The book considers the relationship between governance and participation, and the ways participation has been understood, framed and applied in the context of synthetic biology (SB) governance approaches. Based on fundamental questions about the scope, purpose, and responsibilities assigned to public participation activities, the authors conducted an literature review of policy reports and articles on SB governance. The authors identify key characteristics of synthetic biology, such as the complex interplay of research, engineering and IT expertise in the field, as well (...) as the challenges these characteristics pose in designing governance frameworks. Drawing on insights from a literature review, the authors contest calls for “earlier” and “more” participation on the basis that such calls fail to consider the necessary structural adjustments and resources needed for such endeavors. The brief addresses ethical questions arising in synthetic biology that could be used for developing frameworks of governance in the ongoing COVID-19 crisis and the consequent innovations in vaccine research. (shrink)

Vor allem die philosophische Religionskritik fokussiert sich zu oft auf die Kritik an der Annahme der Existenz Gottes. Dabei gerät aus dem Blick, dass Religionen nicht allein in Überzeugungen bestehen, sondern komplexe soziale Praktiken darstellen, die das Leben ihrer Gläubigen strukturieren, orientieren, stabilisieren und/oder irritieren. Die hier versammelten Beiträge thematisieren diesen Aspekt von Religion in Auseinandersetzung mit dem von Rahel Jaeggi konzipierten Modell einer "Kritik von Lebensformen". Dieser Band liefert damit einen Beitrag sowohl zur Religions-, als auch zur Sozialphilosophie."-- Back (...) cover. (shrink)

Background Big data and AI applications now play a major role in many health contexts. Much research has already been conducted on ethical and social challenges associated with these technologies. Likewise, there are already some studies that investigate empirically which values and attitudes play a role in connection with their design and implementation. What is still in its infancy, however, is the comparative investigation of the perspectives of different stakeholders. Methods To explore this issue in a multi-faceted manner, we conducted (...) semi-structured interviews as well as focus group discussions with patients and clinicians. These empirical methods were used to gather interviewee’s views on the opportunities and challenges of medical AI and other data-intensive applications. Results Different clinician and patient groups are exposed to medical AI to differing degrees. Interviewees expect and demand that the purposes of data processing accord with patient preferences, and that data are put to effective use to generate social value. One central result is the shared tendency of clinicians and patients to maintain individualistic ascriptions of responsibility for clinical outcomes. Conclusions Medical AI and the proliferation of data with import for health-related inferences shape and partially reconfigure stakeholder expectations of how these technologies relate to the decision-making of human agents. Intuitions about individual responsibility for clinical outcomes could eventually be disrupted by the increasing sophistication of data-intensive and AI-driven clinical tools. Besides individual responsibility, systemic governance will be key to promote alignment with stakeholder expectations in AI-driven and data-intensive health settings. (shrink)

Variability is pervasive in spoken language, in particular if one is exposed to two varieties of the same language. Unlike in bilingual settings, standard and dialectal forms are often phonologically related, increasing the variability in word forms. We investigate whether dialectal variability in children’s input affects their ability to recognize words in Standard German, testing non-dialectal vs. dialectal children. Non-dialectal children, who typically grow up in urban areas, mostly hear Standard German forms, and hence encounter little segmental variability in their (...) input. Dialectal children in turn, who typically grow up in rural areas, hear both Standard German and dialectal forms, and are hence exposed to a large amount of variability in their input. We employ the familiar word paradigm for German children aged 12–18 months. Since dialectal children from rural areas are hard to recruit for laboratory studies, we programmed an App that allows all parents to test their children at home. Looking times to familiar vs. non-familiar words were analyzed using a semi-automatic procedure based on neural networks. Our results replicate the familiarity preference for non-dialectal German 12–18-month-old children. Non-dialectal children in the same age range, on the other hand, showed a novelty preference. One explanation for the novelty preference in dialectal children may be more mature linguistic processing, caused by more variability of word forms in the input. This linguistic maturation hypothesis is addressed in Experiment 2, in which we tested older children. These children, who are not exposed to dialectal forms, also showed a novelty preference. Taken together, our findings show that both dialectal and non-dialectal German children recognized the familiar Standard German word forms, but their looking pattern differed as a function of the variability in the input. Frequent exposure to both dialectal and Standard German word forms may hence have affected the nature of lexical representations, leading to more mature processing capacities. (shrink)

