ABSTRACT Pharmacogenetics is a rapidly expanding area of research exploring the relationship between inter‐individual genetic variation and drug response, with the goal of developing genetically optimised therapies. Slippery slope arguments claim that a particular action should be rejected (or supported) because it might be the first step onto a slippery slope leading to undesirable (or desirable) consequences. In this article, several slippery slope arguments relevant to the context of pharmacogenetics are evaluated under consideration of underlying reasons for their popularity. The (...) author concludes that although the examined arguments are unconvincing as slippery slope arguments, they do matter in this context. While positive slippery slope arguments serve as a driving force to fuel the development of pharmacogenetics, their negative counterparts play an important role to sensitise policy makers and the public to potential problems. (shrink)

The paper focuses on the difference between event‐conditionals and premise‐conditionals. An event‐conditional contributes to event structure: it modifies the main clause event; a premise‐conditional structures the discourse: it makes manifest a proposition that is the privileged context for the processing of the associated clause. The two types of conditional clauses will be shown to differ both in terms of their ‘external syntax’ and in terms of their ‘internal syntax’. The peripheral structure of event conditionals will be shown to lack the (...) functional head Force, which encodes illocutionary force. Event conditionals are merged inside the IP of the matrix clause. Premise‐conditionals contain the head Force and they are merged outside the associated CP. (shrink)

This paper takes Zahavi’s view to task that every conscious experience involves a “minimal sense of self.” Zahavi bases his claim on the observation that experience, even on the pre-reflective level, is not only about the object, but also has a distinctive qualitative aspect which is indicative of the fact that it is for me. It has the quality of what he calls “for-meness” or “mineness.” Against this I argue that there are not two phenomena but only one. On the (...) pre-reflective level, experience is transparent. Conscious experience may well be reflexive but this does not imply that I additionally have a sense of what it is like for me to have that experience. I do not just happen to disagree with Zahavi’s account of pre-reflective experience but, more importantly, I am concerned that he imposes it onto his interpretation of Edmund Husserl. Zahavi claims that when Husserl argues that consciousness is necessarily a form of self-consciousness, he must be committed to the view that we necessarily have a sense of ownership. However, Husserl only claims that I am self-conscious but not that I am a self that owns its consciousness. Zahavi thus misses the novelty of Husserl’s position, namely that I do not need to have a sense of abiding ownership, to have experience. (shrink)

Corporate social responsibility has become a much-discussed subject in the business world. The Internet has become one of the main tools for CSR information disclosure, allowing companies to publicise more information less expensively and faster than ever before. As a result, corporations are increasingly concerned with communicating ethically and responsibly to the diversity of stakeholders through the web. This paper addresses the main question as whether CSR information disclosure on corporate websites is influenced by country of origin and/or industry sector. (...) Analysing the websites of 127 corporations from emerging countries, such as Brazil, Chile, China, India, Indonesia, Mexico, Thailand and South Africa, it becomes evident that both country of origin and industry sector have a significant influence over CSR information disclosure on the web . Based on the data studied, country of origin has a stronger influence over CSRIDOW than industry sector. (shrink)

Michel Serres’s philosophy of entropy takes what he famously calls the ‘Northwest Passage’ between the sciences and the humanities. By contextualizing his approach to entropy and affirming the role of a philosophy of difference, this paper explores Serres’s approach by means of ‘entropic differences’. It claims that entropy – or rather, entropies – provide Serres with a paradigmatic case for critical translations between different domains of knowledge. From his early Hermès series, through to The Birth of Physics and later writings (...) on social and ethical themes, he keeps thermodynamical and informational – or ‘hard’ and ‘soft’ – understandings of entropy apart, while simultaneously exploring their relation. By focusing on the systematic significance of Serres’s ‘entropic difference’, this paper shows how it unfolds not necessarily as an ontological difference but as an operative function between the history and philosophy of science, epistemology, and a theory of negentropic (inter)subjectivity. (shrink)

This article focuses on scientific integrity and the identification of predisposing factors to scientific misconduct in Brazil. Brazilian scientific production has increased in the last ten years, but the quality of the articles has decreased. Pressure on researchers and students for increasing scientific production may contribute to scientific misconduct. Cases of misconduct in science have been recently denounced in the country. Brazil has important institutions for controlling ethical and safety aspects of human research, but there is a lack of specific (...) offices to investigate suspected cases of misconduct and policies to deal with scientific dishonesty. (shrink)

