Host‐pathogen arms race is a universal, central aspect of the evolution of life. Most organisms evolved several distinct yet interacting strategies of anti‐pathogen defense including resistance to parasite invasion, innate and adaptive immunity, and programmed cell death (PCD). The PCD is the means of last resort, a suicidal response to infection that is activated when resistance and immunity fail. An infected cell faces a decision between active defense and altruistic suicide or dormancy induction, depending on whether immunity is “deemed” capable (...) of preventing parasite reproduction and consequent infection of other cells. In bacteria and archaea, immunity genes typically colocalize with PCD modules, such as toxins‐antitoxins, suggestive of immunity‐PCD coupling, likely mediated by shared proteins that sense damage and “predict” the outcome of infections. In type VI CRISPR‐Cas systems, the same enzyme that inactivates the target RNA might execute cell suicide, in a case of ultimate integration of immunity and PCD. (shrink)

This study investigates the impacts of intellectual capital through Value-Added Intellectual Capital (VAIC) and its components: human capital efficiency (HCE) and structural capital efficiency (SCE) on financial performance in terms of return on assets (ROA) and return on equity (ROE). In addition, this study compares the effects between firms from financial and pharmaceutical industries. A total of 149 Vietnamese firms comprising of 108 financial firms and 41 pharmaceutical firms were examined. Based on the findings, VAIC and HCE show beneficial impacts (...) on both financial performance measures, ROA, and ROE. However, SCE shows adverse and beneficial implications on ROA and ROE, respectively. In terms of industry comparison, VAIC has positive effects on ROA and ROE among the firms from financial industry, whereas it has no effect in the firms from pharmaceutical industry. The effect of HCE on ROA is stronger in the firms from financial industry than firms from pharmaceutical industry while the effect of HCE on ROE is stronger in the firms from pharmaceutical industry than firms from financial industry. The effect of SCE on ROA is stronger in the pharmaceutical firms than financial firms while the effect of SCE on ROE is stronger in the financial firms than pharmaceutical firms. Lastly, the implications of the importance of knowledge-based resources on value creation were elaborated. (shrink)

The application of genetic technologies in China, especially in the area of prenatal genetic testing, is rapidly increasing in China. In the wealthy regions of China, prenatal genetic testing is already very widely adopted. We argue that the government should actively promote prenatal genetic testing to the poor areas of the country. In fact, the government should prioritize resources first to make prenatal genetic testing a standard routine care with an opt-out model in these area. Healthcare professions would be required (...) to inform pregnant women about the availability of genetic testing and provide free testing on a routine basis unless the parents choose not to do so. We argue that this proposal will allow parents to make a more informed decision about their reproductive choices. Secondarily, this proposal will attract more healthcare professionals and other healthcare resources to improve the healthcare infrastructures in the less-developed regions of the country. This will help to reduce the inequity of accessing healthcare services between in different regions of China. We further argue that this policy proposal is not practicing eugenics. (shrink)

Modern technologies have enabled the development of dynamic game- and simulation-based assessments to measure psychological constructs. This has highlighted their potential for supplementing other assessment modalities, such as self-report. This study describes the development, design, and preliminary validation of a simulation-based assessment methodology to measure psychological resilience—an important construct for multiple life domains. The design was guided by theories of resilience, and principles of evidence-centered design and stealth assessment. The system analyzed log files from a simulated task to derive individual (...) trajectories in response to stressors. Using slope analyses, these trajectories were indicative of four types of responses to stressors: thriving, recovery, surviving, and succumbing. Using Machine Learning, the trajectories were predictive of self-reported resilience with high accuracy, supporting construct validity of the simulation-based assessment. These findings add to the growing evidence supporting the utility of gamified assessment of psychological constructs. Importantly, these findings address theoretical debates about the construct of resilience, adding to its theory, supporting the combination of the “trait” and “process” approaches to its operationalization. (shrink)

The Planteome project provides a suite of reference and species-specific ontologies for plants and annotations to genes and phenotypes. Ontologies serve as common standards for semantic integration of a large and growing corpus of plant genomics, phenomics and genetics data. The reference ontologies include the Plant Ontology, Plant Trait Ontology, and the Plant Experimental Conditions Ontology developed by the Planteome project, along with the Gene Ontology, Chemical Entities of Biological Interest, Phenotype and Attribute Ontology, and others. The project also provides (...) access to species-specific Crop Ontologies developed by various plant breeding and research communities from around the world. We provide integrated data on plant traits, phenotypes, and gene function and expression from 95 plant taxa, annotated with reference ontology terms. (shrink)

