T cells develop in the thymus by expressing a diverse repertoire of either αβ‐ or γδ‐T cell receptors (TCR). While many studies have elucidated how TCR signaling and gene expression control T cell ontogeny, the role of nutrient metabolism is just emerging. Here, we discuss how metabolic reprogramming and nutrient availability impact the fate of developing thymic T cells. We focus on how the PI3K/mTOR signaling mediates various extracellular inputs and how this signaling pathway controls metabolic rewiring during highly proliferative (...) and anabolic developmental stages. We highlight the role of the hexosamine biosynthetic pathway that generates metabolites that are utilized for N‐ and O‐linked glycosylation of proteins and how it impacts TCR expression during T cell ontogeny. We consider the dichotomy in metabolic needs during αβ‐ versus γδ‐T cell lineage commitment as well as how metabolism is also coupled to molecular signaling that controls cell fate. (shrink)

The concept of well-being is one of the oldest and most important topics in philosophy and ethics, going back to ancient Greek philosophy and Aristotle. Following the boom in happiness studies in the last few years it has moved to centre stage, grabbing media headlines and the attention of scientists, psychologists and economists. Yet little is actually known about well-being and it is an idea often poorly articulated. The Routledge Handbook of Philosophy of Well-Being provides a comprehensive, outstanding guide and (...) reference source to the key topics and debates in this exciting subject. Comprising over forty chapters by a team of international contributors, the Handbook is divided into six parts: well-being in the history of philosophy current theories of well-being, including hedonism, and perfectionism examples of well-being and its opposites, including friendship and virtue and pain and death theoretical issues such as well-being and value, harm, identity and well-being and children well-being in moral and political philosophy well-being and related subjects including law, economics, and medicine. Essential reading for students and researchers in ethics and political philosophy, it will also be an invaluable resource for those in related disciplines such as psychology, politics and sociology. (shrink)

This paper examines implicaturist hybrid theories by examining how closely attitude expression by moral utterances fits with the varieties of implicature (conventional, particular conversational, generalized conversational) using five standard criteria for implicature: indeterminacy (§3), reinforceability (§4), non-detachability (§5), cancellability (§6), and calculability (§7). I argue (1) that conventional implicature is a clear non-starter as a model of attitude expression by moral utterances (2) that generalised conversational implicature yields the most plausible implicaturist hybrid but (3) that a non-implicaturist, and non-hybrid, alternative (...) might in fact be superior. (shrink)

This chapter focuses on the responses that proponents of virtue epistemology (VE) make to radical skepticism and particularly to two related forms of it, Pyrrhonian skepticism and the “underdetermination-based” argument, both of which have been receiving widening attention in recent debate. Section 1 of the chapter briefly articulates these two skeptical arguments and their interrelationship, while section 2 explains the close connection between a virtue-theoretic and a neo-Moorean response to them. In sections 3 and 4 I advance arguments for improving (...) the prospects of virtue-theoretic responses, sketching a particular version of VE that by recasting somewhat how we understand the “externalist turn in epistemology” also suggests ways of improving the adequacy of philosophical diagnoses and responses to skepticism. (shrink)

Ever since the eighteenth century, when Kant opened the floodgates of subjectivism in aesthetics, common men and philosophers alike have despaired of finding a basis for judgments about beauty. This book provides a comprehensive theory that encompasses beauty in art and nature, as well as intellectual, utilitarian, and moral beauty. The author argues that the beauty of objects can be reduced to the beauty of properties of those objects, which in turn can be understood in terms of "properties of qualitative (...) degree." The theory, developed first with respect to color, is then extended to include all sensory and non-sensory qualities. The author shows how the theory explicates and resolves disagreements about what is beautiful and discusses its relevance to the traditional notions of harmony and sublimity. His is an objectivist theory of beauty, and it enables him, in conclusion, to demonstrate why we enjoy perceiving beauty. Originally published in 1975. The Princeton Legacy Library uses the latest print-on-demand technology to again make available previously out-of-print books from the distinguished backlist of Princeton University Press. These editions preserve the original texts of these important books while presenting them in durable paperback and hardcover editions. The goal of the Princeton Legacy Library is to vastly increase access to the rich scholarly heritage found in the thousands of books published by Princeton University Press since its founding in 1905. (shrink)

