The progress of electronic health technologies and biobanks holds enormous promise for efficient research. Evidence shows that studies based on sharing and secondary use of data/samples have the potential to significantly advance medical knowledge. However, sharing of such resources for international collaboration is hampered by the lack of clarity about ethical and legal requirements for transfer of data and samples across international borders. Here, the International Clinical Trial Center Network reports the legal and ethical requirements governing data and sample exchange (...) across four continents. The most recurring requirement is ethical approval, whereas only in specific conditions approval of national health authorities is required. Informed consent is not required in all sharing situations. However, waiver of informed consent is only allowed in certain countries/regions and under certain circumstances. The current legal and ethical landscape appears to be very complex and under constant evolution. Regulations differ between countries/regions and are often incomplete, leading to uncertainty. With this work, ICN illuminates the unmet need for a single international collaborative framework to facilitate DSE. Harmonising requirements for global DSE will reduce inefficiency and waste in research. There are many challenges to realising this ambitious vision, including inconsistent terminology and definitions, and heterogeneous and dynamic legal constraints. Here, we identify areas of agreement and significant difference as a necessary first step towards facilitating international collaboration. We propose the establishment of a working group to continue the comparison across jurisdictions, create a standardised glossary and define a set of basic principles and fundamental requirements for DSE. (shrink)

Empirical research in bioethics has developed rapidly over the past decade, but has largely eschewed the use of technology-driven methodologies. We propose “design bioethics” as an area of conjoined theoretical and methodological innovation in the field, working across bioethics, health sciences and human-centred technological design. We demonstrate the potential of digital tools, particularly purpose-built digital games, to align with theoretical frameworks in bioethics for empirical research, integrating context, narrative and embodiment in moral decision-making. Purpose-built digital tools can engender situated engagement (...) with bioethical questions; can achieve such engagement at scale; and can access groups traditionally under-represented in bioethics research and theory. If developed and used with appropriate rigor, tools motivated by “design bioethics” could offer unique insights into new and familiar normative and empirical issues in the field. (shrink)

From an evolutionary perspective, phenotypic, social, and environmental factors help to shape the different costs and benefits of pursuing different reproductive strategies from one individual to another. Since men’s reproductive success is mainly constrained to women’s availability, their mating orientations should be partially calibrated by features that women prefer in a potential partner. For long-term relationships, women prefer traits that signal access to resources, protection skills, and the willingness to share them. Using generalized linear models with laboratory data taken from (...) a Chilean population, this study aimed to test whether real and potential resources, protection skills, and the willingness to provide resources and protection are related to mating orientation in men. Our predictions were: socioeconomic status would be positively associated with long-term and short-term mating orientation but for long-term-oriented individuals, this would be enhanced by having a more favorable parenthood disposition and strength would be positively related to long-term mating orientation in men with higher socioeconomic status and a favorable disposition toward parenthood and it would have a positive and direct association with short-term mating orientation. Our results partially supported the first hypothesis, since men with higher socioeconomic status were more long-term oriented, but parenting disposition did not moderate this effect. Contrary to our expectations, socioeconomic status was not related to short-term mating orientation. Strength appeared not to be significant for long-term mating orientation, even interacting with other traits. However, strength by itself was powerfully linked with a short-term mating orientation. Our results suggest that only some individuals that are attractive for long-term relationships are indeed long-term oriented and may reflect the overall conflict of interests between mating strategies among sexes. (shrink)

