Bone marrow is the main site for hematopoiesis in adults. It acts as a niche for hematopoietic stem cells (HSCs) and contains non‐hematopoietic cells that contribute to stem cell dormancy, quiescence, self‐renewal, and differentiation. HSC also exist in resting spleen of several species, although their contribution to hematopoiesis under steady‐state conditions is unknown. The spleen can however undergo extramedullary hematopoiesis (EMH) triggered by physiological stress or disease. With the loss of bone marrow niches in aging and disease, the spleen as (...) an alternative tissue site for hematopoiesis is an important consideration for future therapy, particularly during HSC transplantation. In terms of harnessing the spleen as a site for hematopoiesis, here the remarkable regenerative capacity of the spleen is considered with a view to forming additional or ectopic spleen tissue through cell engraftment. Studies in mice indicate the potential for such grafts to support the influx of hematopoietic cells leading to the development of normal spleen architecture. An important goal will be the formation of functional ectopic spleen tissue as an aid to hematopoietic recovery following clinical treatments that impact bone marrow. For example, expansion or replacement of niches could be considered where myeloablation ahead of HSC transplantation compromises treatment outcomes. (shrink)

There are several important conceptual issues and questions about the practice of healthcare ethics that can, and should, inform the development of any practice standards. This paper provides a relatively short overview of seven of these issues, with the invitation for further critical reflection and examination of their relevance to and implications for practice standards. The seven issues described include: diversity (from the perspective of training and experience); moral expertise and authority/influence; being an insider or outsider; flexibility and adaptability (...) (for local contexts of practice); the relative weighting of procedural and normative aspects of ethics practice; making mistakes or errors; and conflicts of interest in practice. (shrink)

Background Intestinal transplant in infants with severe short bowel syndrome (SBS) is an emerging therapy, yet without sufficient long-term data or established guidelines, resulting in possible variation in practice. Objectives To assess current attitudes and counselling practices among physicians regarding intestinal transplant in infants with SBS, and to determine whether counselling and management vary between subspecialists or centres. Methods A national sample of practicing paediatric surgeons and neonatologists was surveyed via the American Academy of Paediatrics listserves. Results were analysed (...) by physician subspecialty and again by presence or absence of intestinal transplant at respondent's centre. Results The survey was completed by 433 respondents, consisting of 363 neonatologists and 70 paediatric surgeons. Fifty-seven respondents (13.2%) practiced at a centre that performed intestinal transplants in children. The vast majority of respondents (91% for preterm, 95% for term neonates) felt that maintaining a neonate with SBS on total parenteral nutrition for intestinal transplant was ethically optional (neither impermissible nor obligatory), and that parents should be given an informed choice whether to pursue that option. However, only 33% indicated they often/always offer intestinal transplant as a treatment option to families in this situation. Conclusions There is a marked disparity between individual physicians’ beliefs regarding the acceptability of intestinal transplant for severe SBS and their reported practice. Wide variability exists among physicians with respect to their knowledge, beliefs and practice regarding severe SBS, raising concerns about transparency and justice. Survival data prior to transplant, currently unavailable, are essential to rational decision making and informed parental permission. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Changing Human Nature: Ecology, Ethics, Genes, and God by James C. PetersonDolores L. ChristieChanging Human Nature: Ecology, Ethics, Genes, and God James C. Peterson Grand Rapids, Mich.: Eerdmans, 2010. 259 pp. $18.00Grounding himself in the Christian tradition, James Peterson argues for the moral efficacy of human genetic manipulation. Interpreting intentional intervention as part of human stewardship rather than as a wrongful interference with some divine plan, he takes (...) on the sticky questions, making critical distinctions, for example, between cure and enhancement or welcoming children as they come and making them “better.” Not neglecting future implications of current tinkering with human biology, even in such taboo areas as gamete selection, he contends that engineering a baby free of harmful genes (for example, Tay-Sachs or Down syndrome) not only makes that person better, but it also eliminates an ongoing burden to family, to society, and perhaps to future generations. Treading gingerly among the sacred cows of some Christian ethicists, he advocates the implanting of selected embryos free of unwanted genes; in his view, embryos are not yet persons.Peterson considers serious concerns such as eugenics projects and racial bias but offers standards to address them. He contends that intentionally increasing choices for our children is not only acceptable but also praiseworthy. What parents would not optimize the educational and social opportunities for their child, even without the child’s consent? Interventions should be safe, offer genuine improvement, increase the recipient’s capacity, and make the best use of limited resources. Peterson is not so naive that he does not recognize that technology does not always make us better. He recognizes, too, that his standards do not eliminate risk.Fair enough, but the issue of what “improvement” may mean to the individual as well as to the greater community remains somewhat ambiguous. Peterson suggests that broadening the decision making among a variety of professional and individual cohorts would help, but his argument is not totally persuasive. In sum, Peterson’s treatment falls short of offering a totally satisfying standard for determining which characteristics should be manipulated and which should be accepted. Nor does he demonstrate definitively how a [End Page 187] Christian perspective would contribute to sorting out possible choices. Does the deaf parents’ desire for their child to be deaf like them constitute an instance where intervention should not be attempted? Can the disparate cohorts he suggests as arbiters rise above their own biases? Does Christianity and its belief system offer answers? Readers—even readers who call themselves Christian—will likely be persuaded that genetic intervention is a good, and even compatible with their religious perspective. Nonetheless, they will harbor lingering doubts about how the questions can best be solved, who should solve them, and how Christian belief helps sort among the possibilities. In his closing comments Peterson appears to agree.The book is rich in research and in provocative ideas. It is an exciting book. It is a readable and enlightened contribution to the professional conversation on gene therapy. Peterson’s research is extensive, his argumentation balanced. His attempt to locate the question within the Christian tradition is laudable. Happily, Peterson eschews a creationist approach to world and human origins. Unhappily, his approach to the scriptural text is not always nuanced. His assertion that Jesus himself was different biologically from other human beings (132) seems a stretch. If one takes the passages of Jesus’s biological origins literally, as apparently does the author, what happens to the assertion that Jesus is like other human beings “in all things but sin”? And where did Jesus get the Y chromosomes? While he persuades the reader that genetic intervention is compatible with a Christian worldview, Peterson does not offer—at least in this reviewer’s view—an adequate criterion for navigating this new world of the possible.Dolores L. ChristieJohn Carroll UniversityCopyright © 2013 Society of Christian Ethics... (shrink)

