When a group of agents attempts to reach an agreement on certain issues, it is usually desirable that the resulting consensus be as close as possible to the original judgments of the individuals. However, when these judgments are logically connected to further beliefs, the notion of closeness should also take into account to what extent the individuals would have to revise their entire belief set to reach an agreement. In this work, we present a model for generation of agreement with (...) respect to a given agenda which allows individual epistemic entrenchment to influence the value of the consensus. While the postulates for the transformation function and their construction resemble those of AGM belief revision, the notion of an agenda is adapted from the theory of judgment aggregation. This allows our model to connect both frameworks. (shrink)

Griffiths et al. (2015) have proposed a quantitative measure of causal specificity and used it to assess various attempts to single out genetic causes as being causally more specific than other cellular mechanisms, for example, alternative splicing. Focusing in particular on developmental processes, they have identified a number of important challenges for this project. In this discussion note, I would like to show how these challenges can be met.

Philosophy of Experimental Biology explores some central philosophical issues concerning scientific research in experimental biology, including genetics, biochemistry, molecular biology, developmental biology, neurobiology, and microbiology. It seeks to make sense of the explanatory strategies, concepts, ways of reasoning, approaches to discovery and problem solving, tools, models and experimental systems deployed by scientific life science researchers and also integrates developments in historical scholarship, in particular the New Experimentalism. It concludes that historical explanations of scientific change that are based on local laboratory (...) practice need to be supplemented with an account of the epistemic norms and standards that are operative in science. This book should be of interest to philosophers and historians of science as well as to scientists. (shrink)

Historians of biology have argued that much of the dynamics of experimental disciplines such as genetics or molecular biology can be understood from studying experimental systems and model organisms alone . Such accounts contrast sharply with more traditional philosophies of science which viewed scientific research essentially as a process of inventing and testing theories. I present a case from the history of biochemistry which can be viewed from both the experimental systems perspective and from the methodology of theory testing. I (...) argue that not only are the two perspectives fully compatible, but they are both necessary for a complete account of the research process. (shrink)

Even though it is often presumed that the use of technology like medication administration technology is both safer and more effective, the importance of nurses' know‐how is not to be underestimated. In this article, we accordingly try to argue that nurses' labor, including their different forms of knowledge, must play a crucial role in the development, implementation and use of medication administration technology. Using three different theoretical perspectives (‘heuristic lenses') and integrating this with our own ethnographic research, we will explore (...) how nursing practices change through the use of medication technology. Ultimately, we will argue that ignoring (institutional) complexity and the various types of important knowledge that nurses have, will seriously complicate the implementation of medication administration technology. (shrink)

John Searle has argued that functions owe their existence to the value that we put into life and survival. In this paper, I will provide a critique of Searle’s argument concerning the ontology of functions. I rely on a standard analysis of functional predicates as relating not only a biological entity, an activity that constitutes the function of this entity and a type of system but also a goal state. A functional attribution without specification of such a goal state has (...) no truth-value. But if completed with a goal state, functional attributions understood as four-place relations attain a truth-value. The truth conditions of all attributions of function involve a dependence claim of the goal state on the function bearer’s activity. The nature of this dependence may differ; I consider five different possibilities: causality, mechanistic constitution, mereology, supervenience and metaphysical grounding. If these dependency relations are objective, Searle’s central ontological thesis fails. What he ought to have said is that our valuing survival or other goal states may be the reason why biology seeks functional knowledge, but this has nothing to do with ontology. I will show further that Searle also raised an interesting challenge concerning the relationship of functional and causal truths, but it does not threaten the objectivity of functions either. At best, it could show that functional vocabulary is eliminable. However, I will show that functional vocabulary is not so eliminable. (shrink)

Il est une actualité de la syllogistique aristotélicienne qui impose encore aujourd'hui les règles de l'argumentation logique dans la production du savoir scientifique. Le moyen terme y régule la structure et la forme du raisonnement — cet ensemble de jugements — élaboré de telle sorte que la conclusion découle nécessairement des prémisses. Chez Aristote, le jugement requiert ainsi une multitude de procédures d'application à la réalité. Or, Boole trouve en cela un problème méthodologique largement négligé par les logiciens et certains (...) historiens des sciences modernes : le problème d'Aristote sur le moyen terme, le moyen terme étant à la fois cause, matière et forme du syllogisme catégorique. Les deux penseurs visent pourtant l'infaillibilité du raisonnement par l'élimination du moyen terme dans les procédures de la recherche de la vérité. Ce qui les divise est à la fois d'ordre méthodologique et de degré. Car, Aristote élimine le moyen terme de la conclusion et selon les lois ultimes de l'objet. Boole, en revanche, élimine le moyen terme du raisonnement symbolique sur la base des lois ultimes de la pensée pure en lui reniant le statut que lui conférait Aristote. Cet article vise à montrer, à la lumière de cette éclipse du moyen terme pour Aristote que, pour Boole, la solution nécessaire au problème d'Aristote est la « théorie générale des signes » qui, elle, consacre l'élimination du moyen terme du raisonnement symbolique. C'est une exigence de la pensée connaissante en ce qu'elle constitue son caractère méta-méthodologique. La théorie générale des signes rendrait ainsi l'actualité de l'aristotélisme plus persistante si tant est qu'il est admis que Boole ne s'en est lui-même pas encore démarqué. (shrink)

