Humankind is currently witnessing, and shaping, the most significant and rapid paradigm shift in human history - a paradigm shift of major demographic, economic, ecological, and geo-political dimensions. For the first time in human history - we are faced not with just one crisis - but a confluence of several crises; crises that are not related to a single tribe or community - a single nation -or a single region of the world - but are each global in scale. To (...) meet the challenges of these global crises will require an equally historic paradigm shift; a paradigm shift with a strong environmental ethic that restores ecological balance and integrity to our failing ecosystems, and that addresses the critical issue of climate change; a paradigm shift toward an economic system that brings about an end to poverty — and a paradigm that brings an end to war as a means to solving conflict, as it is only through a global family in harmony and peace with itself, that we can solve the unprecedented global issues facing our one common home, planet earth - and our one common future as a global family. The travel and tourism industry has, and will continue to play a vital and leading role toward this paradigm shift, and as the world's largest industry involving virtually every nation in the world — will be the central pillar of a Peace through Commerce movement. The dramatic growth of tourism in the past 60 years is one of the most remarkable economic and social phenomena of our time. The industry has grown from a total of 25 million international arrivals in 1950 to a projected 1 billion international arrivals in 2010, and a further projection to 1.6 billion by 2020. Beginning with the emergence of "Ecotourism" in the late 1980' s, there are an increasing number of tourism market segments which fall within a broad category that can be called "Peace Tourism," and classified within a framework that includes peace within ourselves, peace with others, peace with nature, peace with past generations, peace with future generations, and peace with our Creator. Since its birth in 1986, the International Institute for Peace through Tourism (IIPT) has been promoting these values of tourism together with its vision of Travel and Tourism as the world's first "Global Peace Industry" - an industry that promotes and supports the belief that every traveler is potentially an "Ambassador for Peace." This "higher purpose of tourism" includes the key role of tourism in promoting international understanding and collaboration among nations; environmental protection and preservation of biodiversity; enhancing cultures and valuing heritage; contributing to sustainable development and poverty reduction; and healing wounds of conflict. (shrink)

This article has as its main theme the disorder of self-love, according to the thought of Louis Lavelle. For this philosopher, self-love is something that not only tarnishes man's conscience but also his relationships with others. In the egoist there is a process of losing consciousness, since the idea or image that he has of himself is unfair to reality, it is always exaggerated. This false self-image, for being unfounded, prevents your conscience from being perfect, thus making it impossible (...) for one of the philosopher's basic principles: to know oneself. The article discusses self-love, supported by the notion of sincerity towards oneself. This sincerity is only possible when there is detachment from fantasies, that is, detachment from vanity. The reflection carried out in this article was guided by the reading, analysis and interpretation of texts by Lavelle, such as The error of Narcissus, Conduite à l’égard d’autrui, Traité des valeurs, De l’Acte. (shrink)

Contrasting the conflicting positions of Fink and Žižek, this article opens and closes with the question: is feminine jouissance ineffable? It solves the mystery of why Lacan associates the Other jouissance with women and presents an account of phallic and the Other jouissance informed by the work of Breuer and Freud. It argues that the satisfactions of Lacan’s feminine subject bear striking affinity to those of the hysteric, while phallic jouissance affords the same sort of enjoyment as that of Freud’s (...) obsessional neurotic. And, while “real” experiences make one lose one-self and may not be represented by one who was absent, this is not to say that we cannot shed light on characteristically feminine pleasure/pains. (shrink)

Long-term potentiation (LTP) is a long-lasting increase in synaptic efficacy that many consider the best candidate currently available for a neural mechanism of memory formation and/or storage in the mammalian brain. In our target article, LTP: What's learning got to do with it?, we concluded that there was insufficient data to warrant such a conclusion. In their commentaries, Jeffery and Zhadin raise a number of important issues that we did not raise, both for and against the hypothesis. Although we agree (...) with a number of these issues, we maintain that there remains insufficient evidence that LTP is a memory mechanism. (shrink)

Long-term potentiation (LTP) is operationally defined as a long-lasting increase in synaptic efficacy following high-frequency stimulation of afferent fibers. Since the first full description of the phenomenon in 1973, exploration of the mechanisms underlying LTP induction has been one of the most active areas of research in neuroscience. Of principal interest to those who study LTP, particularly in the mammalian hippocampus, is its presumed role in the establishment of stable memories, a role consistent with descriptions of memory formation. Other characteristics (...) of LTP, including its rapid induction, persistence, and correlation with natural brain rhythms, provide circumstantial support for this connection to memory storage. Nonetheless, there is little empirical evidence that directly links LTP to the storage of memories. In this target article we review a range of cellular and behavioral characteristics of LTP and evaluate whether they are consistent with the purported role of hippocampal LTP in memory formation. We suggest that much of the present focus on LTP reflects a preconception that LTP is a learning mechanism, although the empirical evidence often suggests that LTP is unsuitable for such a role. As an alternative to serving as a memory storage device, we propose that LTP may serve as a neural equivalent to an arousal or attention device in the brain. Accordingly, LTP may increase in a nonspecific way the effective salience of discrete external stimuli and may thereby facilitate the induction of memories at distant synapses. Other hypotheses regarding the functional utility of this intensely studied mechanism are conceivable; the intent of this target article is not to promote a single hypothesis but rather to stimulate discussion about the neural mechanisms underlying memory storage and to appraise whether LTP can be considered a viable candidate for such a mechanism. (shrink)