Jusqu’à Blaise Pascal, le hasard désigne ce qui se produit en dehors de tout dessein humain ou divin et de tout ordre stable. Après lui, on cherche à préciser de façon constructive ces trois types d’exclusion, ce qui amène à définir les événements merveilleux, les événements aléatoires et les événements accidentels. Chacune de ces trois démarches a ses avantages et ses inconvénients. La première rend compte de tout ce qui étonne, mais écarte la liberté et le miracle et ne permet (...) ni vérification, ni prévision, ni décision. La seconde permet des prévisions et des vérifications expérimentales, mais son emploi ne peut se généraliser sans entrer en conflit avec le déterminisme, qui la considère comme une illusion. La troisième explique beaucoup de choses par la rencontre de séries causales indépendantes, mais ce faisant elle exclut toute finalité. Il faut faire très attention à ne pas les confondre. Until Blaise Pascal, chance meant what happens outside any human or divine design or any stable order. Attempts are made, ever since, to set down in a constructive fashion those three types of exclusion : what it is that leads to define marvellous events, chance events and accidental events. Each of those three endeavours has its advantages and its drawbacks. The first accounts for everything that amazes, but it sets aside freedom and miracle, and does not allow any verification, prevision, or decision. The second permits previsions and experimental verifications, but its use cannot be generalized without entering into conflict with determinism, which considers it an illusion. The third explains a number of things through the encounter of independent causal series, but, while so doing, it excludes all finality. One must be very cautious not to confuse the three. (shrink)

El genoma humano contiene un importante número de retrovirus endógenos (HERVs), es decir, secuencias derivadas de pasadas infecciones retrovirales insertadas de forma permanente; y secuencias similares se pueden observar en prácticamente todos los organismos eucariontes. Muchos de estos HERVs se transcriben y traducen en condiciones fisiológicas normales, llegando a formar partículas virales completas, y participando en procesos tan complejos como la placentación. Por su capacidad de retrotransposición y recombinación entre ellos son una fuente importante de remodelación genómica y, junto con (...) otros retroelementos, participan en la generación de retrogenes y retropseudogenes, que suponen un sustrato de variabilidad informacional fundamental para la aparición de nuevas estructuras y funciones. Puesto que su actividad responde también a las condiciones ambientales, los cambios genómicos generados por ellos no son graduales, sino que aparecen en oleadas, de modo que se puede producir una variedad fenotípica muy extensa en momentos evolutivos concretos, coincidiendo con situaciones ambientales críticas. La consideración de los HERVs como parte integral y consustancial de nuestro genoma obliga a replantearse la utilización de vectores retrovirales en protocolos de terapia génica, así como la utilización de órganos animales -con sus propios retrovirus endógenos- para xenotrasplantes. (shrink)

As is well known, Heinrich Scholz and his academic society maintained good scientific contacts with Polish logicians before, during, and after the Second World War. My interest here is to examine the details of their collaboration by presenting Scholz’s unpublished correspondence with Fr. Józef M. Bocheński. The following topics are discussed here: Polish logicians who survived the war and their current place of work; reorganization of the scholarly environment, didactic activities, duties, scholarly trips; current research topics, prospects for post-war publications, (...) and future publishing plans; information about Jan Łukasiewicz, Bolesław Sobociński, and Joachim Metallmann; personal matters. (shrink)

En el siguiente artículo se analiza "Hopeful Monsters or, The Unfulfilled Figure in Hayden White´s Conceptual System", donde Kellner demuestra que la teoría de la figuralidad está latente desde el inicio de la teoría de Hayden White. Además, aplica el análisis figural a la propia obra de White afirmando que la teoría de los tropos será cumplimentada por el emplotment que, a su vez, será cumplimentado por el figuralismo. Luego se sigue el desarrollo de Kellner que muestra que en los (...) pasajes de White hay dos usos diferentes del concepto de unfulfillment: una noción de incumplimiento como figura que no llegó a su máxima potencia y una noción de incumplimiento como lo sublime indecible. Se examina específicamente la cuestión judía, asumiendo la misma como una figura incumplida y se rescatan las contribuciones del romanticismo y del iluminismo a su cumplimentación. Por último, se realizan algunas críticas a la insistencia de Kellner en el papel post teológico del figuralismo y al lugar del incumplimiento ligado a lo sublime como trascendiendo lo histórico. ARK: ark:/s18537960/eimr/sd31. (shrink)

