Targeted modifications of the human epigenome, epigenome editing (EE), are around the corner. For EE, techniques similar to genome editing (GE) techniques are used. While in GE the genetic information is changed by directly modifying DNA, intervening in the epigenome requires modifying the configuration of DNA, for example, how it is folded. This does not come with alterations in the base sequence (‘genetic code’). To date, there is almost no ethical debate about EE, whereas the discussions about GE are voluminous. (...) Our article introduces EE into bioethics by translating knowledge from science to ethics and by comparing the risks of EE with those of GE. We, first (I), make the case that a broader ethical debate on EE is due, provide scientific background on EE, compile potential use-cases and recap previous debates. We then (II) compare EE and GE and suggest that the severity of risks of novel gene technologies depends on three factors: (i) the choice of an ex vivo versus an in vivo editing approach, (ii) the time of intervention and intervention windows and (iii) the targeted diseases. Moreover, we show why germline EE is not effective and reject the position of strong epigenetic determinism. We conclude that EE is not always ethically preferable to GE in terms of risks, and end with suggestions for next steps in the current ethical debate on EE by briefly introducing ethical challenges of new areas of preventive applications of EE (III). (shrink)

In this paper, I evaluate some recent attacks on Williamson's claim that knowledge is the most general factive stative propositional attitude. Two types of approaches are discussed: The first approach attempts to show that there are factive mental states denoted by factive mental state operators that are not cases of knowing. The second approach aims to show that there are factive mental states that to Williamson count as cases of knowing, but nonetheless fail to entail a corresponding belief. If either (...) of these approaches were successful, it would potentially be damaging for Williamson's theory of knowledge. I argue that recent arguments that exemplify these approaches are unconvincing. (shrink)

This article presents an impact assessment framework that allows for the evaluation of positive and negative local-level impacts that have resulted from "responsible trade" interventions such as fair trade and ethical trade. The framework investigates impact relating to (1) livelihood impacts on primary stakeholders; (2) socio-economic impacts on communities; (3) organizational impacts; (4) environmental impacts; (5) policies and institutional impacts; and (6) future prospects. It identifies relevant local-level stakeholders and facilitates the analysis of conflicting interests. The framework was developed in (...) the context of, and is applied in this article to, the fair trade coffee industry in northern Nicaragua. It was designed, however, so that it can be applied across commodity sectors and responsible trade initiatives. It is able to do this by accommodating for differences in the social, environmental, political and institutional contexts of different areas, and by taking into account the distinct nature of an initiative's overall objectives, different levels of intervention, and the full range of stakeholders involved. (shrink)

Excerpt: 1. Introduction This chapter provides insight into the diverse ethical debates on genetics and epigenetics. Much controversy surrounds debates about intervening into the germline genome of human embryos, with catchwords such as genome editing, designer baby, and CRISPR/Cas. The idea that it is possible to design a child according to one’s personal preferences is, however, a quite distorted view of what is actually possible with new gene technologies and gene therapies. These are much more limited than the editing and (...) design metaphors suggest. Such metaphors are therefore highly problematic phrases in the context of new gene technologies, for two reasons. On one hand, to design a child of choice by modifying the genome would require modifying any gene of choice, which is more than can be done with current gene technologies, such as CRISPR/Cas. On the other hand, a modification of genes would need to be enough to create any characteristic of choice in the future child. The latter presupposes the assumption of genetic determinism. Moreover, the CRISPR/Cas technology can not only be used in a potentially therapeutic manner at the germline level. In addition, there is the (more likely) scenario of a future clinical therapeutic use of these new gene technologies for modifying the DNA sequence of other cells of the body (somatic genome editing). There is also the option of modifying the epigenome, that is, the spatial configuration of DNA (epigenome editing) (see table 1). Like genetics and genome editing, epigenetics has been at the center of recent popular scientific and ethical discourse as well as scientific debates. The concept of epigenetics has given rise to very different notions of inheritability and responsibility for health, which, however, are oftentimes based on scientifically controversial basic assumptions. That there continues to be covert genetic determinism in the form of epigenetic determinism (see table 2) in debates about epigenetics has been pointed out in ethical analyses of epigenetics. Neither genetic determinism nor epigenetic determinism has been confirmed scientifically. It is therefore important to recognize the concepts that are discussed (and sometimes harshly criticized) in debates about genome editing and epigenetics—for example, concepts about the causal role of DNA for our own life course. This importance is based on the fact that if we understand such controversial concepts, we will be able to remain critical when evaluating scientific knowledge and ethical arguments about genome editing and epigenetics. This chapter, therefore, explains some of these concepts. For an ethical analysis of epigenetics as well as of genome editing, it is necessary to understand and critically reflect upon the underlying concepts of genetic determinism and other, related -isms. The following section offers a detailed introduction to these -isms (section 2; see also table 2). Section 3 provides an ethical analysis of genome editing and epigenetics based on the explanations in section 2. Section 3 focuses on inheritability and responsibility, justice, safety, the problem of consent, and the effects of genome editing and epigenetics on embryos and future generations. This section does not discuss in detail further points that can be found in ethical debates about epigenetics as well as in ethical debates about genome editing. These points include (among others): • fear that the findings of epigenetics and that the methods of genome editing are misused—this also with respect to eugenics and enhancement; • naturalness—an issue we mention in passing a few times in the following analysis; • a possible connection between the genome/epigenome and the concept of human dignity, and the derived danger of instrumentalization and infringement of autonomy when intervening in the genome or epigenome. Since current discourse about ethical issues associated with genome editing focuses mainly on germline interventions, which are, for instance, interventions into a human embryo’s genome, we mainly focus on germline interventions when comparing the debates on genome editing and on epigenetics in section 3. (shrink)

