Focal brain metabolic effects detected by proton magnetic resonance spectroscopy (MRS) in obsessive-compulsive disorder (OCD) represent prospective indices of clinical status and guides to treatment design. Sampling bilateral pregenual anterior cingulate cortex (pACC), anterior middle cingulate cortex (aMCC), and thalamus in 40 adult patients and 16 healthy controls, we examined relationships of the neurometabolites glutamate+glutamine (Glx), creatine+phosphocreatine (Cr), and choline-compounds (Cho) with OCD diagnosis and multiple symptom types. The latter included OC core symptoms (Yale-Brown Obsessive-Compulsive Scale - YBOCS), depressive symptoms (...) (Montgomery-Åsberg Depression Rating Scale - MADRS), and general functioning (Global Assessment Scale - GAS). pACC Glx was 9.7% higher in patients than controls. Within patients, Cr and Cho correlated negatively with YBOCS and MADRS, while Cr correlated positively with the GAS. In aMCC, Cr and Cho correlated negatively with MADRS, while Cr in thalamus correlated positively with GAS. These findings present moderate support for glutamatergic and cingulocentric perspectives on OCD. Based on our prior metabolic model of OCD, we offer one possible interpretation of these group and correlational effects as consequences of a corticothalamic state of elevated glutamatergic receptor activity alongside below-normal glutamatergic transporter activity. (shrink)

There have been several calls from LIS researchers for practical or applied research not to ignore the epistemological assumptions underlying the systems and artifacts they design lest they showcase only the dominant theory at a given time. Others have also deplored the "epistemological promiscuity" or "eclecticism" of the field, its incessant borrowing of theories and models from elsewhere and the fact that the field has largely neglected the contributions that philosophy and epistemology could have made in its research. This problem (...) raises that of the boundaries of LIS and is all the more troublesome because boundaries between epistemological theories are fuzzy. Indeed, some epistemological theories share the same basic assumptions or are historically derived from one another. Gathering a wide array of acknowledged theorists in philosophy of science and epistemology, this panel aims to examine how research work in the LIS field can clearly articulate the epistemological assumptions underlying that research and under what constraints this can be achieved. The topic is of prime importance to Information studies as a whole and to ASIST as the scientific flag bearer of information scientists worldwide. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What Has Chalcedon to Do with Lhasa? John Keenan’s and Lai Pai-chiu’s Reflections on Classical Christology and the Possible Shape of a Tibetan Theology of IncarnationThomas CattoiThe starting point of this paper is a critique of John Keenan’s so-called “Mahāyāna Christology” in The Meaning of Christ, in light of Lai Pai-chiu’s “Chinese” response to Keenan’s position. My argument is that Lai correctly construes the Chalcedonian definition as a critique (...) of Hellenist ontology, but fails to critique Keenan’s crucial contention that this same definition ratifies the subjugation of lived spiritual experience to abstract philosophical speculation. I also claim that Lai does not engage Keenan’s flawed use, in his constructive Christology, of the teaching of the Buddha-bodies, which in my opinion could provide an apposite template for the development of a Tibetan contextual Christology. My paper has a twofold purpose: on one hand, I sketch the contours of a possible Tibetan theology of incarnation; on the other hand, I offer a few methodological reflections on the role of classical doctrinal definitions in the development of new contextual theologies.The burden of this paper is to offer a few suggestions toward the formulation of a culturally contextual theology of incarnation, which uses the resources of Mahāyāna speculation on the embodiment of the Buddha. My starting point is Lai’s critique of Keenan’s well-known 1989 volume The Meaning of Christ, in which Keenan sets out to critique traditional Hellenist Chalcedonian Christology and argues for an alternative articulation of the hypostatic union based on the Mahāyāna teaching of the Buddha-bodies.1 Lai’s article revisits Keenan’s critique and argues that the Chalcedonian definition, far from canonizing the uncritical appropriation of a school of thought, evidences the profound limitations of philosophical discourse. Keenan’s underlying contention that traditional Christology subjects the Christian message to the strictures of alien categories is thus deconstructed, although Lai goes on to offer yet one more Christological synthesis based on the Chinese understanding of Buddha nature. In my paper I concur with Lai’s reading of Chalcedonian categories, which I regard [End Page 13] as more accurate and fruitful than Keenan’s, but I also argue that Lai fails to engage the totality of Keenan’s argument and therefore does not appreciate the deeper flaws in Keenan’s appropriation of the Buddhakāya teaching. My constructive suggestion toward the end of this paper is that such teaching could actually provide a most useful template for the development of a “Tibetan” theology of incarnation, which would remain in continuity with the Chalcedonian tradition, and yet resort to the linguistic and philosophical categories of the local culture.Theologians wishing to develop contextual articulations of Christian doctrine often meet considerable resistance, since their emphasis on the culturally contingent nature of traditional formulas is seen as a challenge to their continuing normative character. As early as 1969, Joseph Ratzinger’s Introduction to Christianity expressed serious reservations about the growing tendency to “de-Hellenize” Christian theology and strongly reasserted the enduring “providential” character of traditional Trinitarian and Christological formulas.2 At the same time, the development of a postcolonial Christianity in many Asian and African countries could not but call for inculturated expressions of the Christian faith that embedded the Christian message in the categories of the local culture. Theologian Stephen B. Bevans begins his work Models of Contextual Theology claiming that in the contemporary world, “the contextualization of [Christian] theology [...] is really a theological imperative.” 3 The understanding of theology as an objective and unchanging science of faith is thus superseded by a new approach that gives pride of place to the religious experience of the individual and the community where he or she lives, operates, and worships.4 Bevans’s call for a contextual theology views the “experience of the present” as the ultimately normative benchmark against which the “experience of the past” is assessed, in the search for a new synthesis rooted in a particular cultural and social location.5The development of new Christological formulas that use the resources of Asian Buddhist culture is thus possible only after the... (shrink)

