Individual neurons display characteristic firing patterns determined by the number and kind of ion channels in their membranes. We describe experimental and computational studies that suggest that neurons use activity sensors to regulate the number and kind of ion channels and receptors in their membrane to maintain a stable pattern of activity and to compensate for ongoing processes of degradation, synthesis and insertion of ion channels and receptors. We show that similar neuronal and network outputs can be produced by a (...) number of different combinations of ion channels and synapse strengths. This suggests that individual neurons of the same class may each have found an acceptable solution to a genetically determined pattern of activity, and that networks of neurons in different animals may produce similar output patterns by somewhat variable underlying mechanisms. BioEssays 24:1145–1154, 2002. © 2002 Wiley Periodicals, Inc. (shrink)

This book offers a new approach to the analysis of the multiple meanings of English modals, conjunctions, conditionals, and perception verbs. Although such ambiguities cannot easily be accounted for by feature-analyses of word meaning, Eve Sweetser's argument shows that they can be analyzed both readily and systematically. Meaning relationships in general cannot be understood independently of human cognitive structure, including the metaphorical and cultural aspects of that structure. Sweetser shows that both lexical polysemy and pragmatic ambiguity are shaped by our (...) metaphorical folk understanding of epistemic processes and of speech interaction. Similar regularities can be shown to structure the contrast among root, epistemic and speech act uses of modal verbs, multiple uses of conjunctions and conditionals, and certain processes of historical change observed in Indo-European languages. Since polysemy is typically the intermediate step in semantic change, the same regularities observable in polysemy can be extended to an analysis of semantic change. (shrink)

This dissertation intends to contribute to the discussion about the asymmetry W. V. Quine sees between indeterminacy of translation and underdetermination of theory. Quine often formulates the asymmetry by saying that there is a fact of the matter to physics but none to translation. The first chapters of the dissertation constitute an attempt of clarification of that notion of fact of the matter. They contain an analysis of the relations between Quine's notion of fact of the matter, his physicalism, and (...) his conception of truth. The main conclusion of those chapters is that the notion of fact of the matter is physicalistic, which means that it is what, according to Quine, embodied the nature of extralinguistic reality that determines truth. The next chapters contain an analysis of Quine's indeterminacy of translation thesis and underdetermination of theory. The main conclusions of those chapters are the following: indeterminacy of translation is an ontological thesis, and its content has not changed through Quine's writings, although the formulations of the thesis have varied; Quine's definitive arguments for indeterminacy of translation are not to be found in his physicalism, but in his behaviorism; underdetermination of theory is a methodological doctrine, for it concerns the evidential link between observation and theory; there is an asymmetry between indeterminacy of translation and underdetermination of theory. The remaining chapters of the dissertation constitute a review of the main texts by other authors addressing Quine's claim that there is an asymmetry between indeterminacy of translation and underdetermination of theory. The positions of Noam Chomsky, Richard Rorty, and Micheal Friedman are analyzed and criticized. The positions of Dagfinn Follesdal and Roger Gibson have appeared to our lights as the ones that should be taken most seriously. Follesdal is the one who seems to have accomplished the last progresses in the discussion over the asymmetry between underdetermination of theory and indeterminacy of translation by distinguishing clearly Quine's epistemological arguments for indeterminacy of translation thesis from the ontological content of that thesis. (shrink)

This essay focuses on conceptual engineers who aim to improve other people's patterns of inference and attention by shaping their concepts. Such conceptual engineers sometimes engage in a form of epistemic paternalism that I call paternalistic cognitive engineering: instead of explicitly persuading, informing and educating others, the engineers non-consultatively rely on assumptions about the target agents’ cognitive systems to improve their belief forming. The target agents could reasonably regard such benevolent exercises of control as violating their sovereignty over their own (...) belief formation. This is a pro tanto reason against such engineering. In addition to the relevant projects of conceptual engineering, paternalistic cognitive engineering plausibly includes certain kinds of nudging and evidence suppression. I distinguish the sovereignty-based concern from other ethical worries about conceptual engineering and discuss how one might justify the relevant conceptual engineering projects despite the sovereignty-based reason against them. (shrink)

The decision to publish a doctoral dissertation, especially one which has only been “lightly edited” (foreword, first sentence) and with a bibliography only partially updated to reflect the scholarship of the intervening years, must always seem a risky one. In this case the risk is well taken and the resultant book is a delightful addition to our too meager store of book length overviews of Epictetus’ philosophy in the wider context of Stoic ethics.

