A mechanism-based approach was developed focusing on the psychodynamic, psychological and neuronal mechanisms in healthy and depressed persons. In this integrative concept of depression, the self is a core dimension in depression. It is attributed to negative emotions (e.g., failure, guilt). The increased inward focus in depression is connected with a decreased environmental focus. The development of neuropsychodynamic hypotheses of the altered self-reference is based on the investigation of the emotional-cognitive interaction in depressed patients. It may be hypothesized that the (...) increased negative self-attributions—as typical characteristics of an increased self-focus in depression—may result from altered neuronal activity in subcortical-cortical midline structures in the brain, especially from hyperactivity in the cortical-subcortical midline regions and hypoactivity in the lateral regions. The increased resting state activity in depression is especially associated with an increased resting state activity in the default mode network (DMN) and a dysbalance between DMN and executive network (EN) activity. Possible therapeutic consequences of the neuropsychodynamic approach to depression involve the necessary emotional attunement in psychotherapy of depressed patients and the adequate timing of therapeutic interventions. The hypotheses which have been developed in the context of the neuropsychodynamic model of depression may be used for more specific psychotherapeutic interventions, aiming at specific mechanisms of compensation and defence, which are related to the increased resting state activity and the disturbed resting state-stimulus-interaction. (shrink)

The present work critically examines two assumptions frequently stated by supporters of cognitive neuroenhancement. The first, explicitly methodological, assumption is the supposition of effective and side effect-free neuroenhancers. However, there is an evidence-based concern that the most promising drugs currently used for cognitive enhancement can be addictive. Furthermore, this work describes why the neuronal correlates of key cognitive concepts, such as learning and memory, are so deeply connected with mechanisms implicated in the development and maintenance of addictive behaviour so that (...) modification of these systems may inevitably run the risk of addiction to the enhancing drugs. Such a potential risk of addiction could only be falsified by in-depth empirical research. The second, implicit, assumption is that research on neuroenhancement does not pose a serious moral problem. However, the potential for addiction, along with arguments related to research ethics and the potential social impact of neuroenhancement, could invalidate this assumption. It is suggested that ethical evaluation needs to consider the empirical data as well as the question of whether and how such empirical knowledge can be obtained. (shrink)

In Thomas Thomson's System of chemistry of 1802 Bergman and Scheele are actually considered as creators of the analytical concept of an element. With regard to this, a detailed investigation of the work of Bergman and Scheele shows that Thomson's statement contains mistakes as well as inadmissable simplifications and generalizations. It is correct, however, that Bergman in 1774–1777 specifically anticipated in essential aspects the analytical element concept proposed by Lavoisier in 1787–1789.

Onto-semiotisch kann man eine Theorie nennen, welche angibt, wo die Zeichen an die Welt anknüpfen. Wittgenstein hat über dieses Problem viel nachgedacht, ohne eine rechte Lösung zu finden. Erforderlich ist eine Konzeption, die beide Arten von Zeichen, Repräsentatoren wie Indikatoren zu vereinigen vermag. An eben dieser Aufgabe scheitert Saussure, dem es nicht gelingt, Mentalismus und Strukturalismus so zu verbinden, daß die Konkurrenz von Repräsentatoren und Indikatoren aufgehoben wird. Dies gelingt Heidegger in Sein und Zeit. Er fundiert die Repräsentationssemiotik so in (...) einer onto-semiotischen Lehre von den Verweisungen, daß schließlich der Weltbezug der Zeichen deutlich wird. (shrink)

Tatians nach der Mitte des 2. Jahrhunderts n. Chr. entstandene "Rede an die Griechen" ist die wortgewaltige und inhaltlich vehemente Attacke eines gebildeten Christen gegen die gesamte hellenische Kultur- und Götterwelt; sie bildet damit bereits einen Vorläufer der umwälzenden geistigen Auseinandersetzungen zwischen religiös-paganen Traditionen und Christentum im 4. Jahrhundert n. Chr. Der Band bietet eine Einführung in den Autor und sein Werk sowie in seine hier im Mittelpunkt stehende Schrift, danach den griechischen Originaltext (gegenüber früheren Ausgaben gründlich revidiert) und eine (...) neue deutsche Übersetzung, eine gründliche Kommentierung der zahlreichen inhaltlichen Details, die die Schrift bietet, sowie - im zweiten Teil - eine Reihe von Essays, die die Schrift in ihren theologischen, religiösen und geistesgeschichtlichen Kontext stellen und auch ihre spätere Rezeption beleuchten. (shrink)

At first glance, freedom and coercion, or constraint, appear to be clearcut oppositions. However, in many contexts we find that the two are closely interwoven. Freedom and coercion then rather resemble a continuum: Without notice, elements of freedom resurface as forces of - or preconditions for - constraint and vice versa. Thus, sometimes the two mutually reinforce each other, while at other times they tend to undermine the other. This volume comprehensively explores the complex relationship between the elements and powers (...) of freedom and coercion in various contexts and from various perspectives. It is structured in four systematic sections: I Politics and economy, II. Institutions and personal life, III. Physiological aspects, IV. Aesthetic contexts. Der Band durchleuchtet das keineswegs einfach oppositive Verhältnis von Freiheit und Zwang, wie es sich seit der Formierung der Moderne in der Aufklärung entwickelt hat - politisch, philosophisch, anthropologisch, ästhetisch. Freiheit und Zwang stellen nur auf den ersten Blick binäre Gegensätze dar. Das eine kann graduell und oft unmerklich in das andere übergehen, und beide sind ohne das jeweils andere nicht denkbar. Häufig stehen Freiheit und Zwang in einem - negativen oder positiven - dialektischen Verhältnis zueinander, in dem sie sich gegenseitig bedingen und steigern oder aber unterminieren. Oder sind Freiheit und Zwang in der Moderne sogar zunehmend ununterscheidbar geworden? Der Band verleiht diesem schillernden Vexierbild in vier Abteilungen Ordnung und Struktur: I. Politik und Ökonomie, II. Institutionen und Lebensführung, III. Physiologische Dimensionen, IV. Ästhetische Verhandlungen. (shrink)

Toleration and respect belong to those concepts that in contemporary political debates are very frequently used, but also misused. This review article is an attempt to enter these discussions and clarify the meaning of the concepts. It is done through reference to the most advanced theory on toleration today, by the German philosopher Rainer Forst. Since his approach allows for ill-considered implications, in the final part of my article I introduce arguments that question some of them. It seems too far-reaching (...) to presuppose an ongoing process of advancement in toleration. Furthermore, one cannot argue that we have to establish a ranking in universal morality at the bottom and the particular ethicality above. Forst, however, explains toleration as a balanced conflict between universally accepted moral norms and particular ethical world-views. (shrink)

Palaeontology is an historical science comparable to prehistory, archeology, and history, in that it deals with living beings from past times. The documents needed to write the history of life are the remains of organisms contained in geological deposits from the last four billion years. They are called “fossils.”.