Chora – le «cratère à mélanger» maternel, vannant et secouant de Platon – remplit «l’écart explicatif» entre les paradigmes formels «intelligibles et toujours existants» (48E5) et un monde encosmique «généré et visible». Proclus traite la gamme polysémique des termes utilisés par Platon pour chôra : hypodochê (réceptacle), kratêr (cratère à mélanger), etc., comme désignant des forces actives dans un univers où la sympathie cosmique règne, à partir des plus élevées, jusqu’aux plus basses manifestations de l’ «Un» transcendant. L’univers proclusien est (...) un «hénothéisme», dans lequel une «unité» dominante surgit sur la totalité de l’Être et du Devenir. Chôra permet à la fois au monde immatériel et au monde matériel de recevoir, de manière appropriée à chacun, les mêmes dons transcendants que leurs homologues intellectifs‑intelligibles superieurs. Aucun niveau de la réalité n’est dépourvu de cette donation. La réceptivité (hypodochê), indéterminée, mais toujours active, est présente à tous les niveaux. L’âme reçoit l’Intellect, la temporalité reçoit le temps monadique, la matière reçoit la structure géométrique polyédrique, etc. Chôra n’est pas l’equivalent de la matière, mais permet à la matière d’être imprimée par des paradigmes formels. Dans son rôle de «cratère à mélanger», elle protège la matière de sa potentielle itérabilité et dissolution infinie. Dans l’univers proclusien, le Bien atteint la dernière et la plus extrême de ses limites, il est espace et lieu, recevant à la fois l’expansivité et une capacité à donner place à la forme pour qu’elle puisse s’imposer à la matière. Après tout, les dons lui sont accordés depuis la plus haute hypostase, celle de la Limite et de l’Illimité, premier niveau après l’Un lui‑même. Vitale pour la création, la Chôra est alors la «mère» de tout. Il n’est donc pas étonnant que, comme nous le dit Proclus, la chôra soit, en fait, la déesse Rhéa. En hommage à la littérature révélatrice antique, comme les Oracles chaldaïques, Homère et Hésiode, Proclus fournit une élucidation non seulement philosophique, mais aussi théologique, de la chôra. À la différence de Platon, il théologise la Physique. (shrink)

Through a fieldwork study of the practice of methadone substitution at a French addiction clinic, the classic ‘theory of action’ is criticized and an alternative one proposed. A sketch of the debates among French drug specialists, drug users and legislators shows the pertinence for these practitioners of such a theoretical question; further, the ethnographic data suggest that they can be seen as actually trying out an alternative to this ‘theory of action’.

Many students have experienced the death of a loved one, which increases their risk of grief and mental health problems. Formal and social support can contribute to better coping skills and personal growth in bereaved students. The purpose of this study was to examine the support that students received or wanted to receive and its relation to students’ mental health. We also looked at students’ needs when receiving support and barriers in seeking formal and social support. Participants completed an online (...) survey consisting of questions about their sociodemographic characteristics, the support they received or wanted to receive, and support needs and barriers in seeking support. The survey also included three scales assessing grief, mental health distress, and personal growth. First, we analyzed the data descriptively. Next, we used MANCOVA to examine whether students who did or did not receive or wanted more support differed in terms of their grief, mental health distress, or personal growth. About 30% of students needed more support and experienced more grief and mental health distress than students who had their support needs met. Students who received support experienced more personal growth and grief than students who did not receive support. Students indicated a need for feeling acknowledged and safe. Feeling like a burden to others and perceiving their problems as not serious enough to warrant support were common barriers to seeking support. Our results indicate that support should be provided actively to students after the death of a loved one, and support being available on an ongoing basis. (shrink)

