Information Theory, Evolution and The Origin ofLife: The Origin and Evolution of Life as a Digital Message: How Life Resembles a Computer, Second Edition. Hu- bert P. Yockey, 2005, Cambridge University Press, Cambridge: 400 pages, index; hardcover, US $60.00; ISBN: 0-521-80293-8. The reason that there are principles of biology that cannot be derived from the laws of physics and chemistry lies simply in the fact that the genetic information content of the genome for constructing even the simplest organisms is (...) much larger than the information content of these laws. Yockey in his previous book (1992, 335) In this new book, Information Theory, Evolution and The Origin ofLife, Hubert Yockey points out that the digital, segregated, and linear character of the genetic information system has a fundamental significance. If inheritance would blend and not segregate, Darwinian evolution would not occur. If inheritance would be analog, instead of digital, evolution would be also impossible, because it would be impossible to remove the effect of noise. In this way, life is guided by information, and so information is a central concept in molecular biology. The author presents a picture of how the main concepts of the genetic code were developed. He was able to show that despite Francis Crick's belief that the Central Dogma is only a hypothesis, the Central Dogma of Francis Crick is a mathematical consequence of the redundant nature of the genetic code. The redundancy arises from the fact that the DNA and mRNA alphabet is formed by triplets of 4 nucleotides, and so the number of letters (triplets) is 64, whereas the proteome alphabet has only 20 letters (20 amino acids), and so the translation from the larger alphabet to the smaller one is necessarily redundant. Except for Tryptohan and Methionine, all amino acids are coded by more than one triplet, therefore, it is undecidable which source code letter was actually sent from mRNA. This proof has a corollary telling that there are no such mathematical constraints for protein-protein communication. With this clarification, Yockey contributes to diminishing the widespread confusion related to such a central concept like the Central Dogma. Thus the Central Dogma prohibits the origin of life "proteins first." Proteins can not be generated by "self-organization." Understanding this property of the Central Dogma will have a serious impact on research on the origin of life. (shrink)

A Critique of Artificial Reason Hubert L. Dreyfus . HUBERT L. DREYFUS What Computers Still Can't Do Thi s One XZKQ-GSY-8KDG What. WHAT COMPUTERS STILL CAN'T DO Front Cover.

Cet article constitue la présentation des recherches effectuées par une équipe franco-grecque sur le tell de Kirrha en Phocide entre 2008 et 2015, et représente la publication préliminaire des structures archéologiques mises au jour. Deux secteurs distants l’un de l’autre ont été fouillés, révélant une dense occupation de l’Helladique Moyen, ainsi que des niveaux s’étageant jusqu’à l’Helladique Récent III. Notamment, une nécropole de la période transitionnelle (Helladique Moyen III – Helladique Récent I/II) a été fouillée dans la partie occidentale du (...) site, tandis que des niveaux mycéniens ont été reconnus à proximité du sommet. (shrink)

BackgroundThe overwhelming scarcity of organs within renal transplantation forces researchers and transplantation teams to seek new ways to increase efficacy. One of the possibilities is the use of personalized medicine, an approach based on quantifiable and scientific factors that determine the global immunological risk of rejection for each patient. Although this approach can improve the efficacy of transplantations, it also poses a number of ethical questions.MethodsThe qualitative research involved 22 semi-structured interviews with nephrologists involved in renal transplantation, with the goal (...) of determining the professionals' views about calculating the global immunological risk and the attendant ethical issues.ResultsThe results demonstrate a general acceptance of this approach amongst the participants in the study. Knowledge of each patient's immunological risk could improve treatment and the post-graft follow-up. On the other hand, the possibility that patients might be excluded from transplantation poses a significant ethical issue. This approach is not seen as something entirely new, given the fact that medicine is increasingly scientific and evidence-based. Although renal transplantation incorporates scientific data, these physicians believe that there should always be a place for clinical judgment and the physician-patient relationship.ConclusionsThe participants see the benefits of including the calculation of the global immunological risk within transplantation. Such data, being more precise and rigorous, could be of help in their clinical work. However, in spite of the use of such scientific data, a place must be retained for the clinical judgment that allows a physician to make decisions based on medical data, professional expertise and knowledge of the patient. To act in the best interests of the patient is key to whether the calculation of the global immunological risk is employed. (shrink)