On pp. 47-51, "Fifth Scenario: The Nazi and His Jew", discusses Adorno's theory of mimesis applied to the phenomenon of Nazi antisemitism. Influenced by Freud's theory, Adorno discussed in "Dialektik der Aufklärung" (1947) the Nazi phobic and distorted image of the Jew. In Adorno's interpretation, the imaginary portrait of the Jew created by the Nazis is in fact their self-portrait, expressing their longing for unlimited power and identification with an imaginary aggressor in order to be themselves the real aggressor.

The new evil demon problem amounts to a difficult challenge for the externalist about epistemic justification. Many solutions to the problem have been proffered in the almost 40 years since its first appearance in the literature. Among the more promising responses is indexical reliabilism, a combination of two versions of actual world reliabilism where “actual” denotes either the world of utterance or a rigidly determined actual world. This paper does three things. First, it attempts to clarify indexical reliabilism and how (...) it purports to solve the new evil demon problem. Second, it attempts to mitigate some of the prominent criticism that has been leveled against the theory. Third, it poses an explanatory challenge for the theory which remains even after all of the premises supporting indexical reliabilism are accepted. The conclusion is that indexical reliabilism is not tenable until a linguistic mechanism for the use of “actually reliable” has been offered that explains how the theory avoids collapsing into a two-concepts response to the new evil demon problem. (shrink)

In this article I discuss two counterexamples (the New Evil Demon Problem and Norman‘s Clairvoyance) to reliabilism and a potential solution: dispositional reliabilism. The latter is a recent addition to the many already-existing varieties of reliabilism and faces some serious problems of its own. I argue here that these problems are surmountable. The resulting central argument of the article aims to demonstrate how viewing reliabilism as an intrinsic dispositional property solves many of the issues facing reliabilism to date.

To carry out a bibliographic review of the factors associated with behavioral difficulties in children, but there are global data on these variables. Purpose: The purpose of this study was to review the literature on the factors associated with behavioral difficulties in boys and girls to identify the most influential countries, authors, magazines and institutions, their structures and research directions. Design: This review is based on bibliometric and network analysis of literature published in Scopus and Web of Science. A total (...) of 110 scientifically mapped articles were found in this area. (shrink)

We welcome Blumenthal-Barby’s et al. (2022) plaidoyer for the integration of philosophy in bioethics because of a perceived mutual benefit. Drawing on experience from a collaborative project, funde...