Résumé Aux années soixante-dix, Roland Barthes désigne le Zen japonais par « L’empire des signes », alors que la culture chinoise par la « fadeur des signes ». François Jullien reprend ultérieurement l’idée de la « fadeur » au niveau de son sens « non dualiste » dans le cadre de la philosophie comparée. Depuis les courants poststructuraliste et déconstructionniste, de plus en plus de recherches sémiotiques et philosophiques portent sur l’étude bouddhique, dont le point nodal se situe alors dans (...) un parallélisme au bénéfice des échanges interculturels. En vue d’une déspécialisation du jargon propre à chaque domaine, il semble impératif de mettre en relation les concepts de base en commun. Pour mettre en évidence l’apport de l’étude terminologique et méthodologique, cet article commence par les travaux philologiques sur la « traduction » des textes bouddhiques. Ensuite, la discussion se concentre sur la « dualité » à partir de la « réception » de l’exégétique saussurienne. Il s’agit concrètement d’une étude embryonnaire sur le terme propre couple « signifiant/signifié »: l’exégétique saussurienne s’est répandue efficacement en Chine grâce aux emprunts à la terminologie bouddhique, ce qui offrirait une perspective positive vis-à-vis du dialogue interculturel. En même temps, il serait aussi possible de traduire les termes bouddhiques par le biais sémiotique en regard d’une osmose transdisciplinaire. (shrink)

Patočka has never developed the political and historical concept of dissidence. But trying to sketch its phenomenological foundation in the writings of the Czech philosopher, who experienced human liberty as an act of dissidence, could be an original way in qualifying his alternative idea of the modern subjectivity in phenomenology: between finitude and autonomy. The first part of the article presents the radical criticism aimed by Patočka to the transcendental subjectivism of Husserl, and thinks the requirement of a split between (...) autofoundation and autonomy. Then, it is analysed the articulation between the movement of life and the movement of existence, in which lies the very idea of dissidence. In a third and final part, one shows to what extent the dissident subjectivity fully reveals itself in the political life. (shrink)

Acute starvation can have long-term consequences that are mediated through epigenetic change. Some of these changes are affected by the activity of AMP-activated protein kinase, a master regulator of cellular energy homeostasis. In Caenorhabditis elegans, the absence of AMPK during a period of starvation in an early larval stage results in developmental defects following their recovery on food, while many of them become sterile. Moreover, the loss of AMPK during this quiescent period results in transgenerational phenotypes that can become progressively (...) worse with each successive generation. Our recent data describe a chromatin-based mechanism of how AMPK mediates adjustment to acute starvation in the germ cells, however, the heritable aspect of this AMPK mutant phenotype remains unresolved. Here, we explore how AMPK might affect this process and speculate how the initial transcription that occurs in the germ cells may adversely affect subsequent germline gene expression and/or genomic integrity. AMPK protects germ cell integrity during acute starvation by blocking inappropriate transcription. How these aberrant transcripts cause transgenerational defects is unclear. AMPK likely regulates germline integrity at multiple levels through several targets. The authors speculate here how AMPK disruption during starvation could result in the observed defects seen at each generation. (shrink)

Precarious times have material consequences. Yet, feminist new materialist approaches demonstrate that the concepts of the “ma-terial” and of “matter” are radically different than what is com-monly held in the Western tradition. This article argues that femi-nist new materialism provides practical, essential, and ethical tools for political action in dynamic and entangled worlds. In such worlds (e.g., the Anthropocene), it is critically needed to establish an ethics of responsiveness, a culture of ethical living and dying with others. Yet, this ethic (...) must respond to and acknowledge our relational, entangled, dynamic, and agentic ontology. In response to this, this article proposes the “pluri-person,” a political figure that mobilizes contributions of feminist new materialism to produce an ethical, ontology-making, everyday practice/response to “Precari-ous Times.”. (shrink)

Sympatric speciation illustrates how natural and sexual selection may create new species in isolation without geographic barriers. However, recent genomic reanalyses of classic examples of sympatric speciation reveal complex histories of secondary gene flow from outgroups into the radiation. In contrast, the rich theoretical literature on this process distinguishes among a diverse range of models based on simple genetic histories and different types of reproductive isolating barriers. Thus, there is a need to revisit how to connect theoretical models of sympatric (...) speciation and their predictions to empirical case studies in the face of widespread gene flow. Here, theoretical differences among different types of sympatric speciation and speciation‐with‐gene‐flow models are reviewed and summarized, and genomic analyses are proposed for distinguishing which models apply to case studies based on the timing and function of adaptive introgression. Investigating whether secondary gene flow contributed to reproductive isolation is necessary to test whether predictions of theory are ultimately borne out in nature. (shrink)