The thesis of the present volume is critical and dual. (1) Present day philosophy of man and sciences of man suffer from the Greek mis taken polarization of everything human into nature and convention which is (allegedly) good and evil, which is (allegedly) truth and fal sity, which is (allegedly) rationality and irrationality, to wit, the polar ization of all fields of inquiry, the natural and social sciences, as well as ethics and all technology, whether natural or social, into the (...) totally positive and the totally negative. (2) Almost all philosophy and sci ences of man share the erroneous work ethic which is the myth of man's evil nature - the myth of the beast in man, the doctrine of original sin. To mediate or to compromise between the first view of human nature as good with the second view of it as evil, sociologists have devised a modified utilitarianism with deferred gratification so called, and the theory of the evil of artificial competition (capitalist and socialist alike) and of keeping up with the Joneses. Now, the mediation is not necessary. For, the polarization makes for abstract errors which are simplistic views of rationality, such as reductionism and positivism of all sorts, as well as for concrete errors, such as the disposition to condemn repeatedly those human weaknesses which are inevitable, namely man's inability to be perfectly rational, avoid all error, etc. , thus setting man against himself as all too wicked. (shrink)

The inclusion of morally binding values such as religious—or in a broader sense, spiritual—values fundamentally alter organizational decision-making and ethical behavior. Family firms, being a particularly value-driven type of organization, provide ample room for religious beliefs to affect family, business, and individual decisions. The influence that the owning family is able to exert on value formation and preservation in the family business makes religious family firms an incubator for value-driven and faith-led decision-making and behavior. They represent a particularly rich and (...) relevant context to re-assess the relationship between ethical beliefs, decision-making processes and behaviors in business organizations at the interface between family and professional logics. This Special Issue is dedicated to deepening our understanding of the role religious values and spirituality play in the formation of organizational ethical practices in faith-led family firms and resulting organizational and family-related outcomes. In this editorial, we introduce the 10 papers included in this Special Issue, which investigate the relationship between religion or spirituality and family firm ethical behavior in various geographical, cultural and religious contexts, using a multitude of qualitative and quantitative methodologies. By focusing on the effects of religious or spiritual orientations on both the business and the family, as well as on the values, norms and goals present in the family business system, further research can gain a more nuanced understanding of the relationship between religious and spiritual believes, and sustainable ethical behavior in family firms. (shrink)

This volume is focused on understanding a key idea in modern semantics-direct reference-and its integration into a general semantics for natural language.