RÉSUMÉ: Je propose iei une interprétation de la position quinienne sur l’asymetrie entre l’indétermination de la traduction et la sous-détermination. Je discute les articIes de Chomsky, Rorty et Friedman, qui prétendent montrer que l’asymétrie défendue par Quine est inacceptable. J’examine en outre les points de vue de Føllesdal et Gibson, deux auteurs en accord avec Quine au sujet de l’asymétrie. Je défends l’idée selon laquelle il faut admettre le réalisme de Quine, mais pas son physicalisme, pour être en mesure de (...) reeonnaître l’asymétrie entre le cas des théories scientifiques et celui des manuels de traduction.ABSTRACT: I propose an interpretation of Quine’s position on the asymmetry between indeterminacy of translation and underdetermination of theory. The positions of Chomsky, Rorty, and Friedman, who reject the asymmetry, are presented and criticized. The same is done with Føllesdal’s and Gibson’s views, which are favourable to Quine’s. I argue that we must admit Quine’s realism but not his physicalism in order to accept the asymmetry. (shrink)

The jury remains out about the bottom-line relevance of organisational spirituality. This article reviews the arguments made thus far, using those sources most commonly cited as providing ‹evidence’ that organisational spirituality adds value to the bottom line. Having collated the evidence, this article offers some observation about the robustness of this existing ‹business case’. It then offers some preliminary conclusions on the literature review, examining the merits of pursuing a ‹business case’ in this field and identifying some specific questions for (...) future research. (shrink)

In this paper, the principal objections to unconditional forgiveness are canvassed, primarily that it fails to take wrongdoing seriously enough, and that it displays a lack of self-respect. It is argued that these objections stem from a mistaken understanding of what forgiveness actually involves, including the erroneous view that forgiveness involves some degree of condoning of the offence, and is incompatible with blaming the offender or punishing him. Two positive reasons for endorsing unconditional forgiveness are considered: respect for persons and (...) human solidarity; and it is argued that the latter provides more plausible grounds for it than the former. (shrink)

Le développement du recours aux outils numériques engendre des problèmes nouveaux résultant entre autres de l’imperfection inévitable des logiciels, qui a parfois pour conséquence la divulgation de données confidentielles ou personnelles. La révélation des failles de sécurité est nécessaire pour permettre aux éditeurs de logiciels d’y remédier. Cependant, le droit pénal français, sur la base de la Convention européenne sur la cybercriminalité, sanctionne la mise à disposition de « toute donnée conçue ou spécialement adaptée » pour commettre un piratage : (...) le législateur français réprime donc potentiellement la révélation de failles de sécurité, sans pour autant assurer une indemnisation satisfactoire aux victimes de fuites de données personnelles engendrées par l’exploitation de ces défauts de sécurité. L’adoption d’une démarche éthique de la révélation des failles de sécurité pourrait remédier aux défauts du système actuel. (shrink)

This article analyzes the institutionalization of the global organic agriculture field and sheds new light on the conventionalization debate. The institutions that shape the field form a tripartite standards regime of governance that links standard-setting, certification, and accreditation activities, in a layering of markets for services that are additional to the market for certified organic products. At each of the three poles of the TSR, i.e., for standard-setting, certification, and accreditation, we describe how the corresponding markets were constructed over time (...) and the role of the different actors in their evolution. We analyze the politics at stake among the actors at each pole, their competing or cooperative interests and visions, and the tensions between them in the promotion of markets. Through the lens of the TSR heuristic, we show that the institutionalization of the organic field beginning in the 1990s and its de facto inclusion in the broader sustainability field beginning in the 2000s contribute to a progressive distancing between the organic movement and its initial political project of alterity, to which public and private actors both contribute actively. As a set of interlinked market institutions, the TSR orients and narrows the scope of debate, which becomes restricted to “market-compatible” dimensions and objects. We conclude that the TSR is a promising heuristic for analyzing contemporary global regulation. (shrink)