This work has been selected by scholars as being culturally important, and is part of the knowledge base of civilization as we know it. This work was reproduced from the original artifact, and remains as true to the original work as possible. Therefore, you will see the original copyright references, library stamps (as most of these works have been housed in our most important libraries around the world), and other notations in the work. This work is in the public domain (...) in the United States of America, and possibly other nations. Within the United States, you may freely copy and distribute this work, as no entity (individual or corporate) has a copyright on the body of the work. As a reproduction of a historical artifact, this work may contain missing or blurred pages, poor pictures, errant marks, etc. Scholars believe, and we concur, that this work is important enough to be preserved, reproduced, and made generally available to the public. We appreciate your support of the preservation process, and thank you for being an important part of keeping this knowledge alive and relevant. (shrink)

Faced with the threat of pandemic influenza, several countries have made the decision to put a number of measures in place which have been incorporated into national plans. In view of the magnitude of the powers and responsibilities that States assume in the event of a pandemic, a review of the various national preparedness and response plans for pandemic influenza brought to light a series of extremely important ethical concerns. Nevertheless, in spite of the recent emergence of literature focusing specifically (...) on the ethical aspects of pandemics, too few studies explicitly examine public participation as one means of ethical contribution to public health policies. Thus this article seeks, in the first place, to present an analysis of the various national preparedness and response plans for pandemic influenza, and secondly, to outline the role that the plans envisage for ethics and more importantly for public participation. (shrink)

Les Presses universitaires de France ont publié, en 1994, une Encyclopédie universelle de philosophie, dans laquelle Hubert Mono Ndjana est présenté comme un spécialiste de la pensée des hommes politiques. Il avait en effet traduit en français Obiang Nguema Mbasogo en 1980 (Un Pari pour la liberté), publié un ouvrage en 1985 sur le chef d'Etat de son pays (L'Idée sociale chez Paul Biya), et deux autres sur la pensée et le pays de Kim Il Sung (Révolution et création (...) et Regard sur la Corée), en 1987. Sa pensée s'est également et abondamment préoccupée de la question du politique et des préoccupations épistémologiques. L'entretien que Jean-Philippe Nguemeta a eu le génie d'initier auprès d'Hubert Mono Ndjana permettra au lecteur d'avoir une vue synoptique de ce philosophe attentif, qui a passé toute sa vie à enseigner, sans négliger les grandes questions de son temps. Un décryptage exhaustif des énigmes de la civilisation, utile pour la culture générale et l'éducation... (shrink)

This volume presents a selection of Hubert Dreyfus's pioneering work in bringing phenomenology and existentialism to bear on the philosophical and scientific study of the mind. Each of the thirteen essays interprets, develops, and extends the insights of his predecessors working in the European philosophical tradition. One of Dreyfus' central contributions to reading the historical canon of philosophy comes from his recognition that great philosophers help us to understand the -background practices- of a culture - the practices that shape (...) and embody our most basic understanding of ourselves and the things and situations we encounter in our world. Background practices are all too often overlooked completely, or else their importance is misunderstood. Each chapter in this volume shows in one way or another how a broad range of philosophical topics can only be properly understood when we recognize how they are grounded in the background practices that shape our lives and give meaning to our activities, our tasks, our normative commitments, our aims and our goals. (shrink)

Dit boek is een hommage aan de filosoof Hubert Dethier (°21 juli 1933), die we zeker in de rij kunnen plaatsen van denkers als Jaap Kruithof, Hans Achterhuis en Etienne Vermeersch. Deze hommage is geen chronologische biografie. Het is daarentegen wel een verhaal waarin het leven van Hubert Dethier verweven wordt met de geschiedenis van zijn denken. Een denken dat zich situeert in de tweede helft van de vorige eeuw en het begin van de huidige eeuw en zich (...) moeiteloos projecteert naar de toekomst. Ontegensprekelijk een woelige en gewelddadige periode, maar ook een tijdgewricht van hoop en verwachting van het “nieuwe”.0. (shrink)

For fifty years Hubert Dreyfus has done pioneering work which brings phenomenology and existentialism to bear on the philosophical and scientific study of the mind. This is a selection of his most influential essays, developing his critique of the representational model of the mind in analytical philosophy of mind and mainstream cognitive science.