Although historians and philosophers of science usually try to explain the acceptance or rejection of hypotheses or theories by scientists, there are no well definite criteria to evaluate when a scientist accepts or rejects a theory/hypothesis. This work proposes a new method of analysis. The attitudes of scientists towards a theory or hypothesis are classified according to three dimensions (cognitive, instrumental and strategic). This method is exemplified by the study of the attitude of the British naturalist William Bateson (1861-1924) towards (...) chromosome theory. The analysis shows that Bateson never rejected the chromosome theory – a conclusion opposite to most historical accounts. RESUMEN: Los historiadores y los filósofos de la ciencia intentan explicar la aceptación o lo rechazo de determinadas hipótesis ó teorías por los científicos, pero no hay criterios claros que nos permitan decir lo qué es aceptación o rechazo. Este trabajo propone un nuevo método de análisis. Las actitudes de los investigadores son analizadas en relación a tres dimensiones (cognitiva, instrumental y estratégica). El método es ejemplificado por el estudio de la postura del naturalista inglés William Bateson (1861-1924) frente a la teoria cromosómica. El análisis que se realizó permitió verificar que Bateson jamás rechazó la teoría cromosómica, en contrario de lo que la mayoría de los historiadores afirman. (shrink)

This paper discusses corporate entanglement, impactfulness and responsibility in the Anthropocene, amidst events and conditions that ‘uncontain’ time. It takes its direction of travel from artist Brian Jungen’s ‘Cetology’ (2002), a whalebone sculpture made out of cut-up plastic garden chairs, which conjoins the times of earth and world history, as it hangs in the air of the art gallery, ‘as if’ exhibited in the natural history museum. The paper relates ‘Cetology’s’ engagement with natural history, time, and commodification to matters of (...) corporate entanglement and responsibility within company law and governance. Problems with understanding the comparable imprint of large and multinational companies on matters, places, and communities are identified, after the domination of corporate legal frameworks over nature and the stability and perfection of economic incentives at law. The reading of this (critical-legal) situation is developed through theory and engagement with materialist and critical thinkers, who unite in their concern with distributed human–nature relations and the ‘concreteness’ that attends collisions in time, ruin and affect. Walter Benjamin and Theodor Adorno’s writings are central to this analysis, and strengthen the commentary on ‘natural history’ themes curated by Jungen. The paper contemplates how times’ uncontainment might invoke a change in expectation and method for the company law field, assigning contingency to the corporation and provoking a new mode of reflection about corporate entanglement and responsibility at law. (shrink)

The article re-examines the relationship between the works of Alfred Schütz and Harold Garfinkel, focusing on their respective approaches to temporality in interaction. Although there are good reasons to emphasize the differences between Schütz’s notion of individual projects of action and Garfinkel’s interest in communicative sequencing, there is also an interesting historical connection. In order to elucidate this connection, the article provides a close reading of the steps that lead Schütz from his premise of ‘egological’ time consciousness to his understanding (...) of the reflexive and interactive process of meaning establishment and interpretation developed in his first book, _The Phenomenology of the Social World_ (1967 [1932]). The article reflects further upon which aspects of Schütz’s considerations resonated with Garfinkel in his formative years and how Garfinkel related to them variously in his later development of ethnomethodology. Hence, it appears that Garfinkel’s ethnomethodology successively departs from many of Schütz’s premises while simultaneously incorporating and further developing some of his notions on the sequential organization and temporal flux of interactive processes. (shrink)

Michel Henry wishes to salvage Descartes’s first principle ‘I think, I am’ by claiming that there is no need to appeal to the world or others to make sense of the self. One of his main targets is Edmund Husserl, who claims that thought is necessarily intentional and thus necessarily about something that is other to thought. To show that this is not so, Henry draws on passages from Descartes’s texts which emphasize that we should not equate the cogito with (...) thinking but with sensation and imagination. This allows Henry to explore the notion that the self has its own form of manifestation. This paper questions Henry’s reading of Descartes and his critique of Husserl on two fronts. First, the passages Henry draws upon, if anything only confirm, rather than question Husserl’s claim that consciousness is intentional. Second, Henry believes that he can show that the life of the self is infinitely rich without having to appeal to other persons or, indeed, to the world. Yet, I wish to contend that Henry is mistaken: as Husserl has shown convincingly, a life without others and the world is not only impoverished and bereft of meaning, but remains entirely indeterminate. The self only manifests itself with respect to others and the world. (shrink)

