The paper works towards an account of explanatory integration in biology, using as a case study explanations of the evolutionary origin of novelties-a problem requiring the integration of several biological fields and approaches. In contrast to the idea that fields studying lower level phenomena are always more fundamental in explanations, I argue that the particular combination of disciplines and theoretical approaches needed to address a complex biological problem and which among them is explanatorily more fundamental varies with the problem pursued. (...) Solving a complex problem need not require theoretical unification or the stable synthesis of different biological fields, as items of knowledge from traditional disciplines can be related solely for the purposes of a specific problem. Apart from the development of genuine interfield theories, successful integration can be effected by smaller epistemic units (concepts, methods, explanations) being linked. Unification or integration is not an aim in itself, but needed for the aim of solving a particular scientific problem, where the problem's nature determines the kind of intellectual integration required. (shrink)

The discussion presents a framework of concepts that is intended to account for the rationality of semantic change and variation, suggesting that each scientific concept consists of three components of content: 1) reference, 2) inferential role, and 3) the epistemic goal pursued with the concept’s use. I argue that in the course of history a concept can change in any of these components, and that change in the concept’s inferential role and reference can be accounted for as being rational relative (...) to the third component, the concept’s epistemic goal. This framework is illustrated and defended by application to the history of the gene concept. It is explained how the molecular gene concept grew rationally out of the classical gene concept despite a change in reference, and why the use and reference of the contemporary molecular gene concept may legitimately vary from context to context. (shrink)

What is the modern turn in philosophy? In other words, what are the features that make modern philosophy distinctively ""modern"" in contrast with the pre-modern philosophy from which it emerged? The twelve essays in this volume seek to address this question, and in doing so, exemplify and contribute to a rich debate about the nature and value of modern philosophy.

The agents of a jury have to decide between a good and a bad option through simple majority voting. In this paper the jury consists of N independent couples. Each couple consists of two correlated agents of the same competence level. Different couples may have different competence levels. In addition, each agent is assumed to be better than completely random guessing. We prove tight lower and upper bounds for the quality of the majority decision. The lower bound is the same (...) as the competence of majority voting of N independent agents. The upper bound cases for negatively correlated couples can be much better than the value for 2N\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$2 \, N$$\end{document} independent agents. (shrink)

The ‘death of evidence’ issue in Canada raises the spectre of politicized science, and thus the question of what role social values may have in science and how this meshes with objectivity and evidence. I first criticize philosophical accounts that have to separate different steps of research to restrict the influence of social and other non-epistemic values. A prominent account that social values may play a role even in the context of theory acceptance is the argument from inductive risk. It (...) maintains that the more severe the social consequences of erroneously accepting a theory would be, the more evidence is needed before the theory may be accepted. However, an implication of this position is that increasing evidence makes the impact of social values converge to zero; and I argue for a stronger role for social values. On this position, social values may determine a theory’s conditions of adequacy, which among other things can include co.. (shrink)

European Journal of Philosophy, EarlyView.

Die vorliegende Arbeit zeigt erstmals, dass sich die Vermittlung von Moral und Glück in Immanuel Kants Philosophie strukturell beschreiben lässt. Sie bleibt aber letztlich die nicht endende Aufgabe eines bewussten Lebens, das um seine Neigungen weiß, klug mit diesen umgeht und die Moral als letzten Orientierungspunkt versteht.

ABSTRACTThis article introduces an “ordonomic” approach to corporate citizenship. We believe that ordonomics offers a conceptual framework for analyzing both the social structure and the semantics of moral commitments. We claim that such an analysis can provide theoretical guidance for the changing role of business in society, especially in regard to the expectation and trend that businesses take a political role and act as corporate citizens. The systematicraison d'êtreof corporate citizenship is that business firms can and—judged by the criterion of (...) prudent self-interest—“should” take on an active role in rule-finding discourses and rule-setting processes with the intent of realizing a win-win outcome of the economic game. We identify—and illustrate—four ways that corporate citizens can employ moral commitments as a factor of production to enhance their processes of economic value creation. (shrink)

Editors' introduction to the special issue on homology (Biology and Philosophy Vol. 22, Issue 5, 2007).