I argue that influential recent discussions have whitewashed blame, characterizing it in ways that deemphasize or ignore its morally problematic features. I distinguish “definitional,” “creeping,” and “emphasis” whitewash, and argue that they play a central role in overall endorsements of blame by T.M. Scanlon, George Sher, and Miranda Fricker. In particular, these endorsements treat blame as appropriate by definition (Scanlon), or as little more than a wish (Sher), and infer from blame's having one useful function that it is a good (...) practice overall (Fricker). I use an analogy with revenge to illustrate the mechanisms of whitewashing, including broadening a concept to include available alternatives to it and inference from one feature of a practice to an overall conclusion about that practice. Several features of blame make it particularly prone to whitewashing, including blamers' personal or emotional stake in blaming and widespread disagreement about the nature of blame. I argue that a non‐whitewashing treatment of blame must pay closer attention both to blame's harms, and to comparisons between blame and alternative, non‐blaming reactions. (shrink)

The most compelling arguments for ethical veganism hinge on premise-pairs linking the serious wrongness of factory farming to that of buying its products: one premise claiming that buying those products stands in a certain relation to factory farming itself, and one claiming that entering into that relation with a seriously wrong practice is itself wrong. I argue that all such “linkage arguments” on offer fail, granting the serious wrongness of factory farming. Each relevant relation is such that if it holds (...) between factory farming and buying its products, then it holds between some seriously wrong practice and economic transactions of an absurd number and breadth. Hence, all these premise-pairs would, if true, generate unacceptable moral overreach; each premise-pair contains at least one unacceptable member, and the linkage arguments for ethical veganism fail. (shrink)

Eugene Marshall presents an original, systematic account of Spinoza's philosophy of mind, in which the mind is presented as an affective mechanism that, when rational, behaves as a spiritual automaton. He explores key themes in Spinoza's thought, and illuminates his philosophical and ethical project in a striking new way.

Equally important, he offers much insight into why our own environmental policies have failed and what we can do to better manage our resources.

The aim of this article is to introduce the concept of Cognitive Fitness (CF), identify its key ingredients underpinning both real-time task performance and career longevity in high-risk occupations, and to canvas a holistic framework for their assessment, training, and augmentation. CF as a capacity to deploy neurocognitive resources, knowledge and skills to meet the demands of operational task performance, is likely to be multi-faceted and differentially malleable. A taxonomy of CF constructs derived from Cognitive Readiness (CR) and Mental fitness (...) (MF) literature maps into phases of operational cycles from foundational to advanced, mission-ready and recovery. Foundational cognitive attributes, such as attention, executive control and co-action, were hypothesized to be trainable at the initial Cognitive Gym phase. More advanced training targets at the CR phase included stress and arousal regulation, adaptability, teamwork, situation awareness (including detection, sense-making and prediction) and decision making (de-biasing and confidence calibration). The mission-ready training phase is focused on tolerances (to sleep loss, monotony, pain, frustration, uncertainty) and resistance (to distraction, deception or manipulation). Operational Augmentation phase relies on support tools such as decision aids and fatigue countermeasures, while the Recovery phase employs reflexive (e.g., mindfulness), and restorative practices (e.g., nutrition and sleep hygiene). The periodization of cognitive training in this cycle is hypothesized to optimize both real-time cognitive performance and the resilience that enables life-long thriving. One of the most promising avenues of validating this hypothesis is by developing an expert consensus on the key CF ingredients and their relative importance in high-performance settings. (shrink)

We are beings endowed with “personal capacities”—the capacity for reason, for a concept of self, perhaps more. Among ontologically salient views about what else we are, I focus on the “Big Three.” According to animalism, we are animals that have psychological properties only contingently. According to psychologistic materialism, we are material beings; according to substance dualism, we are either immaterial beings or composites of immaterial and material ones; but according to both psychologistic materialism and substance dualism, we essentially have some (...) psychological properties. I argue that—contrary to what has been argued and is natural to think—none of the Big Three yields different assignments of moral status to early fetuses from any of the others, and consequently the moral status of early abortion doesn’t depend on which (if any) of these views of personal ontology is correct. (shrink)