Psychopathic individuals are characterized by impaired affective processing, impulsivity, sensation-seeking, poor planning skills and heightened aggressiveness with poor self-regulation. Based on brain self-regulation studies using neurofeedback of Slow Cortical Potentials (SCPs) in disorders associated with a dysregulation of cortical activity thresholds and evidence of deficient cortical functioning in psychopathy, a neurobiological approach seems to be promising in the treatment of psychopathy. The results of our intensive brain regulation intervention demonstrate, that psychopathic offenders are able to gain control of their brain (...) excitability over fronto-central brain areas. After SCP self-regulation training, we observed reduced aggression, impulsivity and behavioral approach tendencies, as well as improvements in behavioral-inhibition and increased cortical sensitivity for error-processing. This study demonstrates improvements on the neurophysiological, behavioral and subjective level in severe psychopathic offenders after SCP-neurofeedback training and could constitute a novel neurobiologically-based treatment for a seemingly change-resistant group of criminal psychopaths. (shrink)

Phenomenology questions the centrality that Kant attributes to the “I think.” It claims that on the pre-reflective level experience is selfless as unity is given. I call this the “unity argument.” The paper explores the significance of this claim by focusing on the work of Edmund Husserl. What interests me is that although the unity argument claims that we can account for the unity of experience without appealing to the an “I think,” Husserl agrees with Kant that experience must be (...) owned. Moreover, he endorses Kant's dictum that ‘the “I think” must be capable of accompanying all my presentations’. The aim of the paper is to explore how Husserl can consistently appeal to Kant's account of the “I think” and at the same time contend that on the pre-reflective level experience is selfless. The thesis I wish to advance is that although the unity argument acknowledges that experience is necessarily mine, it reveals that it is a necessary feature of self-reference that I have never taken absolute ownership over my experience. This may explain why our sense of self can often be out of tune with the way we live our lives. (shrink)

Corporate social responsibility (CSR) has become a much-discussed subject in the business world. The Internet has become one of the main tools for CSR information disclosure, allowing companies to publicise more information less expensively and faster than ever before. As a result, corporations are increasingly concerned with communicating ethically and responsibly to the diversity of stakeholders through the web. This paper addresses the main question as whether CSR information disclosure on corporate websites is influenced by country of origin and/or industry (...) sector. Analysing the websites of 127 corporations from emerging countries, such as Brazil, Chile, China, India, Indonesia, Mexico, Thailand and South Africa, it becomes evident that both country of origin and industry sector have a significant influence over CSR information disclosure on the web (CSRIDOW). Based on the data studied, country of origin has a stronger influence over CSRIDOW than industry sector. (shrink)

Although Confucianism is a resilient cultural tradition in Asian societies, its role in their corporate governance systems is ambiguous. Confucian values have been pushed to the periphery because of a preoccupation in these countries to emulate corporate governance systems from the West. This article argues that Confucianism has much to offer in enhancing director conduct and corporate governance standards. As the attention of the global business community turns eastwards, it is opportune to revive interest in Confucianism and to explore ways (...) in which it can be integrated formally into companies' governance systems. (shrink)

The ability to sequence individual genomes is leading to the identification of an increasing number of genetic risk factors for serious diseases. Knowledge of these risk factors can often provide significant medical and psychological benefit, but also raises complex ethical and social issues. This paper focuses on one area of rapid progress: the identification of mutations causing long QT syndrome and other cardiac channel disorders, which can explain some previously unexplained deaths in infants (SIDS) and children and adults (SUDS) and (...) prevent others from occurring. This genetic knowledge, discovered posthumously in many cases, has implications for clinical care for surviving family members who might carry the same mutations. The information obtained from genetic testing, in the context of personal and family history, can guide individually tailored interventions that reduce risk and save lives. At the same time, obtaining and disclosing genetic information raises difficult issues about confidentiality and decision making within families. We draw on the experience of the Montefiore-Einstein Center for Cardiogenetics, which has played a leading role in the genetic diagnosis and clinical management of cardiac channel diseases, to explore some of the challenging ethical questions arising in affected families with adolescent children. We focus on the related issues of (1) family confidentiality, privacy and disclosure and (2) adolescent decision making about genetic risk, and argue for the value of interdisciplinary dialogue with affected families in resolving these issues. (shrink)