Religiose Vielfalt ist nicht erst eine Erscheinung der "westlichen Moderne". Vielmehr existierten schon in fruhen Zeiten und an verschiedenen Orten der Welt oft mehrere Religionen nebeneinander, sei es dass diese unterschiedlichen Ursprungs waren oder sich aufgrund divergierender Auffassungen der religiosen Akteure innerhalb einer gemeinsamen Tradition ausdifferenzierten. Nicht immer war und ist diese Koexistenz eine friedliche. Die Religion der anderen wird haufig als "deviant" wahrgenommen oder gar als "nonkonformistisch" stigmatisiert und sanktioniert, bis hin zur physischen Vernichtung der "Devianten". Im vorliegenden Band (...) gehen vierzehn ausgewiesene Wissenschaftler_innen aus den Fachgebieten Religionswissenschaft, Soziologie, Sinologie und Judaistik aus ihrer jeweiligen fachlichen Perspektive und anhand diverser Fallbeispiele aus Geschichte und Gegenwart der Frage nach, unter welchen Umstanden, aus welchen Grunden und mit welchen Folgen religiose Pluralitat als Problem wahrgenommen wird. Das Buch verbindet so systematische Fragestellungen mit empirischen Fallbeispielen und liefert damit eine ausgezeichnete Grundlage fur die Erforschung des gesellschaftlichen Umgangs mit religioser Pluralitat. (shrink)

_Internet_ is een van de eerste boeken waarin het filosofische inzicht -van Plato tot Kierkegaard - betrokken wordt op het debat over de mogelijkheden en onmogelijkheden van het internet. Dreyfus laat zien dat de onstoffelijke, 'vrij zwevende' websurfer zijn oorsprong vindt in Descartes' scheiding van geest en lichaam, en hoe Kierkegaards inzichten in de opkomst van het moderne leespubliek vooruitlopen op de nieuwsgierige, maar elk risico vermijdende internet-junkie. Uitgaande van recente onderzoeken naar het isolement dat veel internetgebruikers ervaren, toont Dreyfus (...) aan hoe het internet, door zijn nadruk op privé-ervaringen, gebruikers berooft van wezenlijke, belichaamde vermogens zoals vertrouwen, stemmingen en betrokkenheid bij met anderen gedeelde lokale aangelegenheden. _Internet_ is verplichte kost voor iedereen die on line is en is geïnteressseerd in onze plaats in de 'e-revolutie'. (shrink)

My purpose here is to describe a type of argument characterized by the fact that one of its premises is a directive—i.e. what is expressed by a directive sentence: a general instruction how to proceed or act. This directive premise brings an ostensive mechanism for the inclusion of visual or multimodal elements in an argument. If an argument is an invitation to inference, by using such a directive utterance the addresser is inviting the addressee to make an inference from an (...) image, not from a proposition. Hence I will call them arguments from ostension or from deixis. (shrink)

For Descartes, knowledge exists as ideas in the mind that represent the world. In a radical critique, Hubert Dreyfus and Charles Taylor argue that knowledge consists of much more than the representations we formulate in our minds. They affirm our direct contact with reality—both the physical and the social world—and our shared understanding of it.