Dans un régime comme celui de la République populaire de Chine, où prévaut la suprématie d’un Parti-État unique, la politique et le politique constituent, a fortiori plus qu’ailleurs, la chasse gardée de l’élite dirigeante du pays, à savoir les cadres du Parti communiste. Cet article tente de saisir qui sont les élites politiques aux commandes de la Chine d’aujourd’hui à travers l’analyse du modus operandi de l’École des cadres du Parti de Shanghai. L’étude de cette institution, qui participe à la (...) régulation de la circulation des élites et constitue l’un des lieux privilégiés de la transmission et de l’exercice du pouvoir, permet, par-delà son propre fonctionnement, d’éclairer la nature et le devenir même du régime. S’il apparaît que les forces modernisatrices, en assimilant davantage l’École du Parti à un institut d’administration publique, œuvrent à la professionnalisation du métier de cadre, c’est également et avant tout afin de mieux perpétuer l’hégémonie du Parti-État unique.In a regime where the one Party-State rule still prevails, as is the case in the People’s Republic of China, the polity and politics constitute – here more than anywhere else – the private ground of the country’s ruling elite, i.e. the cadres of the Communist Party. This article attempts to grasp who the political elites in control of contemporary China are, by analyzing the modus operandi of the Shanghai Party School for Cadres. The study of an institution that takes part in the circulation of the elites and hence constitutes one of the privileged playing fields for the transmission and the exercise of power, allows, beyond the understanding of its own working, to shed light on the very nature and evolution of the regime. If the modernizing forces appear to work towards the professionalization of the cadres’ craft by equating the Party School to an institute of public administration, they ultimately do so in order to better perpetuate the supremacy ofthe one-Party system. (shrink)

La capacité des êtres humains à obéir aux ordres, même si ceux-ci sont jugés atroces, n’a plus à être prouvée. Comme l’a souligné Howard Zinn, « D’un point de vue historique, les évènements les plus terribles – tels que la guerre, les génocides et l’esclavage – ont résulté non pas de la désobéissance, mais de l’obéissance» (Zinn, 1997). Mais la question de savoir « comment» les individus peuvent commettre des atrocités lorsqu’ils suivent des ordres reste ouverte. Les études de Milgram (...) sont célèbres pour avoir montré une forte soumission aux ordres de l’expérimentateur. Mais ces études n’ont révélé que les facteurs situationnels et sociaux favorisant l’obéissance. Elles n’ont pas permis de comprendre comment tant de personnes ont accepté d’envoyer des chocs douloureux et potentiellement mortels à une autre personne. Dans cet article, j’opposerai les entretiens qualitatifs réalisés avec d’anciens génocidaires au Rwanda et la recherche expérimentale en neurosciences pour tenter de faire émerger un élément de réponse à cette question critique. Je soutiendrai que le dépassement des frontières entre différentes disciplines scientifiques est la clé d’une meilleure compréhension de la façon dont l’obéissance modifie la prosocialité. Je défendrai également l’idée provocatrice que les chercheurs devraient saisir l’opportunité de quitter leur laboratoire pour étudier la question de l’obéissance. (shrink)

