The non-random mixing of biomembrane components, especially saturated phospholipids, exhibits important consequences in molecular biology. Particularly, the distribution of lipids within natural and model membranes is strongly determined by the selective association processes. These processes of phospholipids take place due to the cooperative modes in multiparticle systems as well as the specific lipid-lipid interactions both in the hydrophobic core and in the region of the polar headgroups. We demonstrated that the investigation of the selective association processes of saturated phospholipids might (...) contribute to the insight of the lipid domains appearance inside the bilayer membranes. The association probabilities of like- pairs and cross- pairs from a binary mixture of saturated phospholipids were tested for both parallel and anti-parallel alignments of the polar headgroups. The present model confirms the experimental evidence for saturated phospholipids to have a high tendency for association in parallel configuration of the electric dipole moments of the polar headgroups whether the cross-sectional area of the polar headgroup is in an usual range of 25-55 2. There are three major lipid domains in a binary mixture of saturated phospholipids: lipid domains in non-mixed phase of the first mixture component, in parallel alignment of the polar headgroups; lipid domains in non-mixed phase of the second mixture component, in anti-parallel alignment of the polar headgroups; lipid domains in mixed phase. We think that the selective association processes of phospholipids are neither exclusively, nor only involved in promoting the lipid domains appearance through bilayer phospholipid membranes. (shrink)

Hans-Georg GADAMER, Hermeneutische Entwürfe. Vorträge und Aufsätze ; Pascal MICHON, Poétique d’une anti-anthropologie: l’herméneutique deGadamer ; Robert J. DOSTAL, The Cambridge Companion to Gadamer ; Denis SERON, Le problème de la métaphysique. Recherches sur l’interprétation heideggerienne de Platon et d’Aristote ; Henry MALDINEY, Ouvrir le rien. L’art nu ; Dominique JANICAUD, Heidegger en France, I. Récit; II. Entretiens ; Maurice MERLEAU-PONTY, Fenomenologia percepţiei ; Trish GLAZEBROOK, Heidegger’s Philosophy of Science ; Richard WOLIN, Heidegger’s Children. Hannah Arendt, Karl Löwith, Hans Jonas (...) and Herbert Marcuse ; Ivo DEGENNARO, Logos – Heidegger liest Heraklit ; O. K. WIEGAND, R. J. DOSTAL, L. EMBREE, J. KOCKELMANS and J. N. MOHANTY, Phenomenology on Kant, German Idealism, Hermeneutics and Logic ; James FAULCONER and Mark WRATHALL, Appropriating Heidegger. (shrink)

This is the first book on the provocative and innovative contributions to philosophy of language, metaphysics, the philosophy of mathematics, and logic made by Kit Fine, one of the world's foremost philosophers. Topics covered include meaning and representation, arbitrary objects, essence, ontological realism, and the metaphysics of modality.

Fischer’s approach for structure elucidation of linear aldohexoses is still the most widespread alternative in textbooks for carbohydrates. However, in post-Fischer era, a series of remarkable discoveries and inventions were made in different laboratories, and by their use a more comprehensive and coherent strategy for structure elucidation of linear isomeric aldohexoses can be elaborated. Fischer used the exceptional properties of d-mannose for the knowledge of configuration of C-2 and called it the key of the gate to stereochemistry. We bring the (...) evidence that Fischer had an alternative to this monosaccharide, d-idose. Fischer discovered the correct structure of the enantiomers of tartaric acid by pure intuition but Bijvoet proved it experimentally by means of X-rays. Hybridization, a concept taken by L. Pauling from biology, reconciled physics and chemistry concerning the valence of carbon atom and explained the stereochemical picture that had been empirically elaborated by Van’t Hoff and Le Bel. Other chemical transformations of monosaccharides, useful in the elucidation of their structure, have been also discovered or invented in post-Fischer era. (shrink)

Numerous groups race to discover the gene biomarker whose alteration alone is indicative of a particular disease in all humans. Biomarkers are selected from the most frequently altered genes in large population cohorts. However, thousands of other genes are simultaneously affected, and, in each person, the same disease results from a unique, never-repeatable combination of gene alterations. Therefore, our Genomic Fabric Paradigm (GFP) switches the focus from the alteration of one particular gene to the overall change in selected groups of (...) functionally related genes. Biomarkers are of little therapeutic value, their high alterability indicating low protection by the homeostatic mechanisms as for minor players. Instead of these most alterable genes in all patients, GFP identifies in each patient the genes whose highly protected expression governs major functional pathways by controlling the expression of numerous other genes. Smart manipulation of such (commander) genes would have the maximum therapeutic benefit not for everybody but for the treated person. The genomic fabric is defined as the transcriptome associated with the most interconnected and stably expressed network of genes responsible for a particular functional pathway. The fabric exhibits specificity with respect to race/strain, sex, age, tissue/cell type, and lifestyle and environmental factors. It remodels during development, progression of a disease, and in response to external stimuli. GFP is powered by mathematically advanced analytical tools whose application is illustrated by reprocessing data from previously published gene expression experiments. (shrink)

