T cells develop in the thymus by expressing a diverse repertoire of either αβ‐ or γδ‐T cell receptors (TCR). While many studies have elucidated how TCR signaling and gene expression control T cell ontogeny, the role of nutrient metabolism is just emerging. Here, we discuss how metabolic reprogramming and nutrient availability impact the fate of developing thymic T cells. We focus on how the PI3K/mTOR signaling mediates various extracellular inputs and how this signaling pathway controls metabolic rewiring during highly proliferative (...) and anabolic developmental stages. We highlight the role of the hexosamine biosynthetic pathway that generates metabolites that are utilized for N‐ and O‐linked glycosylation of proteins and how it impacts TCR expression during T cell ontogeny. We consider the dichotomy in metabolic needs during αβ‐ versus γδ‐T cell lineage commitment as well as how metabolism is also coupled to molecular signaling that controls cell fate. (shrink)

Is linguistic understanding a form of knowledge? I clarify the question and then consider two natural forms a positive answer might take. I argue that, although some recent arguments fail to decide the issue, neither positive answer should be accepted. The aim is not yet to foreclose on the view that linguistic understanding is a form of knowledge, but to develop desiderata on a satisfactory successor to the two natural views rejected here.

In this essay, the author describes how he faced institutionalized homophobia during his psychiatric training, and how he later wrote a play inspired by the life of a gay psychiatrist. Despite Freud’s supportive stance, homosexuality aroused the antipathy of American organized psychiatry and psychoanalysis and came to be listed as an illness in the Diagnostic and Statistical Manual. Dr. John E. Fryer outed himself as “Dr. H Anonymous” at a 1972 meeting of the American Psychiatric Association, and the next year (...) homosexuality was removed from the DSM. The 2014 play Doctor Anonymous offers a fictionalized account of this watershed moment in the history of the gay rights movement. The author discusses his own psychotherapeutic work with gay male patients, including those who had previously been treated with conversion therapy, and explores how the play mirrors his own life experience and the experience of his patients. (shrink)

Gilbertson et al present a considered analysis of the abstract problem of ‘sedation’ at the end of life,1 and it is reassuring to see the separation of multiple practises that are often grouped under the heading terminal sedation. In their work, the authors attempt to introduce and justify a new practice in the care of those dying with significant suffering—expanded terminal sedation (ETS). This analysis will not, however, help our colleagues at the bedside. Here, we will focus on the flaws (...) which are most relevant to clinicians: jurisdiction, uncertainty and reversibility. The authors’ focus on a jurisdiction that does already allow medically assisted in dying confuses their analysis. For example, either an instance of their proposed ETS does amount to intentionally hastening death, in which case it should be treated as a means of euthanasia and practised only where that is permitted, subject to its limits and regulations; or it does not amount to intentionally hastening death, in which case there is no reason to specify such jurisdictions. To explain that the most controversial elements of terminal sedation have been tacitly ‘accepted’ by the society in question does not invalidate the concerns. It is beyond the scope of this response to explore these, but to us, …. (shrink)

What is the epistemological role of speech perception in comprehension? More precisely, what is its role in episodes or states of comprehension able to mediate the communication of knowledge? One answer, developed in recent work by Tyler Burge, has it that its role may be limited to triggering mobilizations of the understanding. I argue that, while there is much to be said for such a view, it should not be accepted. I present an alternative account, on which episodes of comprehension (...) are better able to underwrite the interpersonal transmission of knowledge. (shrink)

Quand tu es seul, debout au milieu de la haute plaine d'Asie,sous la coupole insondable où parfois un piloteou un ange sème dans l'azur une coulée d'amidon;quand tu tressailles sentant ta petitesse,apprends-le: l'espace auquel semble-t-il il ne fautrien, a grandement besoin en réalitéd'un regard extérieur, de distance, de vide.Tu es seid à pouvoir lui rendre ce service.Joseph BrodskyIn the course of this century, a number of authors have asserted that geographic knowledge is useful for the development of programs to parcel (...) out land. Hoping to foster this link between insight and action, applied geography saw the light of day. In order to be genuinely effective, the practice of this kind of planning, so it was thought, needed to rely on the expertise of the geographer who studied forms of human settlement. More fundamentally, the utilitarian claim of applied geography rested on the conviction according to which the spatial organization of human societies brought into play the question of justice and commonweal. As Jean Gottmann wrote, our epoch is particularly sensitive to the fact that everyone, whoever or from wherever they may be, consider themselves “to be entitled to live just as well as all others.” In this way a “popular will” was affirmed “that the necessary measures be taken to envisage, prepare, and provide for an improvement of life's comforts …, for a better life.” Inspired by the “modern idea of planning,” applied geography set itself the goal of “establishing justice […] by a more even distribution of people, of their means of subsistence, [and] of their living standard.”. (shrink)

