Genetic research into ageing, longevity and late-onset disease is becoming increasingly common. Yet, there is a paucity of knowledge related to clinical actionability and the return of pathogenic variants to otherwise healthy elderly individuals. Whether or not genetic research in the elderly should be managed differently from standard practices adapted for younger populations has not yet been defined. In this article, we provide an overview of ethical and practical challenges in preparing for a genetic study of over 14 000 healthy (...) Australians aged 70 years or older enrolled in the ASPirin in Reducing Events in the Elderly Healthy Ageing Biobank. At the time of consent, all participants in this study were free of life-threatening illness, cardiovascular disease or cognitive impairment. ASPREE is thus a cohort of healthy elderly individuals with seemingly minimal burden of genetic disease recruited without ascertainment bias. The cohort presents a unique opportunity to address the penetrance of known pathogenic variants in a population without disease symptoms; however, it also raises a number of ethical concerns regarding the interpretation and disclosure of variants with known clinical actionability. Some of the challenges include how to manage the interpretation, disclosure and actioning of pathogenic variants found in otherwise healthy elderly adults without disease symptoms, whether or not to disclose findings for the benefit of family members rather than elderly consented donors themselves, how to manage the return of genetic findings to the elderly individuals who are now in severe cognitive decline or terminal illness, how to ensure quality of information and clinical service upon disclosure of results to this demographic and how to prepare for the insurance implications of disclosing genetic information under Australian law. We discuss these and other dilemmas and propose a defensible plan of management. Trial registration number ISRCTN83772183. (shrink)

The overarching issue with this case study is poor regulation and quality control over direct-to-consumer genetic testing, delivered in the absence of any medical oversight.

fusion theory challenges efforts to see theory as inhibiting by presenting an approach that is innovative, eclectic, and subtle in order to draw out competing and constellating ideas and opinions. This collected volume of essays examines fusion theory and demonstrates how the theory can be applied to the reading of various works of Indian English novelists.

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

In this paper I intend to do two things. The first is to discuss a method of doing philosophy, the method of ‘ordinary language’ philosophy, as it is commonly and misleadingly called. (Its other common title: ‘Oxford Philosophy’ is even more misleading, since the roots of the method lie in Cambridge, and many of the most flourishing branches are in the United States rather than England.)If it needs a name, perhaps the best is—adapting Popper to our purpose—‘piecemeal philosophical engineering’. Such (...) a title would emphasise the attention to detail and the caution about conclusions that characterise the best of such work. The second aim of this paper is to apply the method thus discussed and defended to three questions connected with the concept of freedom. These problems arise out of three recent discussions of freedom—Thought and Action and Spinoza and the Idea of Freedom by Professor Hampshire, and Two Concepts of Liberty by Professor Berlin. (shrink)

Physicians vary in their moral judgments about health care costs. Social intuitionism posits that moral judgments arise from gut instincts, called “moral foundations.” The objective of this study was to determine if “harm” and “fairness” intuitions can explain physicians’ judgments about cost-containment in U.S. health care and using cost-effectiveness data in practice, as well as the relative importance of those intuitions compared to “purity”, “authority” and “ingroup” in cost-related judgments.

At key moments in the Phaedrus and the Republic, Socrates qualifies our capacity to “see” the highest realities (the “place of being,” the “Good beyond being”) with the adverb “mogis” (mogis kathorosa, Phdr. 248a; mogis horisthai, Rep. 517b). Mogis can be used to indicate either the toilsome difficulty of some undertaking or the subject’s proximity to failing to accomplish the undertaking. Socrates uses mogis to qualify the nature of the human soul’s capacity to make the intellectual ascent and see the (...) divine, but it is not prima facie clear whether the qualification is meant to express (1) the difficulty we have in undertaking the intellectual ascent (a comment on the effort required) or (2) the fact that the human soul’s capacity to make the intellectual ascent will, on account of its limitations, only “just barely” be achieved, if at all. After discussing the uses of mogis in classical literature and surveying Plato’s uses of mogis across the corpus, I interpret Plato’s use of mogis at Phaedrus 248a, arguing that mogis kathorosa should be translated as “only gets a good look at the things that are with much toil” rather than the more common “scarcely able to gaze upon the things that are.” I then turn to the parallel passage at Republic 517b and argue against a prominent account, put forward by John Sallis, among others, of Plato’s understanding of divine inaccessibility. Whereas Sallis et al. argue that Plato’s use of mogis indicates that which is to be seen at the acme of the ascent is only “barely glimpsed” on account of the fact that it “withdraws” from our view, I argue instead that Plato’s use of mogis indicates that though we can “get a good look” at the highest realities, that good look is qualified by their inexhaustible excess. The human capacity to see the highest realities is qualified because there is “always more to see,” not because that which is there to be seen “withdraws” from view, and still less because there is some intrinsic limitation to human intellectual vision that prevents us from apprehending the highest realities. Accordingly, the divine is accessible but never exhaustible. (shrink)