With advancing rank in medical training comes increased academic and clinical responsibility, including education and supervision of trainees and junior staff. When I became a senior postdoctoral fellow sub‐specializing in neonatology, I assumed the role of co‐attending in the neonatal intensive care unit. At that point in my training, I felt well prepared for the challenging task. I would be in charge, make decisions independently with the team, and supervise, as well as teach, the junior fellows, residents, and practitioners. In (...) short, I would assume full responsibility for the care of the patients, their families, and the medical team. My mentor, an experienced attending, would discuss every patient with me each day, but would otherwise stand in the shadows, available for help and guidance when needed. On the very first day, one of the smaller premature babies on our service started having difficulty breathing, and it was soon clear that she would need to have her endotracheal tube reinserted. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:The Eternal Present: Slow Knowledge and the Renewal of TimeDouglas E. ChristieA woman is seated in a chair at the center of a large, light-filled atrium. Across from her sits an adolescent girl, Asian or Asian-American, maybe thirteen years old. They are both perfectly still. They look intently at each other. That is all. Minute after minute passes. Neither of them moves. I look more closely. Utter stillness. Not (...) quite repose, for there is a sense of intentionality to their engagement with each other, but deep stillness and calm. I look around the room and see a hundred or so persons also taking in the scene. Everyone is silent, though there are occasional sounds—shoes shuffling on the floor, a cough, a sigh. It takes me a few minutes to understand what is going on, what I am seeing. I feel my own anxiety to place myself somehow in this scene, to find the appropriate categories for grasping what is unfolding before me. I ask a person nearby; he tells me: it’s Marina Abramovic. She is performing “The Artist Is Present,” part of a retrospective of her work at the Museum of Modern Art in New York City.1 “Oh,” I say, “thanks.” It’s performance art. Got it. But knowing this only helps a little. What are they doing? What is going on here? What is my part, if any, in what is happening? My mind, as usual, is racing ahead trying to figure it out. Which in this moment I cannot do. So, I pause (inwardly), take a step back and try to reorient myself. I take a breath, then another. I look again at the two figures.Their stillness is uncanny. This is part of what is making me anxious, I think. They are absorbed completely in the simple act of gazing at each other. I smile, thinking at first of the “stare-downs” I used to have with my brother when we were kids. Who would flinch (and fall into uncontrollable laughter) first? It was a game of chicken. With the eyes. Usually it was of short duration, and someone had to lose. This is different. The quality of attention, in particular, feels utterly different. These two are not trying to knock each other off their chairs. No one is trying to “win” at anything. They are, it seems, simply giving themselves to the work of beholding and being beheld. Extraordinary. I am not sitting in the chair. But I feel a jolt run through my body as I begin to feel the depth and power of this moment. The sense of nakedness, of naked abandon, of vulnerability. What else? Tenderness. Yes, I sense a certain tenderness passing between these two figures. And not just between them. Also touching those of us gathered in the room watching them. How is that possible? We are all [End Page 13] strangers to one another after all. And yet within this space, for these few moments there is a remarkable and palpable sense of intimacy.I am not sure at how long I stand there. But after a while, I feel the need to move, to get some relief from the intensity of this exchange. I leave the room where the artist and her companion are sitting and walk into a nearby gallery. (Later I learn that anyone visiting the museum can occupy the chair opposite the artist and that over the course of the exhibit many, many people do just that.) I am not ready to look at anything else, not yet. I have to gather myself a little first.Eventually, I do begin to take in some of the other art in the museum. But my mind keeps returning to that room and to those two seated figures. During the next couple of hours, I return to the atrium several more times. Each time I do, I am struck by how still these two figures are, how alive. Also how still and alive I feel entering into that space. Those of us beholding the scene are respectful and quiet but also animated, exchanging brief whispers, glances, smiles. We are captivated, enthralled.Suddenly... (shrink)