This article names some of the human under standings and ways of being that are fundamental to teaching and learning, which new educational tech nologies, especially the computer, tend to remake, reduce, or replace altogether in K-12 classrooms. The article asks questions and tells stories about students, teachers, and the authors themselves using computers for educational purposes, investigating three particular uses of technology in detail. The authors argue that new educational technologies change the meaning of words common to teachers' vocabularies, (...) especially words such as classroom community, knowing, and coming to know. The authors also argue that human senses used in learning are nullified, if not assaulted, by new educational technologies. (shrink)

This article focuses on emergency medical care in black urban populations, suggesting that the classification of a “community” within clinical trial language is problematic. The article references a cultural history of black Americans with pre-hospital emergency medical treatment as relevant to contemporary emergency medicine paradigms. Part I explores a relationship between “autonomy” and “community.” The idea of community emerges as a displacement for the ethical principle of autonomy precisely at the moment that institutionalized medicine focuses on diversity. Part II examines (...) a clinical trial for the blood substitute PolyHeme® (Northfield Laboratories, Inc., Evanston, IL). It illustrates the ways in which bias in research paradigms and Institutional Review Board decisions attach to the notion and utility of the language of “community.” The conclusion's contemporary anecdote makes apparent the vitality of the issues of prehospital emergency medical care and the ways in which decisions and practices fall too easily into a narrative of culturally biased treatment. (shrink)

El objetivo de este artículo consiste en abordar algunos argumentos de la filosofía de J. Rancière relacionados con la necesidad de repensar el comunismo. La hipótesis de trabajo insiste en señalar que Rancière no defiende ningún proyecto comunista. Esto al menos por tres razones: no hay igualdad de las inteligencias, el comunista funge como profesor explicador en aras de concientizar a los embrutecidos, el comunismo pertenece a una temporalidad histórica teleológica, lo que a su vez supone un aplazamiento de la (...) emancipación. Finalmente, cerramos este diálogo con las posibilidades presentes de esta otra forma de concebir la igualdad y la emancipación. (shrink)

Together, their work signals a new direction in the field and offers refreshingly original insights into a broad spectrum of texts.

Children with developmental language disorder (DLD) served as a test case for determining the role of extant vocabulary knowledge, endogenous attention, and phonological working memory abilities in cross-situational word learning. First-graders (Mage = 7 years; 3 months), 44 with typical development (TD) and 28 with DLD, completed a cross-situational word-learning task comprised six cycles, followed by retention tests and independent assessments of attention, memory, and vocabulary. Children with DLD scored lower than those with TD on all measures of learning and (...) retention, a performance gap that emerged in the first cycle of the cross-situational protocol and that we attribute to weaknesses in initial encoding. Over cycles, children with DLD learned words at a similar rate as their TD peers but they were less flexible in their strategy use, demonstrating a propose-but-verify approach but never a statistical aggregation approach. Also, they drew upon different mechanisms to support their learning. Attention played a greater role for the children with DLD, whereas extant vocabulary size played a greater role for the children with TD. Children navigate the problem space of cross-situational learning via varied routes. This conclusion is offered as motivation for theorists to capture all learners, not just the most typical ones. (shrink)

A pesar de que Max Horkheimer en Eclipse de la razón había analizado los límites de la razón subjetiva, atendien- do a las posibilidades de retornar a la razón objetiva y a su función después del eclipse, a Jay le parecían aún insuficientes estas respuestas. Por ello, regresó al estudio de las conceptualizaciones filosóficas de los fundadores de la teoría crítica y de quienes se quedaron a cargo del Instituto de Investigación Social en Frankfurt. En este sentido, este texto podría (...) verse en continuidad y a distancia respecto a su primer li- bro: Dialectical Imagination. A History of the Frankfurt School and the Institute of Social Research, 1923-1950 (1973); producto de su trabajo de doctorado, enfocado en la formación del Instituto de Investigación Social; en sus principales integrantes: Herbert Marcuse, Max Horkheimer, Theodor Adorno, Leo Löwenthal, Walter Benjamin,Franz Neumann, Otto Kirchheimer, Henryk Grossmann, Erich Fromm, Karl August Wittfogel; en la integra- ción del psicoanálisis; en su exilio a América; en los estudios empíricos sobre el autoritarismo, la estética y la industria cultural. (shrink)

