Coral reefs have been challenged by the current rate and severity of environmental change that might outpace their ability to adapt and survive. Current research focuses on understanding how microbial communities and epigenetic changes separately affect phenotypes and gene expression of corals. Here, we provide the hypothesis that coral‐associated microorganisms may directly or indirectly affect the coral's phenotypic response through the modulation of its epigenome. Homologs of ankyrin‐repeat protein A and internalin B, which indirectly cause histone modifications in humans, as (...) well as Rv1988 histone methyltransferase, and the DNA methyltransferases Rv2966c, Mhy1, Mhy2, and Mhy3 found in coral‐associated bacteria indicate that there are potential host epigenome‐modifying proteins in the coral microbiome. With the ideas presented here, we suggest that microbiome manipulation may be a means to alter a coral's epigenome, which could aid the current efforts to protect coral reefs. Also see the video abstract here: https://youtu.be/CW9GbChjKM4. (shrink)

This study explores the impact of B Corp certification and its associated impact assessment on four case studies of small and medium-sized Brazilian companies certified as B Corps. The results reveal that although all companies had achieved high scores in the certification assessment, awarded on the basis of existing performance, they did not subsequently develop road maps for the future to improve their scores in the way which the B Corp Impact Assessment process endorses as one of the benefits of (...) certification. Their incremental changes are discussed in the light of the main motivations and expectations of these companies’ founders with regard to the certification. A central role of the B Corp certification for this group of companies was to improve their external reputation with investors, clients and consumers. They were not strongly driven to reshape internal processes in ways which would advance their scores in the impact assessment and which would tackle complex problems of corporate governance. Our findings contribute to enriching the discussion of stakeholder engagement and corporate governance in hybrid organizations and contribute to the emerging agenda on studying change over time in B Corps. (shrink)

Does living on Earth not also for human beings mean being open to the sky? Watching day alternate with night, relying on the seasonal cycle, finding their way according to the position of the stars, humans have always been aware of their dependence on the sky and tried to understand the origin of life in relation to it. And it is up to the sky again that their imagination and thoughts fly whenever they feel cramped in their earthly habitat. Following (...) the axis of their own vertical position, the earth that is the floor for humans is seen as a ‘down here’ by opposition to an ‘up there’, the sky, towards which they turn their heads and raise their eyes. Up there is the origin of the metaphorical figure and /or dream image of the flight up into the high heavens, or the journey to other stars, or to a spiritual land beyond. (shrink)

Decision-making capacity (DMC) is the gatekeeping element for a patient’s right to self-determination with regard to medical decisions. A DMC evaluation is not only conducted on descriptive grounds but is an inherently normative task including ethical reasoning. Therefore, it is dependent to a considerable extent on the values held by the clinicians involved in the DMC evaluation. Dealing with the question of how to reasonably support clinicians in arriving at a DMC judgment, a new tool is presented that fundamentally differs (...) from existing ones: the U-Doc. By putting greater emphasis on the judgmental process rather than on the measurement of mental abilities, the clinician as a decision-maker is brought into focus, rendering the tool more of an evaluation guide than a test instrument. In a qualitative study, the perceived benefits of and difficulties with the tool have been explored. The findings show on the one hand that the evaluation aid provides basic orientation, supports a holistic perspective on the patient, sensitizes for ethical considerations and personal biases, and helps to think through the decision, to argue, and to justify one’s judgment. On the other hand, the room for interpretation due to absent operationalisations, related ambiguities, and the confrontation with one’s own subjectivity may be experienced as unsettling. (shrink)

Brazil, land of miscegenation (métisse). An indisputable fact and an unending process. But how should we understand its genesis and how should we, while respecting the requirements of a historiography worth the name, interpret it in terms of our hopes for the future? This is the horizon binding these reflections, which is to be put in perspective in the studies published in this issue of Diogenes.Foregrounding miscegenation, and understanding its origins, has been one of the constant themes among the most (...) distinguished practitioners of Brazilian thought since the 1930s, and has been accepted, indeed demanded, since the 1920s by the artistic and literary movement known as ‘modernism’, of which one of the major figures was the São Paulo writer, Mário de Andrade. Gilberto Freyre (1900–1987), who would now have been a hundred years old, comes particularly to mind, as does Sergio Buarque de Holanda (1902–1982). Freyre made history with the publication of his two first works, Casa Grande & senzala [Masters and Slaves] of 1933 and Sobrados e mucambos of 1936. The same year Buarque de Holanda published his Raízes de Brasil [Roots of Brasil]. Motivated by the desire to understand their country, its shaping and – with some kind of concern as to identity – their own origins, both had been led to pave the way for what might be called an ‘open’ sociology, which immediately acquired a strongly anthropological character with Freyre and quickly incorporated increasingly historical aspects with Buarque de Holanda. (shrink)

Taking a post-structuralist view of constructionism (a view that privileges symbolic representation and language), this paper uses Piaget''s descriptions of how knowledge is acquired to speculate on the existence of a system of delays underlying thinking.