En 1936, Hubert Elie publiait une these remarquable: Le complexe significabile, accompagnee de l'edition et de la traduction du Traitee de l'infini de Jean Mair. Sous le terme technique de complexe significabile se trouve abordee la question du signifiable par complexe, c'est-a-dire du signifie de la proposition et de son statut objectif. L'ouvrage propose ainsi une double approche de la notion de signification et de ses rapports a la reference ontologique: l'analyse classique depuis Gregoire de Rimini a Leibniz, les (...) points de vue contemporains tels que Meinong ou Russell. (shrink)

Ethics, in the sense of a recognized branch of inquiry, reputedly began with Socrates and the Sophists, at least for the western world. Ethics, understood as a set of moral standards, traditionalized by maxims and admonitions, has existed in human cultures from so early a time that it would be hazardous indeed to conjecture the date of its probable origin. The "Hopi Ethics" which Mr. Brandt has studied is obviously that of this second sense, whereas his own study, at least (...) insofar as it is a "theoretical analysis" and goes beyond mere description, is "ethics" in the first sense. That the Hopi Indians were somewhat astonished and perplexed by Mr. Brandt's line of inquiry is indicated by some of their quoted remarks, such as their mention of the "hard questions" being put to them, and their amazement at the suggestion of the possibility that "there is no right answer to ethical questions." One gathers, thus, that while the problem of ethical relativism was of high concern to Mr. Brandt, such an idea was nigh unthinkable to the Hopi. (shrink)

Existential phenomenologists hold that the two most basic forms of intelligent behavior, learning, and skillful action, can be described and explained without recourse to mind or brain representations. This claim is expressed in two central notions in Merleau-Ponty's Phenomenology of Perception: the intentional arc and the tendency to achieve a maximal grip. The intentional arc names the tight connection between body and world, such that, as the active body acquires skills, those skills are stored, not as representations in the mind, (...) but as dispositions to respond to the solicitations of situations in the world. A phenomenology of skill acquisition confirms that, as one acquires expertise, the acquired know-how is experienced as finer and finer discriminations of situations paired with the appropriate response to each. Maximal grip names the body's tendency to refine its responses so as to bring the current situation closer to an optimal gestalt. Thus, successful learning and action do not require propositional mental representations. They do not require semantically interpretable brain representations either.Simulated neural networks exhibit crucial structural features of the intentional arc, and Walter Freeman's account of the brain dynamics underlying perception and action is structurally isomorphic with Merleau-Ponty's account of the way a skilled agent is led by the situation to move towards obtaining a maximal grip. (shrink)

Essays discuss the themes of worldliness, affectedness, understanding, and the care-structure found in Heidegger's work on the nature of existence.

De acuerdo con Hubert L. Dreyfus, a Heidegger no le preocupaba el problema del control humano de la técnica, que sí concierne a los teóricos que conciben la técnica como ideología. En su texto, Dreyfus sostiene que la cuestión es más bien la comprensión del ser como mera materia prima proyectada en la cosmovisión técnica del Occidente moderno. Sólo dándonos cuenta de que el ser mismo ordena esta dispensación podremos comenzar a distanciarnos de esa visión del mundo. En última (...) instancia, la técnica no es una cuestión política sino un modo de donación específico de la era moderna. Esta comprensión nos sitúa más allá de una visión puramente tecnológica de la vida y nos abre a una relación diferente con la técnica. Lo que se necesita es un nuevo sentido de realidad que privilegie las facetas no-tecnológicas de la experiencia y de la comunidad. En ese contexto, la técnica continuaría existiendo y haciendo su trabajo, pero ya no formaría el horizonte del ser y la comprensión. (shrink)

The Rev’d Roland Allen’s grandson ventures to speculate on the attitudes his grandfather might be expected to have adopted regarding several of today’s controversial issues. After rehearsing briefly Roland’s published and unpublished work, Hubert Allen reviews, both on the basis of Roland’s expressed opinions and by inference from remarks made by him or by members of his immediate family, how he believes his grandfather would have reacted to six matters of current or recent controversy, namely: Modern Translations of the (...) Bible, The Role of Women in the Church, Homosexuality, Ecumenism, Inter-Faith Dialogue, and the proposed Anglican Covenant. (shrink)