In Nicolas of Cusa’s De li non aliud, chapter 19, one should read “in prima seu metaphysicali philosophia” instead of “in prima seu mentali philosophia.” This conjectural emendation is required because the identification of ‘first philosophy’ with ‘mental philosophy’ is attested nowhere else. The paper shows that the huge literature on Cusanus’ alleged re-interpretation of metaphysics as Geistphilosophie rests on a copyist’s mistake.

Francesco Piccolomini (1523–1607) interprets Aristotle’s theory of friendship from a Christian-Neoplatonic perspective. This paper focuses on the various (ancient, medieval, and Renaissance) sources of Piccolomini’s interpretation and shows that he succeeds in expounding a coherent doctrine in which the Aristotelian ideal of civic friendship is integrated into a theocentric ethics of spiritual love.

In his remarkable study Species Intelligibilis. From Perception to Knowledge, L. Spruit succinctly outlines the main points of Henry Bate’s cognitive psychology. Spruit observes that «though endorsing a Neoplatonic innatism, he does not relinquish Peripatetic views on the impact of sensory representations in the generation of intellectual cognition». Moreover, Spruit rightly notes that Bate considers the species doctrine «a pivotal philosophical issue». However, his brief account of Bate’s theory of the sensible species is far from being accurate. The aim of (...) this paper consists in presenting a more or less exhaustive interpretation of Bate’s doctrine of the sensible species. First, an attempt will be made to situate this doctrine in the context of Bate’s Speculum divinorum. Second, I shall summarize the principal views of the authors which Bate discusses in order to shed light on the doctrinal background of his theory of sensible species. Third, I shall analyze Bate’s concept of the sensible species, focusing on its ontological status and its function. Finally, I shall show that Bate’s exposition on sense-perception is profoundly influenced by Platonic theories of the soul. (shrink)

This book offers a solution for the problem of structure and agency in sociological theory by developing a new pair of fundamental concepts: metric and nonmetric. Nonmetric forms, arising in a crowd made out of innumerable individuals, correspond to social groups that divide the many individuals in the crowd into insiders and outsiders. Metric forms correspond to congested zones like traffic jams on a highway: individuals are constantly entering and leaving these zones so that they continue to exist, even though (...) the individuals passing through them change. Building from these concepts, we can understand “agency” as a requirement for group identity and group membership, thus associating it with nonmetric forms, and “structure” as a building-up effect following the accumulation of metric forms. This reveals the contradiction between structure and agency to be a case of forced perspective, leaving us victim to an optical illusion. (shrink)

If you want to challenge or at least weaken the adhesion to a system of values, you can basically adopt two radically opposed rhetorical strategies. Either you will attack the system in a frontal way: for instance, fundamentalists or fascists deny any validity to democratic values and human rights. Or you will pretend to argue from within the system (by saying that you accept some of its basic premises), while subtly distorting the process of reasoning in order to get to (...) your conclusions. If the audience is naïve or poorly informed, you will be able to defend positions that are fundamentally at odds with liberal-democratic values while seeming to argue from inside the system. I would like to show how such a process of “perverse” translation works in the context of the Darwinism/Creationism “controversy”. The attacks on the teaching of evolutionary biology began approximately one century ago. The way Creationists have argued and changed several times their rhetorical strategies seems very interesting to me, in that it exemplifies an important contemporary phenomenon, which I call “perverse translation” or “the wolf in the sheepfold”. (shrink)

Dans cet ouvrage collectif, l'article de Guy Bouchard intitulé "Féminisme, utopie, philosophie" offre d'abord une définition du féminisme et de ses tendances. Il examine ensuite les liens entre le féminisme et la philosophie, laquelle, historiquement, s'est révélée dans l'ensemble à la fois masculine et masculinise. Finalement, il explore les rapports du féminisme à l'hétéropolitique, c'est-à-dire au thème de la société idéalisée soit sur le mode de la fiction (utopie), soit sur celui de la discursivité théorique (para-utopie), afin de faire ressortir (...) les enjeux du rapport des femmes tant à la philosophie qu'à la société nouvelle. (shrink)

[1] Époques et auteurs.--[2] Textes choisis.