« Qui voit ? » C’est à partir de cette question cartésienne, devenue aussi la sienne, et des transformations qu’il lui fait subir, que le privilège de la peinture chez Merleau-Ponty est à comprendre. Du même coup, et a contrario, on saisit pourquoi la musique, comme le regrette Raymond Court, n’a pas donné à penser à Merleau-Ponty, qui, dit-on, écoutait Mozart au moment où la mort l’a frappé. Or, comme la peinture n’existe qu’à prendre corps dans les œuvres des peintres, (...) il y a encore lieu de se demander quels ont été « les peintres » de Merleau-Ponty. Et que lui ont-ils fait voir ?« Who sees ? » It is on the basis of this Cartesian question, which Maurice Merleau-Ponty made his own, that we can understand the sort of « privilege » painting seems to deserve within his thought. At the same time, we can grasp why, when drawing up his ontology of the Flesh, he did not pay attention to music, despite his fondness of it. This lacuna was reproached by Raymond Court, who insisted on the intimate relationship between music and the flesh . But once we acknowledge the main reasons he had to give painting priority, we may ask what he was looking for when he considered some of the modern painters as for instance Cézanne or Paul Klee. And what indeed did they make him see ? (shrink)

Provability, Computability and Reflection.

Purpose The purpose of this paper is to report on empirical work conducted to open up algorithmic interpretability and transparency. In recent years, significant concerns have arisen regarding the increasing pervasiveness of algorithms and the impact of automated decision-making in our lives. Particularly problematic is the lack of transparency surrounding the development of these algorithmic systems and their use. It is often suggested that to make algorithms more fair, they should be made more transparent, but exactly how this can be (...) achieved remains unclear. Design/methodology/approach An empirical study was conducted to begin unpacking issues around algorithmic interpretability and transparency. The study involved discussion-based experiments centred around a limited resource allocation scenario which required participants to select their most and least preferred algorithms in a particular context. In addition to collecting quantitative data about preferences, qualitative data captured participants’ expressed reasoning behind their selections. Findings Even when provided with the same information about the scenario, participants made different algorithm preference selections and rationalised their selections differently. The study results revealed diversity in participant responses but consistency in the emphasis they placed on normative concerns and the importance of context when accounting for their selections. The issues raised by participants as important to their selections resonate closely with values that have come to the fore in current debates over algorithm prevalence. Originality/value This work developed a novel empirical approach that demonstrates the value in pursuing algorithmic interpretability and transparency while also highlighting the complexities surrounding their accomplishment. (shrink)

These are the words Achilles speaks to Hektor, whom he has just struck with a fatal blow. He reminds the son of Priam how, after stripping Patroklos’ fallen body, Hektor made off with the fallen man's armour, which is Achilles’ own.

This essay contests the notion that there was a necessary and fundamental opposition between republicanism and liberalism during the post-Revolutionary period in France. Constant's writings of the Restoration years show his abiding interest in both the construction of viable political institutions and the promotion of a vibrant political life. Worried about what he saw as growing authoritarian trends within the liberal camp, Constant wrote about the need to keep political liberty alive in commercial republics. His refutations of Auguste Comte and (...) the Saint-Simonians, and his writings on religion, should be seen as offering pointed lessons to fellow liberals about the crucial importance of both politics and the moral values promoted by religious freedom. (shrink)

Background: Dignity is a multidimensional construct that includes perception, knowledge, and emotions related to competence or respect. Attitudes to aging are a comprehensive personal view of the experience of aging over the course of life, which can be influenced by various factors, such as the levels of health and self-sufficiency and social, psychological, or demographic factors. Aim: The purpose of this study was to explore the attitudes to aging of home-dwelling and inpatient older adults, and whether dignity and other selected (...) factors belong among the predictors influencing attitudes to aging in these two different groups of older adults. Research design: Cross-sectional study using a set of questionnaires: Patient Dignity Inventory, Attitudes to Aging Questionnaire, and Barthel Index. Pearson and Spearman correlation analyses and multivariable linear regression were used for statistical processing. Participants and research context: 233 inpatients and 237 home-dwelling older adults participated in the research in two regions of the Czech Republic. Ethical considerations: Institutional Review Board approval was received from the authors’ university. Findings: The inpatients had more negative attitudes to aging (M = 74.9±10.9; P <0.0001). The predictors of their attitudes to aging were gender and dignity. Women ( β = −2.969, P = 0.045) and inpatients with poor dignity ratings ( β = −0.332, P <0.0001) had more negative attitudes to aging. The predictors for home-dwelling older adults were education, living arrangement, and dignity. More negative attitudes to aging were found in older adults with lower levels of education ( β = 2.716, P = 0.007) who lived alone ( β = 2.163, P = 0.046) and rated their dignity as low ( β = −0.325, P <0.0001). Discussion and Conclusions: The results of this study add to the understanding that a sense of dignity is an important predictor of attitudes to aging for both home-dwelling older adults and inpatients. (shrink)