El concepto de comunidad, acuñado en el siglo XIX por Ferdinand Tönnies, sigue constituyendo el sustrato del pensamiento de la vida cotidiana, pero también de formulaciones teóricas y políticas. En particular, está detrás de la idea de mediación comunitaria, con la que nos proponemos nuevas utopías de autogestión de los conflictos. Sin embargo, el marco social en el que se creó el concepto ha cambiado profundamente, sobre todo a partir de los últimos 40 años al calor de la llamada “globalización”. (...) El artículo explora estos cambios, y sugiere hacia donde pueden abrirse las nuevas interpretaciones, mostrando además cómo estos afectarían a la mediación comunitaria. (shrink)

Patentowanie ludzkich genów jest zjawiskiem, które w obecnych czasach nabrało intensywności i znaczenia. Jest jedną z kluczowych form zabezpieczania praw własności przemysłowej, zwłaszcza dla ośrodków badawczych i koncernów farmaceutycznych. Ze względu na naturę produktu podlegającego opatentowaniu, pomysł patentowania genów budzi wiele kontrowersji i rodzi spory na różnych płaszczyznach. Celem artykułu jest naszkicowanie ram prawnych dla tego zjawiska (m.in. porównanie regulacji europejskich i amerykańskich) oraz krytyczne omówienie argumentów przemawiających zarówno w obronie tej procedury, jak i przeciwko niej, wysuwane z różnych perspektyw: (...) prawnej (kwestia posiadania przez geny tzw. zdolności patentowej, kontrowersje związane z prawem własności do ludzkiego ciała), społeczno-ekonomicznej (wpływ zjawiska na rozwój badań naukowych oraz na ceny leków i dostępność różnych terapii) oraz etycznej (omówionej na podstawie wybranych kazusów). Artykuł zarysowuje również kilka propozycji rozwiązań praktycznych, które mają usuwać przynajmniej niektóre kontrowersje związane z patentowaniem genów. (shrink)

RESUMEN Recientes intentos por conectar la ética y la biología aristotélicas marcan una suerte de continuidad entre el carácter de los animales no racionales y de los seres humanos, de modo tal que en la descripción de los caracteres de los animales no racionales puede identificarse el punto de partida biológico del propio ser humano en el desarrollo de su carácter moral. En este artículo, propongo señalar los límites de este tipo de lectura, ya que, entendida de cierto modo, ella (...) implica una continuidad entre la normatividad natural y la normatividadpráctica propia de un naturalismo fundacionalista que no puede atribuirse a Aristóteles. En conexión con ello, sostengo que el concepto de virtud natural no es un concepto natural, sino ético, tal que sólo cobra sentido en el marco de la normatividad práctica; la virtud natural, en este sentido, no forma parte de una explicación genética de la virtud sino de un análisis que va del todo a las partes, de acuerdo al cual ella no es anterior sino posterior a la virtud ética. ABSTRACT A recent trend in Aristotelian scholarship tries to link ethics and biology. Within these attempts, some sort of continuity between the character of non-rational animals and that of human beings has been proposed, so that the starting point ofmoral development could be identified in Aristotle’s description of animal’s character. In this article I argue that this reading should strongly qualified, for understood in some ways it entails a sort of continuity between natural normativity and practical normativity that belongs to an Archimedean ethical naturalism, which cannot be reconstructed from Aristotle’s writings. Connected to this, I argue that the concept of natural virtue is not a natural concept, but an ethical one that only makes sense from within the realm of practical normativity; natural virtue, thus understood, is not part of a genetic explanation of virtue, but emerges from a conceptual whole-part analysis. In this manner, natural virtue is no prior, but posterior to ethical virtue. (shrink)

Existen en el campo de las ciencias sociales numerosas investigaciones que abordan la problemática de la praxis, sin embargo, menos común es encontrar estudios que vinculen esta categoría al estudio del movimiento obrero. A lo largo de estas notas se busca construir un marco de análisis desde el cua..

