Coarse-grain models are essential to understand the biological function of DNA molecules because the length and time scales of the sequence-dependent physical properties of DNA are often beyond the reach of experimental and all-atom computational methods. Simulating coarse-grain models of DNA, e.g. using Langevin dynamics, requires the parametrization of both potential and kinetic energy functions. Many studies have shown that the flexibility (i.e., potential energy) of a DNA molecule depends on its sequence. In contrast, little is known about the sequence-dependence (...) of DNA mass parameters required to model its kinetic energy. In this paper, an algebraic expression is derived for the kinetic energy as a function of linear and angular velocities of each DNA base parameterized by its mass, center of mass, and rotational inertia tensor. The parameters of this function are then approximated from a set of fine-grain molecular dynamics simulations representing all combinations of the four DNA base pairs AT, TA, GC, and CG, in different sequence contexts. Compatibility conditions associated with the assumption of each base being modeled as a rigid body were verified to be good approximations. The kinetic parameters were found to be significantly different between the four G, C, A, and T bases, and to not be dependent on the sequence context. This suggests that the effective kinetic parameters of a DNA base may depend only on the base itself, not on its neighbors. (shrink)

Author Jeremy Waldron has thoroughly revised thirteen of his most recent essays in order to offer a comprehensive critique of the idea of the judicial review of legislation. He argues that a belief in rights is not the same as a commitment to a Bill of Rights. This book presents legislation by a representative assembly as a form of law making which is especially apt for a society whose members disagree with one another about fundamental issues of principle.

The philosophy of evidence-based medicine -- What is EBM? -- What is good evidence for a clinical decision? -- Ruling out plausible rival hypotheses and confounding factors : a method -- Resolving the paradox of effectiveness : when do observational studies offer the same degree of evidential support as randomized trials? -- Questioning double blinding as a universal methodological virtue of clinical trials : resolving the Philip's paradox -- Placebo controls : problematic and misleading baseline measures of effectiveness -- Questioning (...) the methodological superiority of "placebo" over "active" controlled trials -- Examining the paradox that traditional roles for mechanistic reasoning and expert -- Judgment have been up-ended by EBM -- A qualified defence of the EBM stance on mechanistic reasoning -- Knowledge that versus knowledge how : situating the EBM position on expert clinical judgment -- Moving EBM forward. (shrink)

Debates about the ethics and effects of placebos and whether ‘placebos’ in clinical trials of complex treatments such as acupuncture are adequate rage. Yet there is currently no widely accepted definition of the ‘placebo’. A definition of the placebo is likely to inform these controversies. Grünbaum’s characterization of placebos and placebo effects has been touted by some authors as the best attempt thus far, but has not won widespread acceptance largely because Grünbaum failed to specify what he means by a (...) therapeutic theory and because he does not stipulate a special role for expectation effects. Grünbaum claims that placebos are treatments whose ‘characteristic features’ do not have therapeutic effects on the target disorder. I show that with four modifications, Grünbaum’s definition provides a defensible account of placebos for the purpose of constructing placebo controls within clinical trials. The modifications I introduce are: adding a special role for expectations, insisting that placebo controls control for all and only the effects of the incidental treatment features, relativizing the definition of placebos to patients, and introducing harmful interventions and nocebos to the definitional scheme. I also provide guidance for classifying treatment features as characteristic or incidental. (shrink)

In this paper we present a schema for describing dualities between physical theories, and illustrate it in detail with the example of bosonization: a boson-fermion duality in two-dimensional quantum field theory. The schema develops proposals in De Haro : these proposals include construals of notions related to duality, like representation, model, symmetry and interpretation. The aim of the schema is to give a more precise criterion for duality than has so far been considered. The bosonization example, or boson-fermion duality, has (...) the feature of being simple, yet rich enough, to illustrate the most relevant aspects of our schema, which also apply to more sophisticated dualities. The richness of the example consists, mainly, in its concern with two non-trivial quantum field theories: including massive Thirring-sine-Gordon duality, and non-abelian bosonization. This prompts two comparisons with the recent philosophical literature on dualities:--- Unlike the standard cases of duality in quantum field theory and string theory, where only specific simplifying limits of the theories are explicitly known, the boson-fermion duality is known to hold {\it exactly}. This exactness can be exhibited explicitly. The bosonization example illustrates both the cases of isomorphic and {\it non-isomorphic} models: which we believe the literature on dualities has not so far discussed. (shrink)