I seem to know that I won't experience spaceflight but also that if I win the lottery, then I will take a flight into space. Suppose I competently deduce from these propositions that I won't win the lottery. Competent deduction from known premises seems to yield knowledge of the deduced conclusion. So it seems that I know that I won't win the lottery; but it also seems clear that I don't know this, despite the minuscule probability of my winning (if (...) I have a lottery ticket). So we have a puzzle. It seems to generalize, for analogues of the lottery-proposition threaten almost all ordinary knowledge attributions. For example, my apparent knowledge that my bike is parked outside seems threatened by the possibility that it's been stolen since I parked it, a proposition with a low but non-zero probability; and it seems that I don't know this proposition to be false. Familiar solutions to this family of puzzles incur unacceptable costs—either by rejecting deductive closure for knowledge, or by yielding untenable consequences for ordinary attributions of knowledge or of ignorance. After canvassing and criticizing these solutions, I offer a new solution free of these costs. Knowledge that p requires an explanatory link between the fact that p and the belief that p. This necessary but insufficient condition on knowledge distinguishes actual lottery cases from typical, apparently analogous ‘quasi-lottery’ cases. It does yield scepticism about my not winning the lottery and not experiencing spaceflight, but the scepticism doesn't generalize to quasi-lottery cases such as that involving my bike. (shrink)

The wide variety of blame presents two difficult puzzles. Why are instances of blame categorized under so many different mental kinds, such as judgment, belief, emotion, action, intention, desire, and combinations of these? Why is “blame” used to describe both interpersonal reactions and mere causal attributions, such as blaming faulty brakes for a car crash? I introduce a new conception of blame, on which blame is attention to something as a source of badness. I argue that this view resolves both (...) puzzles and offers an independently appealing conception of blame. (shrink)

David Chalmers calls the problem of explaining why physical processes give rise to conscious phenomenal experience the ‘hard problem’ of consciousness. He argues convincingly that no reductive account of consciousness can solve it and offers instead a non-reductive account which takes consciousness as fundamental. This paper argues that a theory of the sort Chalmers proposes cannot hope to solve the hard problem of consciousness precisely because it takes the relation between physical processes and consciousness as fundamental rather than explicable. The (...) hard problem of consciousness is, for reasons Chalmers himself gives, insoluble. Its insolubility does not, however, impugn the naturalistic respectability of consciousness. (shrink)

Empirical evidence shows that people have multiple time-biases. One is near-bias, another is future-bias, and a third is present-bias. Philosophers are concerned with the normative status of these time-biases. They have argued that, at least in part, the normative status of these biases depends on the extent to which they tend to promote, or frustrate, wellbeing, where “wellbeing” is taken to be of fundamental value. Since near-bias is thought to be associated with impulsivity, lack of self-control, and poor long-term health (...) and financial outcomes, it has often been supposed that it is associated with lower wellbeing. On those grounds, philosophers have argued that near-bias is rationally impermissible. By contrast, philosophical views about the normative status of future-bias have been mixed, with some arguing that future-bias is impermissible because, they think, it frustrates wellbeing, and others arguing that it is at least permissible (and perhaps obligatory) because it is the product of mechanisms whose functioning can be expected to promote wellbeing. However, to date there are no studies that have directly probed how time-biases correlate with wellbeing. Since it's not a settled matter which psychological mechanisms underlie time-biases, it is not uncontroversial which things serve as proxies for these preferences. We directly empirically investigate the connection between time-biases and measures of wellbeing, to see which of these biases is associated with promoting, or frustrating wellbeing. Contrary to expectation, we found no evidence that near-bias or present-bias are associated with frustrating wellbeing on any of the constructs we measured. On the other hand, and contrary to what some philosophers have supposed, we found that future-bias was associated with higher measures of wellbeing on several measures. We consider the implications of these findings for the evaluation of the normative status of these time biases. (shrink)

Substance‐dualist interactionism faces two sorts of challenge. One is empirical, involving the alleged incompatibility between interactionism and the supposed closure of the physical world. Although widely considered successful, this challenge gives no reason for preferring materialism to dualism. The other sort of challenge holds that interactionism is conceptually impossible. The historically influential version of the conceptual challenge is now discredited, but recent discussions by Chomsky and by Crane and Mellor suggest a new version. In brief, the argument is that anything (...) that interacts causally with physical things would have to be sanctioned by physics,and anything sanctioned by physics is ipso facto physical. I focus on the second premise. I show that plausible arguments for it are in fact fallacious and that counterexamples undermine it. Thus the argument fails: substance‐dualist interactionism cannot be ruled out on conceptual grounds alone. (shrink)

