge and justified belief. However, instead of accepting the dogma that knowledge and justified beliefs are impossible, a neo-Pyrrhonist rejects the philosophical premises that lead to this conclusion. Fogelin argues in particular that contemporary theories of justification cannot avoid dogmatic skepticism, because they are committed to the premises of the skeptical argument deriving from the modes of Agrippa. (...) It is argued against Fogelin that those theories can and typically do deny one or another of the premises and thus can avoid the skeptical conclusion. Neo-Pyrrhonism should rather be defended by arguing that the premises of the Agrippan argument are intuitively plausible and that neo-Pyrrhonism provides the best resolution of the resulting paradox. Only neo-Pyrrhonism both explains the intuitive plausibility of the premises and avoids dogmatic skepticism. (shrink)

The paper defends Cartesian skepticism by an argument relying on internalism and infallibilism. It argues that this sort of skepticism gives the best explanation of our intuitions and ordinary epistemic practices.

Soviet attitude towards Bohr reflects changes in the ideological approach to science. During the last period before Stalin's death ?danov proclaimed the campaign against Western influence in Soviet philosophy and science. Nevertheless the physicist M. A. Markov tried to introduce complementarity as a materialistic interpretation of quantum?mechanics in 1948. He was officially condemned. This was followed by a period (1948?54) during which heavy attacks were made against the Copenhagen school. In 1958, after a personal exchange of thoughts with Bohr, academician (...) Fock declared complementarity and probability to be irreversible steps towards a new insight into physical reality, at the same time correcting some of Bohr's epistemological conceptions. (shrink)

Humphreys and Forde conceptualize object representations as structural descriptions, without discussing the implications of structural description models. We argue that structural description models entail two major assumptions – a part-structure assumption and an invariance assumption. The invariance assumption is highly problematic because it contradicts a large body of findings which indicate that recognition performance depends on orientation and size. We will delineate relevant findings and outline an alternative conception.

The polar orientation of cells within a tissue is an intensively studied research area in animal cells. The term planar polarity refers to the common polar arrangement of cells within the plane of an epithelium. In plants, the subcellular analysis of tissue polarity has been limited by the lack of appropriate markers. Recently, research on plant tissue polarity has come of age. Advances are based on studies of Arabidopsis patterning, cell polarity and auxin transport mutants employing the coordinated, polar localization (...) of auxin transporters and the planar polarity of root epidermal hairs as markers. These approaches have revealed auxin transport and response, vesicular trafficking, membrane sterol and cytoskeletal requirements of tissue polarity. This review summarizes recent progress in research on vascular tissue and planar epidermal polarity in the Arabidopsis root and compares it to findings on planar polarity in animals and cell polarity in yeast. BioEssays 26:719–729, 2004. © 2004 Wiley Periodicals, Inc. (shrink)