Lam, Joseph In an audience for journalists shortly after his election in 2013 Pope Francis revealed not only the reason for his choice of name, but also his vision of the church: 'Francis of Assisi. For me he is the man of poverty, the man of peace, the man who loves and safeguards creation... He is the man who gives us this spirit of peace, the poor man... Oh, how I wish for a Church that is poor and for the (...) poor!' The Pontiff in his 2014 Lenten message re-emphasised the church's commitment to the poor. The responsibility of the church is 'to bear witness to all those who live in material, moral and spiritual destitution the Gospel message of the merciful love of God our Father, who is ready to embrace everyone in Christ. We can do this to the extent that we imitate Christ who became poor and enriched us by his poverty'. Pope Francis' concern for the poor is again reechoed in his latest encyclical, Laudato Si, in which he re-emphasises the church's commitment to the poor by calling Catholics especially to be stewards God's creation. A poor church for the poor, as Pope Francis envisages, has its foundation in the poverty of Jesus Christ: 'For you know the grace of our Lord Jesus Christ, that though he was rich, yet for your sake he became poor, so that by his poverty you might become rich'. (shrink)

This essay introduces Philosophia Christi’s symposium on the book, Philosophical Essays on Divine Causation, edited by Greg Ganssle. A short review of each essay in the symposium follows. A call is given for Christian philosophers to take divine causation into account while doing research in their primary area of philosophy. These updated and expanded essays were first presented in a more limited form at the 2023 Pacific Division Meeting of the American Philosophical Association.

In lieu of an abstract, here is a brief excerpt of the content:Noël Carroll THE PARADOX OFJUNK FICTION Perhaps on your way to some academic conference, if you had no papers to grade, you stopped in die airport gift shop for something to read on the plane. You saw racks of novels authored by die likes of Mary Higgins Clark, Michael Crichton, John Grisham, Danielle Steele, Sidney Sheldon, Stephen King, Sue Grafton, Elmore Leonard, Sara Paretsky, Tom Clancy, and so on. (...) These are the kinds of novels that, when you lend them to friends, you don't care, unless you live in Bowling Green, Ohio, whether you ever get them back. They are mass, popular fictions. In another era, they would have been called pulp fictions. Following Thomas Roberts,1 I will call diem junk fictions, under which rubric I will also include things like Harlequin romances; sci-fi, horror, and mystery magazines; comic books; and broadcast narratives on either the radio or TV, as well as commercial movies. There are a number of interesting philosophical questions diat we may ask aboutjunk fiction. We could, for example, attempt to characterize its essential features. However, for the present, I will assume that the preceding examples are enough to provide you with a rough-andready notion of what I am calling junk fiction, and I will attempt to explore anotiier feature of the phenomenon, viz., what I call the paradox ofjunk fiction. Thejunk fictions that I have in mind are all narratives. Indeed, dieir story dimension is die most important thing about diem. Stephen King, for instance, makes diis point by saying that he is primarily a story teller rather than a writer. Junk fictions aspire to be page-turners—the blurb on the cover of Stillwatch by Mary Higgins Clark says that it is "designed to be read at breatiitaking speed"—and what motivates turning die page so quickly is our interest in what happens next. We do not dawdle Philosophy and Literature, © 1994, 18: 225-241 226Philosophy and Literature over Clark's diction as we might over Updike's nor do we savor die complexity of her sentence structure, as we do widi Virginia Woolfs. Radier, we read for story. Moreover, junk fictions are die sort of narratives that commentators are wont to call formulaic. That is, junk fictions generally belong to well-entrenched genres, which diemselves are typified by tiieir possession of an extremely limited repertoire of story-types. For example, as John Cawelti has pointed out, one such recurring Western narrative is diat of the recendy pacifist gunfighter, like Shane, who is forced by circumstances to take up his pistols again, widi altogedier devastating effect.2 Junk fictions tell diese generic stories again and again with minor variations. Sometimes diese variations may be quite clever and unexpected. Agatiia Christie was the master of this; she was able to use the conventions of the mystery genre in order to "hide" her murderers. In TheMurderofRogerAckroyd, she "secrets" the murderer in the personage of the narrator; in Ten Little Indians, die murderer is a "dead man"; while in Murder on the Orient Express, all the suspects did it. In each of these cases, Christie's brilliance hinges upon her playing (and preying) upon conventional expectations. Neverdieless, even diese surprising variations require a well-established background of narrative forms. That is, in order to appreciate diese variations, die reader must in some sense know die standard story already. And with junk fiction, it is generally fair to say that in some sense, the reader—or, at least, the reader who has read around in die genre before—knows in rough oudine how die story is likely to go. Readers and/or viewers of Jurassic Park surmised, once die dinosaur enclosures were described, diat in fairly short order die dinosaurs would trample them down and go on the rampage—after all we had already seen or read The Lost World, King Kong, and their progeny. So, junk fictions are formulaic. They rehearse certain narrative formats again and again. And, furthermore, in some very general sense, the audience already knows die story in question. But this knowledge on die part of die audience provokes a question, specifically, why if the reader, viewer or listener already... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:494 HISTORY OF PHILOSOPHY in the Haller Zeitung; it will probably not appear at all--it has, among other short, comings, the fault to be too long." In a letter to Schtitz, Niethammer writes from Bamberg on 23 March 1807: "I repeat my urgent demand... to send the review of Salat's book submitted by Prof. Hegel as soon as possible to Jena to hand it in to Hofrat Voigt.... (...) " The volume contains almost 1,000 valuable notes which explain the philosophical and historical background of the newly edited material. HENRY WALTERBRANN Takoma Park, Maryland Peter Yakovlevich Chaadayev: Philosophical Letters and Apology of a Madman. Trans. with Intro. by Mary-Barbara Zeldin. (Knoxville: University of Tennessee Press, 1969. Pp. 203. $7.50) Mary-Barbara Zeldin's translation into English of the Philosophical Letters and the Apology of a Madman, by the enigmatic Russian intellectual leader of the early nineteenth century, Peter Yakovlevich Chaadayev makes available in English for the first time the thought of this figure whose small corpus of writings circulated mostly in manuscript during his own lifetime and waited over a hundred years after his death for their complete translation in their original French. Historically Chaadayev is important as a mediator between Westernizers and Slavophiles in this initial period of the nineteenth-century Russian intellectual awakening. Chaadayev himself remained aloof from either of these parties, was appealed to by both of them and became himself a kind of martyr to intellectual freedom. His own view of Russian-Western relationships incorporates this problem most remarkably into a theological vision of the "education of the human race." Philosophically Chaadayev stands as a unique and somewhat eccentric synthesizer of German idealism with the Christian concept of salvation history. Perhaps the most remarkable insight to be gained by reading these long-buried essays is the ease with which an Eastern Orthodox Christian versed in Patristic hellenism could fuse the ideas of a paedagogy of the human race in Lessing, Herder and Schiller and read this as an expression of an Irenaean doctrine of the progressive development of a mankind through the mediation of the primordial Logos; an Alexandrian idea of the paedagogy of Christ in history and a Eusebian doctrine of Christian universal empire. In so doing this Russian thinker also reveals to what an extent the German idealist movement itself was grounded on much older syntheses of Christian thought. In the process, however, Chaadayev also shows that nineteenth-century men could only appropriate this heritage anew by taking the great credal themes of revelation, Christi, the church and the Kingdom of God and reissuing them in a secularized, humanistic dress, as a philosophy of history. Chaadayev's basic thesis is that knowledge is a divinely-given deposit of certain fundamental primordial ideas, which man would not have arrived at through his own unaided powers, but rather possesses as an imprint upon the mind of the first man implanted by the Creator. Chaadayev weds the western philosophical concept of a fundamental a priori with a doctrine of primordial revelation, revealing the foundation of man himself in the divine Logos. This primordial deposit of ideas existed in BOOK REVIEWS 495 the first man only as a rudimentary 'image' of God. It is only through historical development that man grows to full stature in these truths whereby he attains to the completed 'likeness' of God. These truths, together with their historical development, are passed down by a historical succession, which is not an ecclesiastical succession, but a succession of the human family. These truths are periodically renewed by the advent of certain extraordinary individuals who exemplify them to a high degree, and by certain elect nations who are divinely designated as their culture-bearers. The Jews of the Old Testament were that culture-bearer in antiquity, and, since the time of Jesus Christ, it is Christendom which stands for and bears the development of this primordial truth as it has been renewed and set forth in archetypal perfection by Christ. Chaadayev sharply down grades the role of the Greeks in this development, but does so in a manner remarkably similar to the ancient Christian apologists who stole Greek fire in order to bathe the... (shrink)