Die Gedanken des folgenden Vortrags wurden erstmals am 11. November 1981 im Otto-Braun-Saal der Staatsbibliothek Preu6ischer Kulturbesitz in Berlin vorge­ tragen. Mit diesem Vortrag wurde eine Ausstellung eroffnet, in der die Staatsbiblio­ thek Preu6ischer Kulturbesitz Berlin zusammen mit dem Goethe-Museum Dussel­ dorf (Anton-und-Katharina-Kippenberg-Stiftung) und dem Hegel-Archiv der Ruhr-Universitat Bochum im Rahmen des sog. "Preu6en-Jahres" des 150. Todes­ 1 tages Hegels gedachte. Der Vortrag wurde in erweiterter und veranderter Form in der Rheinisch-Westfalischen Akademie der Wissenschaften am 20. Januar 1982 (...) gehalten - am Tage der Eroffnung der genannten Ausstellung im Goethe-Museum Dusseldorf. An der Diskussion beteiligten sich die Herren Walter Biemel, Heinz Gollwitzer, Walter Hinck, Georg Kauffmann, Clemens Menze, Detlef Muller, Klaus Wolfgang Niemoller, Ernst Vollrath. Die Diskussionsbeitrage brachten wichtige Prazisierungen, die ich aufzunehmen suche; zum Teil fuhrten die Erorte­ rungen aber auch zu F ragestellungen, deren Themen uber den Vortrag weit hinaus­ gehen und der Ausarbeitung bedurfen - zur Frage nach dem Verhaltnis zwischen Hegel und dem Kunsthistoriker Rumohr, nach der Wirkung Wilhelms von Hum­ boldt und der Hegelianer auf padagogischem Feld, nach dem Verhaltnis zwischen Preu6en und dem Reich im spateren 19. Jahrhundert, nach den kulturpolitischen Bemuhungen von heute. Ich habe zuerst versucht, diesen Vortrag weiter auszuarbeiten, dabei genaue Belege fur das Dargestellte zu geben und auch die vorliegende Literatur aufzuarbei­ ten. Diesen Versuch habe ich schlie61ich aufgegeben. (shrink)

In this paper, I present a new semantics for demonstratives. Now some may think that David Kaplan (1989a,b) has already given a more than satisfactory semantics for demonstratives, and that there is no need for a new one. But I argue below that Kaplan's theory fails to describe the linguistic meanings of 'that' and other true demonstratives. My argument for this conclusion has nothing to do with cognitive value, belief sentences, or other such contentious matters in semantics and the philosophy (...) of mind. Rather, it appeals to the obvious fact that there can be true utterances of certain sentences containing several occurrences of the same demonstrative (for instance, 'That is taller than that'). My argument can be answered by making a fairly modest revision in Kaplan's theory. But I believe that the resulting revised version of Kaplan's theory ignores or distorts various important semantic features of 'that'. Thus I ultimately argue in favor of a more substantial departure from Kaplan's theory. Perhaps the most remarkable feature of the theory I favor is that it ascribes three distinct sorts of meanings to demonstratives. (shrink)

Delia Graff Fara maintains that many desire ascriptions underspecify the content of the relevant agent’s desire. She argues that this is inconsistent with certain initially plausible claims about desiring, desires, and desire ascriptions. This paper defends those initially plausible claims. Part of the defense hinges on metaphysical claims about the relations among desiring, desires, and contents.

I modify Grice's theory of conversational implicature so as to accommodate acts of implicating propositions by asking questions, acts of implicating questions by asserting propositions, and acts of implicating questions by asking questions. I describe the relations between a declarative sentence's semantic content (the proposition it semantically expresses), on the one hand, and the propositions that a speaker locutes, asserts, and implicates by uttering that sentence, on the other. I discuss analogous relations between an interrogative sentence's semantic content (the question (...) it semantically expresses), and the questions that a speaker locutes, asks, and implicates by uttering that sentence. (shrink)

This study focuses on the prediction of the engagement of small- and medium-sized enterprises (SMEs) in environmental management practices, based on a random sample of 689 SMEs. The study finds that several endogenous factors, including tangibility of sector, firm size, innovative orientation, family influence and perceived financial benefits from energy conservation, predict an SME’s level of engagement in selected environmental management practices. For family influence, this effect is found only in interaction with the number of owners. In addition to empirical (...) research on SMEs’ environmental behavior, this article draws on the ecological modernization literature as well as the theory of planned behavior. (shrink)

In this paper I present an analysis of causal relevance for properties. I believe that most of us are already familiar with the notion of a causally relevant property. But some of us may not recognize it "under that description." So I begin below with some intuitive explanations and some illustrative examples.

Many philosophers think that the Substitution Objection decisively refutes Russellianism. This objection claims that sentences (1) and (2) can differ in truth value. Therefore, it says, the sentences express different propositions, and so Russellianism is false.