In recent years there has been a general attempt – inspired by P. F. Strawson – to naturalise Kant's notion of the transcendental self. The argument being that self-consciousness should refer to neither a kind of noumenal nor mental self but that the self-conscious subject must conceive of itself as an embodied entity, a person among persons that regards itself as an element of the objective order of the world. While Kant does not make room for the notion of an (...) embodied transcendental self, this is where we need to go as our bodily awareness is central both for self-knowledge and the possibility of cognition and thus a transcendental condition for knowledge claims. In this paper I should like to single out Quassim Cassam's work Self and World to see whether such a position is tenable. Cassam's main claim is that we can only become aware of ourselves as subjects if we are at the very same time aware of ourselves as objects located in the spatio-temporal world. We could not be self-conscious and ascribe experiences to ourselves unless we are also aware of ourselves as a physical object among other physical objects in the world. The central claim is that when we self-refer we do not refer to two distinct entities, one possessing only mental, and the other possessing only physical features, rather we refer to a subject that is both mental and physical at the very same time. Awareness of ourselves qua subject is just awareness of ourselves qua object. This paper will focus on this claim alone and will ask whether it is tenable. The answer will be negative. Drawing on the work of Edmund Husserl, I shall argue that there is an inherent flaw in Cassam's position which he has inherited from Gareth Evans’ depiction of the self. The contention will be that our awareness of ourselves qua subject is not compatible with the awareness of ourselves qua object. (shrink)

This paper asks whether we should still be haunted by scepticism about other minds. It draws on the writings of Cavell and Husserl to show that there is some truth in the Cartesian premise that has given rise to scepticism about other minds, namely, that our self-awareness is of a fundamentally different type from our awareness of objects and other subjects. While this leads Cavell to argue that there is a truth to scepticism, it proves the opposite to Husserl, viz. (...) that other minds scepticism is necessarily non-sensical. The paper shows why Husserl's position is more convincing than Cavell's. 1. (shrink)

Tendo em vista as questões relacionadas à literatura e suas inúmeras possibilidades de materialização, este trabalho debruça-se em analisar a intertextualidade presente entre o livro O Pequeno Príncipe, de Antoine Saint-Exupéry e o filme de mesmo título de Mark Osborne, focando-se, especificamente, na figura das personagens protagonistas. Embora trate-se de materialidades diferentes e que ocorra, de certa forma, a quebra de expectativa do leitor quanto à representação literal da obra literária no filme, nosso interesse é por buscar nas personagens infantis (...) marcas da intertextualidade que as constituem como uma só enquanto ser criança e pensar em como esses elementos funcionam no texto para construir um saber sobre a infância, em diferentes épocas.Palavras-chave: O Pequeno Príncipe. Infância. Intertextualidade. Personagem. (shrink)

La présente contribution analyse dans quelle mesure une approche de précaution permettant de mettre en balance des intérêts de libéralisation commerciale et des préoccupations de diversité culturelle peut être caractérisée en droit international, sous quelles formes et par quels mécanismes. Elle examine l’application d’une telle approche en matière de commerce international en mettant en lumière le besoin de prudence dans l’articulation entre « commerce et culture », ainsi que la manière dont le droit international de la culture peut légitimer et (...) renforcer une telle approche. (shrink)

Un concepto que solía pertenecer al mundo de la informática (hacking) ahora se combina con las ciencias de la vida (bio). Sin gran dificultad, hemos empezado a ver la vida como un conjunto de datos, el ADN como un código, el cuerpo como una máquina y la mente como un software... todos susceptibles de ser leídos, manipulados y ahora incluso hackeados. ¿Pero manipulados por quiénes? Las comunidades de biohackers y DYIbio (do-it-yourself biology) quieren la biotecnología disponible para todos y la (...) información compartida abiertamente. En este trabajo, propongo una reflexión sobre qué está pasando y el posible por qué. En la primera parte, presento el biohacking como un fenómeno social, dando algunos ejemplos de biohackers y diferenciando tipos de biohackers. En la segunda parte, hago un acercamiento al Transhumanismo. La existencia de biohackers sólo es posible gracias a la creciente disponibilidad de información y biotecnología combinada con una cierta mentalidad. El principal objetivo es profundizar en la reflexión sobre la relación entre biohacking y Transhumanismo. Analizo el biohacking como una de las expresiones de este movimiento y uno de los fenómenos que contribuyen a él. Al final, ofrezco una reflexión sobre la cultura, deseos y miedos de nuestra sociedad, reconociendo también algunas de las preguntas que ellos provocan. (shrink)

En Giving Reasons: A Linguistic-pragmatic-approach to Argumentation Theory (Springer, 2011), propongo un nuevo modelo para la evaluación semántica y pragmática de la argumentación. Este modelo se basa en una caracterización de la argumentación como un acto de habla compuesto de segundo orden. Explico las ventajas de este modelo respecto de otras propuestas dentro de la Teoría de la Argumentación, tales como la Pragma-dialéctica, la Lógica Informal, la Nueva Retórica o el Enfoque Epistémico.