Whereas an inference (deductive as well as inductive) is usually viewed as being valid in virtue of its argument form, the present paper argues that scientific reasoning is material inference, i.e., justified in virtue of its content. A material inference is licensed by the empirical content embodied in the concepts contained in the premises and conclusion. Understanding scientific reasoning as material inference has the advantage of combining different aspects of scientific reasoning, such as confirmation, discovery, and explanation. This approach explains (...) why these different aspects (including discovery) can be rational without conforming to formal schemes, and why scientific reasoning is local, i.e., justified only in certain domains and contingent on particular empirical facts. The notion of material inference also fruitfully interacts with accounts of conceptual change and psychological theories of concepts. (shrink)

This article contributes to the debate about the political role of the business firm. The article clarifies what is meant by the “political” role of the firm and how this political role relates to its economic role. To this end, the authors present an ordonomic concept of corporate citizenship and illustrate the concept by way of comparison with the Aristotelian idea of individual citizenship for the antique polis. According to our concept, companies take a political role if they participate in (...) rule-setting processes and rule-finding discourses. Though this political role of the corporation is in principle ambivalent, the authors conclude that in such processes of “new governance” the economic and political roles of the firm need not contradict each other but can follow the same win-win logic of individual self-perfection through cooperative social interactions. (shrink)

This introduction to the special section on integration in biology provides an overview of the different contributions. In addition to motivating the philosophical significance of analyzing integration and interdisciplinary research, I lay out common themes and novel insights found among the special section contributions, and indicate how they exhibit current trends in the philosophical study of integration. One upshot of the contributed papers is that there are different aspects to and kinds of integration, so that rather than attempting to offer (...) a universal construal of what integrations is, philosophers have to analyze in concrete cases in what respects particular aspects of scientific theorizing and/or practice are ‘integrative’ and how this instance of integration works and was achieved. (shrink)

This paper develops an interpretation of the relationship between Kant's various formulations of the categorical imperative in the Groundwork that steers a middle course between the formal and substantive poles of the interpretive spectrum, represented by John Rawls and Barbara Herman, respectively. Accepting and rejecting key aspects of both Rawls's and Herman's interpretations, I argue that the first formulation, understood correctly, does suffice to determine all Kantian moral duties, but only if duties are regarded as situation-specific rather than standing obligations. (...) I also argue, however, that the second and third formulations provide information that is necessary for understanding and applying the first formulation to determine one's duty correctly, and that the formulations are in a sense equivalent even though each plays a distinctive and important role. (shrink)

According to many biologists, explaining the evolution of morphological novelty and behavioral innovation are central endeavors in contemporary evolutionary biology. These endeavors are inherently multidisciplinary but also have involved a high degree of controversy. One key source of controversy is the definitional diversity associated with the concept of evolutionary novelty, which can lead to contradictory claims (a novel trait according to one definition is not a novel trait according to another). We argue that this diversity should be interpreted in light (...) of a different epistemic role played by the concept of evolutionary novelty—the structuring of a problem space or setting of an explanatory agenda—rather than the concept’s capacity to categorize traits as novel. This distinctive role is consistent with the definitional diversity and shows that the concept of novelty benefits ongoing investigation by focusing attention on answering different questions related to comprehending the origins of novelty. A review of recent theoretical and empirical work on evolutionary novelty confirms this interpretation. (shrink)

We address the question of whether and to what extent explanatory and modelling strategies in systems biology are mechanistic. After showing how dynamic mathematical models are actually required for mechanistic explanations of complex systems, we caution readers against expecting all systems biology to be about mechanistic explanations. Instead, the aim may be to generate topological explanations that are not standardly mechanistic, or to arrive at design principles that explain system organization and behaviour in general, but not specific mechanisms. These abstraction (...) strategies serve various aims, including prediction and control, that are central to understanding the epistemic diversity of systems biology. (shrink)

In the 1970s, the position that species are natural kinds characterized by essences came to be challenged, and was replaced by the view that species are individuals. To date, this remains the dominant position, at least among biologists, despite influential arguments that species can be construed as homeostatic property cluster kinds (employing a revised notion of essence). Recent philosophical discussions have broadened the scope by articulating a neo-Aristotelian essentialism for species, developing a post-essentialist account of human nature, and scrutinizing temporal (...) persistence conditions for species in the light of species de-extinction efforts. Yet most such current discussions concerning species have not relied on the notion of an essence, which also parallels recent accounts of natural kinds in the philosophy of science. (shrink)