In this paper we prove polyadic counterparts of the Hájek, Paris and Shepherdson's conservative extension theorems of Łukasiewicz predicate logic to rational Pavelka predicate logic. We also discuss the algebraic correspondents of the provability and truth degree for polyadic MV-algebras and prove a representation theorem similar to the one for polyadic Pavelka algebras.

In trying to control various aspects concerning utterance production in multi-party human–computer dialogue, argumentative considerations play an important part, particularly in choosing appropriate lexical units so that we fine-tune the degree of persuasion that each utterance has. A preliminary step in this endeavor is the ability to place an ordering relation between semantic forms (that are due to be realized as utterances, by the machine), concerning their persuasion strength, with respect to certain (explicit or implicit) conclusions. Thus, in this article, (...) we propose a mechanism for assessing utterances, in terms of their argumentative force. The framework designed conflates insights from Asher and Lascarides’ SDRT (“Segmented Discourse Representation Theory”), and from Anscombre and Ducrot’s AT (“Argumentation Theory”). These mechanisms are included in a language generation component of a multi-party dialogue system for book reservation applications (i.e., a “virtual librarian”), and thus evaluated via typical human–machine conversations. (shrink)

This article argues that there are at least three different versions of methodological nationalism: state-centrism (unjustified supremacy granted to the nation-state), territorialism (understanding space as divided in territories), and groupism (equating society with the nation-state’s society). If these three versions are logically distinct, as it will be shown, the typology can serve as a tool to weight the influence of methodological nationalism in the social sciences. The paper has three sections arguing that 1) the three versions are all present in (...) the literature on methodological nationalism without always being distinguished; 2) the epistemological problems raised by methodological nationalism are sometimes misunderstood as ontological or normative questions about globalization and national borders; 3) the three versions of methodological nationalism can be shown to be logically independent by a few examples. (shrink)

Migrant women are often stereotyped. Some scholars associate the feminization of migration with domestic work and criticize the “care drain” as a new form of imperialism that the First World imposes on the Third World. However, migrant women employed as domestic workers in Northern America and Europe represent only 2% of migrant women worldwide and cannot be seen as characterizing the “feminization of migration”. Why are migrant domestic workers overestimated? This paper explores two possible sources of bias. The first is (...) sampling: conclusions about “care drain” are often generalized from small samples of domestic workers. The second stems from the affect heuristic: imagining children left behind by migrant mothers provokes strong feelings of injustice which trump other considerations. The paper argues that neither source of bias is unavoidable and finds evidence of gender stereotypes in the “care drain” construal. (shrink)

La « féminisation de la migration internationale » constitue la nouvelle formule magique de nombreuses études migratoires. Or, depuis un demi-siècle, la part des femmes dans la migration internationale n’a pas vraiment augmenté. En revanche, les femmes représentent aujourd’hui plus de la moitié des migrants diplômés de l’enseignement supérieur dans les pays de l’OCDE. Pourtant, cette féminisation de la migration qualifiée est moins souvent discutée. Comme si les diplômes des femmes migrantes devaient rester aussi invisibles dans la recherche que sur (...) le marché du travail. (shrink)

If migration is more effective than aid for fighting poverty, should it replace aid? Not always. This article proposes a criterion that may be used to distinguish between cases where migration should serve as a substitute for development assistance and cases where it should supplement such aid. According to this criterion, development agendas are poverty-efficient when they lift the largest possible number of people out of poverty. Therefore, to be poverty-efficient, development agendas should always aim to complement aid with policies (...) for pulling people out of poverty. Development assistance that is not poverty-efficient should be abandoned and replaced by migration and other policies that can effectively fight poverty. (shrink)

The author describes briefly the activities of different ethical centres and gives a survey of the principle directions of ethical research in Romania. These include primarily normative problems, the theoretical problems and translations of classical ethical works. The recent publication of a project for a code of socialist morality gives evidence of the advance and significance of ethical research in Romania.

