L'esthétique, en tant que discipline philosophique traitant de l'art née au sein de la culture occidentale, n'a été introduite que tardivement dans les autres cultures, notamment asiatiques, où existaient pourtant de longue date des notions, formulées dans leurs langues pour rendre compte de l'expérience esthétique et évaluer les oeuvres artistiques. Alors, ne peut-on trouver, des résonances entre langages artistiques entre l'Asie et l'Occident? Tel est le pari qui sous-tend le recueil de textes rassemblés ici.

The practice and development of modern medicine requires large amounts of data, particularly in the domain of cancer. The future of personalized medicine lies neither with “genomic medicine” nor with “precision medicine”, but with “data medicine”. The establishment of this DM has required far-reaching changes, to establish four essential elements connecting patients and doctors: biobanks, databases, bioinformatic platforms and genomic platforms. The “transformation” of scientific research areas, such as genetics, bioinformatics and biostatistics, into clinical specialties has generated a new vision (...) of care. Molecular tumor boards are one response to these changes and are now providing better access to next-generation sequencing and new cancer treatments to patients with inoperable or metastatic cancers, and those for whom the usual treatment has failed. However, MTB face a crucial ethical challenge: maintaining and improving the trust of patients, clinicians, researchers and industry in academic medical centers supported by private or public funding rather than providing genetic data directly to private companies. We believe that, in this era of DM, appropriate modern digital communication networks will be required to maintain this trust and to improve the organization and effectiveness of the system. There is, therefore, a need to reconsider the form and content of informed consent documents at all academic medical centers and to introduce dynamic and electronic informed consent. (shrink)

The hypnosis technique is currently used in the medical field and influences directly the patient's state of relaxation, perception of the body and its visual imagination. There is evidence to suggest that hypnosis state may help patients to better achieve the task of motor imagination, which is central in rehabilitation protocols after a stroke. However, the hypnosis technique could also alter the activity in motor cortex. To the best of our knowledge, the impact of hypnosis on the EEG signal during (...) a movement or an imagined movement is poorly investigated. In particular, how event-related desynchronization (ERD) and event-related synchronization (ERS) patterns would be modulated for different motor tasks may provide a better understanding of the potential benefits of hypnosis for stroke rehabilitation. To investigate this purpose, we recorded EEG signals from 23 healthy volunteers who performed real movements and motor imageries in closed eye condition. Our results suggest that the state of hypnosis changes the sensorimotor beta rhythm during the ERD phase but maintains the ERS phase in the mu and beta frequency band suggesting a different activation of the motor cortex in the hypnotized state. (shrink)

Si l’on peut définir l’homme comme un animal qui interprète tant la réalité que lui-même, c’est que l’on pense qu’il a au monde, aux autres et à lui-même un rapport qui passe essentiellement par la compréhension. Ce n’est cependant pas sur ce niveau fondamental que nous avons pris le parti de faire porter la réflexion dans ce numéro. Il ne s’agissait pas, ou du moins pas principalement, de s’interroger sur ce qu’il en est de l’être de l’homme qui interprète ou (...) de faire ressortir toutes les di. (shrink)

Many studies require standardized and replicable protocols composed of emotional stimuli. To this aim, several databases of emotional pictures are available. However, there are only few images directly depicting interpersonal violence, which is a specific emotion evocative stimulus for research on aggressive behavior or post-traumatic stress disorder. The objective of the current study is to provide a new set of standardized stimuli containing images depicting interpersonal situations. This will allow a sensitive assessment of a wide range of cognitions linked to (...) social interaction. To this aim, 240 participants rated the valence and arousal of 79 pictures collected from online sources in 2018. Results showed a distinctive pattern of valence and arousal regarding the picture content and specific associations between those two dimensions. Taken together, these results suggest a good reliability of the selected images. In conclusion, our study provides an open access set of recent pictures depicting interpersonal situations along with normative valence and arousal ratings, that are available for download from: https://osf.io/ak4m7/?view_only=None. (shrink)