The paper discusses how systems biology is working toward complex accounts that integrate explanation in terms of mechanisms and explanation by mathematical models—which some philosophers have viewed as rival models of explanation. Systems biology is an integrative approach, and it strongly relies on mathematical modeling. Philosophical accounts of mechanisms capture integrative in the sense of multilevel and multifield explanations, yet accounts of mechanistic explanation have failed to address how a mathematical model could contribute to such explanations. I discuss how mathematical (...) equations can be explanatorily relevant. Several cases from systems biology are discussed to illustrate the interplay between mechanistic research and mathematical modeling, and I point to questions about qualitative phenomena, where quantitative models are still indispensable to the explanation. Systems biology shows that a broader philosophical conception of mechanisms is needed, which takes into account functional-dynamical aspects, interaction in complex networks with feedback loops, system-wide functional properties such as distributed functionality and robustness, and a mechanism’s ability to respond to perturbations. I offer general conclusions for philosophical accounts of explanation. (shrink)

This essay analyzes and develops recent views about explanation in biology. Philosophers of biology have parted with the received deductive-nomological model of scientific explanation primarily by attempting to capture actual biological theorizing and practice. This includes an endorsement of different kinds of explanation (e.g., mathematical and causal-mechanistic), a joint study of discovery and explanation, and an abandonment of models of theory reduction in favor of accounts of explanatory reduction. Of particular current interest are philosophical accounts of complex explanations that appeal (...) to different levels of organismal organization and use contributions from different biological disciplines. The essay lays out one model that views explanatory integration across different disciplines as being structured by scientific problems. I emphasize the philosophical need to take the explanatory aims pursued by different groups of scientists into account, as explanatory aims determine whether different explanations are competing or complementary and govern the dynamics of scientific practice, including interdisciplinary research. I distinguish different kinds of pluralism that philosophers have endorsed in the context of explanation in biology, and draw several implications for science education, especially the need to teach science as an interdisciplinary and dynamic practice guided by scientific problems and explanatory aims. (shrink)

Nikolaus von Kues, der große Philosoph und Theologe des 15. Jahrhunderts, hat sich auch mathematischen Problemen gewidmet. Vor allem die Frage nach der Möglichkeit der Quadratur des Kreises beschäftigte ihn. In seinen Lösungsansätzen spielt die Lehre vom Zusammenfall der Gegensätze eine entscheidende Rolle. In den vergangenen Jahren wurde Cusanus’ Technikverständnis an der Kueser Akademie für Europäische Geistesgeschichte intensiv erforscht. Im Ergebnis stellt Ingo Reiss in diesem Buch den cusanischen Zugang zu Mathematik und Technik und zu deren Wechselverhältnis vor.

Evolutionary developmental biology (evo-devo) is considered a ‘mechanistic science,’ in that it causally explains morphological evolution in terms of changes in developmental mechanisms. Evo-devo is also an interdisciplinary and integrative approach, as its explanations use contributions from many fields and pertain to different levels of organismal organization. Philosophical accounts of mechanistic explanation are currently highly prominent, and have been particularly able to capture the integrative nature of multifield and multilevel explanations. However, I argue that evo-devo demonstrates the need for a (...) broadened philosophical conception of mechanisms and mechanistic explanation. Mechanistic explanation (in terms of the qualitative interactions of the structural parts of a whole) has been developed as an alternative to the traditional idea of explanation as derivation from laws or quantitative principles. Against the picture promoted by Carl Craver, that mathematical models describe but usually do not explain, my discussion of cases from the strand of evo-devo which is concerned with developmental processes points to qualitative phenomena where quantitative mathematical models are an indispensable part of the explanation. While philosophical accounts have focused on the actual organization and operation of mechanisms, properties of developmental mechanisms that are about how a mechanism reacts to modifications are of major evolutionary significance, including robustness, phenotypic plasticity, and modularity. A philosophical conception of mechanisms is needed that takes into account quantitative changes, transient entities and the generation of novel types of entities, feedback loops and complex interaction networks, emergent properties, and, in particular, functional-dynamical aspects of mechanisms, including functional (as opposed to structural) organization and distributed, system-wide phenomena. I conclude with general remarks on philosophical accounts of explanation. (shrink)

On one common reading of Kant, emotional states that he calls feelings, desires, and inclinations are thoroughly non-cognitive and play no positive role in the moral life, which is instead about subduing our sensible nature through a discipline of reason. Against this common reading, this paper argues that Kant actually holds a weak cognitivist view of at least some emotions, according to which emotions are responses to judgments – or to what Kant calls maxims – that are about what makes (...) an action right or wrong. Moreover, this paper also argues that a full understanding of Kant’s view of emotions and their role in the moral life requires assessing their relation to his theory about the radical evil of human nature, because he holds that emotions can be responses to the fundamental maxim that reflects our propensity to prioritize self-love over the moral law. Even emotions that are not directly corrupted by evil in this way must be seen in the context of Kant’s view that the moral life is essentially a struggle against the propensity to evil in human nature. So rather than reading Kant as a non-cognitivist about emotion, this paper reads him as a weak cognitivist whose suspicion of emotion reflects the significance he assigns to the human propensity to evil. (shrink)