The Emotions chapter (XXV) in James' Principles of Psychology traverses the entire range of experienced emotions from the “coarser” and more instinctual to the “subtler” emotions intimately involved in cognitive, moral, and aesthetic aspects of life. But Principles limits himself to an account of emotional consciousness and so there are few direct discussions in the text of Principles about what later came to be called moral psychology, and fewer about anything resembling philosophical ethics. Still, James’ short section on the subtler (...) emotions, when read in connection with his later philosophical writings, still provides insight on James’ views about how human emotion colors our moral psychology and agency. The paper tries to articulate how James' somatic account of emotion adds significantly to contemporary discussions at the borders of moral psychology and philosophy: discussions over the foreground/background distinction, emotional temperament, emotional learning, moral imagination, and selfhood and narrativity. The final section focuses on the neo-Jamesian character of "new sentimentalist" moral psychologists. Among the substantial connections I discuss between James and 1) between Jonathan Haidt’s “social intuitionism” and 2) Jesse Prinz’s "emotionism" are the critiques that they each share of the pretensions of hard universalist ethical theories. (shrink)

The traditional organizational boundaries between healthcare, social work, police and other non-profit organizations are fading and being replaced by new relational patterns among a variety of disciplines. Professionals work from their own history, role, values and relationships. It is often unclear who is responsible for what because this new network structure requires rules and procedures to be re-interpreted and re-negotiated. A new moral climate needs to be developed, particularly in the early stages of integrated services. Who should do what, with (...) whom and why? Departing from a relational and hermeneutic perspective, this article shows that professionals in integrated service networks embark upon a moral learning process when starting to work together for the client’s benefit. In this context, instrumental ways of thinking about responsibilities are actually counterproductive. Instead, professionals need to find out who they are in relation to other professionals, what core values they share and what responsibilities derive from these aspects. This article demonstrates moral learning by examining the case of an integrated social service network. The network’s development and implementation were supported by responsive evaluation, enriched by insights of care ethics and hermeneutic ethics. (shrink)

In this paper, I build on recent scholarship concerning the early semantic history of the word “smṛti,” which has been shown to denote “tradition” in the early dharmasūtra material. I seek to add nuance to this work by examining the meaning of smṛti in the early Sāmavedic technical literature. This corpus helps elucidate one of the processes whereby smṛti came to refer to something textual. This paper argues that smṛti’s earliest textualized referent may have been fixed or semi-fixed individual statements (...) rather than definite texts. (shrink)

La vie, la voix, la pensée, le combat de Vladimir Jankélévitch (1903-1985) qui marquèrent le siècle, en philosophie, en musique, en politique, ne pouvaient pas mieux ressortir que dans un "éblouissement". Ce fut celui de Guy Suarès (1932-1996), homme de théâtre, de radio et de télévision, qui s'est particulièrement attaché, par ses traductions et ses mises en scène, à mieux faire connaître la culture hispanique (Lorca, Neruda, Bergamin...) et a dirigé la Comédie de la Loire à Tours à l'invitation d'André (...) Malraux, à qui il a consacré deux ouvrages. Une relation, lumineuse, face aux mystères de la vie et de la mort ; et dont les voix portent encore. (shrink)