Like Joan Didion's The Year of Magical Thinking, an extraordinarily moving and engaging look at loss and death. Eve Joseph is an award-winning poet who worked for twenty years as a palliative care counselor in a hospice. When she was a young girl, she lost a much older brother, and her experience as a grown woman helping others face death, dying, and grief opens the path for her to recollect and understand his loss in a way she could not as (...) a child. In the Slender Margin is an insider's look at an experience that awaits us all, and that is at once deeply fascinating, frightening, and in modern society shunned. The book is an intimate invitation to consider death and our response to it without fear or morbidity, but rather with wonder and a curious mind. Writing with a poet's precise language and in short meditative chapters leavened with insight, warmth, and occasional humor, Joseph cites her hospice experience as well as the writings of others across generations--from the realms of mythology, psychology, science, religion, history, and literature--to illuminate the many facets of dying and death. Offering examples from cultural traditions, practices, and beliefs from around the world, her book is at once an exploration of the unknowable and a very humane journey through the land of grief. (shrink)

We readily claim that great moral catastrophes such as the Holocaust involve evil in some way, although it' not clear what this amounts to in a secular context. This paper seeks to provide a secular account of what evil is. It examines what is intuitively the most plausible account, namely that the evil act involves the production of great suffering (or other disvalue), and argues that such outcomes are neither necessary nor sufficient for an act to be evil. Only an (...) appeal to distinctive patterns of motivation, so it is argued, will allow us to accommodate our intuitionsabout which acts are evil, and hence will provide an adequate account of the nature of evil. (shrink)

Abstract“Science Is Politics By Other Means” (SIPBOM) was coined in The Pasteurization of France, Latour’s 1984 empirical study of the birth of microbiology. Yet, it encapsulates an outstanding political theory of science that Latour has never formalized and that has remained unnoticed to this day. The theory is comprised of two dimensions. The first one is the ontological labor performed by science, that is, the laboratory production of new nonhumans. The second one is the ability of science to devise and (...) implement novel policies targeted at the new beings it produces. These “other means” are incorporated in political projects and contribute to the shaping of society. Fifteen years later, Latour published Politics of Nature ([1999] 2004), a full-blown political treatise equally devoted to the political character of science. It would be mistaken, however, to assume that it falls in the same SIPBOM paradigm as the Pasteur study. The compositionist theory it offers redefines politics as the institution of the nonhumans that make up external reality, a task that has traditionally been monopolized by Science. In this sense, “science is politics by other means” has become “politics is science by other means,” these “other means” now referring to “cosmopolitics,” that is, the due process advocated by compositionism. The first claim of the present paper is that the respective weight ascribed to politics and ontology is different in The Pasteurization of France and in Politics of Nature. The second claim is that compositionism is not as successful as Latour’s early theory to account for the politicity of science. (shrink)

Nagel ist es nicht geglückt, die Möglichkeit des Verzichts auf teleologische Formulierungen und Erklärungen plausibel zu begründen. Bei seinem Versuch, die Äquivalenz teleologischer und nichtteleologischer Erklärungen nachzuweisen und den Bedeutungsüberschuß teleologischer Sprache hinwegzuformulieren, ist er immer schon an die Voraussetzung dieses Bedeutungsüberschusses gebunden, dessen er sich nicht, wie seine Beschreibung zielgerichteter Systeme beweist, entledigen kann. Unser Ergebnis dispensiert jedoch nicht von der Frage, ob der Anspruch 'der in teleologischen Wendungen geltend gemacht wird, auch zu Recht besteht. Denn die semantische Unmöglichkeit (...) der Reduktion von Relevanzrelationen auf Bedingungsrelationen verbürgt ja noch nicht, daß die teleologische Sprache den Gegenstandsbereich der Biologie auch adäquat trifft. Eine über unsere Studie hinausgehende Untersuchung müßte daher die hier aufgeworfene Frage in den größeren Zusammenhang der als klassisch geltenden Stellungnahmen einbetten und unter Einbeziehung der Resultate der kybernetischen Wissenschaften dem Problem nachgehen, ob Teleologie nur heuristischer Leitfaden der Reflexion ist, der aus forschungsstrategischen Gründen der Organisation des Gegenstandes an diesen von außen herangetragen wird, oder darüberhinaus eine Struktureigenschaft von Objekten selbst bezeichnet. Ist Teleologie also nur eine "Sache der Formulierung" oder eine "Formulierung der Sache"? (shrink)

Deficits in cognitive flexibility have been associated with anxiety and worry, however few studies have assessed cognitive flexibility in the context of emotional stimuli (i.e. affective flexibilit...