Leitbilder pragen das Erscheinungsbild vieler Einrichtungen und Unternehmen. Sie geben Zeugnis vom Selbstverstandnis, dem Wertefundament und der Unternehmenskultur. Oft bleibt das Ideal jedoch hinter der Realitat zuruck oder lauft Gefahr, Mitarbeitende und Strukturen zu uberfordern. Speziell Krankenhauser in konfessioneller Tragerschaft stehen heute mehr denn je vor der Herausforderung, die ethische Selbstverpflichtung von Leitbildern mit Leben zu fullen. Ingo Proft zeigt in seiner Studie mithilfe der Epikie als Handlungsprinzip methodische Schritte auf, die Leitbilder bereits in der Entstehung auf Praktikabilitat und (...) Umsetzbarkeit ausrichten. Daruber hinaus helfen sie, bestehende Konzepte umzusetzen und weiterzuentwickeln. (shrink)

Philosophical discussions of systems biology have enriched the notion of mechanistic explanation by pointing to the role of mathematical modeling. However, such accounts still focus on explanation in terms of tracking a mechanism's operation across time (by means of mental or computational simulation). My contention is that there are explanations of molecular systems where the explanatory understanding does not consist in tracking a mechanism's operation and productive continuity. I make this case by a discussion of bifurcation analysis in dynamical systems, (...) articulating the distinctive way in which explanatory understanding is provided, especially about the reversibility or irreversibility of molecular processes. (shrink)

In this chapter I lay out a notion of philosophical naturalism that aligns with pragmatism. It is developed and illustrated by a presentation of my views on natural kinds and my theory of concepts. Both accounts reflect a methodological naturalism and are defended not by way of metaphysical considerations, but in terms of their philosophical fruitfulness. A core theme is that the epistemic interests of scientists have to be taken into account by any naturalistic philosophy of science in general, and (...) any account of natural kinds and scientific concepts in particular. I conclude with general methodological remarks on how to develop and defend philosophical notions without using intuitions. (shrink)

Review essay of The Philosophy of Experimental Biology by Marcel Weber (Cambridge University Press, 2005).

Ausgangspunkt der vorliegenden Arbeit über Gilles Deleuze ist die Frage nach dem Verhältnis von Ironie und Humor, weil bei Deleuze der Humor zu einer Methode des Denkens wird. Das erste Kapitel beschäftigt sich mit der Beziehung des Denkens zu Malerei, Theater, Kino und Literatur, sowie mit der Kunst der Herstellung von Begriffen und der Sprache der Philosophie. Im zweiten Kapitel wird der Begriff des reinen Ereignisses entwickelt, der im Zentrum des Denkens von Deleuze steht. Das dritte Kapitel handelt hingegen vom (...) Körper und vom Eintreten von Ereignissen: vom Verhältnis von Virtualität und Aktualität, von Singularität und Individuation und von einer bestimmten Umkehrung des Platonismus, die Voraussetzung für eine deleuzeianische Ideenlehre ist. Das Schlusskapitel versteht sich als Einführung in einen fröhlichen Atheismus und entwickelt Ansätze zu einer deleuzeianischen Ethik. Der Anhang enthält eine umfassende Bibliographie der Schriften von Deleuze und ihrer deutschsprachigen Übersetzungen, sowie der vorliegenden Sekundärliteratur. (shrink)

This review article summarizes various functions of the dorsolateral prefrontal cortex that are related to language processing. To this end, its connectivity with the left-dominant perisylvian language network was considered, as well as its interaction with other functional networks that, directly or indirectly, contribute to language processing. Language-related functions of the DLPFC comprise various aspects of pragmatic processing such as discourse management, integration of prosody, interpretation of nonliteral meanings, inference making, ambiguity resolution, and error repair. Neurophysiologically, the DLPFC seems to (...) be a key region for implementing functional connectivity between the language network and other functional networks, including cortico-cortical as well as subcortical circuits. Considering clinical aspects, damage to the DLPFC causes psychiatric communication deficits rather than typical aphasic language syndromes. Although the number of well-controlled studies on DLPFC language functions is still limited, the DLPFC might be an important target region for the treatment of pragmatic language disorders. (shrink)