Este artículo tiene como objetivo plantear la posibilidad de desprecarizar la vida a través de la biopolítica afirmativa de Roberto Esposito y el concepto de disenso de Jacques Rancière. La hipótesis de trabajo que guía nuestra reflexión indica que ya no es suficiente señalar cómo el poder se ejerce sobre la vida; por el contrario, hoy más que nunca es necesario afirmar el poder de la vida a través de una biopolítica afirmativa y posibilitar disensos como nuevas formas de pensar, (...) decir y sentir. Finalmente, pensamos en cómo transformar las vidas precarias subsumidas en la sobrevivencia a través del poder de una vida que no se conforma con discursos derrotistas sin potencia política alguna. (shrink)

Peter Wollen _Signs and Meaning in the Cinema_ Expanded and revised edition London: British Film Institute, 1998 ISBN 0-85170-646-0 hbk; 0-85170-647-9 pbk 188 pages.

En el presente artículo se pretende dar cuenta de cómo opera el hábito en el cuerpo de las mujeres, particularmente con respecto a la relación amorosa heterosexual-patriarcal. Para ello, se recurrirá a Simone de Beauvoir y a Jean Paul Sartre, desde ahí explicar a qué nos referimos con cuerpo. También se tomará la noción de hábito de Pierre Bourdieu para señalar el orden simbólico patriarcal en las relaciones amorosas sexo-afectivas. En cuanto al abordaje de la idea del amor, se realizará (...) un recorrido histórico a partir del desarrollo de Marcela Lagarde, así como de su concepto de cautiverio, y, finalmente, apuntaremos algunas consideraciones de la ética del placer de Graciela Hierro a modo de conclusión. Palabras clave: hábito, cuerpo, relación amorosa, orden simbólico patriarcal, violencia simbólica. (shrink)

Slightly modified excerpt from the section 13.4 Zusammenfassung und Ausblick (translated into englisch): This chapter is based on an analysis of ethical debates on epigenetics and genome editing, debates, in which ethical arguments relating to future generations and justice play a central role. The analysis aims to contextualize new developments in genetic engineering, such as genome and epigenome editing, ethically. At the beginning, the assumptions of "genetic determinism," on which "genetic essentialism" is based, of "epigenetic determinism" as well as "genetic" (...) and "epigenetic exceptionalism" are analyzed and critically discussed. The remarks on the ethical discourse on epigenetics show that the notion of "epigenetic determinism" can sometimes be discerned not only in popular scientific discourse but also in ethical discourse. Ethical debates on epigenetics, however, have distanced themselves from this deterministic understanding. As a result, the focus in the ethical discourse on epigenetics shifts from responsibility for one's own health and that of subsequent generations to justice. What is meant here is justice, for example, in terms of access to healthy environmental conditions, regardless of whether these contribute to health with or without epigenetic agency. An analysis of the discourse on genome editing reveals that it is primarily germline interventions that are being ethically examined, with a concentration on the aspect of inheritance. The question is whether this is accompanied by an implicit "genetic determinism" or even a "genetic essentialism": the determinism could lie in the centrality of the aspect of heritability, since only genetic information is inherited. Does the aspect of heritability and genome modification play a more decisive role in debates on genome editing than the safety issue? Is the problem of embryos and their potential offspring not being able to consent to germline intervention given such a high priority because it is a genetic intervention? Under such a premise of "strong genetic determinism" supplemented by "epigenetic determinism," not only genome editing but also epigenome editing would be ethically relevant precisely because it too would have an influence on the genome. How this influence of genome editing and epigenome editing is ethically evaluated in each case therefore depends initially on whether the assumptions of "genetic" and "epigenetic determinism" are advocated. These assumptions are increasingly viewed critically in ethical discourse because they cannot be confirmed from a scientific perspective. In popular scientific debates in particular, however, they seem to persist, which ultimately also influences the public discussion. Since a broad public discussion is required especially on genome editing, a reflective approach to the various "-isms" analyzed in this chapter is central. DOI: 10.5771/9783748927242. (shrink)

Dupras and Bunnik’s strong statement against the normative approach of genetic exceptionalism, which can no longer be justified in the midst of multi-omic research, is of great importance fo...

