BackgroundIn the Canadian Alliance for Healthy Hearts and Minds (CAHHM) cohort, participants underwent magnetic resonance imaging (MRI) of the brain, heart, and abdomen, that generated incidental findings (IFs). The approach to managing these unexpected results remain a complex issue. Our objectives were to describe the CAHHM policy for the management of IFs, to understand the impact of disclosing IFs to healthy research participants, and to reflect on the ethical obligations of researchers in future MRI studies.MethodsBetween 2013 and 2019, 8252 participants (...) (mean age 58 ± 9 years, 54% women) were recruited with a follow-up questionnaire administered to 909 participants (40% response rate) at 1-year. The CAHHM policy followed a restricted approach, whereby routine feedback on IFs was not provided. Only IFs of severe structural abnormalities were reported.ResultsSevere structural abnormalities occurred in 8.3% (95% confidence interval 7.7–8.9%) of participants, with the highest proportions found in the brain (4.2%) and abdomen (3.1%). The majority of participants (97%) informed of an IF reported no change in quality of life, with 3% of participants reporting that the knowledge of an IF negatively impacted their quality of life. Furthermore, 50% reported increased stress in learning about an IF, and in 95%, the discovery of an IF did not adversely impact his/her life insurance policy. Most participants (90%) would enrol in the study again and perceived the MRI scan to be beneficial, regardless of whether they were informed of IFs. While the implications of a restricted approach to IF management was perceived to be mostly positive, a degree of diagnostic misconception was present amongst participants, indicating the importance of a more thorough consent process to support participant autonomy.ConclusionThe management of IFs from research MRI scans remain a challenging issue, as participants may experience stress and a reduced quality of life when IFs are disclosed. The restricted approach to IF management in CAHHM demonstrated a fair fulfillment of the overarching ethical principles of respect for autonomy, concern for wellbeing, and justice. The approach outlined in the CAHHM policy may serve as a framework for future research studies.Clinical trial registrationhttps://clinicaltrials.gov/ct2/show/nct02220582. (shrink)

J. L. Ackrill's work on Plato and Aristotle has had a considerable influence upon ancient philosophical studies in the late twentieth century. In his writings the rigour and clarity of contemporary analytic philosophy are brought to bear upon ancient thought; in many cases he has provided thefirst analytic treatment of a key issue. Gathered now in this volume are the best of Ackrill's essays on the two greatest philosophers of antiquity. With philosophical acuity and philological expertise he examines a wide (...) range of texts and topics--from ethics and logic to epistemology andmetaphysics--which continue to be in the focus of debate. (shrink)

The study of post-Aristotelian philosophy is constantly confused by the perplexing way in which the names of philosophers recur. Zeno, the founder of Stoicism, is sufficiently well known not be confused with either Zeno the Eleatic or the later Stoic, Zeno of Tarsus, a disciple of Chrysippus; but when we come to less distinguished names the opportunity of error is greater. If two philosophers of the same name are prominent members of different schools, there ought to be no obscurity, but (...) in an age of eclecticism one school will sometimes adopt doctrines from another, and so make classification difficult. (shrink)

No tragic poet uses the phrase μxs22EFνος πνxs22EFουσαν, except Aeschylus, who employs it in describing the Erinyes, not a Greek maiden. Similarly Homer of his ‘Mut-schnaubende’ heroes and of the savage steeds of Diomed. Hence, in the Sophoclean passage, some scribe may have mistaken the familiar ΜΕΝΟCΠΝΕΟΤCΑΝ for the more unusual ΜΕΝΕΙCΙCΤΝΟΤCΑΝ. Initial C attached itself to the preceding word, and ΤΝΟΤCΑΝ became ΠΝΟΤCΑΝ, which was promptly changed to πνxs22EFουσαν.

“Multiculturalism”, “pluralism” and “tolerance” have become buzz words in applied ethics. While serious and well thought out work is going on in these areas, a misunderstanding of the importance of tolerance, and the difficulties raised by multicultural moral conflict seems common. In this paper I argue that intolerance of some cultural traditions is morally required, and suggest that the forging of a moral mono-culture is preferable to pluralism.

The statement, that these or those philosophers do not accept the distinction between what is, and what is not, ?given? in perception, has very little content; and should receive only a corresponding degree of emphasis.

Barrett finds lines 1010–15 difficult. He says that ‘hovers between “an heiress as my wife” and “marriage with an heiress”’, that ‘a Greek heiress did not inherit property as her own: it passed not to her but with her, to her husband and ultimately to her children.—In Attic law a widow was never : a man's property went to his legitimate children.

The object of this article is to discuss, defend, and supplement the only definite piece of evidence we possess which deals with the musical scalesreferred to by Plato in the Republic . In this first section I shall consider the list of scales given by Aristides Quintilianus and suggest the source from which it is derived; in the second part the employment of certain abnormal intervals will be established and elucidated; and finally the evidence of the preceding sections will be (...) reviewed from the standpoint of the Pythagorean musical theory. (shrink)

A number of Democritean fragments may loosely be called ‘political’, concerned as they are with questions to do with the πλις – with government, with the duties and dangers of public office, with justice, law and order. The majority of them have been preserved in chapters of Stobaeus’ anthology entitled ‘On the State’ , ‘On Laws and Customs’ , ‘On Government’.

The achievements of the textile industry in Roman Britain are often underestimated as a result of the meagreness of our available evidence. The Edict on maximum prices issued by Diocletian in A.D. 301 shows that British capes commanded high prices on the markets of the Empire, and that in the late third century A.D. British rugs were the best in the world. In view of the competition from the traditional centres of rug manufacture in the East, this is an astonishing (...) achievement. (shrink)

According to the legend, Bishop Wilberforce at a meeting of the British Association for the Advancement of Science in Oxford on Saturday, June 30th, 1860, turned to Thomas Huxley, and asked him ``Is it on your grandfather's or your grandmother's side that you claim descent from a monkey''; whereupon Huxley delivered a devastating rebuke, thereby establishing the primacy of scientific truth over ecclesiastical obscurantism. Although the legend is historically untrue in almost every detail, its persistence suggests that it may nonetheless (...) be true in some deeper, mythical, sense. To explore this possibility the British Academy has invited Dr Janet Browne to be a neo-Huxley confronting Mr J.R. Lucas, as a neo-Wilberforce, with each reconsidering their earlier arguments. (shrink)

The term Volkskerk in the Church Order of the Nederduitsch Hervormde Kerk van AfrikaThe Nederduitsch Hervormde Kerk states in its Church Order that it is a volkskerk. In this article the term volkskerk and the historical line of how it came to use in the Nederduitsch Hervormde Kerk, is researched. In the light of these statements the term volkskerk and its meaning in the contemporary Order of the Nederduitsch Hervormde Kerk, is dealt with.