What we pay attention to is influenced by both reward learning and aversive conditioning. Although early attention tends to be biased toward aversively conditioned stimuli, sustained ignoring of such stimuli is also possible. How aversive conditioning influences how a person chooses to search, or the strategic control of attention, has not been explored. In the present study, participants learned an association between a colour and an aversive outcome during a training phase, and in a subsequent test phase searched for one (...) of two targets presented on each trial; one target was rendered in the aversively conditioned colour (CS+) and the other in a neutral colour (CS-). Given the distribution of colour stimuli in the search array, it was more optimal to search for and report a target in one of the two colours on some trials. Our results demonstrate that participants were biased away from the CS+ target, which resulted in non-optimal search on some trials. Surprisingly, rather than accentuate this bias, greater state anxiety was associated with a stronger tendency to find and report the CS+ target. Our findings have implications for our understanding of the learning-dependent control of attention and abnormal attentional biases observed in high-anxious individuals. (shrink)

Building a meaningful model of biological regulatory network is usually done by specifying the components and their interactions, by guessing the values of parameters, by comparing the predicted behaviors to the observed ones, and by modifying in a trial-error process both architecture and parameters in order to reach an optimal fitness. We propose here a different approach to construct and analyze biological models avoiding the trial-error part, where structure and dynamics are represented as formal constraints. We apply the method to (...) Hopfield-like networks, a formalism often used in both neural and regulatory networks modeling. The aim is to characterize automatically the set of all models consistent with all the available knowledge. The available knowledge is formalized into formal constraints. The latter are compiled into Boolean formula in conjunctive normal form and then submitted to a Boolean satisfiability solver. This approach allows to formulate a wide range of queries, expressed in a high level language, and possibly integrating formalized intuitions. In order to explore its potential, we use it to find cycles for 3-nodes networks and to determine the flower morphogenesis regulatory network of Arabidopsis thaliana. Applications of this technique are numerous and concern the building of models from data as well as the design of biological networks possessing specified behaviors. (shrink)

Stroke is a severe health issue, and motor recovery after stroke remains an important challenge in the rehabilitation field. Neurofeedback, as part of a brain–computer interface, is a technique for modulating brain activity using on-line feedback that has proved to be useful in motor rehabilitation for the chronic stroke population in addition to traditional therapies. Nevertheless, its use and applications in the field still leave unresolved questions. The brain pathophysiological mechanisms after stroke remain partly unknown, and the possibilities for intervention (...) on these mechanisms to promote cerebral plasticity are limited in clinical practice. In NFB motor rehabilitation, the aim is to adapt the therapy to the patient’s clinical context using brain imaging, considering the time after stroke, the localization of brain lesions, and their clinical impact, while taking into account currently used biomarkers and technical limitations. These modern techniques also allow a better understanding of the physiopathology and neuroplasticity of the brain after stroke. We conducted a narrative literature review of studies using NFB for post-stroke motor rehabilitation. The main goal was to decompose all the elements that can be modified in NFB therapies, which can lead to their adaptation according to the patient’s context and according to the current technological limits. Adaptation and individualization of care could derive from this analysis to better meet the patients’ needs. We focused on and highlighted the various clinical and technological components considering the most recent experiments. The second goal was to propose general recommendations and enhance the limits and perspectives to improve our general knowledge in the field and allow clinical applications. We highlighted the multidisciplinary approach of this work by combining engineering abilities and medical experience. Engineering development is essential for the available technological tools and aims to increase neuroscience knowledge in the NFB topic. This technological development was born out of the real clinical need to provide complementary therapeutic solutions to a public health problem, considering the actual clinical context of the post-stroke patient and the practical limits resulting from it. (shrink)