En 1965, Karl Rahner et Karl Lehmann publièrent une étude documentée et systématique sur les rapports entre kérygme et dogme, quintessence des travaux en cours dans ce domaine, au moment où s'achevait le concile Vatican II. Un premier principe consensuel allait se dégager de ces travaux. Son impact touchera directement la fonction régulatrice des langages de la foi, autrement dit du caractère principiel et originaire de cette fonction dévolue aux formules de confessions présentes dans l'écriture néotestamentaire. Il s'agissait en somme (...) de poser et de justifier les principes d'une interprétation dogmatique de l'Ecriture. L'une des questions cruciales alors débattues tournait autour de la signification d'un objet de foi saisissable en énoncés de vérité, objet qui ne pouvait consister en une simple sequela Christi, ou être ramené à une anthropologie existentiale. Une place pour le dogme semblait subsister. Ce processus va déboucher sur une interprétation " extensive " du dogme à laquelle V. Holzer consacre ici l'essentiel de ses analyses. In 1965, Karl Rahner and Karl Lehmann published a documented and systematic study of the relationship between kerygma and dogma, the quintessence of work being done in the field when the Second Vatican council was coming to an end. An initial consensual principle would come out of this work. It was to have a direct impact on the regulating function of the languages of faith, in other words the nature of this function as principle and origin allotted to the formulas of confessions present in New Testament writing. In short, it involved laying down and justifying the principles of a dogmatic interpretation of Scripture. One of the crucial questions debated at the time revolved around the meaning of an object of faith that can be grasped in true statements, an object that could not consist of a mere sequela Christi or be reduced to an existential anthropology. A place for dogma seemed to remain. This process was going to culminate in an "extensive" interpretation of dogma, to which V. Holzer devotes most of his analyses here. (shrink)

