Rare copy number variants have a prominent role in the aetiology of schizophrenia and other neuropsychiatric disorders. Substantial risk for schizophrenia is conferred by large CNVs at several loci, including microdeletions at 1q21.1, 3q29, 15q13.3 and 22q11.2 and microduplication at 16p11.2. However, these CNVs collectively account for a small fraction of cases, and the relevant genes and neurobiological mechanisms are not well understood. Here we performed a large two-stage genome-wide scan of rare CNVs and report the significant association of copy (...) number gains at chromosome 7q36.3 with schizophrenia. Microduplications with variable breakpoints occurred within a 362-kilobase region and were detected in 29 of 8,290 patients versus 2 of 7,431 controls in the combined sample. All duplications overlapped or were located within 89 kilobases upstream of the vasoactive intestinal peptide receptor gene VIPR2. VIPR2 transcription and cyclic-AMP signalling were significantly increased in cultured lymphocytes from patients with microduplications of 7q36.3. These findings implicate altered vasoactive intestinal peptide signalling in the pathogenesis of schizophrenia and indicate the VPAC2 receptor as a potential target for the development of new antipsychotic drugs. © 2011 Macmillan Publishers Limited. All rights reserved. (shrink)

Background: Serious games have shown positive results in increasing motivation, adherence to treatment and strengthening the therapeutic alliance in multiple psychiatric disorders. In particular, patients with impulse control disorders and other disorders in which the patient suffers from inhibitory control deficits have been shown to benefit from serious games.Aim: The aim of this study was to describe the characteristics and to evaluate the usability of a new serious videogame, e-Estesia. This serious videogame was designed to improve emotion regulation in patients (...) with gambling disorder. Preliminary results from a pilot sample are also reported.Method: A pilot sample of 26 patients undergoing treatment for GD was recruited. Participants used e-Estesia on a tablet, which was connected to a thoracic band that sent heart rate and heart rate variability data to the videogame platform in order to provide biofeedback. The System Usability Scale was completed by patients to determine the usability of e-Estesia.Results and Discussion: e-Estesia performed comparatively well for all the explored groups. Around 84.6% of the patients endorsed that it was easy to use. Female patients with GD presented higher HRV during the use of the serious videogame compared to men. (shrink)

Die Analyse von R. M. Rilkes »Atmen« ( Sonette an Orpheus ) zeichnet einen Begriff von Rhythmus nach, der das Gedicht als exemplarischen Beitrag zur Rhythmusdebatte um 1900 lesbar macht. Das Sonett wird zum Ausgangspunkt von Überlegungen zur Logik von zeitgenössischen Rhythmuskonzepten: Indem das Gedicht genau die neuen Raummodelle aufruft, die Wissenschaften und Kunst der Jahrhundertwende entwerfen, läßt es einen modernen Rhythmusbegriff denkbar werden. Zugleich stellt das Sonett die zentrale Frage nach poetischer Repräsentation unter den Bedingungen jener rhythmischen Räume.

Die Analyse von R. M. Rilkes »Atmen« (Sonette an Orpheus) zeichnet einen Begriff von Rhythmus nach, der das Gedicht als exemplarischen Beitrag zur Rhythmusdebatte um 1900 lesbar macht. Das Sonett wird zum Ausgangspunkt von Überlegungen zur Logik von zeitgenössischen Rhythmuskonzepten: Indem das Gedicht genau die neuen Raummodelle aufruft, die Wissenschaften und Kunst der Jahrhundertwende entwerfen, läßt es einen modernen Rhythmusbegriff denkbar werden. Zugleich stellt das Sonett die zentrale Frage nach poetischer Repräsentation unter den Bedingungen jener rhythmischen Räume.

Frankfurt/M., Berlin, Bern, Bruxelles, New York, Oxford, Wien. Herausgegeben von Wilhelm Lutterfelds, Richard Raatzsch und Andreas Roser. The works of both Goethe and Wittgenstein are a permanent challenge. Goethe's lasting effectiveness is to be found in the alternative nature of his world-view (Weltan-Schauung), which may be characterized as a morphological access to the manifold of phenomena. Lasting in a similar way to the effect of Goethe, one could certainly say today that Wittgenstein's effect has lasted. This is no coincidence. (...) The fact that late Wittgenstein goes together with Goethe in fundamental respects, or even follows him, cannot be overseen. Wittgenstein's lasting legacy has, to a large extent, the same source as that of Goethe's. - This relation is the subject of this book. Contents: Fritz Breithaupt/Richard Raatzsch: Introduction - James C. Klagge: The Puzzle of Goethe's Influence on Wittgenstein - Matthias Kross: Engineering Phenomena: Wittgenstein and Goethe on Scientific Method - Nikos Psarros: "Water is one individual thing - it never changes." Quoting Faraday in the Philosophical Investigations: A Riddle with a Goethean Solution? - Joachim Schulte: Goethe and Wittgenstein on Morphology - Fritz Breithaupt: Non-Referentiality: A Common Strategy in Goethe's Urphanomen and Wittgenstein's Language-Game - Alfred Nordmann: "I have changed his way of seeing" -Goethe, Lichtenberg, and Wittgenstein - Garry Hagberg: The Mind shown. Wittgenstein, Goethe and the Question of Person-Perception - Richard Eldridge: Romantic Subjectivity in Goethe and Wittgenstein - Richard Raatzsch: Goethe's Wahlverwandtschaften - The Ethical Investigations of Late Wittgenstein? (shrink)

Background: Older, frail patients with multimorbidity are at an especially high risk for disease severity and death from COVID-19. The social restrictions proved challenging for the residents, their relatives, and the care staff. While these restrictions clearly impacted daily life in Norwegian nursing homes, knowledge about how the pandemic influenced nursing practice is sparse. Aim: The aim of the study was to illuminate ethical difficult situations experienced by Norwegian nurses working in nursing homes during the COVID-19 pandemic. Research design and (...) participants: The research design involved semistructured individual interviews conducted with 15 nurses working in 8 nursing homes in 3 health regions in Norway, within both urban and rural areas. Ethical considerations: Oral and written information about the study was provided before the participants gave their written consent. The transcribed interviews were de-identified. The study was approved by the Norwegian Centre for Research Data. Findings: Four ethical difficult situations were identified: (a) turning the nursing home into a prison; (b) using medication to maintain peace and order; (c) being left alone with the responsibility; and (d) s. impact on decision-making. Conclusions: The nurses’ ethical challenges were intertwined with external factors, such as national and local guidelines, and the nurses’ own internalized factors, which were connected to their subjective professionality. This duality inflicted emotional distress and gave nurses few opportunities to perform nursing in a professionally sound and safe manner. (shrink)