The reliability of clinical practice guidelines has been disputed because guideline panel members are often burdened with financial conflicts of interest. Current recommendations for COI regulation advise not only detailed declaration but also active management of conflicts. To continuously assess COI declaration and management in German guidelines we established the public database LeitlinienWatch. We analyzed all German guidelines at the highest methodological level that included recommendations for pharmacological therapy according to five criteria: declaration and assessment of COI, composition of the (...) guideline development group, independence of the coordinators and lead authors, imposed abstentions because of COI and public external review. Each criterion was assessed using predefined outcome categories. Most guidelines contained a detailed declaration of COI. However, none of the guidelines provided full transparency of COI assessment results. The guideline group was composed of a majority of participants with COI in 55% of the guidelines, no guideline was free of participants with COI. Only 9% of guidelines had coordinators and lead authors without any financial COI. Most guidelines did not provide a rule for abstentions for participants with COI. In 21% of guidelines there was a rule, but abstentions were either not practiced or not documented, whereas in 7% partial abstentions and in 2% complete abstentions were documented. Two thirds of the guideline drafts were not externally reviewed via a public website. COI are usually documented in detail in German guidelines of the highest methodological level. However, considerable improvement is needed regarding active management of COI, including recruitment of independent experts for guideline projects, abstention from voting for participants with COI and external review of the guideline draft. We assume that the publicly available ratings on GuidelineWatch will improve the handling of conflicts of interest in guideline development. (shrink)

Hendrik Lorenz presents a comprehensive study of Plato's and Aristotle's conceptions of non-rational desire. They see this as something that humans share with animals, and which aims primarily at the pleasures of food, drink, and sex. Lorenz explores the cognitive resources that both philosophers make available for the explanation of such desires, and what they take rationality to add to the motivational structure of human beings. In doing so, he finds conceptions of the mind that are coherent and deeply (...) integrated with both philosophers' views about such topics as the relation between body and soul, or the nature of the virtues. (shrink)

An architect and architectural philosopher, Berlage created a series of buildings and a body of writings that probed the problems and possibilities of Modernism. His principal texts, given here in English for the first time, present a vital chapter in the history of European Modernism.

""Catching Ourselves in the Act" is no less than an attempt to explain intelligence. Delightful how the author dismantles traditional views in.

Inleidend overzicht van de wetenschapsfilosofische basisproblemen van de rechtswetenschap.

The paper scrutinizes the literary output of George Moore with reference to the expectations of the new generation of Irish writers emerging at the beginning of the twentieth century. Although George Moore is considered to belong to the Anglo-Irish ascendancy writers, he began his writing career from dissociating himself from the literary achievements of his own social class. His infatuation with the ideals of the Gaelic League not only brought him back to Dublin, but also encouraged him to write short (...) stories analogous to famous Ivan Turgenev’s The Sportsman’s Sketches. The idea of using a Russian writer as a role model went along with the Gaelic League advocating the reading of non-English European literature in search for inspiration. However the poet’s involvement in the public cause did not last long. His critical view on Ireland together with his uncompromising approach towards literature resulted in a final disillusionment with the movement. The paper focuses on this particular period of Moore’s life in order to show how this seemingly unfruitful cooperation became essential for the development of Irish literature in the twentieth century. The Untilled Field, though not translated into Irish, still marks the beginning of a new genre into Irish literature—a short story. More importantly, the collection served as a source of inspiration for Joyce’s Dubliners. These and other aspects of Moore’s literary life are supposed to draw attention to the complexity of the writer’s literary output and his underplayed role in the construction of the literary Irish identity. (shrink)