A masterful survey of the history of Marxist philosophy of science. Now with a new afterword. Skillfully deploying a large cast of characters, Sheehan retraces the development of Marxist philosophy of science through detailed and highly readable accounts of the debates that have characterized it. Approaching Marxism from the perspective of the philosophy of science, Sheehan shows how Marx's and Engel's ideas on the development and structure of natural science had a crucial impact on the work of early twentieth-century natural (...) philosophers, historians of science, and natural scientists. From the ideas of Marx and Engels, those of the Marxist theoreticians of the Second International to the debates within Russian Marxism up to World War II, Sheehan masterfully surveys the history of marxist philosophy of science, concluding with a close analysis of the development of the debate among non-Soviet Marxists, placing particular emphasis on the contributions of leading British Marxists in the 1930s. (shrink)

Klacel's "introduction to aesthetics" is the first attempt at aesthetic system according to hegelian and neohegelian system in neoczech language. in this work it is possible to differentiate three thematic parts: aesthetics as philosophy of beauty and art, the category of aesthetics, and the system of art. (edited).

The role of values in the scientific process is widely debated. But evidence and values cannot be neatly separated. Instead, values infuse the entire scientific process, starting with the choice of research questions. Research avenues are selected based on prior beliefs about the workings of the world. In fact, informally assigned prior probabilities and normalizing constants play an essential role in distinguishing causes from correlations and ignoring irrelevant associations that would otherwise be suggested by raw data. But since these initial (...) probabilities often have a heterogeneous pedigree – often not all that went into their formation is known or knowable – it becomes difficult to cleanly separate evidence from values. At the same time, this reality does not undermine science’s unique status in generating knowledge. This is because it is not the evidence per se generated by science, but rather the method by which science generates it, that justifies science’s privileged role. (shrink)

Owing to intensive development of the theory of self-organization of complex systems called also synergetics, profound changes in our notions of time occur. Whereas at the beginning of the 20th century, natural sciences, by picking up the general spirit of Einstein's theory of relativity, consider a geometrization as an ideal, i.e. try to represent time and force interactions through space and the changes of its properties, nowadays, at the beginning of the 21st century, time turns to be in the focus (...) of attention. It turns to be possible to represent space through time, because synergetics shows that historical and evolutionary stages of development of a complex structure can be found now, in its present spatial configuration. A whole series of paradoxical notions, such as "the influence of the future upon the present", a "possibility of touching of a rather remote future today", "availability of the past and the future now, in praesenti", "irreversibility and elements of reversibility in the course of evolutionary processes in time", "discrete unites, quanta of time", appear in synergetics. (shrink)

This paper investigates the role of a pre-existing body-model that is an enabling constraint for the incorporation of objects into the body. This body-model is also a basis for the distinction between body extensions (e.g., in the case of tool-use) and incorporation (e.g., in the case of successful prosthesis use). It is argued that, in the case of incorporation, changes in the sense of body-ownership involve a reorganization of the body-model, whereas extension of the body with tools does not involve (...) changes in the sense of body-ownership. (shrink)

The European Commission has recently proposed the introduction of legally binding quotas for women on corporate boards of European companies. This proposal has put the spotlight on the question of whether increasing female representation on the board brings economic benefits to the firm. In order to shed light on the issue, this study investigates the direct and indirect effects of women on the board on firm value. We use a simultaneous equation model to estimate the effects of women on the (...) board on firm value, financial performance, and compliance with ethical and social principles adopted by the firm. We find no evidence that a higher female representation on the board directly affects firm’s value. However, we find indirect effects. Women on the board are positively related with financial performance (measured in terms of return on assets and return on sales) and with ethical and social compliance, which in turn are positively related with firm value. The findings in this study suggest that greater female representation on corporate boards of large European firms can increase firm value indirectly. Further, part of the indirect effect comes from stronger compliance with ethical principles, something that is not captured by accounting-based financial performance. (shrink)