Going back at least to Duhem, there is a tradition of thinking that crucial experiments are impossible in science. I analyse Duhem's arguments and show that they are based on the excessively strong assumption that only deductive reasoning is permissible in experimental science. This opens the possibility that some principle of inductive inference could provide a sufficient reason for preferring one among a group of hypotheses on the basis of an appropriately controlled experiment. To be sure, there are analogues to (...) Duhem's problems that pertain to inductive inference. Using a famous experiment from the history of molecular biology as an example, I show that an experimentalist version of inference to the best explanation (IBE) does a better job in handling these problems than other accounts of scientific inference. Furthermore, I introduce a concept of experimental mechanism and show that it can guide inferences from data within an IBE-based framework for induction. 1. Introduction2. Duhem on the Logic of Crucial Experiments3. ‘The Most Beautiful Experiment in Biology’4. Why Not Simple Elimination?5. Severe Testing6. An Experimentalist Version of IBE 6.1. Physiological and experimental mechanisms6.2. Explaining the data6.3. IBE and the problem of untested auxiliaries6.4. IBE-turtles all the way down7. Van Fraassen's ‘Bad Lot’ Argument8. IBE and Bayesianism9. Conclusions. (shrink)

Biological modalities, i.e., biologically possible, impossible, or necessary states of affairs have not received much attention from philosophers. Yet, it is widely agreed that there are biological constraints on physically possible states of affairs, such that not everything that is physically possible is also biologically possible, even if everything that is biologically possible is also physically possible. Furthermore, biologists use concepts that appear to be modal in nature, such as the concept of evolvability in evolutionary developmental biology, or “evo-devo.” The (...) present chapter investigates what kind of modality underlies the concept of evolvability. This concept tries to capture the capacity of an organism or a lineage to sustain genetic changes that enable it to evolve or to evolve adaptively. The basic idea of the proposed approach is to construe evolvability as a kind of accessibility in a modal space. The difficult part is to specify this modal space and the relevant accessibility relation. While there may not be a general way of defining such a relation, there exist model systems for which it is possible, e.g., evolving small RNAs. The modal space in such cases turns out to be quite distinct from those constructed by philosophers, e.g., David Lewis’s similarity metric for possible worlds. Even though the biological case examined here is quite special, attending to the way in which biological possibilities are modeled in this case harbors some general lessons about biological modalities, in particular their dependence on the explanatory goals of the models modeling modality. (shrink)

This is an agenda-setting exploration of the relationship between green politics and liberal ideology. Ecological problems provide unique challenges for liberal democracies.; This challenge is examined by the author who aims to fill the gap between short-term ecological modernization and the politically infeasible longer term utopian approaches.

The theory of opposition has always been viewed as the founding principle of structuralism within contemporary linguistics and semiotics. As an analytical technique, it has remained a staple within these disciplines, where it continues to be used as a means for identifying meaningful cues in the physical form ofsigns. However, as a theory of conceptual structure it was largely abandoned under the weight of post-structuralism starting in the 1960s — the exception tothis counter trend being the work of the Tartu (...) School of semiotics. This essay revisits opposition theory not only as a viable theory for understanding conceptual structure, but also as a powerful technique for establishing the interconnectedness of language, culture, and cognition. (shrink)

The recent literature on causality has seen the introduction of several distinctions within causality, which are thought to be important for understanding the widespread scientific practice of focusing causal explanations on a subset of the factors that are causally relevant for a phenomenon. Concepts used to draw such distinctions include, among others, stability, specificity, proportionality, or actual-difference making. In this contribution, I propose a new distinction that picks out an explanatorily salient class of causes in biological systems. Some select causes (...) in complex biological systems, I argue, have the property of enabling coherent causal control of these systems. Examples of such control variables include hormones and other signaling molecules, e.g., TOR (target of rapamycin), morphogens or the products of homeotic selector genes in embryonic pattern formation. I propose an analysis of this notion based on concepts borrowed from causal graph theory. (shrink)