The neurophysiological phenomenon of LTP (long term potentiation) is considered by many to represent an adequate mechanism for acquiring or storing memories in the mammalian brain. In our target article, we reviewed the various arguments put forth in support of the LTP/memory hypothesis. We concluded that these arguments were inconsistent with the purported data base and proposed an alternative interpretation that we suggested was at least as compatible with the available data as the more widely held view. In doing so, (...) we attempted to illustrate that the inadequacy of present experimental designs did not permit us to distinguish between equally viable hypotheses. In the four years since we wrote the first draft of our target article, hundreds of additional studies on LTP have been published and their results have been incorporated into current theories about memory. A diverse group of commentators responded to our target article with their own theories of how memories might be stored in the brain, some of which rely on LTP. Some commentators doubted whether memories can be stored through modifications of synaptic strength. Some assert that it will never be possible to understand the neural mechanisms of memory; still others remain hopeful that we will accomplish some semblance of a resolution, provided we appreciate LTP's role in a subset of seemingly amorphous memory systems. In summary, although it is commonly written that “LTP is a memory storage device,” the divergence of views among the commentators suggests, at least as strongly as our target article, that such conviction is unwarranted and fails to acknowledge both the lack of consensus regarding the role of LTP in memory and the complexity of the phenomenon of memory itself. (shrink)

Recent public hearings on misconduct charges belie the conjecture that due process will perforce defeat informed scientific reasoning. One notable case that reviewed an obtuse description of experimental methods displays some of the subtleties of differentiating carelessness from intent to deceive. There the decision of a studious nonscientist panel managed to reach sensible conclusions despite conflicting expert testimony. The significance of such a result may be to suggest that to curtail due process would be both objectionable and unproductive.

The integration of artificial intelligence (AI) into healthcare and research introduces sophisticated diagnostic and treatment capabilities but also raises significant ethical challenges from development to deployment and evaluation, requiring comprehensive ethical training and interdisciplinary collaboration to ensure the responsible use of AI technologies. The “CONNECT with AI”- Collaborative Opportunity to Navigate and Negotiate Ethical Challenges and Trials with Artificial Intelligence) workshop was a three-day event, engaging multi-institutional interdisciplinary and interprofessional participants (both industry professionals and academicians) from diverse fields such as (...) Medicine, Dentistry, Nursing, Engineering, Law, and Allied Health Sciences from India. There was equal distribution of participants from diverse fields. A mixed-method approach utilizing pre- and post-workshop assessments, confidence level surveys and thematic analyses of small group discussions and open-ended questions to evaluate the impact of the workshop on participants’ ethical understanding and decision-making skills regarding AI. Post-workshop evaluations indicated a significant improvement in both theoretical knowledge and practical application of AI ethics, with assessment scores rising markedly from pre-workshop levels (p < 0.0001). Confidence in handling ethical dilemmas related to AI saw substantial increases across all domains, particularly in ensuring patient privacy and data security (p < 0.0001). Qualitative feedback highlighted diverse perceptions and sector-specific concerns about AI, emphasizing the importance of customized ethical guidelines and the integration of AI into healthcare practices. The workshop effectively enhanced participants’ competence and confidence in addressing AI-related ethical issues, demonstrating the critical role of interprofessional education in fostering an ethical AI implementation framework. Continuous, interdisciplinary and interprofessional training is essential to navigate the evolving ethical landscape of AI in healthcare, ensuring safe, effective, and responsible technology use. (shrink)

Michaël Crevoisier : Fraichement retraité, vous avez été Maître de conférences au département de philosophie de l’Université de Franche-Comté. Toute votre carrière, mais en réalité déjà vos études, se sera déroulée ici, à Besançon. Je souhaiterais donc commencer par cette ville, cet ancrage. Est-ce que cela revêt une signification particulière pour vous? Et s’il fallait nous le rappeler en quelques mots, qu’avez-vous fait et vécu à Besançon à travers vos travaux philosophiques? Louis Uccian...