ZusammenfassungMein kurzer Beitrag besteht darin, zwei Texte Luthers auszulegen, die in Bayers Buch eine wichtige Rolle spielen, besonders dort, wo die Trinitätstheologie verhandelt wird: den Hymnus »Nun freut euch lieben Christen g'mein« und einen Abschnitt aus dem Großen Katechismus . Bayer benutzt in seiner Analyse des Hymnus zwei Gegensätze, die Luthers neue Einsicht erhellen sollen: der eine betrifft das motivum incarnationis, der andere die Trinitätstheologie. Aufgrund von neueren Forschungen zu Thomas von Aquin und vor dem Hintergrund neuerer Entwicklungen in der (...) Trinitätstheologie müssen diese Gegensätze eine nuanciertere Betrachtung erfahren. Bayers Auslegung des Abschnittes des Großen Katechismus übersieht die Unterscheidung, die Luther zwischen wahren und falschen Christen macht. Wegen seiner starken, beinahe ausschließlichen Betonung der Rolle Jesu Christi übersieht er zudem, dass Luther eindeutig die Wichtigkeit der Rolle des Geistes anerkennt.SummaryMy short contribution is a reading of two texts by Luther that play an important role in Bayers book, especially where the theology of the Trinity is concerned: the hymn »Nun freut euch lieben Christen g'mein« and a passage from the Great Catechism . Bayer, in his analysis of the hymn uses two contrasts that should highlight the new insights of Luther: one is concerned with the motivum incarnationis, the other with the theology of the Trinity. On the basis of research in Aquinas and recent developments in the theology of the Trinity these contrasts need to be nuanced. Bayers interpretation of the passage from the Great Catechism overlooks the distinction Luther makes between true and false Christians and because of his strong and almost exclusive emphasis on the role of Jesus Christ overlooks that Luther acknowledges clearly the importance of the role of the Spirit. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:To Paul Lachance, ioculator Domini1. IntroductionWith the expression “inner experience” we refer to a complex linguistic and philosophical problem which is present even in the most recent theology. If, in general, this concept expresses the experience of something which is perceived by an individual in the absence of external stimulus or observable sensations, in Christian and mystical tradition it indicates more precisely the action and the transformation which God (...) arouses in the inner conscience. I propose investigating the specific way the Provençal Franciscan Pierre de Jean Olieu used this concept and presented it, both philosophically and theologically, in a small collection of writings which critical tradition has defined in various ways, but which I continue defining, with a term which maintains a Franciscan suggestion, as opuscula.1 These short devotional texts were written by Olieu and his followers in both Provençal and in Latin, and explicitly addressed the Beguins of the so-called “poverty houses,” as well as the laity which congregated around the Franciscan Order.2 Unlike the prayers and treatises concerning prayer by Olieu, these texts are not completely set but are conceived and written as models of continuous meditation on the part of the reader.3 In view of the critique I am editing, I here furnish a list of these texts, with the aim of updating the incomplete lists complied by Efrem Bettoni4 and Antonio Ciceri:5Cavalier armat Exercens se sacris orationibus et meditationibus Informatio Petri Ioannis De 14 gradibus amoris gratiosi 12De [12/10] gradibus humilitatis 13Grases de vera penitentia 14Modus quomodo quilibet potest referre gratias Deo de Beneficiis ab eo receptis Brevis monitio ad amorem Dei obtinendum 17Remedia contra temptationes spirituales De 7 sentimentis Christi Jhesu 20 Tractatus de 7 tentationibus 21Tractatulus de fugiendis, desiderandis, meditandis 22This approach is particularly interesting, because it is my conviction that, in these texts the author focuses on the paths and transformations of conscience, on the inter-communication of them and on the potential of repeating and recreating, autonomously, an uninterrupted process of spiritual transformation and strengthening. In this sense, as we will see, the concept of “inner experience” is central to the opuscula and, anticipating the results of my analysis, I can say that being in a significant position of the spiritual and meditative path delineated by the text, it constitutes its structural core. Such a placement finds meaning and justification within the philosophical, theological and apocalyptical reflections of the author.23 For Olieu, inwardness and outer activity, although remaining distinct, are balanceable and organizable in a reassemblage founded on devotio. We can say that the devotion of the reader, confirmed and strengthened by the inner experience of his personal reflection on mercy, is the element which allows this reassembling. We will see in what sense we can speak about an element of fracture and an entirely new forma mentis, which opens the way to modern secular spirituality.2. Inner Experience and the Structure of the opusculaI begin with the text entitled Informatio ad virtutum opera. This could be considered the manifesto text of the opuscula, because in this work Pierre de Jean Olieu clarifies the principle subject of the meditations offered to the reader, and proposes a stylistic, structural model which is respected, more or less precisely, in all the other texts of the corpus. This structure is very simple: the author lists twenty-eight subjects which the reader is invited to reflect upon during his personal endeavor towards virtuous perfection. The text is divided in two parts: the first presents fourteen orderly reflections centered on pedagogical-moral subjects like the meditation on God and the Passion of Christ, on the example of the Saints, the awareness of one’s sins, and on the coming of the Day of Judgement; in the second, the author.. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:The Christian PhilosopherKerry S. WaltersThe Christian Philosopher, by Cotton Mather; edited by Winton U. Solberg; cxlii & 488 pp. Urbana: University of Illinois Press, 1994, $49.95.Poor Cotton Mather! For well over two centuries now he has been a popular icon of unctuous self-righteousness, superstitious fanaticism, and dogmatic intolerance. Nor has endorsement of this stereotype been confined to casual laypersons who know of Mather only from lurid accounts of (...) Salem witch-hunting. Scholars who ought to know better often buy into it. Perry Miller, the doyen of early American studies, consistently wrote of Mather in a particularly unsympathetic manner. More odious, as Professor Solberg reminds us (p. xciii), was the treatment by historians at a Florida planetarium who in 1982 put together a short film on early European and American doomsday predictors which included segments on Mather the astronomer. When these segments appeared, a projector was programmed to flash the words “Feel Free to Boo and Hiss” on the planetarium’s dome—an invitation which audiences, presumably, gleefully accepted.Mather deserves better than this, and Winton Solberg’s critical edition of The Christian Philosopher goes a long way towards rehabilitating the Puritan divine. Along with recent studies such as Kenneth Murdock’s edition of Mather’s Magnalia Christi Americana (1977) and Kenneth Silverman’s masterful The Life and Times of Cotton Mather (1984), Solberg’s study painstakingly presents us with a detailed account of a man who undoubtedly was one of the most important literary figures in early America.Mather published The Christian Philosopher in 1721, seven years before his [End Page 167] death and eight years after being named to the Royal Society of London. The book was both the culmination of a lifetime of learning as well as a calculated effort on Mather’s part to show that his election to the prestigious Royal Society was deserved. The book is the first attempt by an American-born author to take a comprehensive look at the “new learning” associated with that period known since as the Enlightenment. Mather was an omnivorous reader and an equally thorough observer of natural phenomena, and he welcomed the scientific interpretations of reality offered by such savants as Isaac Newton, Robert Boyle, and John Ray. In the mind of Mather, such explanations posed no challenge to the Christian worldview. On the contrary, he concluded, they supported it by providing clear and indisputable evidence of design in nature. The Christian Philosopher (or, in more contemporary jargon, The Christian Scientist) is Mather’s attempt to defend this thesis. It is an exhaustive (and sometimes exhausting!) compendium of data gleaned from the natural realm which, in Mather’s judgment, irrefutably points to the existence of a grand Designer. Although Mather explicitly claimed that his primary goal in writing the book was to demonstrate that atheism is contrary to reason, he also penned one of the New World’s first systematic Enlightenment documents.One of the difficulties in reading The Christian Philosopher traditionally has been the sheer breadth of learning that went into its composition. Mather cites over four hundred books, includes hundreds of allusions to classical and scriptural sources, and so inundates the reader with evidence in support of his fundamental design argument that it is quite easy to lose one’s way. Professor Solberg has considerably lightened these burdens with his critical edition. He prefaces Mather’s text with a masterful 115-page introduction which places the work in its historical context as well as analyzes its methodology and arguments. Moreover, his edition includes 170 pages of endnotes, biographical notes, biblical references and a recapitulation of Mather’s own sources. Finally, Solberg supplies almost each page of Mather’s text with footnotes that identify literary or scriptural allusions and translate Mather’s liberal use of Greek and Latin quotations.Solberg’s edition of The Christian Philosopher will prove, I’m confident, to be the definitive text. It is an invaluable reference tool for the specialist, but it can also serve as a friendly and intriguing introduction for the layperson. Convinced Puritan-bashers who read this study may still regard Mather’s worldview with distaste, but I suspect that Solberg’s sensitive... (shrink)