The paper aims to circumscribe, through a specific history of ideas approach, the relevance of Benedict Spinoza’s theological rationalism to the major debate which generated the Early Enlightenment, the radical conception on the new status of philosophy in relation to theology, on libertas philosophandi and rational philosophizing. The main lines of Spinoza’s theological rationalism are sustained as being inspired and encouraged by Hobbes’ “negative theology,” the only theology considered consonant with the “true philosophy.” The paper also indicates the originality of (...) Spinoza’s theological criticism and the reasons under which Hobbes—despite the radicalism of his biblical interpretation and of his thesis of separating the philosophy (natural science) from theology—Hobbes enjoyed an attenuated critical reception compared to that one applied to Spinoza and the “acute” tone of which was set by Leibniz. (shrink)

En este trabajo proponemos abordar, desde un enfoque interdisciplinar, los cambios históricos en la definición y representación de la naturaleza patagónica, a partir de indagar el caso del proyecto de Vivero y arboretum en la Isla Victoria, en el lago Nahuel Huapi. Pretendemos dar cuenta cómo las representaciones que se realizan desde las instituciones científicas y gubernamentales acompañan los proyectos político-ideológicos cada período histórico. Tomaremos como fuentes de análisis parte de las representaciones visuales pertenecientes al arte institucional, algunas entrevistas realizadas (...) a profesionales vinculados a nuestro objeto de estudio y otras fuentes bibliográficas históricas. Nuestra hipótesis es que el proyecto de forestación en Isla Victoria-que se inicia en 1925 con Gross y la creación del arboretum- reflejó la cosmovisión ilustrada moderna, mediante la cual se ha buscado “construir naturaleza” bajo una lógica positivista. Se enfatiza un vínculo con la naturaleza como Otredad y como objeto a dominar, ya sea de modo ornamental o productivo. Esta cosmovisión se plasma en las representaciones científicas de la naturaleza de la Isla. Esta perspectiva de una “Naturaleza a mejorar”, pareciera ser antagónica a las nuevas miradas ecológicas. Desde la década de 1970 cambia el paradigma sobre el uso de exóticas y se advierten sus peligros, promoviendo acciones de conservación de especies nativas. (shrink)

Este artículo presenta una caracterización del proceso de autogestión laboral ocurrido en la Argentina en el período 1990-2006, apuntando especialmente sobre el universo de las Empresas Recuperadas por sus Trabajadores. En esta dirección, se argumenta sobre una serie de dimensiones analíticas que singularizan a este proceso con referencia a otras experiencias autogestionarias ocurridas antecedentemente. Esta singularidad descansa específicamente en que estas experiencias pueden ser estudiadas como procesos de recolectivización laboral, cuya emergencia y desarrollo se ubica en un escenario atravesado por (...) un profundo proceso de descolectivización social, económica y política. Las dimensiones destacadas y analizadas para aludir al proceso de recolectivización suponen la exposición de argumentos en torno a los siguientes elementos interpretativos: la reconstrucción de un espacio y una experiencia colectiva de trabajo que recuperó parte de la historia asalariada de los trabajadores, la reconfiguración de vínculos de sociabilidad al interior del espacio productivo, la relación con organizaciones sociales y gremiales que representaron los intereses de los trabajadores de estas empresas recuperadas. (shrink)

This paper challenges a widespread reading of Aristotle’s use of dialectic in the treatment of aporiai. According to this reading, the search for a resolution of an aporia is supposed to proceed by arguing against conflicting theses to refute one of them. I argue that this reading is not satisfactory and propose an alternative, based on an often overlooked distinction between two dialectical procedures, the refutation (elenchos) of a thesis and the resolution (lysis) of an argument. These two terms are (...) employed fairly consistently by Aristotle in the treatises as well. Since an aporia requires not merely conflicting theses, but conflicting arguments for those theses, I contend that the ideal way out of aporiai involves a critical analysis of those arguments, akin to that involved in the dialectical resolution. A relevant implication of this reading is that it expands the critical use of dialectic for philosophy, and points to the specific philosophical utility of the Sophistical Refutations. (shrink)

In a situation of advance and consolidation of the ultra-right in Latin America, in which security claims and government interventions in the name of the “combat against insecurity” have been one of its most dynamic vectors, this work is aimed at exploring the contours of another approach to the question of crimes and punishments. During the seventies, in the heat of dictatorships and exiles, a critical, combative, partisan criminological model was forged in Argentina. This other model is tributary of a (...) strategic assembly between the “Foucault effect” in Argentina and Latin American critical criminology. Specifically, the traces of this process are covered through three strong ideas: 1) the “Foucault effect” in Argentina and critical criminology are the ties of a certain critical attitude; 2) that history is realized in a topological structure: it unfolds in the ups and downs experienced by intellectuals here in the dictatorship and there in forced exile; 3) these imports, readings and uses of Foucault overflow and dislocate Foucauldian analysis itself. (shrink)