Issues pertaining to sex and gender continue to be some of the most hotly debated topics of our time. While many of the most heated disputes occur at the level of politics and public policy, metaphysics, too, has a crucial role to play in these debates. In this essay, I explore several key metaphysical debates concerning sex and gender through the lenses of two important areas in contemporary metaphysics: the metaphysics of essence and the ontology of the human person. The (...) goal here is not to advocate any particular position on these issues, but to show how the tools of contemporary metaphysics can help to offer a more comprehensive map of the conceptual terrain, indicating where major areas of agreement can be found and where the most important disagreements really lie. (shrink)

Lady Mary Shepherd’s critique of Hume’s account of causation, his worries about knowledge of matters of fact, and the contention that it is possible for the course of nature to spontaneously change relies primarily on three premises, two of which – that objects are merely bundles of qualities and that the qualities of an object are individuated by the causal powers contributed by those qualities – anticipate contemporary metaphysical views in ways that she should be getting credit for. The remaining (...) premise – that it is impossible for an object to begin to exist uncaused – seems more old fashioned. I argue that Shepherd can do without her old-fashioned premise and that she provides the materials for arguing that her remaining premises demonstrate a stronger anti-Humeanism than is maintained even by the contemporary representatives of those views, even though she may have to concede more to Humeanism than she would like. (shrink)

The epsilon calculus is a logical formalism developed by David Hilbert in the service of his program in the foundations of mathematics. The epsilon operator is a term-forming operator which replaces quantifiers in ordinary predicate logic. Specifically, in the calculus, a term εx A denotes some x satisfying A(x), if there is one. In Hilbert's Program, the epsilon terms play the role of ideal elements; the aim of Hilbert's finitistic consistency proofs is to give a procedure which removes such terms (...) from a formal proof. The procedures by which this is to be carried out are based on Hilbert's epsilon substitution method. The epsilon calculus, however, has applications in other contexts as well. The first general application of the epsilon calculus was in Hilbert's epsilon theorems, which in turn provide the basis for the first correct proof of Herbrand's theorem. More recently, variants of the epsilon operator have been applied in linguistics and linguistic philosophy to deal with anaphoric pronouns. (shrink)

I have two main aims. The first is general, and more philosophical. The second is specific, and more closely related to physics. The first aim is to state my general views about laws and causation at different ”levels’. The main task is to understand how the higher levels sustain notions of law and causation that ”ride free’ of reductions to the lower level or levels. I endeavour to relate my views to those of other symposiasts. The second aim is to (...) give a framework for describing dynamics at different levels, emphasizing how the various levels’ dynamics can mesh or fail to mesh. This framework is essentially that of elementary dynamical systems theory. The main idea will be, for simplicity, to work with just two levels, dubbed ”micro’ and ”macro’, which are related by coarse-graining. I use this framework to describe, in part, the first four of Ellis’ five types of top-down causation. (shrink)

Regulating affective responses to acute stress has the potential to improve health, performance, and well-being outcomes. Using the biopsychosocial model of challenge and threat as an organizing framework, we review how appraisals inform affective responses and highlight research that demonstrates how appraisals can be used as regulatory tools. Arousal reappraisal, specifically, instructs individuals on the adaptive benefits of stress arousal so that arousal is conceptualized as a coping resource. By reframing the meaning of signs of arousal that accompany stress, it (...) is possible to break the link between stressful situations, and malignant physiological responses and experiences of negative affect. Applications of arousal reappraisal for academic contexts and clinical science, and directions for future research are discussed. (shrink)