The term "callous" has not, to this point, been studied empirically or considered philosophically in the context of healthcare professionalism. It should be, however, because its uses seem peculiar. Sometimes "callous" is used to suggest that becoming callous confers a benefit of some protection against emotional distress, which might be considered expedient in the healthcare work environment. But, "callous" also refers to a person's unappealing demeanor of hardened insensitivity. The tension between these different moral connotations of "callous" prompts several empirical, (...) psychological, and moral questions; I introduce and entertain a few here. I also suggest a distinction between callousness and inurement and argue for why this distinction is important to appreciate and uphold in health professions education. (shrink)

ABSTRACT When hope is discussed in bioethics’ literature, it is most often in the context of ‘false hopes’ and/or how to maintain hope while breaking bad news to patients. Little or no time is generally devoted to the description of hope that supports these analyses. In this paper, I present a detailed description of hope, one designed primarily for the healthcare context. Noting that hope is an emotional attitude, four key aspects are explored. In particular, the function of imagination in (...) hope is discussed in depth. Through an examination of the relationship between hope and vulnerability, I demonstrate how adequately describing hope can broaden the normative inquiry into the role of hope in healthcare. Three ways in which persons with hope can be vulnerable are illustrated, and the challenge of how healthcare providers can attend in moral ways to the hopes of patients is identified. (shrink)

This target article focuses on dynamics that arise in three typical ethically complex cases in which psychiatric consultations are requested by physicians: a dying patient refuses life-prolonging treatment, an uncooperative patient demands to be allowed to go outside and smoke, and an angry patient demands to be admitted to the hospital. The discussion canvasses what is at stake morally and clinically in each of these cases and explores clinician–patient interactions, dynamics in relationships between consulting physicians and consultant psychiatrists, patient transference, (...) and physician countertransference. The article defines legalism and countertransference and argues that an ethically and clinically important consequence of these phenomena for patients is distortion of clinicians' perceptions of patients' decisions and vulnerabilities. The discussion also describes how legalism and countertransference adversely affect how clinicians treat their psychiatrist colleagues. Finally, the article suggests how the effects of legalism and countertransference can be mitigated. (shrink)

Roots are good to think with indeed most of us use them as a metaphor every day. A root can signify the hiddenness of our beginnings, or, in its bifurcating structure, the various possibilities in the life of an individual or a collective. This book looks at rootedness as a metaphor for the genealogical origins of people and their attachment to place and how this metaphor transformed so rapidly in twentieth-century Europe. Christy Wampole s case study is France, with its (...) contradictory legacies of Enlightenment universalism, anti-Semitism, and colonialism. At one time, French nationalist rhetoric portrayed the Jews as unrooted and thus unrighteous people. After the two world wars, the root metaphor figured in the new French philosophy (notably Deleuze and Guattari). And recently, Caribbean thinkers in Haiti, Guadeloupe, and Martinique have debated whether their roots were in Africa, France, the Caribbean, or in some pan-national network that could not be identified on a map. Walpole argues that while the metaphor was perhaps once useful in the establishment of communities and identities, that usefulness has expired. The longer we remain attached to the figure of rootedness, the more discord it sows. Giving up on the metaphor of rootedness, Wampole urges, allows us to see at last that we are in fact unbound by the land we inhabit.". (shrink)

Christie is a member of the Department of Religious Studies at Baldwin-Wallace College, Cleveland, Ohio (U.S.A.).