Russellianism (also called `neo-Russellianism, `Millianism, and `thenaive theory') entails that substitution of co-referring names inattitude ascriptions preserves truth value and proposition expressed.Thus, on this view, if Lucy wants Twain to autograph her book, thenshe also wants Clemens to autograph her book, even if she says ``I donot want Clemens to autograph my book''. Some philosophers (includingMichael Devitt and Mark Richard) claim that attitude ascriptions canbe used to predict behavior, but argue that if Russellianism weretrue, then this would not be so. (...) They conclude that Russellianism isfalse. I defend Russellianism from this objection. I present severalanalyses of ``sentence S can be used to predict event E''. I arguethat, on each of these analyses, attitude ascriptions can be used topredict behavior, even if Russellianism is true. Furthermore, if myarguments are incorrect, and attitude ascriptions cannot be used topredict behavior under Russellianism, then Russellians can explainaway the intuition that they can be so used. (shrink)

The aim of this study was to explore the coping resources of hope and sense of coherence, which are rooted in positive-psychology theory, as potential resilience factors that might reduce the emotional distress experienced by adults from three cultural groups in Israel during the chronic-stress situation of a pandemic. The three cultural groups examined were secular Jews, Ultra-Orthodox Jews, and Arabs. We compared these cultural groups during the second wave of the Covid-19 pandemic, just before the Jewish New Year (mid-September (...) 2020) as a second lockdown was announced. Data were gathered from 248 secular Jews, 243 Ultra-Orthodox Jews, and 203 Arabs, who were 18–70 years old (M= 37.14,SD= 12.62). The participants filled out self-reported questionnaires including the Brief Symptom Inventory as a measure of emotional/psychological distress (i.e., somatization, depression, and anxiety) and questionnaires about sense of coherence and different types of hope (i.e., intrapersonal, interpersonal, and transpersonal) as measures of coping resources and resiliency. Differences were found between the three groups in terms of several variables. The Arab participants reported the highest levels of emotional distress and the lowest levels of interpersonal and transpersonal hope; whereas the Ultra-Orthodox participants revealed the highest levels of sense of coherence and other resilience factors. A structural equation model revealed that, in addition to the sociodemographic factors, only sense of coherence and intrapersonal hope played significant roles in explaining emotional distress, explaining 60% of the reported distress among secular Jews, 41% among Ultra-Orthodox Jews, and 48% among Arabs. We discuss our findings in light of the salutogenic and hope theories. We will also discuss their relevancy to meaning-seeking and self-transcendence theory in the three cultural groups. (shrink)

In the article ‘Represent Me: Please! Towards an Ethics of Digital Twins in Medicine’, I analysed and tried to better understand the main ethical challenges associated with Digital Twins. For those who are just entering the debate with this article: DT is a metaphor for a bundle of artificial intelligence driven simulation technologies that constantly, in real time and ad personam simulate single or multiple parts of the body and make predictions about future health states based on these simulations. My (...) argument addresses the need to look at the breadth of challenges through a perspective of representation. From such a take, key consequences can be drawn for the further development of such technologies, the required means of control and not least the way to think about the interaction between humans and ‘their’ simulations. I am very grateful for the subsequent suggestions, criticisms and further arguments, which have helped me to elaborate my arguments more clearly and have led to a substantial advancement of the debate and the discussion about ethical questions in dealing with DT. Jenny Blumenthal-Barby,1 Deborah Lupton,2 Jenny Krutzinna,3 Janina Loh,4 Brent Mittelstadt,5 Sven Nyholm,6 Daniel Tigard7 and Max Tretter8 have made excellent points, which, in the following, I will not be able to reply to individually and in detail. In this response, I will try to bundle the open points and questions along the comments and considerations mentioned above and attempt to outline their significance for an ethics of DT. Four challenges seem to be central. A first point addresses anthropological issues. It is concerned …. (shrink)

ABSTRACTThis article assesses whether the contemporary consensus of just war thinking to allow only for defence as just cause for war between states should also be applied to the practice of target...

In der Reihe werden herausragende monographische Untersuchungen und Sammelbände zu allen Aspekten der Philosophie Kants veröffentlicht, ebenso zum systematischen Verhältnis seiner Philosophie zu anderen philosophischen Ansätzen in Geschichte und Gegenwart. Veröffentlicht werden Studien, die einen innovativen Charakter haben und ausdrückliche Desiderate der Forschung erfüllen. Die Publikationen repräsentieren damit den aktuellsten Stand der Forschung.