"Fénelon is arguably the most neglected of all the major philosophers of early modernity. His political masterwork was the most-read book in eighteenth-century France after the Bible, yet to now we have lacked a single interpretive monograph in English devoted specifically to his thought. This monograph aims to correct this by providing the first such book-length study. In focusing specifically on Fénelon's political thought, it has three primary aims. The first is to provide a reconstruction of Fénelon's political ideas accessible (...) to those who might be encountering Fénelon directly or at length for the first time. The second is to demonstrate the connections between Fénelon's political thought and several other fields to which he made significant and long-recognized contributions, including not only philosophy and political science but also economics, education, literature, theology, and spirituality. Third, the book aims to cut several new edges in our extant understanding and appreciation of Fénelon's political thought and its significance. On this front, it specifically argues that Fénelon is better understood as a moderate and modern thinker rather than as a radical or reactionary, and that Fénelon deserves to be seen not merely as a political thinker but as a political philosopher. Finally, The Political Philosophy of Fénelon argues for Fénelon's relevance to our political world today. Fénelon was a nuanced and insightful diagnostician of ills from egocentrism and social atomism to authoritarianism and imperialism, and our understanding of these phenomena so familiar to us today can benefit from attending to his insights"--. (shrink)

As Josef Pieper writes in his study “On Hope,” the virtue of hope is the virtue that completes the human being in its intermediary, temporal state (the “status viatoris,” or condition of being “on the way”). To be human is always to be “on the way” toward a fulfillment and completion not yet available to it (the “status comprehensoris”). Those who are hopeful direct themselves toward this end as to their fulfillment despite recognizing that it, in some sense, exceeds their (...) grasp, whereas those who are not hopeful either reject the possibility of such a fulfillment (despair) or prematurely suppose themselves to have attained it (presumption). While Pieper’s account of hope is largely based on the theologically-inflected account found in Thomas Aquinas, Pieper draws his conception of the nature of philosophy and philosophical reasoning ultimately from Plato. Philosophy, for Plato, on Pieper’s view, is essentially structured by the “not yet” condition that Pieper calls the status viatoris, as we see mythically depicted in Diotima’s account of Eros as being an intermediary daimon who, partaking of his parents’ opposed natures, is fundamentally characterized by poverty and lack (the “not”) on the one hand and by resourcefulness (the “yet”) on the other. The human soul, erotic at its very core, is structured by this twofold relation to the object of its greatest longing, Beauty Itself, which it doesn’t yet possess but for which it strives with all of its being. In this essay, I show that Plato has a “hopeful” sense of reason on account of the erotic condition (the status viatoris) that essentially characterizes the human soul’s spatio-temporal life during its incarnate, earthly state. If reason is, for Plato, to be true to itself, it must strive for the whole of wisdom even as it lacks that wisdom. Because reason is directed toward a fulfillment it can’t quite fathom, it must relate to that fulfillment essentially in the mode of hope. When, by contrast, reason becomes presumptuous, thinking that it already has a clear and secure cognition of the truth for which it seeks, it becomes dogmatic and runs the risk of falling into the misology diagnosed in the Phaedo when it inevitably comes up against some crack in its understanding. Likewise, when reason succumbs to despair—as we see, for example, in Meno’s eristic argument about the impossibility of learning—it becomes excessively skeptical and inert. Only when reason avoids the twin errors of presumption and despair can it continue in its pursuit of the whole of wisdom while remaining mindful of its limitations. (shrink)

A common view holds that consciousness is needed for knowledge acquired in one domain to be applied in a novel domain. We present evidence for the opposite; where the transfer of knowledge is achieved only in the absence of conscious awareness. Knowledge of artificial grammars was examined where training and testing occurred in different vocabularies or modalities. In all conditions grammaticality judgments attributed to random selection showed above-chance accuracy , while those attributed to conscious decisions did not. Participants also rated (...) each string’s familiarity and performed a perceptual task assessing fluency. Familiarity was predicted by repetition structure and was thus related to grammaticality. Fluency, though increasing familiarity, was unrelated to grammaticality. While familiarity predicted all judgments only those attributed to random selection showed a significant additional contribution of grammaticality, deriving primarily from chunk novelty. In knowledge transfer, as in visual perception , the unconscious may outperform the conscious. (shrink)