Este artigo discute a noção de gentrificação do queer, de Sarah Schulman (2018), tomando como corpus o documentário Línguas Desatadas (Marlon Riggs, 1989). Tem como objetivo refletir como a materialidade (autobiográfica) desta obra fílmica cria um arquivo queer-multissensorial que pode ser lido à luz do conceito de Sarah Schulman. Reúne autores dos estudos sobre sensorialidade, arquivo, cinema, queer e gentrificação. Busca contribuir com uma reflexão sobre como a noção de gentrificação do queer dialoga esteticamente com os paradigmas de invisibilidade no (...) documentário. Palavras-chave: Línguas desatadas; arquivo; gentrificação do queer. (shrink)

Aldo Leopold (1887-1948) foi um professor e pesquisador que contribuiu para o campo da ecologia da vida selvagem, destacando-se no ambientalismo norte-americano do século XX. O objetivo deste artigo é discutir sob uma perspectiva filosófica a conservação da biodiversidade adotada por Aldo Leopold a partir de análise de trechos da sua última obra A sand county almanac and sketches here and there (1949). O livro, elaborado em seus anos de experiência na fazenda da família, apresenta uma série de ensaios com (...) uma abordagem ecológica da relação do ser humano com a natureza. As duas primeiras partes contêm ensaios resultantes da leitura da paisagem, adotando a perspectiva de elementos bióticos e abióticos do ambiente, assim como, ponderações resultantes de sua experiência profissional. A terceira parte da obra traz reflexões de caráter filosófico a respeito da estética da conservação e ética da Terra promovendo uma reinterpretação da identidade humana e do relacionamento com a terra. (shrink)

How do we reevaluate the role of individuals whose contributions have not been erased—they are still visible—but whose labor has been demoted in the historical narrative because of their gender, class, or ethnicity? This brief essay is about more than simply bringing in overlooked actors; instead, it ponders why the act of mislabeling a person’s labor merits further deliberation. Mislabeled archival evidence, such as the erroneous description accompanying a photograph that this essay discusses, might uphold problematic assumptions in the history (...) of science about who can perform certain labors. Such mistakes, careless or otherwise, produce enduring historiographic harm because such errors make it harder to construct other versions of the past. (shrink)

Informed consent is recognized as a primary ethical requirement to conduct research involving humans. In the investigations with the use of human biological material, informed consent (IC) assumes a differentiated condition on account of the many future possibilities. This work presents suitable alternatives for IC regarding the storage and use of human biological material in research, according to new Brazilian regulations. Both norms – Resolution 441/11 of the National Health Council, approved on 12 May 2011, and Ordinance 2.201 (NATIONAL GUIDELINES (...) FOR BIOREPOSITORIES AND BIOBANKS OF HUMAN BIOLOGICAL MATERIAL FOR RESEARCH PURPOSE) of the Brazil Ministry of Health, approved on 14 September 2011 – state that the consent of subjects for the collection, storage and use of samples stored in Biobanks is necessarily established by means of a Free and Informed Consent Form (ICF). In order to obtain individual and formal statements, this form should contain the following two mutually exclusive options: an explanation about the use of the stored material in each research study, and the need for new consent or the waiver thereof when the material is used for a new study. On the other hand, ICF suitable for Biorepositories must be exclusive and related to specific research. Although Brazilian and international regulations identify the main aspects to be included in the IC, efforts are still necessary to improve the consent process, so that the document will become a bond of trust between subject and researcher. (shrink)