The integration of artificial intelligence into bioethics education represents a new pedagogical approach that addresses complex moral issues in healthcare. The use of AI-driven platforms like ChatGPT in bioethics education can enhance critical thinking and decision-making skills among students by providing a diverse range of perspectives and solutions. To assess the ability of ChatGPT-4 to understand and resolve ethical dilemmas using validated clinical case vignettes, thereby determining its suitability as a teaching aid in bioethics. Ten clinical scenarios, each with inherent (...) ethical issues, were presented to ChatGPT-4. These scenarios were expert-validated to ensure relevance and complexity. ChatGPT's responses were evaluated by two blinded external raters to eliminate bias. The assessment criteria included identification of bioethical principles, recognition of stakeholders and their outcomes, and comprehension of ethical and legal frameworks. Additionally, the quality of responses was scored on a scale of 1–10. ChatGPT showed proficiency in identifying the pertinent bioethical principles and stakeholders involved in the ethical dilemmas presented. It achieved an overall score of 84.5%, with high marks for its analytical capabilities in complex scenarios. However, the study identified areas for improvement, particularly in proposing comprehensive solutions and alternative actions. ChatGPT demonstrates potential as an effective tool for bioethics education, capable of guiding learners through the resolution of ethical issues in clinical practice. However, to fully integrate ChatGPT into bioethics education, it requires enhancements in delivering detailed, actionable guidance in ethical decision-making. Future development should focus on refining ChatGPT’s ability to offer nuanced solutions aligned with patient values and clinician needs. (shrink)

Socially responsible investing (SRI) is the practice of making investment decisions on the basis of both financial and social performance. The SRI movement has grown into a $1.185 trillion business, accounting for about 1 in 10 U.S. invested dollars. Not surprisingly, the industry has suffered severe growing pains along the way in the form of issues of credibility, demand, and performance. And, to date, the product itself has been limited to equity investing. This article explores these critical issues and whether (...) socially screened bonds can perform as well as or better than unscreened bonds. If so, whole new sets of opportunities are open to the social investor bent on making a buck and a difference. (shrink)

La logique de Leibniz: d'apres des documents inedits / par Louis Couturat,...Date de l'edition originale: 1901Sujet de l'ouvrage: Leibniz, Gottfried Wilhelm (1646-1716)Logique moderneCollection: Collection historique des grands philosophesCe livre est la reproduction fidele d'une oeuvre publiee avant 1920 et fait partie d'une collection de livres reimprimes a la demande editee par Hachette Livre, dans le cadre d'un partenariat avec la Bibliotheque nationale de France, offrant l'opportunite d'acceder a des ouvrages anciens et souvent rares issus des fonds patrimoniaux de la (...) BnF.Les oeuvres faisant partie de cette collection ont ete numerisees par la BnF et sont presentes sur Gallica, sa bibliotheque numerique.En entreprenant de redonner vie a ces ouvrages au travers d'une collection de livres reimprimes a la demande, nous leur donnons la possibilite de rencontrer un public elargi et participons a la transmission de connaissances et de savoirs parfois difficilement accessibles.Nous avons cherche a concilier la reproduction fidele d'un livre ancien a partir de sa version numerisee avec le souci d'un confort de lecture optimal. Nous esperons que les ouvrages de cette nouvelle collection vous apporteront entiere satisfaction.Pour plus d'informations, rendez-vous sur www.hachettebnf.frhttp: //gallica.bnf.fr/ark: /12148/bpt6k110843d. (shrink)

- "Le reve est toujours en avance sur la vie" -, ecrit Louis Althusser a Claire, une de ses passions.Au moment d ecrire son autobiographie, "L Avenir dure longtemps," en 1985, dans laquelle il cherche a comprendre et expliquer le meurtre de sa femme Helene Rytmann, Louis Althusser a consulte l ensemble des recits de reves, dont certains etrangement premonitoires du drame de novembre 1980. Il les avait soigneusement conserves dans ses archives, avec des notes sous la forme (...) d un journal, prises et redigees avant ou apres des seances avec ses differents psychanalystes.C est cet ensemble de reves que nous donnons ici, avec l espoir que leur lecture et interpretation permettra de mieux comprendre les processus qui ont conduit Louis Althusser a commettre l acte irreparable qui a fait du philosophe un meurtrier."- Quand je suis sorti du reve, il n y avait plus rien, ecrit-il dans un de ses recits de reve, rien qu un bruit de sabots dans la gorge. Rien qu une main qui dessinait sans fin dans l air comme un contour. -"En epilogue parait ici pour la premiere fois un texte fascinant intitule "Un meurtre a deux" la note attribuee par Althussera son psychiatre traitant apres le meurtre de sa femme Helene - mais dont tout donne a penser qu'elle est en realite un dialogue avec lui-meme.". (shrink)

Le De Veritate de Herbert de Cherbury (1624) et son idée d’un « consentement universel » ont fait l’objet, au xvii e siècle, d’une importante discussion. Après avoir examiné la critique, d’inspiration sceptique, voyant dans toute tentative de passer outre la diversité de l’« opinion commune » une forme d’intolérance épistémique, sont restituées les grandes décisions qui, dans le De Veritate, justifient le recours au consentement universel. Enfin, on montre que Descartes, ne trouvant pas chez Herbert de critère suffisant pour (...) distinguer une « notion commune » d’une erreur universellement partagée, substitue la « lumière naturelle » au consentement universel et l’idée d’un « sens commun à tous » à la tyrannie d’une opinion particulière se donnant l’allure de l’universel. (shrink)