Conflicts in Interpretation applies novel methods of constraint interaction, derived from connectionist theories and implemented in linguistics within the framework of Optimality Theory, to core semantic and pragmatic issues such as polysemy, negation, (in) definiteness, focus, anaphora, and rhetorical structure. It explores the hypothesis that a natural language grammar is a set of potentially conflicting constraints on forms and meanings. Moreover, it hypothesizes that competent language users not only optimize from an input form to the optimal output meaning for this (...) form, or vice versa, but also consider the opposite direction of optimization, thus taking into account the speaker as a hearer and taking into account the hearer as a speaker. The book aims to show that such a bidirectional constraint-based grammar sheds new light on the relation between form and meaning, within a sentence as well as across sentence boundaries, within a single language as well as across languages, and within competent adult language users as well as during language development. An important dimension of the book is the structured investigation of issues at the interface of semantics with syntax and pragmatics, such as the effects of distinguishing between speaker's perspective and hearer's perspective in comprehension and production, stable and instable patterns of form and meaning across languages, and the development of a coherent pattern of form and meaning in children. Conflicts in Interpretation will be of interest to any researcher or advanced student in linguistics, cognitive science, language typology, or psycholinguistics who is interested in the capacity of our human mind to map meaning onto form, and form onto meaning. (shrink)

This paper explores the role and resolution of disagreements between physicians and their diagnostic AI-based decision support systems. With an ever-growing number of applications for these independently operating diagnostic tools, it becomes less and less clear what a physician ought to do in case their diagnosis is in faultless conflict with the results of the DSS. The consequences of such uncertainty can ultimately lead to effects detrimental to the intended purpose of such machines, e.g. by shifting the burden of proof (...) towards a physician. Thus, we require normative clarity for integrating these machines without affecting established, trusted, and relied upon workflows. In reconstructing different causes of conflicts between physicians and their AI-based tools—inspired by the approach of “meaningful human control” over autonomous systems and the challenges to resolve them—we will delineate normative conditions for “meaningful disagreements”. These incorporate the potential of DSS to take on more tasks and outline how the moral responsibility of a physician can be preserved in an increasingly automated clinical work environment. (shrink)

ABSTRACT:I argue that there are, according to Aristotle, two importantly different kinds of goals or ends in the domain of human agency and that one of these two kinds has been frequently, though not universally, overlooked. Apart from psychological goals, goals that agents adopt as their purposes, there are also, I submit, goals that actions have by being the kinds of actions they are and, in some cases, by occurring in the circumstances in which they do. These latter goals belong (...) to suitable actions whether or not agents adopt them as purposes and whether or not agents are aware of them. There is evidence both in Aristotle's ethical writings and in his discussion of chance and luck in Physics II.4–6 that he recognizes goals of this latter kind. (shrink)

In this paper, we first classify different types of second opinions and evaluate the ethical and epistemological implications of providing those in a clinical context. Second, we discuss the issue of how artificial intelligent could replace the human cognitive labour of providing such second opinion and find that several AI reach the levels of accuracy and efficiency needed to clarify their use an urgent ethical issue. Third, we outline the normative conditions of how AI may be used as second opinion (...) in clinical processes, weighing the benefits of its efficiency against concerns of responsibility attribution. Fourth, we provide a ‘rule of disagreement’ that fulfils these conditions while retaining some of the benefits of expanding the use of AI-based decision support systems in clinical contexts. This is because the rule of disagreement proposes to use AI as much as possible, but retain the ability to use human second opinions to resolve disagreements between AI and physician-in-charge. Fifth, we discuss some counterarguments. (shrink)

In response to the critique of his work by William Sweet, Hendrik Hart first offers some terminological clarifications. The important difference between ‘faith’ (trust in God) and ‘belief’ (our network of accepted understandings of things, expressed in concepts and propositions) is emphasized and his use of terms such as ‘religion,’ ‘knowledge,’ and ‘truth’ are explained. Hart then clarifies his approach to the Western philosophical tradition. He argues that Christian accommodation to philosophy and its idea of ‘reason’ as ultimate arbiter (...) have hindered proper understanding of biblical faith. He finds support for his critique within the philosophical tradition itself, particularly in the form of feminist and postmodern thought. In the end, he offers a vision of religious truth, encapsulated in Jesus’ proclamation, “I am the truth,” that is based upon the embodiment of God’s will and intent. (shrink)

Overzicht van het gedachtegoed van de Tsjechisch-Nederlandse geleerde (1592-1670), die streefde naar een synthese van wetenschap, waarden en wijsheid.