Highly mobile computing devices promise to improve quality of life, productivity, and performance. Increased situation awareness and reduced mental workload are two potential means by which this can be accomplished. However, it is difficult to measure these concepts in the ‘wild’. We employed an ultra-portable battery operated and wireless functional near infrared spectroscopy (fNIRS) to non-invasively measure hemodynamic changes in the brain’s prefrontal cortex. Measurements were taken during navigation of a college campus with either a hand-held display, or an augmented (...) reality wearable display. Hemodynamic measures were also paired with secondary tasks of visual perception and auditory working memory to provide behavioral assessment of situation awareness and mental workload. Navigating with an augmented reality wearable display produced the least workload during both secondary tasks. The hemodynamics associated with errors were also different between the two devices. Errors with an augmented reality wearable display were associated with increased prefrontal activity and the opposite was observed for the hand-held display. This suggests that the cognitive mechanisms underlying errors between the two devices differ. These findings show fNIRS is a valuable tool for assessing new technology in ecologically valid settings and that head-mounted displays offer benefits with regards to mental workload while navigating, and potentially superior situation awareness with improved display design. (shrink)

When thinking of Plato’s discussions of virtue, many dialogues come to mind, but, assuredly, the Phaedrus does not. The word ἀρετή is used only six times in the dialogue. Unlike other dialogues, the Phaedrus thematizes neither the general concept of virtue nor any of the particular virtues. Given the centrality of virtue to Plato’s ethics and politics, it is surprising to see little reference to virtue in a dialogue devoted to love and to rhetoric, topics that have deep ethical and (...) political significance. -/- I argue that the Phaedrus makes important contributions to our understanding of virtue in Plato despite the infrequency of references. First, the dialogue juxtaposes competing conceptions of virtue: the “urbane” (cf. 227d) capacity to make things conform to one’s happenstance desires, championed by Lysias, and the “manic” capacity to conform oneself to reality, championed by Socrates. After clarifying that enslavement to pleasure-lust is the underlying condition of soul for Lysianic virtue, Socrates reveals that the non-lover’s “virtue” is, in truth, virtue in name only. Rather, true virtue emerges only when the soul becomes harmoniously ordered under reason’s guidance, a condition which is achieved through the soul’s encounter with beauty. Second, in the process of articulating how true virtue comes to be in the soul, Socrates gives grounds for distinguishing it from “self-restraint” (ἐγκράτεια), a condition of soul whose outward aspect may be indistinguishable from that of virtue. While a soul in which reason does not take the reins may act from self-restraint, it does not yet act from virtue. Third, the dialogue gives us resources for seeing how other people, such as artful rhetoricians, can influence one’s cultivation of virtue. At first glance, Socrates’s claim that artful rhetoricians can “hand over” virtue (270b) seems incompatible with his claim that virtue is unteachable (cf. Meno 86d-99e). However, the dialogue offers some resources for seeing that the unteachability of virtue and the capacity for rhetoricians to “hand over” virtue are not, in fact, incompatible. From these three points, we will see that the Phaedrus offers an intellectualist account of virtue reminiscent of what we see in other dialogues. The intellectualist vision here, however, is one that includes a positive role for the subrational elements of the soul rather than one that excludes them from relevance or actively seeks to suppress them. (shrink)

The debate between ontological reductionists and emergentists in chemistry has revolved around quantum mechanics. What Franklin and Seifert (BJPS 2020) add to the long-running dispute is an attention to the measurement problem. They contend that all three realist interpretations of the quantum formalism capable of resolving the measurement problem also obviate any need for chemical emergence. I push their argument further, arguing that the realist interpretations of quantum mechanics actually subvert the basis for reduction as well, by undercutting the idea (...) that fundamental physical particles are actual parts of molecules. With both reduction and traditional synchronic emergence pictures ruled out, the only option for realists about quantum chemistry is strong Thomistic emergence. (shrink)