This paper examines Irish campaigns for condom access in the early 1990s. Against the backdrop of the AIDS crisis, activists campaigned against a law which would not allow condoms to be sold from ordinary commercial spaces or vending machines, and restricted sale to young people. Advancing a conception of ‘transformative illegality’, we show that illegal action was fundamental to the eventual legalisation of commercial condom sale. However, rather than foregrounding illegal condom sale as a mode of spectacular direct action, we (...) show that tactics of illegal sale in the 1990s built on 20 years of everyday illegal sale within the Irish family planning movement. Everyday illegal sale was a long-term world-making practice, which gradually transformed condoms’ legal meanings, eventually enabling new forms of provocative and irreverent protest. Condoms ‘became legal’ when the state recognised modes of condom sale, gradually built up over many years and publicised in direct action and in the courts. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Rhetoric of Romantic ProphecySara GuyerThe Rhetoric of Romantic Prophecy. Ian BalfourStanford: Stanford University Press, 2002. Pp. 368. $70.00, cloth; $29.95, paperback.Not insignificantly, Walter Benjamin and Maurice Blanchot are the first two names to appear in Ian Balfour's excellent study The Rhetoric of Romantic Prophecy. Benjamin and Blanchot are authors of two of the most influential essays on romanticism, essays that, it just so happens, Ian Balfour is (...) responsible for introducing to an English-reading audience. 1 Thus, The Rhetoric of Romantic Prophecy is not only a long awaited, prize-winning book by a major theorist of romanticism, it is also a book written by the first English translator of Benjamin's and Blanchot's essays. Both Blanchot's "The Athenaeum" and Benjamin's "On the Concept of Criticism in German Romanticism" expose the incompletion of the romantic project and unsettle the relation between the past and the present. They also provide a context for understanding the kind of book that Ian Balfour has written. Like its eminent predecessors, this book focuses on local phenomena, yet its force far exceeds the field that it so thoughtfully treats. In it, Balfour shows how a turn to the past (to a set of historical texts) has the effect of unsettling the present, and he argues that an apparent turn to the future (prophecy) has as its issue the present.The book's introduction, entitled "The Call of Prophecy and the Future (After Benjamin)," alerts us to the fact that Benjamin and Blanchot, who have written extensively on language, also have written compellingly on the prophetic. While the prophetic today most often seems to signify religion's naive or violent claims on the future (and by implication on the present), in Benjamin's and Blanchot's work—and in Balfour's work—"the prophetic" (by which Balfour means not a genre, but a "mode") poses problems of referentiality and interpretation. Benjamin's treatment of messianism and allegory in the "Theses on the Philosophy of History" offers Balfour a clear framework for undertaking this examination. And, in style and approach, Benjamin is the thinker with whom Balfour has the closest kinship. Like Benjamin's The Origin of German Tragic Drama, Balfour's The Rhetoric of Romantic Prophecy is a historical study that is not historicist, that is, it does not aim to account for a historical phenomenon, but is a philosophical and rhetorical investigation into language.However, it is Blanchot's brief essay "Prophetic Speech"—a review of André Neher's L'essence du prophétisme—that informs Balfour's thinking about the prophetic. Indeed, Balfour's book can be read as a meditation on the rhetorical implications of Blanchot's suggestion that: [End Page 257]Prophetic speech announces an impossible future, or makes the future it announces, because it announces it, something impossible, a future one would not know how to live and that must upset all the sure givens of existence. When speech becomes prophetic it is not the future that is given, it is the present that is taken away, and with it any possibility of a firm, stable, lasting presence. 2With this passage, Blanchot not only recasts the conventional account of prophecy (and, implicitly, the symbolic reading upon which prophecy relies), but also shows that if prophecy turns the future into a referent—and hence becomes history—the present is lost. Balfour's transfer of Blanchot's account of the prophetic to romanticism is broadly explained by the debates within romanticism (and contemporary criticism of romanticism) about referentiality and the primacy of symbol over allegory, debates that today are most well-known to non-romanticists through Paul de Man's "The Rhetoric of Temporality."Balfour offers a lucid account of his project—and its relation to history and historicist criticism—when he explains:If there is a historical force to the analysis here, it lies not in the attempt to show how representative these texts were of some larger, pervasive phenomenon—although they sometimes are—but rather to mark what was possible to be thought and done at a given moment. More than that, the analysis implicitly and sometimes explicitly confronts... (shrink)