ספר ויקרא, או תורת כוהנים, נראה היום פחות מעניין מאשר ספרי-קודש אחרים, כי הוא ספר מצוות - הוא כולל כארבעים אחוז מכל תרי"ג המצוות - ואף במידה רבה מצוות שאינן בתוקף מאז חורבן בית-המקדש. אך יש בו עניין, שכן הוא מוכר כספר השלם ביותר מבחינת סגנונו ותכנו, ואולי אף בכך שעריכתו כנראה עתיקה ביותר - לא לדעת דון יצחק אברבנאל, שכן הוא לא הטיל בספק כי תורה נתנה למשה מפי הגבורה - אמנם לא בסיני אך בכל-זאת למשה מפי הגבורה. החוקרים (...) המתעלמים מדעה זו.. (shrink)

Generalization is a fundamental problem solved by every cognitive system in essentially every domain. Although it is known that how people generalize varies in complex ways depending on the context or domain, it is an open question how people learn the appropriate way to generalize for a new context. To understand this capability, we cast the problem of learning how to generalize as a problem of learning the appropriate hypothesis space for generalization. We propose a normative mathematical framework for learning (...) how to generalize by learning inductive biases for which properties are relevant for generalization in a domain from the statistical structure of features and concepts observed in that domain. More formally, the framework predicts that an ideal learner should learn to generalize by either taking the weighted average of the results of generalizing according to each hypothesis space, with weights given by how well each hypothesis space fits the previously observed concepts, or by using the most likely hypothesis space. We compare the predictions of this framework to human generalization behavior with three experiments in one perceptual (rectangles) and two conceptual (animals and numbers) domains. Across all three studies we find support for the framework's predictions, including individual‐level support for averaging in the third study. (shrink)

Bacon's inductivist philosophy of science divides thinkers into the scientific and the prejudiced, using as a standard the up-to-date science textbook. Inductivists regard the history of science as progressing smoothly, from facts rather than from problems, to increasingly general theories, undisturbed by contending scientific schools. Conventionalists regard theories as pigeonholes for classifying facts; history of science is the development of increasingly simple theories, neither true nor false. Conventionalism is useless for reconstructing and weighing conflicts between schools, and overemphasizes science's internal (...) organic growth. For Popper, not for inductivists or conventionalists, the successful criticism of theories is the heart of science. Popper's view admits the existence of valuable errors and enables us to avoid being wise after the event, thereby improving our understanding of the history of science through reconstructions of the actual interplay of theories and facts. (shrink)

Philosophical Issues, Volume 31, Issue 1, Page 146-166, October 2021.

Positivists identify science and certainty and in the name of the utter rationality of science deny that it rests on speculative presuppositions. The Logical Positivists took a step further and tried to show such presuppositions really no presuppositions at all but rather poorly worded sentences. Rules of sentence formation, however, rest on the presuppositions about the nature of language. This makes us unable to determine the status of mathematics, which is these days particularly irksome since this question is now-since Abraham (...) Robinson-one that mathematicians cannot ignore. Since mathematics is the paradigm of a logical discourse, logic must offer a system adequate enough to serve mathematics. This fact makes it difficult to avoid making question-begging moves in both mathematics and logic. We must therefore view the rationality of logic as partial and hope it is stepwise improvable. The theory of rationality thus turns to be the major presupposition of logic, and one which has ample metaphysical background to it. The very supposition, basic to all logic, that language is divisible into form andcontent is under suspicion-mathematics perhaps belongs to neither. (shrink)