Business leadership increasingly requires a master’s degree in business and graduate management admission test scores continue to be an important component of applications for admission to such programs. Given the ubiquitous use of GMAT scores as gatekeepers for business leadership, GMAT scores are likely to influence organizational ethical behavior through gender, cultural, and other biases in the GMAT. There is little prior literature in this area and we contribute by empirically documenting that GMAT scores are negatively related to the cultural (...) dimensions of masculinity and power distance and are positively related to math literacy, uncertainty avoidance, and individualism. We estimate that cultural factors may account for as much as an 80-point difference in cross-national mean GMAT scores which are also related negatively to local language literacy, national educational spending, wealth per capita, wealth inequality, and gender development. Most interestingly, we also find a significant negative association of GMAT scores with ethical orientation. These findings have important implications for business schools and corporate ethics and leadership. (shrink)

'Communities of practice', like 'social capital' and 'networks', is an idea that has been widely adopted in the social sciences, particularly in discussion of innovation and creativity. This book evaluates the concept and its uses, and will be an essential guide for students and researchers.

This article focuses on Auguste Comte’s understanding of the organism–environment relationship. It makes three key claims therein: (a) Comte’s metaphysical position privileged materiality and relativized the intellect along two dimensions: one related to the biological organism, one related to the social environment; (b) this twofold materiality confounds attempts to reduce cognition to either nature or nurture, so Comte’s position has interesting parallels to the field of ‘epigenetics’, which sees the social environment as a causative factor in biology; and (c) although (...) Comte ultimately diverged from the ‘postgenomic’ view in crucial ways, he remains a forerunner of the trend towards viewing the social and biological as entangled. Tending to these dimensions challenges the view that Comte is notable from a classical standpoint but ignorable from a contemporary one. It consequently invites renewed attention to his theoretical system. (shrink)

The influence of prior familiarity with components on the implicit learning of relations was examined using artificial grammar learning. Prior to training on grammar strings, participants were familiarised with either the novel symbols used to construct the strings or with irrelevant geometric shapes. Participants familiarised with the relevant symbols showed greater accuracy when judging the correctness of new grammar strings. Familiarity with elemental components did not increase conscious awareness of the basis for discriminations but increased accuracy even in its absence. (...) The subjective familiarity of test strings predicted grammaticality judgments. However, prior exposure to relevant symbols did not increase overall test string familiarity or reliance on familiarity when making grammaticality judgments. Familiarity with the symbols increased the learning of relations between them thus resulting in greater familiarity for grammatical versus ungrammatical strings. The results have important implications for models of implicit learning. (shrink)

Fools rush in. ALEXANDER POPE, AN ESSAY ON CRITICISM (London, 1711). The full quotation is, “For Fools rush in where Angels fear to tread.” Id. at 66. She who hesitates is lost. Adaptation of the line, “The woman that deliberates is lost.” JOSEPH ADDISON, CATO: A TRAGEDY, AND SELECTED ESSAYS 30 (2004). See also OLIVER WENDALL HOLMES, SR., THE AUTOCRAT AT THE BREAKFAST TABLE 29 (1858) (“The woman who ‘calculates’ is lost.”). American legal realism numbers among the most important theoretical (...) contributions of legal academia to date. Given the movement’s influence, as well as the common centrality of certain key figures, it is surprising that privacy scholarship in the United States has paid next to no attention to the movement. This inattention is unfortunate for several reasons, including that privacy law furnishes rich examples of the indeterminacy thesis — a key concept of American legal realism — and because the interdisciplinary efforts of privacy scholars to explore extra-legal influences on privacy law arguably further the plot of legal realism itself. (shrink)

Social norms are an important input for ethical decisions in any business context. However, the cross-cultural discovery of extant social norms presents a special challenge to international management because norms may be inscrutable to outsiders. This article considers the contribution of Integrative Social Contracts Theory (ISCT) to the analysis of social norms in business ethics. It questions the origins and dynamics of norms from a sociological perspective, and identifies a tension between prescriptive efforts to make norms obligatory and positivist accounts (...) that describe norms as evolving and unstable. In the presence of dynamic and incomplete norms, managers can either deliberate with stakeholders to make norms flexible or codify norms to make them rigid. This essay argues that deliberation is the only reliable method for anticipating emergent norms. (shrink)

If Large Language Models can make real scientific contributions, then they can genuinely use language, be systematically wrong, and be held responsible for their errors. AI models which can make scientific contributions thereby meet the criteria for scientific authorship.