Adaptive phenotypic plasticity allows organisms to cope with environmental variability, and yet, despite its adaptive significance, phenotypic plasticity is neither ubiquitous nor infinite. In this review, we merge developmental and population genetic perspectives to explore costs and limits on the evolution of plasticity. Specifically, we focus on the role of modularity in developmental genetic networks as a mechanism underlying phenotypic plasticity, and apply to it lessons learned from population genetic theory on the interplay between relaxed selection and mutation accumulation. We (...) argue that the environmental specificity of gene expression and the associated reduction in pleiotropic constraints drive a fundamental tradeoff between the range of plasticity that can be accommodated and mutation accumulation in alternative developmental networks. This tradeoff has broad implications for understanding the origin and maintenance of plasticity and may contribute to a better understanding of the role of plasticity in the origin, diversification, and loss of phenotypic diversity. (shrink)

In recent years, humans’ ability to selectively modify genes has increased dramatically as a result of the development of new, more efficient, and easier genetic modification technology. In this paper, we argue in favor of using this technology to improve the welfare of agricultural animals. We first argue that using animals genetically modified for improved welfare is preferable to the current status quo. Nevertheless, the strongest argument against pursuing gene editing for welfare is that there are alternative approaches to addressing (...) some of the challenges of modern agriculture that may offer ethical advantages over genetic modification; namely, a dramatic shift towards plant-based diets or the development of in vitro meat. Nevertheless, we provide reasons for thinking that despite these possible comparative disadvantages there are important reasons for continuing the pursuit of welfare improvements via genetic modification. (shrink)

The thymus is a unique primary lymphoid organ that supports the production of self‐tolerant T‐cells essential for adaptive immunity. Intrathymic microenvironments are microanatomically compartmentalised, forming defined cortical, and medullary regions each differentially supporting critical aspects of thymus‐dependent T‐cell maturation. Importantly, the specific functional properties of thymic cortical and medullary compartments are defined by highly specialised thymic epithelial cells (TEC). For example, in the medulla heterogenous medullary TEC (mTEC) contribute to the enforcement of central tolerance by supporting deletion of autoreactive T‐cell (...) clones, thereby counterbalancing the potential for random T‐cell receptor generation to contribute to autoimmune disease. Recent advances have further shed light on the pathways and mechanisms that control heterogeneous mTEC development and how differential mTEC functionality contributes to control self‐tolerant T‐cell development. Here we discuss recent findings in relation to mTEC development and highlight examples of how mTEC diversity contribute to thymus medulla function. (shrink)

In this proof-of-concept study, we assessed the potential for immersive virtual reality to measure transfer following strategic memory training, and whether efficacy and transfer are increased when training is complemented by practice in an immersive virtual environment. Forty older adults with subjective memory complaints were trained with the method of loci. They were randomized to either a condition where they practiced the strategy in VR or a control condition where they were familiarized with VR using a non-memory task. Training efficacy (...) was measured with word recall, and transfer of the training benefit was measured with a recall task completed in two VR tasks as well as a self-report memory questionnaire. Testing was administered before, midway, and after training. Participants improved their scores on word recall. Regarding transfer measures, participants improved their performance in the two VR recall tasks but not on the self-report memory questionnaire. No significant group effect was observed. Improvement was found when comparing PRE to POST 3 with no further improvement at POST 6. Thus, strategic memory training improved the memory of seniors with memory complaints on word recall and a transfer task relying on a VR scenario that resembles real-life. However, no evidence supporting an increase in transfer effects was found when enriching training with VR memory exercises. (shrink)

In this comment on Johan Von Essen’s contribution on the meaning of volunteering we make some remarks about Von Essen’s starting point, which reveals a particular perspective on meaningfulness, namely that people perceive reality as meaningful when their actions and the things they encounter are part of a meaningful whole. By introducing another perspective on meaningfulness, namely that the shattering of a meaningful whole is full of meaning, we question if practices of volunteering which occur in face-to-face situations—and thus outside (...) the public realm—can be fully captured by the five predicates that make up the phenomenological structure of volunteering. (shrink)