This article focuses on emergency medical care in black urban populations, suggesting that the classification of a "community" within clinical trial language is problematic. The article references a cultural history of black Americans with pre-hospital emergency medical treatment as relevant to contemporary emergency medicine paradigms. Part I explores a relationship between "autonomy" and "community." The idea of community emerges as a displacement for the ethical principle of autonomy precisely at the moment that institutionalized medicine focuses on diversity. Part II examines (...) a clinical trial for the blood substitute PolyHeme® (Northfield Laboratories, Inc., Evanston, IL). It illustrates the ways in which bias in research paradigms and Institutional Review Board decisions attach to the notion and utility of the language of "community." The conclusion's contemporary anecdote makes apparent the vitality of the issues of prehospital emergency medical care and the ways in which decisions and practices fall too easily into a narrative of culturally biased treatment. (shrink)

La ira interior, la tristeza, el disgusto, el nerviosismo, la impotencia, más que conceptos, son en realidad sentimientos que por carne propia podemos experimentar, además de ser constantes dentro de nuestra vida anímica, incluso más que el sentido de gozo y placer, que tanto buscamos dentro de nuestras actividades ordinarias. Sin embargo, al experimentar estas emociones en sí mismas parecen no generar algún problema mayor. El problema mismo viene en la acción para poder colmar estas intensas emociones que muchas veces (...) se presentan dentro de nosotros mismos “como criterio el dolor es inmutable, variable es, en cambio, el modo y manera como el ser humano se enfrenta a él”. (shrink)

Abstract: This working paper focuses on the question whether there is a therapeutic imperative that, in specific situations, would oblige us to perform genome editing at the germline level in the context of assisted reproduction. The answer to this central question is discussed primarily with reference to specific scenarios where preimplantation genetic diagnosis (PGD) does not represent an acceptable alternative to germline genome editing based on either medical, or ethical, or – from the perspective of the potential parents – moral (...) or religious grounds. This article deals with four different types of case constellations that result from these possible reasons against PGD as well as from the necessity or dispensability of a subsequent “control PGD.” These cases are discussed based on hypotheses concerning contextual factors and theoretical assumptions. In conclusion, we point out that if our assumptions are correct, there is probably no therapeutic imperative for genome editing at the germline level. We draw this rationale from the fact that germline interventions are likely not person-affecting. However, we caution the reader that our result is preliminary and needs to be more carefully examined in future work in light of the bioethical debate and potential objections. -/- // Abstract: Im Zentrum dieses Working Papers steht die Frage, ob es einen therapeutischen Imperativ geben kann, der uns, in bestimmten Situationen, verpflichten würde, eine Genomeditierung (genome editing) auf Keimbahnebene im Rahmen der assistierten Befruchtung vorzunehmen. Die Antwort auf diese zentrale Frage wird insbesondere mit Bezug auf Fälle diskutiert, in denen das Verfahren der Präimplantationsdiagnostik (PID) keine aus entweder medizinischen oder ethischen oder – aus Sicht der potentiellen Eltern – moralischen bzw. religiösen Gründen akzeptable Alternative zu einem Keimbahneingriff darstellt. Die möglichen Gründe gegen die PID sowie die Erforderlichkeit oder Verzichtbarkeit einer nachfolgenden «Kontroll-PID» ergeben vier verschiedene Fallkonstellationen, denen sich der Beitrag zuwendet. Auf Grundlage von Hypothesen zu kontextuellen Faktoren und theoretischen Annahmen diskutieren wir diese Fälle. Im Ergebnis verweisen wir darauf, dass es, wenn unsere Annahmen zutreffen, vermutlich keinen therapeutischen Imperativ zum genome editing auf Keimbahnebene gibt. Dies begründet sich daraus, dass der Keimbahneingriff vermutlich nicht als personenbezogen (person-affecting) zu bezeichnen ist. Wir weisen jedoch darauf hin, dass unser Ergebnis vorläufig ist und unter Berücksichtigung der bioethischen Debatte und möglicher Einwände genauer geprüft werden muss. -/- // Résumé: Ce Working Paper se concentre sur la question de l’existence d’un impératif thérapeutique qui, dans des situations spécifiques, nous obligerait à réaliser une édition du génome au niveau de la lignée germinale dans le cadre de la procréation assistée. Afin de répondre à cette question centrale nous développons quatre scénarios spécifiques dans lesquels le diagnostic préimplantatoire (DPI) ne représente pas une alternative acceptable à l’édition du génome germinal pour des raisons médicales, éthiques ou – du point de vue des futurs parents – morales ou religieuses. Cet article traite de quatre constellations différentes de cas résultant des raisons mises en avant pour s'opposer au DPI ainsi que de la nécessité ou de l’inutilité d’un ultérieur « DPI de contrôle » Ces cas sont discutés sur la base d’hypothèses portant sur les facteurs contextuels et sur les présupposés théoriques. En conclusion, nous soulignons que si nos hypothèses sont correctes, il n’y a probablement aucun impératif thérapeutique justifiant l’édition du génome au niveau de la lignée germinale. Nous arrivons à cette conclusion parce qu’une intervention au niveau de la lignée germinale n’est probablement pas susceptible d’affecter la personne. Cependant, nous mettons en garde le lecteur sur le fait que notre conclusion est préliminaire et qu’elle doit être examinée avec soin dans des futurs travaux instruits par le débat bioéthique et par les éventuelles objections. (shrink)