This is the first volume of a two-volume project whose aim is to publish all the known Middle English manuscript translations of the French Somme le mi, a thirteenth-century manual of religious instruction offering teaching on the Decalogue, the seven deadly sins and their remedies, compiled by the Dominican friar Laurent of Orleans. The project extends and deepens our knowledge of the influence of this popular French text, known today only from the versions entitled The Ayen bite of Inwit (...) and The Book of Vices and Virtues, published in 1866 and 1942, respectively. This volume presents the versions extant in BL MSS Royal 18. A. x and Add. 37677; the second will cover the versions in Cambridge, Corpus Christi College, MS 494, Oxford, Bodleian Library, MS Ashmole 1286, and Oxford, Bodleian Library, MS e Musaeo 23. The texts of both volumes have been prepared with the help of the recently-published edition of the French text, a circumstance from which the earlier English editions were unable to benefit. It is likely that the versions edited here for the first time will make a considerable contribution to our understanding of the processes of textual transmission and to that of translation itself in English literary circles of the fifteenth century. (shrink)

Shaul Magid's Meir Kahane: The Public Life and Political Thought of an American Jewish Radical (2021) stresses the American character of Kahane's thought. This review analyzes this claim in two ways. First, it offers a transnational perspective on Kahane's philosophy. Second, it examines Magid's concept of neo‐Kahanism in light of Kahane's legacy in Israel.

chapter The whole and its parts Towards a holistic understanding of language Human beings are social entities. We are a family member, a brother or a sister ...

Science indicators are increasingly used in policy-making. However, failure to relate interpretations of specific measures to the historical development of science can lead to errors in assessing past investments and in prioritizing future investments. This article outlines some of these sources of error, and argues for the more systematic use of historical evidence in the formulation of science policy.

Résumé Où va la peinture est un livre de Laurent Marissal qui se présente à la fois comme un traité sur la peinture et comme une œuvre peinte. Les actions qu’il relate sont elles-mêmes revendiquées comme des actions picturales. L’article s’interroge sur ces usages hétérodoxes de la notion de « picturalité », tout d’abord au niveau de la mise en forme narrative du livre, puis à celui des actions que cette forme a pour dessein de relater. Une dernière partie (...) étudie la relation du travail de Laurent Marissal avec le courant du narrative art. (shrink)

The purpose of this paper1 is to rationalise why and how philosophy can help today’s managers in their daily practices. I will first explain why today’s managers particularly should engage themselves in profound and enduring dialogue with philosophers. To this end, I will present the close links between the major managerial activities and the major philosophical domains. In the second section, I will sketch out how such a dialogue can be facilitated. To this end, I will present some of the (...) methods and conditions used to ensure the success of the practice of philosophy in organisations. (shrink)

The traditional characterization of Charles Darwin as a strong advocate of physiological experimentation on animals was posited in Richard French’s Antivivisection and medical science in Victorian England, where French portrayed him as a soldier in Thomas Huxley’s efforts to preserve anatomical experimentation on animals unfettered by government regulation. That interpretation relied too much on, inter alia, Huxley’s own description of the legislative battles of 1875, and shared many historians’ propensity to foster a legacy of Darwin as a leader among a (...) new wave of scientists, even where personal interests might indicate a conflicting story. Animal rights issues concerned more than mere science for Darwin, however, and where debates over other scientific issues failed to inspire Darwin to become publicly active, he readily joined the battle over vivisection, helping to draft legislation which, in many ways, was more protective of animal rights than even the bills proposed by his friend and anti-vivisectionist, Frances Power Cobbe. Darwin may not have officially joined Cobbe’s side in the fight, but personal correspondence of the period between 1870 and 1875 reveals a man whose first interest was to protect animals from inhumane treatment, and second to protect the reputations of those men and physiologists who were his friends, and who he believed incapable of inhumane acts. On this latter point he and Cobbe never did reach agreement, but they certainly agreed on the humane treatment of animals, and the need to proscribe various forms of animal experimentation. (shrink)