The aim of this article is to investigate whether choosing the appropriate referring expression requires taking into account the hearer’s perspective, as is predicted under some versions of bidirectional Optimality Theory but is unexpected under other versions. We did this by comparing the results of 25 young and 25 elderly adults on an elicitation task based on eight different picture stories, and a comprehension task based on eight similar written stories. With respect to the elicitation task, we found that elderly (...) adults produce pronouns significantly more often than young adults when referring to the old topic in the presence of a new topic. With respect to the comprehension task, no significant differences were found between elderly and young adults. These results support the hypothesis that speakers optimize bidirectionally and take into account hearers when selecting a referring expression. If the use of a pronoun will lead to an unintended interpretation by the hearer, the speaker will use an unambiguous definite noun phrase instead. Because elderly adults are more limited in their processing capacities, as is indicated by their smaller working memory capacity, as speakers they will not always be able to reason about the hearer’s choices. As a result, they frequently produce non-recoverable pronouns. (shrink)

When heterogeneous players make strategic investment decisions in multi-stage contests, they might conserve resources in a current contest to spend more in a subsequent contest, if the degree of heterogeneity in the current contest is sufficiently large. We confirm these predictions using data from German professional soccer, in which players are subject to a one-match ban if they accumulate five yellow cards. Players with four yellow cards facing the risk of being suspended for the next match are less likely to (...) be fielded when the heterogeneity in the current match increases and more likely to receive a fifth yellow card in the current match when heterogeneity in the next match increases or heterogeneity in the next match but one decreases. (shrink)

Aristotle takes practical wisdom and arts or crafts to be forms of knowledge which, we argue, can usefully be thought of as ‘empiricist’. This empiricism has two key features: knowledge does not rest on grasping unobservable natures or essences; and knowledge does not rest on grasping logical relations that hold among propositions. Instead, knowledge rests on observation, memory, experience and everyday uses of reason. While Aristotle’s conception of theoretical knowledge does require grasping unobservable essences and logical relations that hold among (...) suitable propositions, his conception of practical and productive knowledge avoids such requirements and is consistent with empiricism. (shrink)

Ancient philosophical theories of soul are in many respects sensitive to ways of speaking and thinking about the soul psuchê] that are not specifically philosophical or theoretical. We therefore begin with what the word ‘soul’ meant to speakers of Classical Greek, and what it would have been natural to think about and associate with the soul. We then turn to various Presocratic thinkers, and to the philosophical theories that are our primary concern, those of Plato (first in the Phaedo, then (...) in the Republic), Aristotle (in the De Anima or On the Soul ), Epicurus, and the Stoics. These are by far the most carefully worked out theories of soul in ancient philosophy. Later theoretical developments — for instance, in the writings of Plotinus and other Platonists, as well as the Church Fathers — are best studied against the background of the classical theories, from which, in large part, they derive. (shrink)

Large Language Models are one of the most prominent examples of current uses of AI, and one of the most urgently pursued normative tasks is to make them and their interactive user-interfaces—open-domain chatbots—safe. However, in this paper, we elaborate first on why such a limited view on the permissibility and desirability of their utterances falls conceptually flat, is philosophically insufficient, and leads to severe technological limits. We then propose a positive normative concept, appropriateness, that can provide the required orientation for (...) determining what chatbots may or may not say, and distinguish between technical-discursive, social, and moral appropriateness. Lastly, we explore the requirements for social and conversational contexts to fulfill appropriateness-requirements, and find that positionality is a key element for their position in discourse. (shrink)