This paper offers a new argument that your reasons for believing or acting need not be true. It proceeds indirectly through an account of what it takes to be happy that p. To be happy that p is for p to be among your reasons for being happy. That’s because questions about why you’re happy and what you’re happy is the case are interchangeable. But, I argue, it is possible to be happy that p even when p is false. In (...) cases in which you believe falsely that p and sincerely assert that you are happy that p, you are still expressing happiness about something. To be happy about something is to be happy that some proposition is the case. In the cases in question, it is implausible that the proposition you are happy is the case is a proposition about the evidence or how things seem or what you believe. The only other option is that the proposition you are happy is the case is p itself. Along the way, I discuss linguistic data that seems to counter the view that you can be happy that falsehoods are true. Though initially suggesting a more principled argument that you can only be happy about truths, both the linguistic data and the principled argument can ultimately be defused. A similar principled argument for the factivity of ‘knows,’ however, remains happily untouched. (shrink)

The metamathematical tradition, tracing back to Hilbert, employs syntactic modeling to study the methods of contemporary mathematics. A central goal has been, in particular, to explore the extent to which infinitary methods can be understood in computational or otherwise explicit terms. Ergodic theory provides rich opportunities for such analysis. Although the field has its origins in seventeenth century dynamics and nineteenth century statistical mechanics, it employs infinitary, nonconstructive, and structural methods that are characteristically modern. At the same time, computational concerns (...) and recent applications to combinatorics and number theory force us to reconsider the constructive character of the theory and its methods. This paper surveys some recent contributions to the metamathematical study of ergodic theory, focusing on the mean and pointwise ergodic theorems and the Furstenberg structure theorem for measure preserving systems. In particular, I characterize the extent to which these theorems are nonconstructive, and explain how proof-theoretic methods can be used to locate their "constructive content.". (shrink)

Hypnosis is considered a unique tool capable of modulating cognitive processes. The extent to which hypnotic suggestions intervenes is still under debate. This study was designed to provide a new insight into this issue, by focusing on an unintentional emotional process: attentional bias. In Experiment 1, highly suggestible participants performed three sessions of an emotional Stroop task where hypnotic suggestions aiming to increase and decrease emotional reactivity towards emotional stimuli were administered within an intra-individual design. Compared to a baseline condition (...) (without hypnotic suggestion), a significant increase in attentional bias was found when a hypnotic suggestion to increase emotional reactivity was administered. In contrast, the bias was eliminated when a suggestion to decrease emotional reactivity was administered. Experiment 2 investigated the effect of session repetition on attentional bias across three successive experimental sessions without hypnosis, and showed that the emotional Stroop effect did not vary across sessions. Hence, session repetition could not account for part of the modulation of attentional bias in Experiment 1. Taken together, the results suggest that specific hypnotic suggestions can influence elicitation of unintentional emotional processing. The implications are discussed regarding the locus of intervention of hypnotic suggestion in cognitive and emotional processes. (shrink)

According to Michael Friedman, Ernst Cassirer’s “outstanding contribution [to Neo-Kantianism] was to articulate, for the first time, a clear and coherent conception of formal logic within the context of the Marburg School” (Friedman 2000, p. 30). In his paper “Kant und die moderne Mathematik” (1907), Cassirer argued not only that the new relational logic of Frege1 and Russell was a major breakthrough with profound philosophical implications, but also that the logicist thesis itself was a “fact” of modern mathematics. Cassirer summarizes (...) his evaluation of Russell’s work: Here logic and mathematics have been fused into a true, henceforth indissoluble unity; and from this inner connection there arises for each... (shrink)

The biopsychosocial model of challenge and threat posits that resource and demand appraisals interact in situations of acute stress to determine affective responses, and concomitant physiological responses, motivation, and decisions/behaviors. Regulatory approaches that alter appraisals to regulate challenge and threat affective states have the potential to facilitate coping. This reply clarifies the conceptualization of one such regulatory approach, arousal reappraisal, and suggests avenues for future research. However, it is important to note that arousal reappraisal is not a “silver bullet” for (...) improving stress outcomes, nor should this strategy be expected to positively impact all individuals. More work is needed to better elucidate how psychological and biological stress processes interact to shape health. (shrink)