These essays define transformation by blending the familiar with the conflicted and plural. Transformation refers to the shifting ground in our present culture between the familiar and the unfamiliar. These essays are viewed as examples of new intellectual 'genres' rather than 'theories.' If they do belong to a post-theoretical, intellectual genre of writing, it is because they blend philosophical vocabularies with expressions of curiosity, novelty and plurality.

Philosopher Kings? The Adjudication of Conflicting Human Rights and Social Values, by George C. Christie, examines the attempts by courts to sort out conflicts involving freedom of expression, including religious expression, on the one hand, and rights to privacy and other important social values on the other. It approaches the subject from a comparative perspective, using principally cases decided by European and United States courts. A significant part of this book analyzes conflicts between freedom of expression and the right (...) to privacy. In a world in which, freedom of expression and privacy are said to be of equal value, the book explores whether it is possible to develop, through case-by-case adjudication, a legal regime which can give clear direction as to what expression is or is not permitted. Otherwise, if such a regime proves impossible, in the guise of recognizing the equal value of expression and privacy, privacy may become de facto the preferred value. (shrink)

The Ozone Layer: A Philosophy of Science Perspective provides the first thorough and accessible history of stratospheric ozone, from the discovery of ozone in the nineteenth century to current investigations of the Antarctic ozone hole. Drawing directly on the extensive scientific literature, Christie uses the story of ozone as a case study for examining fundamental issues relating to the collection and evaluation of evidence, the conduct of scientific debate and the construction of scientific consensus. By linking key debates in (...) the philosophy of science to an example of real-world science, the author not only provides an excellent introduction to the philosophy of science but also challenges many of its preconceptions. This accessible book will interest students and academics concerned with the history, philosophy and sociology of science, as well as having general appeal on this topic of contemporary relevance and concern. (shrink)

Condom use among college men in the United States is notoriously erratic, yet we know little about these men’s approaches to other contraceptives. In this paper, accounts from 44 men attending a university in the western United States reveal men’s reliance on culturally situated ideas about gender, social class, race, and age in assessing the risk of pregnancy and STI acquisition in sexual encounters with women. Men reason that race- and class-privileged college women are STI-free, responsible for contraception, and will (...) pursue abortion services if necessary. Since men expect women will take responsibility, they often stay silent about condoms and other contraceptives in sexual encounters—a process we term “strategic silence.” Men’s strategic silence helps uphold local constructions of hegemonic masculinity that prioritize men’s sexual desires and protects these constructions by subtly shifting contraceptive and sexual health responsibility onto women. Our analysis demonstrates the importance of men’s expectations of women for upholding constructions of hegemonic masculinity, which legitimate gender inequality in intimacy and are related to men’s underestimation of the risks associated with condom-free sex. (shrink)

Is a feminist political liberalism possible? Political liberalism’s regard for a wide range of comprehensive doctrines as reasonable makes some feminists skeptical of its ability to address sex inequality. Indeed, some feminists claim that political liberalism maintains its position as a political liberalism at the expense of securing substantive equality for women. We claim that political liberalism’s core commitments actually restrict all reasonable political conceptions of justice to those that secure genuine substantive equality for all, including women and other marginalized (...) groups. In particular, we argue that political liberalism’s criterion of reciprocity limits reasonable political conceptions of justice to those that eliminate social conditions of domination and subordination relevant to reasonable democratic deliberation among equal citizens and that the criterion of reciprocity requires the social conditions necessary for recognition respect among persons as equal citizens. As a result, we maintain that the criterion of reciprocity limits reasonable political conceptions of justice to those that provide genuine equality for women along various dimensions of social life central to equal citizenship. (shrink)

The selected effects or ‘etiological’ theory of Proper function is a naturalistic and realist account of biological teleology. It is used to analyse normativity in philosophy of language, philosophy of mind, philosophy of medicine, and elsewhere. The theory has been developed with a simple and intuitive view of natural selection. Traits are selected because of their positive effects on the fitness of the organisms that have them. These ‘selected effects’ are the Proper functions of the traits. Proponents argue that this (...) analysis of biological teleology has the unique advantage that the selected effect function of a trait is also a causal explanation of the trait: the trait exists because it performs this function. We show, however, that selected effect functions as currently defined explain the existence of traits only under highly restrictive assumptions about evolutionary dynamics. In many common scenarios in which traits evolve by natural selection, selected effect functions do not explain those traits. This is because definitions of selected effect function extract from any evolutionary scenario only the information that would be explanatorily relevant in the simple evolutionary scenario implicit in those definitions. When applied to more complex scenarios, selected effect functions omit the key information that is explanatorily relevant in those scenarios. The assumptions required for selected effect functions to be explanatory are particularly unlikely to hold in the domain that its proponents care most about—the evolution of representation. A more adequate selected effects theory of Proper functions may be possible, but will require much greater attention to the structure of actual evolutionary explanations. (shrink)

By using examples drawn from the periodical Nature, I show that research into the history of logic in the nineteenth century involves journals and periodicals which are normally not considered as standard sources for logic or its history.