Excerpt from Scepsis Scientifica: Or, Confest Ignorance, the Way to Science; In an Essay of the Vanity of Dogmatizing, and Confident Opinion He seems to have been brought up, if not as an extreme sectary, at least in some school of Puritanism which allowed small scope for independent judgment. Thus he tells us, in his "Plus Ultra" (p. 142): "In my first education I was continually instructed into a religious and fast adherence to everything I was taught, and a dread (...) of disputing in the least article," - a mode of education which he was wont in after life vehemently to denounce. He entered the University of Oxford in 1652, and took his degree three years after. In the dearth of more direct information, his love of culture and mental independence may fairly be inferred from his associates. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works. (shrink)

The rapidly changing field of genetics affects society through advances in health-care and through implications of genetic research. This study addresses the impacts of new genetic discoveries and technologies on different segments of today's society. The book begins with a chapter on genetic complexity, and subsequent chapters discuss moral and ethical questions arising from today's genetics from the perspectives of health care professionals, the media, the general public, special interest groups and commercial interests.

JOSEPH AGASSI 1. Sir Karl Popper has offered two different theories of scientific progress, his theory of conjectures and refutations and corroboration, as well as his theory of verisimilitude increase. The former was attacked by some old-fashioned inductivists, yet is triumphant; the latter has been refuted by Tichy and by Miller to Popper’s own satisfaction. Oddly, however, the theory of verisimilitude was developed because of some deficiency in the theory of corroboration, and though in its present precise formulation it (...) was refuted, Popper still holds it in general terms, and I think he still hopes to find a better precise formulation of it. My aims in the present note are to pin-point the deficiency of Popper’s theory of corroboration and to use this for a precise formulation of verisimilitude increase acceptable to him. For my part, however, I see the situation in a different way, as will be indicated at the end of this note. (shrink)

: The March 2003 American preemptive strike on Iraq and related events pose entirely new conceptual questions about the notion of a valid war. A “war on terrorism” goes well beyond any usual version of the “just‐war” concept, which is itself notoriously difficult, if not impossible, to apply in current international circumstances. The implications of the emerging forms of war are examined and are found to bear in an unexpected way on justifying war, “just war,” and justice in distributional and (...) related respects. (shrink)

Stanislas Breton's _A Radical Philosophy of Saint Paul_, which focuses on the political implications of the apostle's writings, was an instrumental text in Continental philosophy's contemporary "turn to religion." Reading Paul's work against modern thought and history, Breton helped launch a reassessment of Marxism, introduce secular interpretations of biblical and theological traditions, develop "radical negativity" as a critical category, and rework modern political ideas through a theoretical lens. Newly translated and critically situated, this edition takes a fresh approach to Breton's (...) classic work, reacquainting readers with the remarkable ways in which an ancient apostle can reset our understanding of the political. Breton begins with Paul's biography and the texts of his conversion, which challenge common conceptions of identity. He broaches the question of allegory and divine predestination, introduces the idea of subjectivity as an effect of power, and confronts Paul's critique of Law, which leads to an exploration of the logics and limits of agency and power. Breton develops these and other insights in relation to Paul's subversive reflections on the crucified messiah, which challenge meaning and reason and upend our current world order. Neither a coherent theologian nor a stable humanist, Breton's Paul becomes a fascinating figure of excess and madness, experiencing a kind of being that transcends philosophy, secularity, and religion. (shrink)

O objetivo deste artigo é descrever o grau de parentesco existente entre várias famílias de origem chinesa que se estabeleceram em Nicoya e analisar como isso influenciou suas contribuições para o desenvolvimento socioeconômico da cidade e seus padrões de mobilidade em todo o Pacífico da Costa Rica desde final do século XIX até meados do século XX. Os participantes do estudo são descendentes de imigrantes que se enraizaram em Nicoya entre 1880 e 1950, que possuíam duas peculiaridades: pertenciam aos mesmos (...) clãs familiares, apesar dos diferentes sobrenomes com os quais estavam registrados ou eram da mesma área geográfica e, às vezes, até da mesma aldeia, que desenvolveu laços de afinidade tão fortes quanto laços consanguíneos. Isso lhes permitiu apoiar-se mutuamente para alcançar o desenvolvimento coletivo do grupo de imigrantes chineses em Nicoya. (shrink)