This is a three-part study and defense of the idea of basic human equality. (This is the idea that humans are basically one another's equals, as opposed to more derivative theories of the dimensions in which we ought to be equal or the particular implications that equality might have for public policy.) Part (1) of the paper examines the very idea of basic equality and it tries to elucidate it by considering what an opponent of basic human equality (e.g. a (...) philosophical racist) might hold. It explores the idea of there being no morally significant fundamental divisions among humans (of the kind that some people insist on as between humans and others animals). Part (2) considers whether basic human equality must be based on some descriptive similarity among us (naturalistic or metaphysical); it considers the positions of a number of thinkers who have denied this. Part (3) considers John Rawls's conception of basic equality in terms of range properties. (Being in Ohio is a range property; Columbus and Cincinnati are both equally in Ohio even though even though Columbus is in the center of the state, while Cincinnati is just over the river from Kentucky.) It explores the application of this Rawlsian idea to the descriptive properties that might be thought relevant to human equality. This three part paper is a rather technical philosophical exploration. And it is just a beginning; we need much more work on the idea of basic equality. Some of the energy that has gone into discussions of equality as a policy aim (e.g. in the Dworkin/Sen literature or in the literature surrounding Rawls's Difference Principle) needs to be devoted to this more fundamental conception. (shrink)

This article investigates the history of the relation between idealism and pragmatism by examining the importance of the French idealist Charles Renouvier for the development of William James's ‘Will to Believe’. By focusing on French idealism, we obtain a broader understanding of the kinds of idealism on offer in the nineteenth century. First, I show that Renouvier's unique methodological idealism led to distinctively pragmatist doctrines and that his theory of certitude and its connection to freedom is worthy of reconsideration. Second, (...) I argue that the technical vocabulary and main structure of the argument from the ‘Will to Believe’ depend upon Renouvier's idealist theory of knowledge and psychology of belief, and that taking account of this line of influence is of crucial importance for establishing the correct interpretation of James's work. (shrink)

Using a social exchange perspective of narcissism as the foundation for study hypotheses, this study explored the relationship between leaders’ narcissism and the well-being of both leaders and subordinates at the individual and group levels. Results from a sample of 1017 subordinates working under 424 leaders generally support the hypothesized models finding leaders’ narcissism negatively relates to leader-member exchange, and that LMX subsequently relates to subordinates’ job satisfaction and emotional exhaustion. At the group level, leaders’ narcissism also negatively relates to (...) three forms of leaders’ personal well-being but these relationships go through average LMX. Elaboration on theoretical and empirical implications for business ethics is offered to provide a clearer direction for future research in this area. (shrink)

Time, along with concepts as space and matter, is bound to be a central concept of any physical theory. The chapter first discusses how time is treated similarly in quantum and classical theories. It then provides a few references on time‐reversal. The chapter discusses three chosen authors' (Paul Busch, Jan Hilgevoord and Jos Uffink) clarifications of uncertainty principles in general. Next, the chapter follows Busch in distinguishing three roles for time in quantum physics. They are external time, intrinsic time and (...) observable time. It also provides a brief discussion on time operators, in particular Pauli's influential proof. Finally, the chapter talks about time‐energy uncertainty principles with intrinsic times. (shrink)

Why does Foucault's work continue to be of central importance in current debates in sociology, political science and philosophy? Why do we still read him as a guide to contemporary social and cultural life? Foucault's work presents a provocative challenge to orthodox, habitual forms of belief and practice. The Later Foucault, with an impressive interdisciplinary focus, argues that one of the keys to understanding Foucault is his political thought. It is this which he expressed clearly in his last writings and (...) which pulled together his earlier interests in power, agency and subjectivity. In this volume a distinguished array of Foucauldian scholars and commentators on politics explore the significance of these l. (shrink)

What can Stoicism offer to contemporary debates about forgiveness? Given their outright rejection of a reactive attitudes framework for responding to wrongdoing and their bold suggestions of how to revise our moral practices, the Stoics provide a valuable lens through which to re-evaluate various central claims in the debates about forgiveness. In this chapter, I highlight four common assumptions that the Stoics would consider problematic: firstly, that forgiveness is opposed to justice; secondly, that anger and resentment are necessary for registering (...) wrongdoing; thirdly, that anger and resentment are generally reliable at tracking the severity of wrongdoing; fourthly, that reconciliation with wrongdoers is an option rather than an imperative of virtue. Insofar as the Stoics provide defensible and often compelling alternatives to these positions, Stoicism offers a number of philosophical resources to re-conceptualize the way we think about forgiveness and suggests ways in which forgiveness might be better integrated into a virtue ethical framework. (shrink)