The Brute Within proceeds in three parts, the first two (amounting to half the book) on Plato and the third on Aristotle. Each part, as well as the book itself, has an Introduction in which Lorenz helpfully signals what he is up to; the author frequently (though sometimes repetitively) summarizes his argument as he goes along. There is no mistaking his central claims: that in both Plato and Aristotle there are three types of desires--reason, spirit and appetite--such that the last (...) two may motivate conduct without any participation in reason at all. In human beings, reason may itself motivate conduct and also may share information with appetite and spirit to modify behavior. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 41.1 (2003) 122-123 [Access article in PDF] Andreas Kamp. Philosophiehistorie als Rezeptionsgeschichte. Die Reaktion auf Aristoteles' De Anima-Noetik. Der frühe Hellenismus. Amsterdam: B. R. Grüner, 2001. Pp. viii + 315. Cloth, $82.00. This book is the first installment of an extraordinarily ambitious project. The plan is to investigate the reception of Aristotle's conception of the intellect, set out in De Anima 3.4-5, in (...) the subsequent history of philosophy, from Theophrastus to the present.The current volume deals with the natural starting-point for this project, philosophy in the early Hellenistic period, centering on Theophrastus and his tenure as head of the Peripatos, the school that Aristotle founded.Kamp begins with an engaging, somewhat lengthy introduction, which remains curiously remote from what one might expect it to concentrate on, namely Aristotle's conception of the intellect. Apart from presenting an outline of the reception of Aristotle's philosophical work in general from Theophrastus to Sigmund Freud, the introduction includes only one short paragraph specifically on the topic of the intellect (12). This paragraph, which comes closest to revealing Kamp's reason for focusing, of all things, on Aristotle's discussion of the intellect in De Anima3.4-5, simply makes two unsubstantiated claims. First, Kamp claims that the conception of the intellect, as presented in those chapters, is at the center of the Aristotelian system; and secondly, that this is, of all Aristotelian and perhaps all philosophical theories, the one that received the highest level of attention in the subsequent history of philosophy. The reader might be content to wait and let the second claim be borne out, in the present volume and beyond; but the first claim—concerning the centrality of the intellect, and of De Anima3.4-5, to Aristotle's thought—should at least have received some specification and illustration.The central part of the book, and philosophically by far the most interesting, concerns Theophrastus. Kamp begins with an extensive discussion of the political, social, and economic circumstances of Theophrastus's biography and of the history of the Peripatos. He then offers a reconstruction of Theophrastus's remarks on the nature of the intellect in the fifth book of his Physics. This reconstructive effort is based on a number of fragments [End Page 122] preserved in Themistius's De Anima paraphrase (written at about 350ad) and in Priscianus Lydus's Metaphrasis in Theophrastum (about 530ad). Kamp's discussion of these fragments is well informed, judicious, and illuminating throughout.It may be in order, though, to indicate one misgiving. One of the problems that Theophrastus addresses is that it might appear as if thinking were a matter of the intellect being changed by intelligibles, much as perceiving is, or may appear to be, a matter of sense being changed by sensibles. (If so, the question arises as to what the principle of thought is, the intellect itself or the intelligibles.) Kamp reconstructs the train of thought as follows (124-5).(1) The intellect stands to intelligibles the way sense stands to sensibles (intellect-sense analogy).(2) Sense is changed by sensibles.Therefore, the intellect is changed by intelligibles.Kamp proceeds to suggest (126) that Theophrastus attempted to avoid the conclusion by denying the first premise. According to Kamp, Theophrastus rejected the intellect-sense analogy by drawing attention to significant differences between (the activity of) the intellect and sense perception, one of these being that the intellect (in thinking) is changed only in a special sense, namely inasmuch as it undergoes a transition to activity, energeia. Kamp is right that the notion of a special kind of change that consists in a transition to activity is Aristotelian; it is presented in considerable detail in De Anima2.5 (417b2-16). But it would surely be puzzling if Theophrastus thought that one significant difference between (the activity of) the intellect and sense perception was that the intellect (in thinking) was changed in a special sense (whereas sense perception, to complete the... (shrink)