Germany is an interesting case with respect to the governance of reprogenetics. It has a strong profile in the technosciences and high aims regarding the global bioeconomy, yet her regulation of human genetics, reproductive medicine and embryo research has for a long time been rather restrictive. German biopolitical exceptionalism has often been explained by reference to Catholicism and the legacy of the Nazi past. The Germans, so goes the common story, have learnt the lessons of history and translated them into (...) unconditional respect for human dignity, which in turn translates into unconditional protection of human life, including the human embryo, and the firm repudiation of any eugenic distinction between ‘life worth to live’ and ‘life not worth to live’. This, however, is not the whole story. Alongside deontological strictness we find another strand of governing body politics and reprogenetics in Germany, the rule-and-exception model, running from the mid-1970s abortion law via the 2002 Stem Cell Act to the 2011 regulation of pre-implantation genetic diagnosis. In contrast to the former, that strongly draws on Kant and his concept of human dignity, the latter bears resemblances to Carl Schmitt's concept of state of exception. The article will show that the rule-and-exception model builds the exception into the rule and transforms the meaning and mandate of ethics, namely from safeguarding ethical standards to deciding about the exception. Given that the exception has now tended to become the rule, the question is whether the lessons of history will govern German reprogenetics for much longer. (shrink)

When reproductive and genetic technologies spurred an extended German policy debate, the issues at stake went beyond the technologies to include the very meaning of “ethics” and the respective roles of ethicists and of the public in thinking about ethical questions.

This article reports findings of a survey of college students in 3 educational settings regarding student perceptions of mass media ethics pedagogy, including course objectives, value systems examined, the use of civil law and/or ethics codes as standards of media ethics, and teaching techniques used in media ethics instruction. Of particular interest was how closely student expectations correlate with previous research findings indicating instructor techniques and goals. The results revealed several areas in which instructor goals and the student rankings were (...) not in accordance, including marked discrepancies between professor and student views on ethical standards employed, values systems examined, and teaching techniques preferred. The study concluded that most students would respond well to a stand-alone media ethics course employing a variety of teaching methods. Respondents felt the course should not emphasize universal ethics, but should respect pluralistic principles and examine various cultural interpretations of media ethics. (shrink)

Contemporary just war thinking has mostly been split into two competing camps, namely, Michael Walzer’s approach and its revisionist critics. While Walzerians employ a casuistical method, most revisionists resort to analytical philosophy’s reflective equilibrium. Importantly, besides employing different methods, the two sides also disagree on substantive issues. This article focuses on one such issue, the moral equality of combatants, arguing that while a methodological reconciliation between the two camps is impossible, contemporary debate would benefit from a ‘third-way’ approach. Presenting James (...) Turner Johnson’s historical method as such an approach, the article suggests that while revisionists are correct in considering the symmetry thesis as ethically indefensible, in order to arrive at this judgement, it is not necessary to employ far-fetched thought experiments and the use of historical cases is preferable. The root cause of Walzer’s problematic reasoning vis-à-vis the symmetry thesis, the histori... (shrink)

This essay examines different viewpoints taken by historians and theorists in three important debates about the Holocaust and the Nazi past in Germany. Analysis shows that the content and form of historical judgment, the limits of historical narratives, and the referential connections between "facts," "representation," and "truth" are more problematic than historians and social theorists taking part in these debates would like to believe. Examples show that attempts to represent past "reality" are closely related to the politically and socially significant (...) interplay between individual and communal search for legitimation, and the legitimation of the past by the authority of the present. A hidden similarity--the fundamental belief in the ability of representation to capture past "reality" and thus its universal validity--appears amid the seemingly antithetical opinions and theoretical assumptions in these debates. Even in cases of historical phenomena as morally, politically, and intellectually challenging as the Holocaust, understanding historical representation in the framework of the self-referentiality of historical texts, and accepting the propositional nature of historical writing, is crucial. (shrink)

Libertarians famously contend that the minimal state is the most just social arrangement because it secures individual freedoms and basic political rights. They also oppose wealth transfer taxation, i.e. taxation of inheritances, bequests, and inter vivos gifts, arguing that it violates people's right to use their wealth freely. However, as I argue, libertarian opposition to wealth transfer taxation causes practical problems for their commitment to a minimal state, as there is strong empirical evidence demonstrating that wealth transfer taxation is required (...) to secure the political rights necessary for a free and stable society. In other words, I contend that without an effective wealth transfer tax, it will be difficult to ensure political rights and basic freedoms, thus leaving the libertarian minimal state in peril of collapse. (shrink)