The relationship between statistical mechanics and population genetics has a long history. Both take advantage of statistics to address the behavior of large groups of entities. The main objective of this article is to assess the obstacles population genetics is meeting in its claim to explain biological phenomena from the conceptual apparatus of statistical mechanics according to two recent articles. Several tools available to the latter are missing in the former. Thus, in the absence of an adequate justification of the (...) relevance of the analogy and without the satisfaction of certain basic assumptions, I argue that the explanatory strategy of the analogously based model is seriously compromised. La relation entre mécanique statistique et génétique des populations a une longue histoire. À l’instar de la première, la seconde tire profit des statistiques afin de traiter le comportement des grands ensembles d’entités. L’objectif principal du présent article est d’identifier les obstacles que rencontre la génétique des populations dans sa prétention d’explication des phénomènes biologiques à partir de l’appareillage conceptuel de la mécanique statistique selon deux articles récents. Or, plusieurs outils dont dispose cette dernière manque à la première. Ainsi, en l’absence d’une justification adéquate de la pertinence de l’analogie et sans la satisfaction de certaines hypothèses fondamentales, je soutiens que la stratégie explicative du modèle analogue est sérieusement compromise. (shrink)

Dubreuil provocatively proposes an extremist rethinking of the limits of politics - toward a break from politics, the political and policies. He calls for a refusal of politics, suggesting a form of apolitics that would make our lives more liveable. The first chapter situates the refusal of politics in relation to different contemporary theoretical attempts to renew politics, and makes the case for a greater rupture. The second moment takes up what is liveable in life by way of apolitical experience, (...) in contrast to appropriations of the collective, including a discussion of the arts. Finally, Laurent Dubreuil draws up an incomplete inventory of means, forms of existence - often frail and fleeting - that make an exit toward atopia. (shrink)

Volume 28, Issue 5, September 2020, Page 944-965.

Nuclear pre‐mRNAs must be precisely processed to give rise to mature cytoplasmic mRNAs. This maturation process, known as splicing, involves excision of intron sequences and ligation of the exon sequences. One of the major problems in understanding this process is how splice sites, the sequences which form the boundaries between introns and exons, can be accurately selected. A number of studies have defined conserved sequences within introns which were later shown to interact with small nuclear ribonucleoproteins (snRNPs). However, due to (...) the simplicity of these conserved sequences it has become clear that other elements must be involved and a number of studies have indicated the importance of secondary structures within pre‐mRNAs. Using various examples, we shall show that such structures can help to specify splice sites by modifying physical distances within introns or by being involved in the definition of exons and, lastly, that they can be part of the regulation of alternative splicing. (shrink)

The opposition between community and society set out by Collingwood in hisNew Leviathan(1942) should be compared with the distinction betweenGemeinschaftandGesellschaftthat Tönnies had introduced in 1887. The debate on ideal types of social organizations apparently pertains to «pure sociology» and was continued by Durkheim and Weber. However, Collingwood's use of this distinction may be construed as an attack on the very idea of sociology in the name of the primacy of rational will.

Cognitive forms vary considerably as a human being detaches herself from what is closest and most personal and moves to communicate — in the broad sense of taking part in a common matter — across increasing relational distances. The article proposes to deal with the variety of cognitive formats which cannot `commonize' cognition to an equal degree, relating them to a set of regimes of engagement with the world that are identified in terms of the dependency between the human agent (...) and her environment. The good that engagement aims to guarantee orients how reality is grasped and specifies the format of what constitutes relevant information. This analysis offers new insight into the composition of communities as well as persons who have to cope with the plurality of cognitive formats and engagements from the very familiar to the most public. (shrink)