A stunning exploration of the relation between desire and psychopathology, The Death of Desireis a unique synthesis of the work of Laing, Freud, Nietzsche, and Heidegger that renders their often difficult concepts brilliantly accessible to and usable by psychotherapists of all persuasions. In bridging a critical gap between phenomenology and psychoanalysis, M. Guy Thompson, one of the leading existential psychoanalysts of our time, firmly re-situates the unconscious - what Freud called "the lost continent of repressed desires" - in phenomenology. In (...) so doing, he provides us with the richest, most compelling phenomenological treatment of the unconscious to date and also makes Freud's theory of the unconscious newly comprehensible. In this revised and updated second edition to the original published in 1985, M. Guy Thompson takes us inside his soul-searching seven-year apprenticeship with radical psychiatrist R. D. Laing and his cohorts as it unfolded in counterculture London of the 1970s. This rite de passage culminates with a four-year sojourn inside one of Laing's post-Kingsley Hall asylums, where Laing's unorthodox conception of treatment dispenses with conventional boundaries between "doctor" and "patient." In this unprecedented exploration, Thompson reveals the secret to Laing's astonishing alternative to the conventional psychiatric and psychoanalytic treatment schemes. Movingly written and deeply personal, Thompson shows why the very concept of "mental illness" is a misnomer and why sanity and madness should be understood instead as inherently puzzling stratagems that we devise in order to protect ourselves from intolerable mental anguish. The Death of Desireoffers a provocative and challenging reappraisal of depth psychotherapy from an existential perspective that will be of interest to psychoanalysts, psychotherapists, philosophers, social scientists, and students of the human condition. (shrink)

Presents 3 hermeneutic answers to the problem of relativism. The 1st answer is drawn from L. Wittgenstein's anthropological hermeneutics. Wittgenstein went beyond relativism by making explicit universal anthropological categories that are specified differently in different cultures. The 2nd answer lies in H.-G. Gadamer's historical hermeneutics. By introducing the concepts of tradition and fusion of horizons, Gadamer evades both absolutism and relativism. The 3rd answer is developed by J. Habermas in his critical hermeneutics. By situating communicative action in the life-world, and (...) stressing the possibility of discussion and critique, Habermas can ascertain that there is no absolute truth without having to surrender to relativism. 2012 APA, all rights reserved). (shrink)

This essay seeks first to clarify the type of complementary understanding two disciplines such as philosophy and sociology can bring to the investigation of the concept of morality. The present study concerns Durkheim, attempts to show how the sociological concept of morality that he develops in his works on the division of labor, solidarity, anomie, suicide, elementary forms of religion, collective ideals, etc..., inevitably spills over into essentially philosophical considerations. Should philosophical inquiry into the concept of morality also make reference (...) to essentially sociological considerations? It is ultimately to this question that this essay addresses itself.Cet article a pour but premier de mettre en lumière le type de complémentarité que peuvent apporter deux disciplines comme la philosophie et la sociologie dans l'approfondissement du concept de moralité. La présente étude porte sur l'exemple de Durkheim et tente de montrer comment le concept sociologique de moralité qu'il a développé dans ses thèses portant sur la division du travail, la solidarité, l'anomie, le suicide, la religion élémentaire, les idéaux collectifs, etc... débouche inévitablement sur des considérations d'ordre philosophique. Inversement, la philo- sophée qui s'interroge sur le concept de moralité se voit-il dans l'obligation de faire appel à des considérations d'ordre sociologique' C'est la question que soulève en dernière analyse cet article. (shrink)

RésuméCet article est consacréà la présentation et à l'examen critique des principes de la justice élaborés dans l'ouvrage du professeur John Rawls intituléA Theory of Justice. L'auteur examine notamment l'approche contractuelle utilisée par Rawls de même que son inspiration Kantienne et le type de rationalité qu'il met en œuvre pour construire sa théorie.

Depuis que le structuralisme a franchi le seuil de Ia mode et que l'on parle maintenant volontiers d’ une ère post-structuraliste, le moment se prête davantage à une réflexion philosophique et critique sur ce type d'épistémè qui a pratiquement envahi tout le champ des sciences humaines. Quoique le structuralisme ait été une mode, et une mode qui a réussi, selon l'expression de Raymond Boudon,1 il reste toutefois encore difficile d'apprécier ses succès dans des travaux comme ceux de Foucault, d'Aithusser, de (...) Barthes ou de Lacan. Là où cependant le succès est le plus évident c'est du côté des sciences sociales, en particulier du côté de Ia linguistique et de l'anthropologie. (shrink)