In Nuu-chah-nulth, the word tsawalk means "one." It expresses the view that all living things - humans, plants, and animals - form part of an integrated whole brought into harmony through constant negotiation and mutual respect for the other. Contemporary environmental and political crises, however, reflect a world out of balance, a world in which Western approaches for sustainable living are not working. In Principles of Tsawalk, hereditary chief Umeek builds upon his previous book, Tsawalk: A Nuu-chah-nulth Worldview, to elaborate (...) an alternative framework for responding to global environmental and political crises and to indigenous peoples' poverty, dispossession, and displacement in the realms of education and politics. These problems, Umeek argues, stem from an historical and persistent failure to treat all peoples and life forms with respect and accord them constitutional recognition. By contrast, the Nuu-chah-nulth principles of recognition, consent, and continuity, embodied in songs, language, and ceremonies, hold the promise of achieving sustainable lifeways in this shared struggle for balance. By weaving together Nuu-chah-nulth and Western worldviews, hereditary chief Umeek creates a new philosophical foundation for building more equitable and sustainable communities. Umeek (E. Richard Atleo), a hereditary Nuu-chah-nulth chief, is a research liaison at the University of Manitoba and an associate adjunct professor at the University of Victoria. He is the author of Tsawalk: A Nuu-chah-nulth Worldview. (shrink)

Multi-level selection can be understood via the Price equation or contextual analysis, which offer incompatible statistical decompositions of evolutionary change into components of group and individual selection. Okasha argued that each approach suffers from problem cases. I introduce further problem cases for the Price approach, arguing that it is appropriate for MLS 2 group selection but not MLS 1. I also show that the problem cases Okasha raises for contextual analysis can be resolved. For some such cases, however, it emerges (...) that there is no determinate answer to the question of how much of the total selective effect was due to group selection compared to individual selection. This suggests that when there is interaction between the effect of group character and individual character, one cannot separate selection into distinct ‘levels’ at all. (shrink)

Fear and concerns regarding AI and robots have existed for a long time, and the emergence of strong artificial intelligence, on par with human intelligence, is likely just a few decades away. The primary purpose of this article is to establish a theoretical framework for navigating the relationship between humans and this advanced form of artificial intelligence. This article first points out that the most fundamental characteristic of life is its continuous process of evolution and iteration. By analyzing the developmental (...) history of intelligence in different species, it can be observed that intelligence also exhibits a similar evolutionary phenomenon. Therefore, from this perspective, intelligence can be defined as a new form of information life. Under this premise, similarities and differences between information life forms and conventional biological life become apparent. The most significant distinction lies in the fact that the survival of biological life is based on non-replicable matter and energy, leading to extensive competition and food chain phenomena within ecosystems. In contrast, the survival of information life relies more on replicable information, fostering tendencies towards peace and communication. Based on this theoretical premise, there is a potential for a harmonious coexistence between humans and AI. This theory also provides guidance for the positive development of human society. (shrink)

Meritocracy claims to reward the meritorious with more resources, thereby achieving social efficiency and justice in a level playground. This article argues that the rise of meritocracy in a society is the institutional consequence of adopting progressive humanism, an ideal-type worldview that advocates the harmonious co-realization of individual achievement and social contribution. However, meritocracy is a self-defeating illusion because, even in a level playground, it only rewards conspicuous and wasteful display of ‘merit’ rather than genuine contributions to society. Similar to (...) the promise of an afterlife to Catholicism, the illusion of meritocracy constitutes an indispensable theodicy to progressive humanism. For societies holding such worldviews, meritocracy is a necessary illusion that cannot be dispelled by institutional reforms or political movements. (shrink)

Improving the quality of public policy-making is a matter of great importance for nearly everyone. Significant improvements, however, require major (and unlikely?) changes in the epistemological foundations accepted by social inquirers—changes that make possible a conception of “policy” that can be used to achieve real world purposes reliably. A theory of knowledge adequate for that purpose is outlined, and some of its major implications for inquiry (and for policy-making) are explored very briefly.