The Life of Aesop the Philosopher, an anonymous Greek literary work, presents one version of the novelistic biography of Aesop, which dates to the fourth to fifth century CE. In this volume, Grammatiki A. Karla offers an extended introduction to the Life of Aesop in general, the history of the textual tradition, and the MORN manuscript family and its relationship to other versions and papyrus fragments. She then presents a new edition of the late antique version (MORN) alongside David (...) Konstan's English translation. A commentary addresses editorial choices and focuses on words and phrases that are of interest for the history of the Greek language. (shrink)

O marketing esportivo, que movimenta bilhões de dólares em todo o mundo, assumiu um novo perfil com a entrada em campo das mídias sociais. A gestão das marcas nestes espaços virtuais exige agilidade, pró-atividade e sobretudo disposição para interagir com os consumidores. Este estudo analisa as estratégias da Nike e da Adidas no Facebook e no Twitter durante a realização da Copa do Mundo de 2014 no Brasil e conclui que, apesar da tradicional agressividade das marcas no mercado, a apropriação (...) deste espaço ainda se faz de modo tímido e nem sempre adequado pela ausência de uma cultura digital de comunicação. (shrink)

Until recently, economics conceived of poverty solely as a lack of material resources. This view likely captures the reality of poverty experienced by many people around the globe. However, two waves of behavioral economics demonstrate that the narrowing of people’s external environments may change people themselves: poverty lowers the quality of decision-making and poverty and oppression may depress the capacity to aspire. Poverty and a history of oppression also change how individuals are perceived. To overcome these effects may require helping (...) people acquire new mental models. This essay discusses key findings from behavioral economics, the implications for agency, and some interventions with promising outcomes. We hope to inspire scholars and policymakers to think more deeply about the nature of poverty and oppression and to consider policies that target the psychological and sociological factors that create cycles of poverty. (shrink)

ABSTRACT: In this paper, I intend to review the intentionalist account of perceptual experience in order to deal with some difficulties that it faces in adequately specifying the nature and object of perceptual experience. My aim is to show that it is possible for the intentionalists to incorporate the disjunctivist thesis that the object of perception is part of perceptual experiences, without renouncing the common factor principle. I argue that, in order to do this, it is necessary to engage with (...) the concept of biological function and to review the concept of a perceptual object. RESUMO: Este artigo visa a abordar algumas das dificuldades que o intencionalismo perceptivo enfrenta, ao especificar a natureza da experiência perceptiva e o objeto da percepção. Meu objetivo é mostrar que o intencionalista pode incorporar a tese associada ao disjuntivismo de que o objeto da percepção é parte da experiência perceptiva, sem abrir mão do princípio do fator comum. Eu defendo que, para fazer isso, é necessário recorrer ao conceito de função biológica e realizar uma revisão do conceito de objeto da percepção. (shrink)

One of the most difficult problems for those who defend evolutionary ethics is the naturalist fallacy. In this article, we examine the solutions proposed by W. Rottschaefer and R. Richards. We believe that these solutions are not good enough to completely eliminate the problem of the naturalist fallacy without compromising the specificity of morality.