On the day on which Dr Harold Shipman, the Manchester serial killer, was convicted, there was wall-to-wall coverage of it in the media. During the course of one of the many reports, the daughter of one of his victims was interviewed, and asked for her views on why Shipman had acted as he did. What she said was this: she’d tried and tried to understand or explain his deeds, and she could only come to the conclusion that he was a (...) really evil man. In saying this, she clearly meant to convey more than the obvious truth that what Shipman did was very wrong and entirely to be condemned. It seems to me that a secular as well as a religious audience would find the daughter’s appeal to evil as an appropriate explanation perfectly comprehensible. But what exactly was it that was being attributed to Shipman, and how was it thought to explain his actions? (shrink)

"These essays advance a reinterpretation of pivotal categories such as self-knowing, moral agency, and altruism.

Aristotle’s writings contain more direct statements about priorities and rankings among the various sciences, degrees of accuracy within them, routes to knowledge from first principles, “first philosophy” and its characteristics, and the relation between sciences and practical concerns than almost any other philosopher we know.Yet taken together, Aristotle’s statements on these matters belie the apparent systematicity of his philosophical temperament. Almost every devotee of Aristotle is compelled to choose certain texts as authoritative and relegate others to some specific topic-context in (...) which they have limited validity. An only slightly shaky consensus among Aristotle’s readers has emerged through this process over time: on that consensus, Aristotelian first philosophy equals what later came to be called metaphysics, and is characterized by its remoteness from particular human discourses and desires, and from the types of knowledge we connect most directly with perception. First principles are also divorced from perception and are known through an incompletely explained intuitive process, but remain indemonstrable. Theoretical wisdom or contemplation soars above the domain of the human struggle, providing a stabilizing but distanced and abstract mode of considering the highest and most divine matters of which we are capable of thinking. (shrink)

"These essays advance a reinterpretation of pivotal categories such as self-knowing, moral agency, and altruism... A must for all students and researchers/faculty engaged in the study of ethics." —Choice "This is an extraordinarily valuable collection of essays in feminist ethics." —Teaching Philosophy A range of recent work in feminist ethics, exploring such issues as the ethic of care, a viable feminist ethics, Pythagoreanism, existentialism, utilitarianism, self-knowing, emotion, and moral vision. Also discussed is the process of applying feminist ethics to work (...) situations. The concluding essays point to the future and present new visions for the field. (shrink)

Decisions related to births in the “gray zone” of periviability are particularly challenging. Despite published management guidelines, clinicians and families struggle to negotiate care management plans. Stakeholders must reconcile conflicting values in the context of evolving circumstances with a high degree of uncertainty within a short time period. Even skilled clinicians may struggle to guide the patient in making value–laden decisions without imposing their own values. Exploring the experiences of one pregnant woman and her caregivers, this case study highlights how (...) bias may undermine caregivers’ ability to meet their obligation to enhance patient autonomy and the moral distress they may experience when a patient’s values do not align with their own. Management strategies to mitigate the potential impact of bias and related moral distress are identified. The authors then describe one management strategy used in this case, facilitated ethics consultation, which is focused on thoughtful consideration of the patient’s perspective. (shrink)

Hoerl & McCormack's dual systems framework provides a new avenue toward the scientific investigation of temporal cognition. However, some shortcomings of the model should be considered. These issues include their reliance on a somewhat vague consideration of “systems” rather than specific computational processes. Moreover, the model does not consider the subjective nature of temporal experience or the role of consciousness in temporal cognition.

O menino afeminado, que optamos por chamar de “criança viada”, éo cupim das arquiteturas normatizantes de gênero e sexualidade. Não porescolha, mas por imposição. “Quem defende a criança queer?” perguntou-nos,posteriormente, Paul Preciado. Poucas pessoas. O que Sedgwick provocavaé que, mesmo para adultos gays bem resolvidos, o trauma e a assombraçãoque vivenciamos nos faziam repelir e nos afastar de qualquer discussão queexigisse posicionamento diante da criança viada que fomos.

I will clarify when and how a tension arises between epistemic environmentalism (a new focus on assessing and improving the epistemic environment) and respect for epistemic autonomy (allowing, empowering, and requiring people to each govern their own beliefs). Using the example of participatory conceptual engineering (improving the linguistic environment through rational discussion with broad participation), I will also identify an option for avoiding the tension—namely, participatory environmentalism. This means a new focus on how people can each contribute to improving the (...) shared epistemic environment through rational deliberation and thereby govern their own beliefs that are shaped by that environment. (shrink)