Lynne Rudder Baker offers an account of what it is to be a human person, involving what she calls a “first person perspective,” that is separable from her constitution-view of human persons and adaptable to a variety of rival views of personal ontology. I argue that this account fails, no matter what view of personal ontology it is coupled with, on account of giving biological humanity an absurd role in determining the personhood of both possible human and non-human person-candidates. The (...) failure of Baker’s account suggests difficulties for any view that would grant personhood to marginal case humans while denying it to non-humans with relevantly similar psychological properties. (shrink)

This paper presents a story that introduces the philosophical problem of personal identity in a way that students find clear and compelling. While the story neither offers a solution to the paradox it raises nor fully explores the relation of personal identity and “what matters” for prudence and responsibility, the story can be used to clear up initial confusions about personal identity and thereby provide a framework for organizing further reading and discussion. Besides presenting this story, the paper provides a (...) discussion of the pedagogical benefit of the use of paradox, offers a schematic account of the argument of the story, and addresses common student responses. (shrink)

On September 11, 2001, many of us experienced life as what it is not: we lived an extreme instance of the spectacle, of the sublime outside the realm of ethics. Starting with a few compelling questions that the media representations of the attack on the New York World Trade Center inevitably raise, this paper explores a series of similarities, continuums, and extrapolations of the aesthetic in different types of discourse from Friedrich Schiller to Guy Debord. My assessment of the individual‘s (...) dissolution in the ritual (former dissident and present Czech President Václav Havel‘s phrase) rejects the bleak Marxist theories of manipulation, without overlooking, at the same time, the potential dangers of unfreedom that the process of surrendering to the spectacle implies. Living life as show time may ultimately, and oxymoronically, prove to be the only option toward an infinitude of choices. (shrink)

Jeffrey conditionalization is a rule for updating degrees of belief in light of uncertain evidence. It is usually assumed that the partitions involved in Jeffrey conditionalization are finite and only contain positive-credence elements. But there are interesting examples, involving continuous quantities, in which this is not the case. Q1 Can Jeffrey conditionalization be generalized to accommodate continuous cases? Meanwhile, several authors, such as Kenny Easwaran and Michael Rescorla, have been interested in Kolmogorov’s theory of regular conditional distributions as a possible (...) framework for conditional probability which handles probability-zero events. However the theory faces a major shortcoming: it seems messy and ad hoc. Q2 Is there some axiomatic theory which would justify and constrain the use of rcds, thus serving as a possible foundation for conditional probability? These two questions appear unrelated, but they are not, and this paper answers both. We show that when one appropriately generalizes Jeffrey conditionalization as in Q1, one obtains a framework which necessitates the use of rcds. It is then a short step to develop a general theory which addresses Q2, which we call the theory of extensions. The theory is a formal model of conditioning which recovers Bayesian conditionalization, Jeffrey conditionalization, and conditionalization via rcds as special cases. (shrink)

The article deals with currents and tides. We look at the history of their observation in antiquity as well as alternative theories, designed to explain their nature. Major theories accessed are those by Aristotle, Posidonius and Seneca. Special attention is given to ancient explanation of the phenomenon of the periodical change of the stream in Euripus’ channel. Throughout we refl ect on an analogy between natural phenomena and the processes occurring in living organisms, common to our philosophers of nature, as (...) well as the peculiarities of their interpretation of the theory of mutual transformation of the elements. Besides, it is important to note the place of the method of analogy in their observations and theoretical constructions. (shrink)

The Hardy–Weinberg equilibrium has been argued by Sober, Stephens and others to represent the zero-force state for evolutionary biology understood as a theory of forces. I investigate what it means for a model to involve forces, developing an explicit account by defining what the zero-force state is in a general theoretical context. I use this account to show that Hardy–Weinberg equilibrium is not the zero-force state in biology even in the contexts in which it applies, and argue based on this (...) that drift should not be understood as an evolutionary force. (shrink)

Margaret Cavendish Margaret Lucas Cavendish, the Duchess of Newcastle, was a philosopher, poet, playwright and essayist. Her philosophical writings were concerned mostly with issues of metaphysics and natural philosophy, but also extended to social and political concerns. Like Hobbes and Descartes, she rejected what she took to be the occult explanations of the Scholastics. […].

Drawing on recent scholarship and delving systematically into Iamblichean texts, these ten papers establish Iamblichus as the great innovator of Neoplatonic philosophy who broadened its appeal for future generations of philosophers.