This study tested the hypothesis that overt rehearsal is sufficient to explain enhanced memory associated with emotion by experimentally manipulating rehearsal of emotional material. Participants viewed two sets of film clips, one set of emotional films and one set of relatively neutral films. One set of films was viewed in each of two sessions, with approximately 1 week between the sessions. Participants were given a free recall test of all of films viewed approximately 1 week after the second session. Rehearsal (...) was manipulated by instructing one group of participants not to discuss the films with anyone (no talkgroup) and instructing a second group to discuss both sets of films with at least three people (forced talkgroup). A third group consisted of participants instructed not to discuss the films with anyone, but who did not comply with these instructions (talkersgroup). All groups recalled significantly more of the emotional films than the neutral films. Furthermore, the relative number of emotional and neutral films recalled did not differ significantly among the three groups. The results indicate that overt rehearsal is insufficient to explain the enhancing effects of emotion on memory. (shrink)

Pedro Abelardo apresenta na sua obra uma teoria da virtude de natureza, à primeira vista, aristotélica. Ao que parece, essa concepção também contém diferentes elementos estoicos, que não se opõem necessariamente à visão do Estagirita. Todavia, o essencial da interpretação da Escola do Pórtico acerca da virtude difere da explicação dada por Aristóteles. No presente estudo, pretendemos examinar, primeiro, a índole da virtude como habitus na obra de lógica de Abelardo. Nesse caso, não há dúvida de que predomina a influência (...) aristotélica. Em seguida, indicamos outras particularidades da virtude encontradas, desta vez, em tratados éticos e teológicos do nosso protagonista, as quais se revelam antes de caráter estoico. Em suma, projetamos identificar as diferentes fontes antigas e os principais intermediários latinos usados por Abelardo para elaborar a sua própria teoria da virtude. Trata-se de deixar clara a influência filosófica dominante em Abelardo sobre essa questão da virtude, já que este lógico não pode harmonizar teses substancialmente inconciliáveis. Peter Abelard in his work presents a theory of virtue, which is, at first sight, of Aristotelian nature. It seems that this view also contains different Stoic elements, but they are not necessarily opposed to Stagirite's vision. However, the essentials of the Stoa School about virtue differ from the explanation given by Aristotle. In this paper, we intend to examine, first, the nature of virtue as habitus in Abelard's work on logic. In this case, there is no doubt that Aristotle's influence on this topic predominates. Next, we specify other features related to virtue found, this time, in ethical and theological treatises of our protagonist that appear to be basically Stoic. In short, we want to identify the different ancient sources and the main Latin mediators used by Abelard to elaborate his own theory of virtue. In other words, we would like to shed light on the predominant philosophical authority on Abelard's theory of virtue since this logician cannot harmonize theses that are fundamentally irreconcilable. (shrink)

There are two main claims that Bradley makes concerning negative judgment in the Principles of Logic: Negative judgment ‘stands at a different level of reflection’ from affirmative judgment. Negative judgment ‘presupposes a positive ground’.I will consider what Bradley means by these claims, and draw comparisons with Wittgenstein's views on negation as they developed between the Tractatus and the Philosophical Remarks.

Many recent studies on network technologies and cities share an alarmist view of the impact of technological or regulatory change in utility sectors on the social and spatial fabric of cities, pointing to growing discrimination and inequalities, alienation, enhanced social exclusion and urban “splintering” on a universal scale. A science and technology study perspective on these matters is helpful in moving beyond this “universal alarmism” by emphasizing the ambivalence inherent to all technologies, the significant potential of contestation of, and resistance, (...) to technology-supported forms of discrimination, and the deeply contingent nature of the process of appropriation of new technologies and, as a consequence, of the social “effects” of technologies. Adopting this perspective would mean actively searching for and exploring these context-dependent and often conflictive appropriation processes. For it is in these spaces that we might begin to identify urban technological politics that break free from an intellectually and politically disabling technological pessimism. (shrink)