In this paper we aim to examine a novel view on distributive justice, i.e. limitarianism, which claims that it is morally impermissible to be rich. Our main goal is to assess the two arguments provided by Ingrid Robeyns in favour of limitarianism, namely the democratic argument and the argument from unmet urgent needs and the two distinct limitarian views which these arguments give rise to. We claim that strong limitarianism, which is supported by the democratic argument, should be rejected as (...) it fails to fully instantiate the value of political equality, while having some other unattractive implications as well. By contrast, we argue that weak limitarianism, which is supported by the argument from unmet urgent needs, should be endorsed, albeit in a qualified version which also takes responsibility constraints into consideration. (shrink)

This article is devoted to analysing the ethical commitments underlying research methodology on “brain drain” and leading participants in the public debate to deny the human right of emigration for skilled persons. Here, we identify five such commitments : to consequentialism, prioritarianism and nationalism, we add sedentarism and elitism. Based on this analysis, we argue that even though the emigration of the most talented would be a loss for the country of origin, this loss is not sufficient to require that (...) migrants themselves compensate it – either by tax payments (e.g. Bhagwati’s tax proposal) or by not exercising their right to emigrate. Moreover, to interpret public investment in education as the source of migrants’ further obligations to their country is to view education rather as a source of dividends than an access to opportunity that present generations owe to futures ones. (shrink)

Les derniers écrits de John Rawls sont marqués à la fois par la reconnaissance du « fait du pluralisme » et par la défense d’une conception « politique » de justifica-tion publique, indépendante de considérations métaphysiques et épistémiques. Le but de cet article est de montrer que l’abstinence épistémique n’est ni une façon d’assurer le respect mutuel des citoyens, ni un moyen de diminuer le désaccord dans une société pluraliste. Faire de son mieux dans l’observance des normes épistémiques de la (...) justification est une façon certes indirecte, mais plus solide de faire montre du respect dû à autrui, en tant que personne capable non seulement de former sa conception du bien, mais aussi de la réviser. (shrink)

In the conventional approach to quantum mechanics, indeterminism is an axiom and nonlocality is a theorem. We consider inverting the logical order, making nonlocality an axiom and indeterminism a theorem. Nonlocal “superquantum” correlations, preserving relativistic causality, can violate the CHSH inequality more strongly than any quantum correlations.

Many important criticisms to the possibility of global justice are advanced following one or another operationalization of the Rawlsian concept of a basic structure. The purpose of this paper is twofold: i) to show that the existence of a global basic structure is irrelevant from the standpoint of justice; ii) to set the stage for a cosmopolitan theory of global justice that employs satisficing sufficientarianism as a distributive principle. One of the main contentions is that the institutional-interactional cut in the (...) recent literature should be transcended. That is, the site of justice should be extended to incorporate both the efficiency of discharging one’s duties through a just institutional scheme and the moral value of promoting a good state of affairs through one’s own efforts. In order to avoid the overdemandingness objection, however, the selected principles of justice ought to belong to the sufficientarian family. Towards the end of the paper I sketch one such theory, satisficing sufficientarianism. (shrink)

« Utopique » se dit d’un projet irréalisable, qui ne saurait exister. Or, un monde où les passeports n’étaient pas obligatoires pour traverser une frontière a bel et bien existé : c’est celui d’avant la Première Guerre Mondiale. Cet article résume l'histoire des efforts pour abolir le régime des passeports obligatoires après la Première Guerre Mondiale.

In Reference without Referents, Mark Sainsbury aims to provide an account of reference that honours the common-sense view that sentences containing empty names like "Vulcan" and "Santa Claus" are entirely intelligible, and that many such sentences -"Vulcan doesn't exist", "Many children believe that Santa Claus will give them presents at Christmas", etc.- are literally true. Sainsbury's account endorses the Davidsonian program in the theory of meaning, and combines this with a commitment to Negative Free Logic, which holds that all simple (...) sentences containing empty names are false. In this critical review, we pose a number of problems for this account. In particular, we question the ability of Negative Free Logic to make appropriate sense of the truth of familiar sentences containing empty names, including negative existential claims like "Vulcan doesn't exist". /// En Reference without Referents, Mark Sainsbury se propone ofrecer una explicación de la referencia que respete la idea de sentido común de que las oraciones con nombres vacíos como "Vulcano" y "Santa Claus" son completamente inteligibles, y que muchas de oraciones de este tipo -"Vulcano no existe", "Muchos niños creen que Santa Claus les traerá regalos en Navidad", y demás- son literalmente verdaderas. La propuesta de Sainsbury se inscribe dentro del programa davidsoniano en teoría del significado, y combina éste con un compromiso con la Lógica Libre Negativa, según la cual todas las oraciones simples que contienen nombres vacíos son falsas. En este estudio crítico, presentamos varios problemas de esta explicación. En particular, ponemos en duda la habilidad de la Lógica Libre Negativa de entender de manera apropiada la verdad de oraciones conocidas que contienen nombres vacíos, incluidas negaciones de existencia como "Vulcano no existe". (shrink)