“Austrian” (or “Austro-German”) philosophy of language is characterized, among other things, by the following two features: (1) Problems of language are considered within the broader framework of an intentionality-based philosophy of mind—or, to put it more precisely, questions of meaning are considered as involving a quite articulated theory of intentions; (2) several aspects of such an account are explicitly presented as inspired by or somehow already at work in the Medieval Scholastic tradition. In this study we follow the track indicated (...) by these two features and use some “Austrian” reflections on the articulation between meanings and intentions as a “heuristic filter”, as it were, to shed a new and different light on some Medieval debates in philosophy of language on the relationship between significare and intendere. It will be roughly divided into three parts. We begin by singling out some distinctive tenets of the “Austrian” strategy aimed at describing the relationship between meaning and intentions (section I), and then turn to various Medieval texts from the 13th and 14th century dealing with the two related notions of significatio and intentio (section II). The upshot of our investigation is to show how, for both “Austrian” and Medieval philosophers of language (and beyond their differences), a proper understanding of linguistic meaning—in the twofold sense of words or sentences having a lexical content and utterances having a determinate pragmatic function—presupposes an account of what one could call the “agentive intentionality”, i.e. the complex intentionality proper to practical goal-directed human behaviours. Some final remarks about outcomes, meaning, scope and perspectives opened by the method applied will conclude the study (section III). (shrink)

This article argues that many situations in social life can be analyzed by their requirement for the justification of action. It is in particular in situations of dispute that a need arises to explicate the grounds on which responsibility for errors is distributed and on which new agreement can be reached. Since a plurality of mutually incompatible modes of justification exists, disputes can be understood as disagreements either about whether the accepted rule of justification has not been violated or about (...) which mode of justification to apply at all. The article develops a grammar of such modes of justification, called orders of worth (grandeur), and argues that the human capacity for criticism becomes visible in the daily occurrence of disputes over criteria for justification. At the same time, it is underlined that not all social situations can be interpreted with the help of such a sense of justice, which resides on a notion of equivalence. Regimes of love, of violence or of familiarity are systematically distinct from regimes of justification. (shrink)

While modern theories of emotion emphasize the role of higher-order cognitive processes such as semantics in human emotion, much research into emotional learning has ignored the potential contribut...

English summary: The collected essays in this volume examine the question of experience and consciousness in philosophy, from the ancient Greeks, Descartes, and German Idealism, to contemporary phenomenology. French description: Ce volume est consacre au concept de phenomene. Les etudes rassemblees se proposent de contribuer a son intelligence en revenant sur quelques-uns des moments les plus marquants de son histoire, sans pretendre a l'exhaustivite. L'ouvrage s'ouvre par deux etudes de philosophie antique. Arnaud Mace restitue tout d'abord la problematique seminale du (...) phenomene, telle qu'elle s'elabore chez les presocratiques (Homere, Anaxagore, Parmenide) et chez Platon. Baptiste Bondu etudie ensuite la question du phenomene dans l'ecole stoicienne. Suivent deux contributions qui expose, pour l'une, la philosophie cartesienne des phenomenes (Delphine Bellis) et examine, pour l'autre, les principes et les difficultes du phenomenisme de Berkeley (Luc Peterschmitt). Deux articles attestent du renouvellement de l'approche philosophique des phenomenes dans l'idealisme allemand. Francois Calori rappelle le role decisif joue par le criticisme et explicite la definition kantienne du phenomene comme objet indetermine d'une intuition empirique. Comme le souligne Olivier Tinland, Hegel compose avec le legs de la philosophie kantienne tout en deplacant le site meme de la reflexion conduite sur les phenomenes, puisqu'il refere desormais l'apparaitre a une idealite objective. Concernant la periode contemporaine, Laurent Perreau examine la redefinition du concept de phenomene operee par la phenomenologie husserlienne. Enfin, la contribution de Vincent Bontems est consacree a la philosophie de G. Bachelard: informee des developpements historiques de la science physique, cette derniere voit dans le phenomene le produit d'une construction a la fois theorique et experimentale. (shrink)