For contagious diseases like measles a successful immunization program can result in herd protection. Small outbreaks may still occur but fade out soon, because the possibilities for the pathogen to spread in the ‘herd’ are very small. This implies that people who refuse to participate in such a program will still benefit from the protection it offers, but they don’t do their part in maintaining protection. Isn’t that a case of freeriding—and isn’t that unfair towards all the people who do (...) collaborate? If so, that might be considered an additional ground for making vaccination mandatory or compulsory.In this paper I argue that vaccination refusal can be considered as freeriding, but that this might not be unfair. The public good of herd protection is a peculiar public good because it supervenes on private benefits that are enjoyed by all who do opt for vaccination. For vaccinated individuals, the additional benefit of herd protection comes about, as it were, for free, and hence they can’t complain that others benefit without sharing in the burdens. There are however still other grounds for making vaccination compulsory or at least for seeing refusal as a morally wrong choice. (shrink)

One of the societal problems in a new influenza pandemic will be how to use the scarce medical resources that are available for prevention and treatment, and what medical, epidemiological and ethical justifications can be given for the choices that have to be made. Many things may become scarce: personal protective equipment, antiviral drugs, hospital beds, mechanical ventilation, vaccination, etc. In this paper I discuss two general ethical principles for priority setting (utility and equity) and explain how these principles will (...) often point in diverging directions. Moreover, each of these principles can be understood in different, again often competing, ways. Notwithstanding these controversies and conflicts, in the context of pandemic response there are at least some points of convergence: several policies can be justified by appeal to different ethical principles and theories. Convergence may be found with respect to a focus on saving the most lives (instead of other aggregative accounts); giving priority antiviral prophylaxis and therapy for life-saving pandemic responders; and, partly depending on epidemiology of the pandemic, to prioritise vaccination of children. Although decision-making about access to intensive care will involve choices with immediate tragic implications, the ethical complexity of these choices is relatively modest (although decisions will not be easy): there are persuasive moral reasons for giving priority to patients who are expected to benefit most within the shortest time. Finally, in the last section I tentatively argue that constraints on people’s freedom, as necessary for an effective public health approach, may support giving somewhat more weight to saving the most lives, than to concerns of equity. (shrink)

Many nursing homes have an influenza vaccination policy in which it is assumed that express (proxy) consent is not necessary. Tacit consent procedures are more efficient if one aims at high vaccination rates. In this paper I focus on incompetent residents and proxy consent. Tacit proxy consent for vaccination implies a deviance of standard proxy consent requirements. I analyse several arguments that may possibly support such a deviance. The primary reason to offer influenza vaccination is that vaccinated persons have a (...) significantly reduced risk of getting the flu. This reason however cannot support the assumption that each nursing home resident is ‘better off ’ if she is vaccinated. Neither can it support tacit proxy consent policies. More promising are arguments that take the collective nature of infectious diseases into account. A potentially strong, but ultimately insufficient, argument for non‐express consent is that vaccination contributes to prevention of harm to others. Other arguments emphasise the importance of group protection: herd immunity. I discuss three collective reasons for aiming at herd immunity: solidarity, a common interest in reducing the risk of illness, and a common interest in the prevention of an influenza outbreak. The latter argument appears to be most important. An outbreak is not just detrimental to the health of residents; it is detrimental to their everyday social life as well. Outbreaks can be seen as a collective evil. My analysis shows that there are valid (though not necessarily sufficient) moral arguments for a tacit proxy consent policy. (shrink)

This paper presents the notion that verbal discourse is structured, in form and contents, by metaphorical reasoning. It discusses the concept of “metaphorical network” as a framework for relating the parts of a speech act to each other, since such an act seems to cohere into a meaningful text on the basis of “domains” that deliver common concepts. The basic finding of several research projects on this concept suggest that source domains allow speakers to derive sense from a verbal interaction (...) because they interconnect the topic of discussion to culturally-meaningful images and ideas. This suggests, in turn, that language is intertwined with nonverbal systems of meaning, reflecting them in the contents of verbal messages. Overall, the concept of metaphorical networks implies that human cognition is highly associative in structure. (shrink)