This paper employs recent developments in the theory of truthmakers to offer a novel solution to the most discussed philosophical challenge presented by the Christian doctrine of the Trinity. According to the view developed, the Father, Son, and Spirit each serve as the only substantial constituent of equally minimal truthmakers for claims about God. Because they do, there is a clear and robust sense in which each is a substance that “is” God as much as anything is, while the three (...) remain distinct from each other. The view is shown to hold certain prima facie advantages over rival extant approaches. (shrink)

This paper examines the broad social purpose of US climate science, which has benefitted from a public investment of more than $30 billion over the last 20 years. A public values analysis identifies five core public values that underpin the interagency program. Drawing from interviews, meeting observations, and document analysis, I examine the decision processes and institutional structures that lead to the implementation of climate science policy, and identify a variety of public values failures accommodated by this system. In contrast (...) to other cases which find market values frameworks (the profit as progress assumption) at the root of public values failures, this case shows how science values ( knowledge as progress ) may serve as an inadequate or inappropriate basis for achieving broader public values. For both institutions and individual decision makers, the logic linking science to societal benefit is generally incomplete, incoherent, and tends to conflate intrinsic and instrumental values. I argue that to be successful with respect to its motivating public values, the US climate science enterprise must avoid the assumption that any advance in knowledge is inherently good, and offer a clearer account of the kinds of research and knowledge advance likely to generate desirable social outcomes. (shrink)

This book provides a unique examination on the ways in which educating the whole child in the community school serves to ameliorate the conditions of poverty and obstacles to learning faced by students. Using a case study approach the book will highlight the successful journey of one school that transformed itself into a "community" school.

The author reviews the work of select theologians, ethicists, and biblical scholars who suggest that the difference between humans and animals should serve not solely as an ascription of a special status to humans but also as the foundation for a responsibility that humans bear toward animals. As an added reflection, the author explores common categorical differentiations in systematic theology: God and creation, human and nonhuman, elect and non-elect. In the first and last of these categorical differentiations, unique identity entails (...) both a special status and a responsibility. The latter is normatively directed to those who are categorically different. As such, the categorical difference between humans and animals establishes a foundation for moral concern. (shrink)

Wittgenstein’s Private Language Argument holds that language requires rule-following, rule following requires the possibility of error, error is precluded in pure introspection, and inner mental life is known only by pure introspection, thus language cannot exist entirely within inner mental life. Fodor defends his Language of Thought program against the Private Language Argument with a dilemma: either privacy is so narrow that internal mental life can be known outside of introspection, or so broad that computer language serves as a counter-example. (...) I suggest that the developing field of artificial intelligence (deep learning neural networks) tends to vitiate Fodor’s defense and hence vindicate the Private Language Argument. The first horn of Fodor’s dilemma requires language to encompass genuinely internal mental life, i.e. non-projected intentional states, which are not exhibited in classical machine learning but only by deep learning neural networks (artificial intelligence). Such networks act as black boxes, however, whose state cannot be understood by tracking the changes in their supervenience bases without shared context, and that shared context introduces the possibility of error. The language of artificial intelligence is not private. (shrink)

The radical evolutionary step that divides human decision-making from that of nonhumans is the ability to excite the reward process for its own sake, in imagination. Combined with hyperbolic over-valuation of the present, this ability is a potential threat to both the individual's long term survival and the natural selection of high intelligence. Human belief is intrinsically or under-founded, which may or may not be adaptive.

The implementation of sustainable development goals forces the leaders of organizations to develop cognitive and behavioural capacities to manage the resulting complexity. These abilities can be associated with authentic leadership. Reflective approaches are recognized as showing promise for developing this type of leadership. However, they are rarely used in the context of university training. This article compares two learning approaches that target leadership development in master’s level students. It emerges that experiential learning through collaborative action games would help to develop (...) certain components of authentic leadership more than coaching. (shrink)

Steroid hormones are signaling molecules important for normal growth, development and differentiation of multicellular organisms. Brassinosteroids (BRs) are a class of polyhydroxylated steroids that are necessary for plant development. Molecular genetic studies in Arabidopsis thaliana have led to the cloning and characterization of the BR receptor, BRI1, which is a transmembrane receptor serine/threonine kinase. The extracellular domain of BRI1, which is composed mainly of leucine‐rich repeats, can confer BR responsivity to heterologous cells and is required for BR binding. Although downstream (...) components of BR action are mostly unknown, multiple genes whose expression are regulated by BRs have been identified and suggest mechanisms by which BRs affect cell elongation and division. BioEssays 23:1028–1036, 2001. © 2001 John Wiley & Sons, Inc. (shrink)