I argue that addiction is not an appropriate category to support generalizations for the purposes of scientific prediction. That is, addiction is not a natural kind. I discuss the Homeostatic Property Cluster (HPC) theory of kinds, according to which members of a kind share a cluster of properties generated by a common mechanism or set of mechanisms. Leading accounts of addiction in literature fail to offer a mechanism that explains addiction across substances. I discuss popular variants of the disease conception (...) and demonstrate that at least one class of substances that fails to confirm a major prediction of each account. When no mechanism can be found to explain the occurrence of the relevant properties in members of a category, the HPC view suggests that we revise our categories. I discuss options offered by the HPC view, including category revision and category replacement. I then conclude that talk of addiction as a prediction-supporting category should be replaced with categories such as “S-addiction” and “T-addiction,” where S and T are substances or sets of substances of abuse, as these categories are genuine natural kinds. (shrink)

The ethical and political dilemmas raised byInformation and Communication Technology (ICT)have only just begun to be understood. Theimpact of centralised data collection, masscommunication technologies or the centrality ofcomputer technology as a means of accessingimportant social institutions, all poseimportant ethical and political questions. As away of capturing some of these effects I willcharacterise them in terms of the type of powerand, more particularly, the ‘Power-over’ peoplethat they exercise. My choice of thisparticular nomenclature is that it allows us todescribe, firstly, how specific (...) technologiesoperate and second, exactly what sorts ofconstraints they impose on people. The reasonfor this focus has to do with a further aim ofthe essay, which is to intervene in aparticular type of debate that is often hadaround the appropriate use and scope oftheories of power that are employed in thinkingabout ICT, especially those theories associatedwith the work of Michel Foucault. There isconsiderable use of his work in computerethics, but my claim will be that despite theproductive uses of his work in the areas ofsurveillance, for instance, it does not exhaustthe larger potential of his work on power and,in part, `government.' I will argue that inorder to properly understand the politicalimpact of some aspects of ICT, especially thedigital divide, one needs an account of howpower operates that includes more traditionaltypes of power-over. To the extent that I willdeal with these concerns, the paper is both acontribution to debates about the nature andscope of Foucault's theory of power and to theissue of the effects of the digital divide. (shrink)

Despite concern that patients in the intensive care unit (ICU) may not be treated with respect and dignity, there is not conceptual clarity regarding what constitutes such treatment. In addition, measures specific to treatment with respect and dignity in the ICU are unavailable. Accordingly, a multidisciplinary group developed a conceptual model for treatment with respect and dignity in the ICU and used mixed methods to gather data on this issue. This effort included interviews with patients and families, focus groups with (...) health care professionals, and direct observations. These data were then compared and contrasted to synthesize what was learned. Finally, pilot quantitative patient and family survey data were collected and analyzed. Each of these approaches, which comprise the papers in this supplement to Narrative Inquiry in Bioethics, is briefly described in this article. (shrink)

In Science, Truth, and Democracy, Philip Kitcher challenges the view that science has a single, context‐independent, goal, and that the pursuit of this goal is essentially immune from moral critique. He substitutes a context‐dependent account of science’s goal, and shows that this account subjects science to moral evaluation. I argue that Kitcher’s approach must be modified, as his account of science ultimately must be explicated in terms of moral concepts. I attempt, therefore, to give an account of science’s goal that (...) is free of direct moral entanglements but still makes this goal context‐dependent and leaves the choice of which projects to pursue subject to moral scrutiny. (shrink)