Renowned neurologist and author Dr Oliver Sacks is a visiting professor at the University of Warwick as part of the Institute of Advanced Study. Dr Sacks was born in London. He earned his medical degree at the University of Oxford (Queen’s College) and the Middlesex Hospital (now UCL), followed by residencies and fellowships at Mt. Zion Hospital in San Francisco and at University of California Los Angeles (UCLA). As well as authoring best-selling books such as Awakenings and The Man Who (...) Mistook His Wife for a Hat, he is clinical professor of neurology at NYU Langone Medical Center in New York. Warwick is part of a consortium led by New York University which is building an applied science research institute, the Center for Urban Science and Progress (CUSP). Dr Sacks recently completed a five-year residency at Columbia University in New York, where he was professor of neurology and psychiatry. He also held the title of Columbia University Artist, in recognition of his contributions to the arts as well as to medicine. He is a fellow of the Royal College of Physicians and the Association of British Neurologists, the American Academy of Arts and Sciences, and the American Academy of Arts and Letters, and has been a fellow of the New York Institute for the Humanities at NYU for more than 25 years. In 2008, he was appointed CBE. (shrink)

This paper critiques Rothbard’s concept of gross investment. Rothbard introduced the concept in order to demonstrate his point that it is not consumer spending that primarily drives the economy, like the mainstream Keynesian view maintains, but the capitalists’ spending. In this paper, it is argued that, contrary to Rothbard’s opinion, the amount of gross investment as he defines it does not contain significant information concerning the question as to whether the capital structure of a society can be upheld or not. (...) Instead, it is an arbitrary figure that depends on the length of the different stages of production. This problem has not been recognized by Rothbard because his exposition rests upon the assumption of an equal time length for all stages. Apparently, he has been led astray by his intention to find arguments against the importance of consumer spending in the determination of output. (shrink)

In eukaryotic cells intron sequences are usually spliced out with a high degree of precision from heterogenous nuclear RNA (hnRNA) to give functional mRNA with exons in their right order. Provided with the right substrates, cell extracts can achieve the same. With exotic substrates, on the other hand, the same extracts can cut exons from one RNA and join them to exons from another RNA, a process termed trans‐splicing. In vivo, RNA trans‐splicing could lead to faulty, but also to novel (...) proteins and, through reverse transcription, to genomic rearrangements. So far, in living cells trans‐splicing has only been invoked to occur in trypanosomes. In these unicellular organisms most if not all mRNAs are made discontinuously, so that the mature mRNAs carry, at their 5′ end, a common 35‐nucleotide sequence, called a miniexon, encoded separately in the genome. The miniexon is most likely joined to the body of the mRNA by trans‐splicing. (shrink)

The power of finance vis-à-vis the nonfinancial sector is changing. Macroeconomic developments and financial innovations have reduced financial actors’ exit options, thus diminishing exit-based structural power. At the same time, shareholdings have become more concentrated in the hands of large asset managers, thus increasing control-based power. This article documents these trends, before examining whether asset managers wield their power and why, despite being universal shareholders, they have not steered corporate behavior toward decarbonization. Rather than assuming orderly, good-faith interactions between shareholders (...) and managers, this article argues that in the United States today, political considerations govern the use of control-based power. Asset managers’ corporate governance policies are subservient to the—increasingly inconsistent—goals of maximizing assets under management while avoiding regulatory backlash. Unlike exit-based power, control-based power is constrained by being highly visible and, therefore, easily politicized. (shrink)

This article discusses the famous Popperian terms of 'empirical content' and 'falsifiability' or 'refutability'. They are all synonymous with another and are all fundamental principles, not for Popper's philosophy exclusively, but for Lakatos's and for Sneed's rational reconstruction of the ideas of Kuhn's book The Structure of Scientific Revolutions.

This article traces the semantics of ?life? and ?vitality? in Carl Schmitt up to the 1930s. It shows that Schmitt deploys these vitalist elements against the modern ?spirit of technicity? in his attempt to combat the lack of substantial ideas in modern politics. However, Schmitt himself cannot escape a fundamental political relativism. There remains an unstable tension at the heart of his thought between the quest for substance and the quest for order. The latter is relativist because it is a (...) quest for order as such, any order. Although Schmitt's semantics of life and vitality is not drawn from a biological register, it adopted a völkisch meaning in 1933. Anti-Semitism becomes a form of life and racial homogeneity fills in for substance. The article concludes that, while there are good reasons for criticizing the modern ?spirit of technicity,? Schmitt's critical model is fundamentally flawed. (shrink)