L'idée que comprendre permet de prévoir est une idée moderne. Elle est fondée sur la découverte, que le monde physique obéit à des lois (Galilée, et surtout Newton). Elle a mis fin à la pensée magique, et elle est à la base de la révolution scientifique et du monde moderne. Or nous assistons à la dissociation de ces deux choses. D'une part, on réalise par exemple que les lois mathématiques de certains phénomènes, mêmes parfaitement connues, sont si sensibles à la (...) moindre imprécision dans les données que cela rend la prévision impossible en pratique. C'est le fameux "effet papillon" : un battement d'ailes à Rio pourrait être la cause d'une tornade au Texas. D'un autre côté, la puissance des big data rendrait inutile, selon certains essayistes et quelques scientifiques, le raisonnement théorique. On n'aurait plus besoin de comprendre les causalités puisque la corrélation suffirait. Un retour au CASSINI Moyen Age en somme, aux recettes qui ont marché, mais avec des données des millions de fois plus nombreuses. En termes économiques, on a découvert avec la révolution scientifique qu'une explication théorique coûtait moins cher que certaines observations : Newton avait prévu l'aplatissement de la Terre sans qu'on ait besoin d'aller voir aux pôles ; aujourd'hui grâce à la rapidité des ordinateurs et des réseaux, les termes de la comparaison s'inversent. A ceci, Hubert Krivine répond notamment que les big data et l'intelligence artificielle qui se fonde sur elles sont conservatrices, et que si elles conviennent aux assureurs, elles ne peuvent pas prévoir des choses nouvelles et extraordinaires. Les ordinateurs composent aujourd'hui sur demande du Mozart ou des ballades celtiques, aucun n'invente de musique nouvelle. Ils conduisent des voitures, mais aucun n'explique le mystère de la "matière noire". La machine peut aider l'homme, elle ne le remplacera pas. (shrink)

"This book provides a representative survey of early and more recent concerns in cognitively inspired lexical semantics.

Husserl and Searle agree that, for a bodily movement to be an action, it must be caused by a propositional representation. Husserl's representation is a mental state whose intentional content is what the agent is trying to do; Searle thinks of the representation as a logical structure expressing the action's conditions of satisfaction. Merleau-Ponty criticises both views by introducing a kind of activity he calls motor intentionality, in which the agent, rather than aiming at success, feels drawn to reduce a (...) felt tension. I argue that Searle can account for Merleau-Ponty's kind of coping only by broadening his notion of propositional representation to include indexicals, but that, in so doing, he covers up the way representational intentionality depends upon motor intentionality. (shrink)

This book is the first to provide a sustained, coherent analysis of Foucault's work as a whole. To demonstrate the sense in which Foucault's work is beyond structuralism and hermeneutics, the authors unfold a careful, analytical exposition of his oeuvre. They argue that during the of Foucault's work became a sustained and largely successful effort to develop a new method - "interpretative analytics" - capable of explaining both the logic of structuralism's claim to be an objective science and the apparent (...) validity of the hermeneutical counterclaim that the human sciences can proceed only by understanding the deepest meaning of the subject and his tradition. (shrink)

Human intuition and perception are basic and essential phenomena of consciousness. As such, they will never be replicated by computers. This is the challenging notion of Hubert Dreyfus, Ph. D., archcritic of the artificial intelligence establishment. It's important to emphasize that he doesn't believe that AI is fundamentally impossible, only that the current research program is fatally flawed. Instead, he argues that to get a device (or devices) with human-like intelligence would require them to have a human-like being in (...) the world, which would require them to have bodies more or less like ours, and social acculturation (i.e. a society) more or less like ours. This helps to explain the practical problems in implementing artificial intelligence algorithms. (shrink)

MICHAEL WHEELER Cambridge, MA: MIT Press, 2005432 pages, ISBN: 0262232405 (hbk); $35.001.When I was teaching at MIT in the 1960s, students from the Artificial Intelligence Laboratory would come to...