This research aimed to examine the agreement between body mass index -based nutritional status and perceived nutritional status overall and by socio-demographic factors and to state the association between the accuracy of weight perception and weight control practices in the Chilean adult population. A population-based cross-sectional study was carried out with 5,192 Chilean adult participants from the Chilean National Health Survey 2016–2017. Agreement between BMI-based weight status and body weight perception for the total sample and across subgroups was determined using (...) the weighted kappa coefficient. The agreement between BMI-based and perceived nutritional status of the total sample was fair. A higher rate of weight perception accuracy was identified in women, younger respondents, and participants with higher education, a higher income, and from urban areas than their counterparts. Respondents with overweight or obesity tended to underestimate their nutritional status. Actions to lose weight were higher in those who had the right perception of their overweight/obesity condition and those who overestimated their body weight, regardless of their nutritional status. In all groups, weight loss behaviors were more related to the perceived than the BMI-based nutritional status. The consequences of accurate perception of the nutritional status are discussed including its effects on body weight and mental health. (shrink)

O objetivo é apresentar, do ponto de vista filosófico, a relação existente entre o cosmopolitismo kantiano e a figura do refugiado à luz do Direito à Hospitalidade. Orienta-se pelo procedimento da pesquisa bibliográfica. Apresenta o ideal filosófico de Kant para a instituição da Paz Perpétua com ênfase no Direito Cosmopolita. Demonstra a correspondência entre Direito Cosmopolita, Direitos Humanos e Direito Natural. Analisa o refugiado sob a perspectiva filosófica. Viabiliza o diálogo entre o cosmopolitismo e o refugiado. Por fim, conclui que (...) há um entrelaçamento teórico e filosófico entre o refugiado e o Direito Cosmopolita baseando-se na concepção da cidadania universal. (shrink)

The history of influence of the old testamentary Maccabees is the focus of the essays collected in this book, which extend thematically and chronologically from the cult of martyrs in late antiquity to the time of the modern wars of liberation.

The paper attempts to demonstrate the contemporary relevance of Spinoza’s ethics of virtue and responsibility—a non-deontic ethics whose foundation is not obligation and duty, not the normative laws which regulate the relations with the fellows, or the prescriptions, but an intuitive knowledge on the essence of things and on the choice of a proper way of life. The choice of the best way of life is equivalent with the responsibility to identify the opportunities to control the own life.

Este trabalho constata a necessidade de uma formação de professores emancipada do sistema capitalista e discute a possibilidade de o movimento estudantil proporcionar uma formação política aos estudantes e futuros profissionais. A formação de professoras e professores é cada vez mais influenciada pelas determinações dos organismos internacionais, e mais difícil fica organizar a resistência ao capitalismo. As atividades das entidades do movimento estudantil, seu histórico de ação e questionamentos das condições do ensino e da sociedade brasileira podem permitir uma formação (...) contra-hegemônica. (shrink)

O artigo apresenta os resultados de uma pesquisa que investigou a apropriação do referencial teórico de Paulo Freire em teses e dissertações nas áreas de Ensino de Ciências e Educação CTS. Através de uma análise bibliométrica e epistemológica de quatro matrizes que agregam os niveis epistemológico, ontológico e gnosiológico foi identificada a presença do referencial teórico de Paulo Freire nesses trabalhos.

Worldwide interest in understanding art and creative practices as valid forms of knowledge production has led to the establishment of research-creation as an interdisciplinary academic field in the last twenty years in Canada as elsewhere. Its establishment relates to a growing interest in critical making and technological innovation and to the legacies of feminism(s) and its critique of the power dynamics of knowledge production within academia. This article outlines a series of interactive projects that bring visibility to Latin American women (...) in art, science and technology and speculates on the legacies of feminism(s) in the emergence of research-creation. The four projects discussed build on each other and explore re-mediation, re-activation and re-enactment as part of a collaborative feminist research-creation methodology. I theorize their potential to activate political memory by highlighting how these three approaches to creation share a preoccupation for revisiting the past through repetition, iteration and the facilitation of intergenerational encounters among humans, non-humans and across media and technologies. While discussing the feminist orientation of these approaches, I suggest a critique of dominant modes of knowledge production that have obscured the contributions of Latin American women and offer four research-creation interventions in the media arts archive. (shrink)