This book gives a concise history of biophysics in contemporary China, from about 1949 to 1976. It outlines how a science specialty evolved from an ambiguous and amorphous field into a fully-fledged academic discipline in the socio-institutional contexts of contemporary China. The book relates how, while initially consisting of cell biologists, the Chinese biophysics community redirected their disciplinary priorities toward rocket science in the late 1950s to accommodate the national interests of the time. Biophysicists who had worked on biological sounding (...) rockets were drawn to the military sector and continued to contribute to human spaceflight in post-Mao China. Besides the rocket-and-space missions which provided the material context for biophysics to expand in the late 1950s and early 1960s, Chinese biophysicists also created research and educational programs surrounding biophysics by exploiting the institutional opportunities afforded by the policy emphasis on science's role to drive modernization. The book explores and demonstrates the collective achievements and struggles of Chinese biophysicists in building their scientific discipline. (shrink)

This Companion centers on the fictitious social contract that can be used to justify liberalism. As justification, the theory of the contract either fully justifies a regime as liberal or it fully condemns it as illiberal. This conflicts with the common recognition that liberalism is a matter of degree. John Rawls is taken as the leading light; yet at best the Companion manages to picture him as well-intended but hopelessly confusing.

The studies of theoretical bias in evidence are these days developed by many clever psychologists, social psychologists, and philosophers. It therefore comes as a surprise to realize that most of the material one can find in the up-to -date literature repeats discoveries which are due to the heroes of the present sketch, namely Galileo Galilei, Sir Francis Bacon, and Robert Boyle; William Whewell, Pierre Duhem, and Karl Popper. We may try to raise scholarly standards by familiarizing ourselves with their ideas (...) and studying them with a little appreciation. (shrink)

Third version of a long-standing textbook that examines the self in everyday life. Visit our website for sample chapters!

Bioethics, and indeed much ethicalwriting generally, makes its point throughnarratives. The religious parable no less thanthe medical teaching case uses a simple storyto describe appropriate action or theapplication of a critical principle. Whilepowerful, the telling story has limits. In thispaper the authors describe a simple teachingcase on ``end-of-life'' decision making that wasill received by its audience. The authors ill-receivedexample, involving the disconnection ofventilation in a patient with ALS (Lou Gherig'sDisease) was critiqued by audience members withlong-term experience as ventilation users. Inthis (...) case, the supposedly simple narrative ofthe presenters conflicted with the lifehistories of the audience. The lessons of thisstory, and the conflict that resulted, speakcritically to the limits of simple teachingcases as well as the strengths of narrativeanalysis as a tool for the exploration ofbioethical case histories. (shrink)

This essay considers 'modern' poetry and music as interrelated signifying practices in the works of Charles Baudelaire and Theodor Adorno through a focus on their approach to understanding dissonance. For Baudelaire, dissonance depends on consonance in order to be perceived at all, a fact which allows us to read the modern not just in terms of a break with the past but also as dependent on it. This essay demonstrates the mutually constitutive nature of consonance and dissonance by placing Baudelaire (...) and Adorno’s writings on dissonance, with reference to the music of Beethoven, into a constellation that allows for insight into the function of ‘modern’ dissonance. It argues that Baudelaire’s approach is both new and dependent on long-standing understandings of dissonance and harmony, and that Adorno’s writings, in conjunction with Baudelaire’s, can make us attentive to the dissonance that operates within harmony rather than standing opposed to it. (shrink)

The thesis or theses I wish to present here may, and hopefully should, sound rather trivial. The public role which concerned philosophers should take these days, I suppose, is somewhat similar to the role of preachers in earlier days, namely to state what should be obvious and treated as obvious but is nonetheless systematically overlooked.