Background A psychosocial problem faced by people with early-stage dementia (PwESD) is the perception of threats to personal dignity. Insights into its dynamics are important for understanding how it changes as dementia advances and to develop suitable interventions. However, longitudinal studies on this change in PwESD are lacking. Aims To determine how perceptions of dignity and selected clinical and social factors change over 1 year in home-dwelling PwESD and the predictors associated with changes in perceptions of dignity over 1 year. (...) Research design and methods A longitudinal study was conducted. The sample included 258 home-dwelling Czech PwESD. Data were collected using the Patient Dignity Inventory (PDI-CZ), Mini-Mental State Examination, Bristol Activities of Daily Living Scale, Geriatric Depression Scale and items related to social involvement. Questionnaires were completed by the PwESD at baseline and after 1 year. Ethical considerations The study was approved by the ethics committee and informed consent was provided by the participants. Results People with Early-Stage Dementia rated the threat to dignity as mild and the ratings did not change significantly after 1 year. Cognitive function, self-sufficiency, vision, and hearing worsened, and more PwESD lived with others rather than with a partner after 1 year. Worsened depression was the only predictor of change in perceived personal dignity after 1 year, both overall and in each of the PDI-CZ domains. Predictors of self-sufficiency and pain affected only some PDI-CZ domains. Conclusions Perceptions of threat to dignity were mild in PwESD after 1 year, although worsened clinical factors represented a potential threat to dignity. Our findings lead us to hypothesise that perceived threats to personal dignity are not directly influenced by health condition, but rather by the social context. (shrink)

Although indisputably one of the most important thinkers in the Western intellectual tradition, Rousseau's actual place within that tradition, and the legacy of his thought, remains hotly disputed. Thinking with Rousseau reconsiders his contribution to this tradition through a series of essays exploring the relationship between Rousseau and other 'great thinkers'. Ranging from 'Rousseau and Machiavelli' to 'Rousseau and Schmitt', this volume focuses on the kind of intricate work that intellectuals do when they read each other and grapple with one (...) another's ideas. This approach is very helpful in explaining how old ideas are transformed and/or transmitted and new ones are generated. Rousseau himself was a master at appropriating the ideas of others, while simultaneously subverting them, and as the essays in this volume vividly demonstrate, the resulting ambivalences and paradoxes in his thought were creatively mined by others. (shrink)

The European Union’s policies regarding genetically modified food are based on the precautionary principle and the requirement of respecting consumers’ autonomy. We ask whether the requirement of respecting consumers’ autonomy regarding GMF implies that both GMF and non-GMF products should be available in the market. According to one line of thought, consumers’ choices may be autonomous even when the both types of products are not available. A food market with only GMF or only non-GMF products does not strictly speaking compel (...) people to buy the type of products available, and a possibility to refuse to buy is enough for consumers’ choice to be autonomous. According to another line of thought, the unavailability of GMF or non-GMF products restricts the autonomy of those consumers who are unwilling to use the only type of products available in the market. From the point of view of autonomy, a food market with only GMF or only non-GMF products does not offer enough alternatives for consumers. Moreover, the whole point of the European Union’s requirement of respecting consumers’ autonomy is to enable an autonomous choice between GMF and non-GMF—not just to give a possibility to refrain from buying. However, this does not imply that producers, processors, wholesalers, retailers, or public authorities have a moral duty to see that there are both GMF and non-GMF products available in the market. The requirement to respect autonomy is prima facie in nature, and in the context of GMF, other prima facie requirements are often stronger and override it. Not only the consumers’ autonomy of choice but also environmental values, other people’s well-being, and the autonomous choice of farmers, retailers, and other relevant parties should be respected. Thus, according to the both lines of thought, the requirement to respect consumers’ autonomy of choice does not imply that there should be both GMF and non-GMF products available in the market. (shrink)

ver since the traditional criteria for medical decision-making capacity (understanding, appreciation, reasoning, evidencing a choice) were formulated, they have been criticized for not taking sufficient account of emotions or values that seem, according to the critics and in line with clinical experiences, essential to decision-making capacity. The aim of this paper is to provide a nuanced and structured overview of the arguments provided in the literature emphasizing the importance of these factors and arguing for their inclusion in competence evaluations. Moreover, (...) a broader reflection on the findings of the literature is provided. Specific difficulties of formulating and measuring emotional and valuational factors are discussed inviting reflection on the possibility of handling relevant factors in a more flexible, case-specific, and context-specific way rather than adhering to a rigid set of operationalized criteria. (shrink)