ArgumentIt would have been easy for a less imaginative historian of mathematics than Herbert Mehrtens to have portrayed the work of Hilbert, Hausdorff, and other modernists as pioneers, and those who did not subscribe to their program as people who failed, were not good enough to make the turn, and were eventually and convincingly left behind. That he did not do so is not only because this would have been a shallow, selective view of the facts: it is incompatible with (...) his Foucauldian approach to the relations between knowledge and power. Instead, he defined what I see as the most intriguing category of actor in his Moderne—Sprache—Mathematik (1990), the Gegenmoderner, or counter-moderns. The three men who characterize this position are Felix Klein, Henri Poincaré, and Luitzen Brouwer, and each merits a section in the book.Of the three, Poincaré is the hardest to contain within that category. The range of his work, the nature of his influence, and the shifting standards by which mathematical significance has been evaluated by mathematicians, historians of mathematics, and society at large, all contribute to the problem. After thirty years, the methodological presumptions and aspirations of historians of mathematics have also changed, and I shall suggest that one way to appreciate the richness of Mehrtens’ book, to gain insight into what is meant by mathematical modernism, and to acknowledge a generation of work by other historians since 1990, is to re-examine aspects of Poincaré’s life and work and scholarship about him. Prodded by remarks by Leo Corry, Moritz Epple, and David Rowe, I shall suggest that the simple but useful dichotomy modern/counter-modern must be seen as a way into a more complicated situation, one in which different aspects of mathematics, specifically applied mathematics and the relationship of mathematics to contemporary physics, require fresh accounts of the role of modern mathematics in society. (shrink)

Since his death in 1986, Michel de Certeau's reputation as a thinker has steadily grown both in France and throughout the English-speaking world. His work is extraordinarily innovative and wide-ranging, cutting across issues in historiography, literary and cultural studies, anthropology, sociology, theology, philosophy and psychoanalysis. This book represents the first full-length study of Certeau's thought. It is organized around the central theme of interpretation and alterity, which Ahearne uses to illuminate Certeau's work as a whole. The author also examines Certeau's (...) theory and practice of historiography; his reflection on the relations between changing historical forms of writing, reading and orality; and his distinction between the "strategic" programmes of the politically powerful and the "tactics" of the relatively powerless. Ahearne places Certeau's work in its general intellectual context, relating it to the views of important contemporary thinkers, such as Pierre Bourdieu and Michel Foucault, and demonstrating the decisive importance to Certeau's thought of the writings of the early modern mystics and travellers. This book constitutes an excellent critical introduction to Certeau's work, while also providing a comprehensive and nuanced reading for those already familiar with his thought. (shrink)

In this paper, I compare two prominent positions within contemporary “Analytic” and “Continental” political philosophy: philosophical anarchism and the paradox of politics. I compare each through an analysis of their respective criticisms of state legitimacy and the internal difficulties each position has in accounting for the legitimacy of state violence. I argue that these internal difficulties force each position to ask questions and criticize assumptions commonly found in the other position. I hope to show through this comparison that work across (...) the analytic/continental divide can tell us a great deal about a range of intractable political phenomena. (shrink)

For a quarter of a century, the Council for Responsible Genetics has provided a unique historical lens into the modern history, science, ethics, and politics of genetic technologies. Since 1983 the Council has had leading scientists, activists, science writers, and public health advocates researching and reporting on a broad spectrum of issues, including genetically engineered foods, biological weapons, genetic privacy and discrimination, reproductive technologies, and human cloning. Biotechnology in Our Lives examines how these issues affect us daily whether we realize (...) it or not. Written for the nonscientist, it looks at the many applications of genetics on the world around us by posing questions such as: What should we know about genetics and childbirth? Can our genes keep us from qualifying for health insurance? Can gene therapy cure cancer? Is behavior genetically determined? Why would the FBI want our genes? Are foreign genes in our food? And much more Ultimately, this definitive book on the subject also encourages us to think about the social, environmental, and moral ramifications of where this technology is taking us. (shrink)

: In light of information uncovered about human radiation experiments conducted during the Cold War, an important charge for the Advisory Committee on Human Radiation Experiments was to assess the current state of protections for human research subjects. This assessment was designed to enhance the Committee's ability to make informed recommendations for the improvement of future policies and practices for the protection of research subjects. The Committee's examination of current protections revealed great improvement over those from the past, yet some (...) problems remain. Although the data collected by the Committee highlight specific areas in need of attention, the Committee's work should be viewed in part as the beginning of a series of ongoing assessments of the adequacy and effectiveness of the protections afforded to human subjects. (shrink)