Laurent Stern here provides a concise account of the difficulties that arise within the interpretive process and in the context of interpretive conflict. Speakers and agents are expected by others to be occasionally insincere. Attempting to be tolerant of alternative interpretations, and dealing with the insincerity of others, often motivates interpreters themselves to become insincere. Accordingly, moral issues emerge for both speakers and interpreters. Interpretive Reasoning discusses such issues in the literature on interpretation. Stern offers a carefully argued account (...) of the very idea of interpretation. What are the constraints on interpretations? What are our grounds for demanding that others agree with our interpretations? How do we support our interpretations? What are the types of interpretations we encounter? How are problems of first-person authority and self-knowledge connected with interpreting? While the author argues for interpretations supported by principles rather than by the consensus of interpreters, he also shows that even well-supported interpretations may be mistaken, and that some interpretive conflicts are interminable. Although this is a book in philosophy, scholars and students in the humanities, the social sciences, and disciplines concerned with interpretive reasoning can read it profitably. (shrink)

Today, it becomes more and more common to combine services from different providers into one application. Service composition is however difficult and cumbersome when there is no common trust anchor. Hence, delegation of access rights across trust domains will become essential in service composition scenarios. This article specifies abstract delegation, discusses theoretical aspects of the concept, and provides technical details of a validation implementation supporting a variety of access controls and associated delegation mechanisms. Abstract delegation allows to harmonize the management (...) of heterogeneous access control mechanisms and to offer a unified user experience. The authors observe standardization efforts to reduce application and domain-specific delegation mechanisms, but this variety is very unlikely to completely disappear. (shrink)

In the year 308 CE, the African army raised to the purple the agens vices praefectorum praetorio Lucius Domitius Alexander. This rather unique case of a vicarius becoming emperor is deserving of investigation. Scholarly interest on the matter has traditionally focused on the broader political significance, treating Alexander as a traditional usurper. This paper argues that, contrary to traditional studies, the regime of Alexander focused on very local, African tropes. The uniqueness of the advertisement suggests that this African usurpation was (...) the product of discontent internal to Africa; in other words, it is a departure from the usurpations of the third century. The achievements of Diocletian, who supposedly stabilized the Empire, ended when he withdrew, and the rebellion of 308–310 demonstrates that there remained unaddressed tensions between the provinces and the remaining tetrarchs. (shrink)

Ce texte a déjà paru dans Intermédialités : histoire et théorie des arts, des lettres et des techniques / Intermediality : History and Theory of the Arts, Literature and Technologies, n° 16, 2010, p. 105-128, puis sur Erudit.org. Nous remercions Laurent Guido de nous avoir autorisé à le reproduire ici. Depuis une vingtaine d'années, l'idée de mondialisation s'est imposée au sein des discours et des pratiques culturelles, dans un contexte où sont apparues de nouvelles techniques d'information et de - (...) Cinéma, animation et vidéo – GALERIE – Nouvel article. (shrink)

This article is the result of collaboration between a linguist and an anthropologist. In La Troisième planète. Structures familiales et systèmes idéologiques (The Third Planet: Family Structures and Ideologies) (Todd, 1983), anthropologist Emmanuel Todd provided a world map of family types, which he used to explain the distribution of major political philosophies around the world. However, this did not explain the distribution of the family types themselves. Indeed, a concluding chapter entitled “Le Hazard” (The Effects of Chance) stated that the (...) distribution of family types did not seem to be the result of any particular economic or ecological factor and was therefore a prime example of the uncertainty principle at work. However, Laurent Sagart, a linguist specializing in Chinese dialects, noticed that this map of family types exhibited a structure well known to experts in historical linguistics and dialectology, contrasting a large, continuous zone in the center with a number of small, independent zones located around the periphery of the central zone or in isolated enclaves within it. When such maps appear in linguistic atlases, dialectologists usually conclude that the central zone was the innovative area while the peripheral and isolated zones conserved the original features. The same analysis, if applied to the map of family types, would lead to the conclusion that the communal family system in the center of the map represented a more recent innovation than the systems around the periphery. (shrink)