El modelo viquiano propuesto en este trabajo tiene hoy día implicaciones concretas para la lingüística y las ciencias cognitivas. A nuestro parecer, hoy las investigaciones en estos campos no hacen otra cosa que verificar la existencia de un vínculo gnoseológico entre sentido, concepto y metáfora que Vico exponía en la Scienza nuova. Vico demostró, ante todo, que la lógica poética constituye la facultad preliminar que permite el comportamiento simbólico humano. Dicha noción falta del todo en las actuales investigaciones sobre la (...) metáfora; y falta claramente la noción de Homo Poeticus en todas las visiones hasta ahora expuestas en lingüística. La concepción viquiana de la lógica poética permitirá a estas ciencias trazar el recorrido científico que deberán seguir en el futuro.Recent researches in linguistics and cognitive sciences may be brought as to show that there exist a empistemological bound between sense, concept and metaphor which Vico already acknowledged in his Scienza nuova. While Vico clearly showed that poetical logic helps to developing the human symbolic behavior; the concept of Homo poeticus is lacking in recent scholar contributions on issues related with metaphors and linguistics. It is assumed that the Vichian conception on poetical logic may improve a better understanding of the problems with which those sciences have hitherto been concerned. (shrink)

Several authors have used the notion of causal specificity in order to defend non-parity about genetic causes (Waters 2007, Woodward 2010, Weber 2017, forthcoming). Non-parity in this context is the idea that DNA and some other biomolecules that are often described as information-bearers by biologists play a unique role in life processes, an idea that has been challenged by Developmental Systems Theory (e.g., Oyama 2000). Indeed, it has proven to be quite difficult to state clearly what the alleged special role (...) of genetic causes consists in. In this paper, I show that the set of biomolecules that are normally considered to be information-bearers (DNA, mRNA) can be shown to be the most specific causes of protein primary structure, provided that causal specificity is measured over a relevant space of biological possibilities, disregarding physical as well as logically possible states of the causal variables. (shrink)

Journal Name: Semiotica Issue: Ahead of print.

The Italian philosopher Giambattista Vico foreshadowed many of the ideas currently being entertained by the modem cognitive and human sciences. By emphasizing the role of the imagination in the production of meaning, Vico showed how truly ingenious the fIrst forms of representation were. His view that these forms were "poetic" is only now being given serious attention, as more and more linguists and psychologists come to realize the role of metaphor in the generation of abstract systems of representation. The Estonian (...) semiotician Yuri Lotman espoused a basically similar view, highlighting the role of the poetic imagination in the generation of the textuality that holds cultures together in meaningful ways. A comparison of these two exceptional thinkers has never been entertained. This note aims to do exactly that. Specifically, it takes a first glimpse at the parallels of thought and method that inhere in the main works of these two ground-breaking thinkers. Such a comparison will establish a theoretical framework to make semiotics a true "science of the imagination". It will show that semiosis and representation are not tied to any innate neural mechanisms, but rather to a creative tendency in the human species to literally "invent itself'. (shrink)

The concept of accuracy in mathematics is something that is rarely discussed. It is taken for granted, mainly because the various symbolic tools of the discipline, such as the digits and its equations, are meant to have a precise interpretation within the primary referential field. Yet, mathematics is full of inaccuracies and imprecise notions and techniques. The science of limits or the calculus, for example, is the science of imprecision, since it is based on the notions of “approximation”. Yet, the (...) calculus is a marvelous tool of science and discovery. This paper looks at this paradox in a general way considering the relation between mathematics as a sign system and its ability to glean discoveries from within its own system. (shrink)

Control measures directed at carriers of multidrug-resistant organisms are traditionally approached as a trade-off between public interests on the one hand and individual autonomy on the other. We propose to reframe the ethical issue and consider control measures directed at carriers an issue of solidarity. Rather than asking “whether it is justified to impose strict measures”, we propose asking “how to best care for a person’s carriership and well-being in ways that do not imply an unacceptable risk for others?”. A (...) solidarity approach could include elevating baseline levels of precaution measures and accepting certain risks in cases where there is exceptionally much at stake. A generous national compensation policy that also covers for costs related to dedicated care is essential in a solidarity approach. An additional benefit of reframing the questions is that it helps to better acknowledge that being subjected to control measures is a highly personal matter. (shrink)

Darwin famously held that his use of the term "chance" in evolutionary theory merely "serves to acknowledge plainly our ignorance of the causes of each particular variation". Is this a tenable view today? Or should we revise our thinking about chance in evolution in light of the more advanced, quantitative models of Neo-Darwinian theory, which make substantial use of statistical reasoning and the concept of probability? Is determinism still a viable metaphysical doctrine about biological reality after the quantum revolution in (...) physics, or dowe have to abandon it in favor of an objective indeterminism? In light of such reflections, what is the relevant interpretation of probability in evolutionary theory? Do biologists use the concept of probability because they are finite cognitive agents or because the evolutionary process is fundamentally probabilistic? In this paper, I will show that we do not yet fully understand the nature of chance in evolution. (shrink)

Ecological thought has made a deep and apparently lasting impact on virtually every tradition in political theory (cf. e.g. Dobson, 2007) with the exception of libertarianism. While left- and right...