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Retinoids play an important role in development and differentiation(1,2). Their effect is mediated through nuclear receptors, RAR (α, β and γ) and RXR (α, β and γ),Abbreviations. RAR: retinoic acid receptor; RXR: retinoid X receptor; T3:thyroid hormone receptor; VD3R: vitamin D3 receptor; PPAR: peroxisome proliferator activated receptor; EcR ecdycsone receptor; USP, ultraspiracle; NGFI‐B: also referred to as nur77a; ELP: embryonal long terminal repeat‐binding protein; FTZ‐F1: positive regulator of the fushi tarazu gene in blastodermstage embryos of Drosophila melanogaster; GR: glucocorticoid receptor; (...) ER: estrogen receptor; RARE, retinoic acid response element; PR: progesterone receptor; DR+x: direct repeat with a spacing of x nucleotides; DBD: DNA‐binding domain; CRABP I and II: cellular retinoic acid binding protein type I and II, respectively; MoMLV: Moloney Murine Leukemia Virus; TBP: TATA‐binding protein; TAF: TBP associated factor. which are members of a distinct subclass (hereafter referred to as type II) of the nuclear receptor superfamily that includes the thyroid hormone receptor (T3R), the vitamin D3 receptor (VD3R) and the peroxisome proliferator activated receptor (PPAR). Type II receptors transactivate through binding sites composed of closely related half‐sites (consensus sequence AGG/T TCA) arranged as direct repeats and, with the possible exception of RXR, do not bind to their cognate binding sites as homodimers but require RXR for high affinity binding. RXR thus provides a link between biologically distinct ligand induced pathways and is a potential target for cross‐regulation. In addition, RAR can utilize alternative routes to enhance transcription initiation mediated through transcriptional co‐activators which are expressed in a cell‐type specific manner. (shrink)

Wnt glycoproteins are signaling molecules that control a wide range of developmental processes in organisms ranging from the simple metazoan Hydra to vertebrates. Wnt signaling also plays a key role in the development of the nematode C. elegans, and is involved in cell fate specification and determination of cell polarity and cell migration. Surprisingly, the first genetic studies of Wnt signaling in C. elegans revealed major differences with the established (canonical) Wnt signaling pathways of Drosophila and vertebrates. Thus, the Wnt-dependent (...) induction of endoderm in the early embryo and the specification of several asymmetric cell divisions during larval development are mediated by as yet novel Wnt signaling pathways that repress, rather than activate the TCF/LEF-1 transcription factor POP-1. Recently, however, it has been shown that, in addition to these divergent Wnt pathways, C. elegans also has a canonical Wnt pathway that converts POP-1 into an activator and controls the expression of several homeobox genes. Interestingly, these different Wnt pathways use distinct beta-catenins to control POP-1 function: the endoderm induction pathway requires the beta-catenin WRM-1 and parallel input from a mitogen-activated kinase (MAPK) pathway to downregulate POP-1, whereas the canonical Wnt pathway employs the beta-catenin BAR-1 to activate Wnt target gene expression. (shrink)

The aim of this article is to elucidate the processes that characterize natural language interpretation. The basic hypothesis is that natural language interpretation can be characterized as an optimization problem. This innovative view on interpretation is shown to account for the crucial role of contextual information while avoiding certain well-known problems associated with compositionality. This will become particularly clear in the context of incomplete expressions. Our approach takes as a point of departure total freedom of interpretation in combination with the (...) parallel application of soft constraints on possible interpretations. These constraints can be contextual, intonational or syntactic in nature. The integration of pragmatic and syntactic/semantic information in a system of ranked constraints is proposed to correctly derive the optimal interpretations in cases of nominal anaphorization, determiner quantification and elliptical comparatives. (shrink)

Research Ethics is a key element of Responsible Research and Innovation (RRI). In spite of an increased interest in this topic there is little empirical evidence about scientists’ practice and perception of Research Ethics. Drawing on a large-scale survey among 4,180 European researchers we present unique insights into Research Ethics activities, researchers’ motivation for ethical behavior, the perceived barriers and benefits as well as the role of institutional support. According to the survey results, most researchers consider ethical issues in their (...) research projects and see it as part of good research practice or are convinced that research must be ethical. Perceived benefits of Research Ethics are higher quality of scientific outputs, higher social relevance of research, increased societal impact and a changed approach to risk. Barriers to ethics activities are particularly seen in the absence of institutional support and incentives. With regard to institutional support, we show that offers and infrastructures of Research Performing Organisations for Research Ethics are not well known among the employed researchers in general. Through a regression analysis about the influence of institutional support on Research Ethics we see at the same time that the provision of an Ethics team that researchers can address and the existence of a policy for designing ethical values and principles into research practice have a positive influence on researchers to engage in Research Ethics activities. The results underlines the importance of low-threshold services and personal contacts for researchers with ethical questions. (shrink)