"Challenging myths about the power-filled life"--Cover.

The idea of public reason is central to political liberalism's aim to provide an account of the possibility of a just and stable democratic society comprised of free and equal citizens who nonetheless are deeply divided over fundamental values. This commitment to the idea of public reason reflects the normative core of political liberalism which is rooted in the principle of democratic legitimacy and the idea of reciprocity among citizens. Yet both critics and defenders of political liberalism disagree over whether (...) or not the idea of public reason permits citizens to appeal to their comprehensive conceptions of the good in public deliberation over matters of basic justice. Our aim in this paper is to provide a defense of an exclusive idea of public reason, and at the same time we aim to dispel the underlying concerns of two prominent criticisms of the idea of public reason—the concern of alienation from the political process, as expressed by religiously oriented critics, and the concern over women's equality, as expressed by feminist critics. We argue that inclusive accounts of the idea of public reason are not consistent with political liberalism's core commitments. Further, we claim, inclusive accounts of the idea of public reason deepen feminist concerns. We think that, properly understood, an exclusive account of the idea of public reason can address feminist concerns about political liberalism and avoid alienating (reasonable) religious persons in an unacceptable way. Thus, we conclude that an exclusive account of the idea of public reason is our best hope for reconciliation. (shrink)

This book is a defense of political liberalism as a feminist liberalism. A novel and restrictive account of public reason is defended. Then it is argued that political liberalism's core commitments restrict reasonable conceptions of justice to those that secure genuine, substantive equality for women and other marginalized groups.

Recasting French literary history in terms of the cultures and peoples that interacted within and outside of France's national boundaries, this volume offers a new way of looking at the history of a national literature, along with a truly global and contemporary understanding of language, literature, and culture. The relationship between France's national territory and other regions of the world where French is spoken and written (most of them former colonies) has long been central to discussions of "Francophonie." Boldly expanding (...) such discussions to the whole range of French literature, the essays in this volume explore spaces, mobilities, and multiplicities from the Middle Ages to today. They rethink literary history not in terms of national boundaries, as traditional literary histories have done, but in terms of a global paradigm that emphasizes border crossings and encounters with "others." Contributors offer new ways of reading canonical texts and considering other texts that are not part of the traditional canon. By emphasizing diverse conceptions of language, text, space, and nation, these essays establish a model approach that remains sensitive to the specificities of time and place and to the theoretical concerns informing the study of national literatures in the twenty-first century. (shrink)

This essay describes an example of how we—one professor of the elective course Art, Medicine, and Clinical Moral Perception at Creighton University School of Medicine, one Director of Adult Programs at the Joslyn Museum of Art in Omaha, Nebraska, and fourth year medical students—practice perception skills using art objects. This essay presents one example of the journal assignments to which students respond in written narratives about their own perception habits. We also share questions any health professions educator can use to (...) guide students’ study of their habits of perception using art objects. (shrink)

Recent downward trends in corporate giving have renewed interest in the factors that shape corporate philanthropy. This paper examines the relationships between charitable contributions, firm size and industry. Improvements over previous studies include an IRS data base that covers a much broader range of firm sizes and industries as compared to previous studies and estimation using an instrumental variable technique that explicitly addresses potential simultaneity between charitable contributions and profitability. Important findings provide evidence of a cubic relationship between charitable giving (...) and firm size and evidence of strong industry effects. The plus-minus-plus regression coefficient sign pattern for the cubic firm size model suggests that small and large firms give more relative to total receipts with lower giving ratios among medium size firms. One interpretation for this finding is that small firms are close to the communities they serve while high visibility creates a need for large firm philanthropy. Strong industry effects provide evidence of inter-industry differences in giving culture and/or different public relations requirements across industries. (shrink)

Wait, what? I've been fired?” I repeated, in the middle of morning rounds in the neonatal intensive care unit. Finally, the nurse who was taking care of our patient, Angela, responded, “Her parents fired you last night. They've already called Patient Relations. They want a new doctor.” My heart sank. Only days into my block of service time as the attending physician in the NICU and I was fired, axed, canned, rejected by a family. How could this have happened? On (...) my first day of service, I had introduced myself to Angela's parents, and I had then met with them daily to review results and the plan and to answer their questions. I thought we had connected well. I thought I had done everything right. I thought they trusted me to care for their daughter. (shrink)

This commentary canvasses a few prominent themes of ethical relevance drawn from the stories in this issue. I develop the metaphor of cartography to illuminate critical experiences in the moral lives of parents of children with brain tumors. Relationship transformation within families along the timeline of a child’s illness and recovery is one such set of experiences. Points for consideration in health professions education are also featured: clinical humility regarding “second opinions,” cultivating therapeutic efficacy from the clinician–parent relationship, error, and (...) medical care itself as a source of trauma. (shrink)

Social cooperation based on reciprocity is the cornerstone of many theories of justice. However, what is central to social cooperation based on reciprocity? How does basing social cooperation on reciprocity structure and constrain theories of justice? In this paper, I consider what is central to reciprocity. I argue that the purpose of reciprocal exchange among persons is important for determining the appropriateness of reciprocal exchanges and that sustaining mutually advantageous relations is not always the point or the only point of (...) reciprocity. This has important implications for theorizing about justice. I show this by outlining two conceptions of justice as reciprocity. (shrink)