The word "brain-washing", translated from Chinese communist jargon, is a very strong metaphor, first popularized by Robert Jay Lifto n. It vividly describes one person interfering with the personality make-up of another, removing the other's ideology and replacing it, and similarly tampering with the other's tastes, pool of information to rely upon and whatever else goes into the make-up of the other's personality. Clearly, in some sense or another everyone interferes with the personality of people with whom they interact; yet (...) what is meant here is something much more drastic than friends influencing one another's tastes or opinions; it is something more dramatic and more large scale. (shrink)

This Companion to the philosophy of science reflects fairly well the gloomy state of affairs in this subfield at its best—concerns, problems, prejudices, and all. The field is still stuck with the problem of justification of science, refusing to admit that there is neither need nor possibility to justify science and forbid dissent from it.

Abstract and Introduction. This essay is an attempt to dispense with the negative aspects of Romanticism and examine whatever positive it has to offer--in the light of ideas scattered through diverse writings of Ernest Gellner.

1. The Real Claim of the Chicago School If anything dramatic has happened in economic theory over the last one hundred years – namely, since the advent of marginalism – then, everyone agrees, it was not the rise of the Chicago neo -classical school which, after all, only synthesized the various versions of marginalism, but the Keynesian Revolution. Assessments of this revolution were repeatedly invited, particularly by opponent, chiefly from Chicago. F. A. von Hayek has explicitly and bitterly blames Keynes (...) for all our economic troubles; Harry Johnson has repeatedly declared the most revolutionary work of Keynes, his General Theory of 1936, so poor that but for its author's name on its title page it would have totally flopped. Can such a flop cause so much damage? Are these two assessments – of Hayek and of Johnson – in conflict or no t? Don Patinkin has raised a different question: how different is Keynes from his Chicago opponents, say, Milton Friedman? How many heads need roll, to use his metaphor, before a revolution may be declared? Patinkin sees Keynes as slightly deviant but stil l a member of the mainstream – the mainstream of the mainstream being Friedman and his Chicago followers, of course. Now, can a minor deviant be a flop? Can minor deviations from the true blue doctrine be to blame for all of our economic woes? I do not kno w. Joan Robinson sees in Keynes a minor deviation from classical theory because he said once his correction of classical theory is implemented, that theory takes over once again. Moreover, Samuelson and Friedman have endorsed a (poor) version of Keynes' theory of shortterm relative price and ignored his general theory of price and money. (shrink)

presents Heidegger as a devout mystic who viewed the Nazi Party as the sacred vessel of a divine message—even though, the author adds, his religion is secular and so it has no divinity and no immortal soul. Rickey sees him as a utopian. This makes some sense: the unique in the Shoah involves the unique descent of a highly cultured, enlightened nation to the rock bottom of barbarism. Ricky’s text belies his effort to exonerate Heidegger. Key Words: Rickey • Heidegger (...) • secular religion • barbarism. (shrink)

Karl Popper's methodology can be seen as the situational logic of research. Popper called his method "Epistemology without a Knowing Subject." It was dismissed as metaphysical by those who refuse to give up an ideal knowing subject (a perfect human inductive processor). This article surveys the failure of modem discussions of this ideal, from the earliest (the writings of Sir Francis Bacon) to the latest (Kripke). The knowing subject exits at last, but leaves behind interesting results. The ideal knowing subject (...) embodied ideal rationality, outside culture and history. Giving up this ideal invites us to integrate science with its background, to grade rationality (from magic to science), and to integrate different degrees of rationality under one rule. (shrink)

In recent years, Hempel has questioned the universal applicability of the deductive model of causal explanation, and suggested supplementing it with a probability model.' When we explain the fact that one child got the measles by the suggestion that he caught it from another child, we are not using the deductive model, he says, since catching measles is a matter of mere probability and not of strict causality: playing with an infected child is not a sufficient condition for infection.