I argue against the idea (made popular by H.L.A. Hart) that the key to a legal system is its "rule of recognition." I argue that much of the work allegedly done by a rule of recognition is either done by a different kind of secondary rule (what Hart called "a rule of change") or it is not done at all (and doesn't have to be done). A rule of change tells us the procedures that must be followed and the substantive (...) conditions that must be satisfied if law is to be changed legislatively; and a judge "recognizes" changes simply by using this checklist. In common law, there is no clear rule of change (because we are profoundly ambivalent about judicial lawmaking). But we get by without one, and without a determinate rule of recognition that would tell us precisely how to infer rules from precedents. It is quite liberating, really, to abandon the idea of a rule of recognition. Apart from anything else, it relieves us from having to participate in endless debates about whether the US Constitution is (or contains) a rule of recognition for American law. The Constitution contains rules of change; that's what matters. (shrink)

Strong reasoning skills are an important aspect to cultivate in life, as they directly impact decision making on a daily basis. By examining the different ways the world views logic and order, new methods and techniques can be employed to help expand on this skill further in the future. -/- Philosophical Perceptions on Logic and Order is a pivotal scholarly resource that discusses the evolution of logical reasoning and future applications for these types of processes. Highlighting relevant topics including logic (...) patterns, deductive logic, and inductive logic, this publication is an ideal reference source for academicians, students, and researchers that would like to expand their understanding of how society currently employs the use of logical reasoning techniques. (shrink)

Jamin Asay has recently argued that deflationists about the concept of truth cannot satisfactorily account for our alethic desires, i.e., those of our desires that pertain to the truth of our beliefs. In this brief reply, I show how deflationists can draw on well‐established psychological findings on framing effects to explain how the concept of truth behaves within the scope of our alethic desires.

Although sensorimotor contingencies may explain visual perception, it is difficult to extend this concept to speech perception. However, the basic concept of perception as active hypothesis testing using attention does extend well to speech perception. We propose that the concept of sensorimotor contingencies can be broadened to sensory-attentional contingencies, thereby accounting for speech perception as well as vision.

. CHRESTOMATHIA: BEING A COLLECTION OF PAPERS EXPLANATORY OF THE DESIGN OF AN INSTITUTION PROPOSED TO BE SET ON FOOT UNDER THE NAME OF THE ...

Since its introduction just over two decades ago, evidence-based medicine (EBM) has come to dominate medical practice, teaching, and policy. There are a growing number of textbooks, journals, and websites dedicated to EBM research, teaching, and evidence dissemination. EBM was most recently defined as a method that integrates best research evidence with clinical expertise and patient values and circumstances in the treatment of patients. There have been debates throughout the early 21st century about what counts as good research evidence between (...) EBM proponents and philosophical critics and even within the EBM community itself. Similar controversy arises about the relative worth of patient values and clinical expertise (and how these can be integrated). EBM has also evolved in ways that have come under scrutiny. Specifically, policymakers have used EBM research methodology to increase the relative importance of clinical guidelines that some clinicians have argued are tyrannical. Philosophers have addressed all of these controversies, and with very few exceptions have been critical of EBM. In addition most philosophical attention has been on the epistemic role of Randomization and evidence hierarchies, with relatively little attention being paid to the role of Diagnosis, expertise, patient values, and Systematic Reviews within EBM. (shrink)

In his Reasons and Persons, Derek Parfit argues from the possibility of cases of fission and/or fusion of persons that one must reject identity as what matters for personal survival. Instead Parfit concludes that what matters is “psychological connectedness and/or continuity with the right kind of cause,” or what he calls an R-relation. In this paper, I argue that, if one accepts Parfit’s conclusion, one must accept that R-relations are what matter for moral responsibility as well. Unfortunately, it seems that (...) accepting that the R-relation is what matters for both survival and moral responsibility leads to a contradiction. My goal, however, is not merely to point out a problem in Parfit’s account. Instead, I believe that once we understand the basic intuitions which lead to this contradiction, it is clear that there is no fully satisfactory way to account for what matters with respect to survival and moral responsibility. (shrink)

Name der Zeitschrift: Semiotica Jahrgang: 2016 Heft: 208 Seiten: 79-101.