The development of genomics has dramatically expanded the scope of genetic research, and collections of genetic biosamples have proliferated in countries with active genomics research programs. In this essay, we consider a particular kind of collection, national biobanks. National biobanks are often presented by advocates as an economic ‘‘resource’’ that will be used by both basic researchers and academic biologists, as well as by pharmaceutical diagnostic and clinical genomics companies. Although national biobanks have been the subject of intense interest in (...) recent social science literature, most prior work on this topic focuses either on bioethical issues related to biobanks, such as the question of informed consent, or on the possibilities for scientific citizenship that they make possible. We emphasize, by contrast, the economic aspect of biobanks, focusing specifically on the way in which national biobanks create biovalue. Our emphasis on the economic aspect of biobanks allows us to recognize the importance of what we call clinical labor—that is, the regularized, embodied work that members of the national population are expected to perform in their role as biobank participants—in the creation of biovalue through biobanks. Moreover, it allows us to understand how the technical way in which national biobanks link clinical labor to databases alters both medical and popular understandings of risk for common diseases and conditions. (shrink)

The notion of the ‘reasonable expectations of the parties’ plays an important justificatory role in contract law, yet the notion has not been subjected to any sustained analysis in the contract law literature. This article examines the various roles that reasonable expectation plays in contract law and explores the different understandings of the notion that are revealed. It identifies three possible bases for reasonable expectations—an institutional basis, an empirical basis and a normative basis—and examines how reasonable expectations arguments in contract (...) reflect each of these differing justificatory bases. This makes appeals to reasonable expectation in contract law problematic since the differently grounded expectations of the contracting parties are usually the precise site of conflict between them. It is therefore doubtful that conflicts between contracting parties can be resolved solely by identifying and protecting their ‘reasonable expectations’. In the conclusion some speculative comments are offered as to why, given its limited explanatory power, the notion has proved attractive in attempts to explain contract law. (shrink)

Jürgen Habermas is one of the most important thinkers of this century. His work has been highly influential not only in philosophy, but particularly in the fields of politics, sociology and law. This is the first collection that explores the connections between his body of work and North America's biggest philosophical movement, pragmatism. Habermas and Pragmatism investigates the influences of pragmatism on Habermas' thought in a collection of stellar essays with contributions by Habermas himself, leading representatives of pragmatism, as well (...) as critical and legal theorists. The essays cover a range of subjects including philosophy of language, democracy, nature of rationality and social theory as well as the relation of major figures such as Hegel, Pierce, Mead and Dewey to Habermas and pragmatism. (shrink)

The authors surveyed hospitals across the country on their policies regarding overlapping surgery, and found large variation between hospitals in how this practice is regulated. Specifically, institutions chose to define “critical portions” in a variety of ways, ultimately affecting not only surgical efficiency but also the autonomy of surgical trainees and patient experiences at these different hospitals.

Barsalou's interesting model might benefit from defining simulation and clarifying the implications of prior critiques for simulations (and not just for perceptual symbols). Contrary to claims, simulators (or frames) appear, in the limit, to be amodal. In addition, the account of abstract terms seems extremely limited.

Ethical reasoning and decision-making may be thought of as 'professional skills', and in this sense are as relevant to efficient clinical practice as the biomedical and clinical sciences are to the diagnosis of a patient's problem. Despite this, however, undergraduate medical programmes in ethics tend to focus on the teaching of bioethical theories, concepts and/or prominent ethical issues such as IVF and euthanasia, rather than the use of such ethics knowledge (theories, principles, concepts, rules) to clinical practice. Not surprisingly, many (...) students and clinicians experience considerable difficulty in using what they know about ethics to help them make competent ethical decisions in their day-to-day clinical practice. This paper describes the development of a seminar programme for teaching senior medical students a more systematic approach to ethical reasoning and analysis and clinical decision-making. (shrink)

This article examines the claim that there are two different and often incompatible ‘worlds’ within which contractual relationships can be placed—a real world created by the parties and an artificial world created by contract law and formal contract documents. This distinction, often made by sociolegal scholars, is usually accompanied by the suggestion that legal reasoning might be improved by more attention to the real world of contracting at the expense of the artificial world of documents and classical doctrine. After examining (...) the relationship between trust and contract, the role of legal institutions in supporting agreement-making and the reasons parties might have for formalizing commercial relationships, the article argues that a sharp distinction between the real and paper deal cannot be drawn and that in many commercial agreements these must be understood as integrated phenomena, rather than wholly discrete aspects of contracting behaviour. The article then considers the capacity of contract law to respond to this finding, with particular reference to the law's approach to uncertainty in agreements and the contextual approach to contract interpretation as developed by Lord Hoffmann in Investors Compensation Scheme and subsequent cases. (shrink)

The successful demonstration that antiretroviral (ARV) drugs can be used in diverse ways to reduce HIV acquisition or transmission risks – either taken as pre-exposure prophylaxis (PrEP) by those who are uninfected or as early treatment for prevention (T4P) by those living with HIV – expands the armamentarium of existing HIV prevention tools. These findings have implications for the design of future HIV prevention research trials. With the advent of multiple effective HIV prevention tools, discussions about the ethics and the (...) feasibility of future HIV prevention trial designs have intensified. This article outlines arguments concerning the inclusion of newly established ARV-based HIV prevention interventions as standard of prevention in HIV prevention trials from multiple perspectives. Ultimately, there is a clear need to incorporate stakeholders in a robust discussion to determine the appropriate trial design for each study population. (shrink)

Although risky decision-making has been posited to contribute to the maladaptive behavior of individuals with psychopathic tendencies, the performance of psychopathic groups on a common task of risky decision-making, the Iowa Gambling Task (IGT; Bechara, Damasio, Damasio, & Anderson, 1994), has been equivocal. Different aspects of psychopathy (personality traits, antisocial deviance) and/or moderating variables may help to explain these inconsistent findings. In a sample of college students (N = 129, age 18–27), we examined the relationship between primary and secondary psychopathic (...) features and IGT performance. A measure of impulsivity was included to investigate its potential as a moderator. In a joint model including main effects and interactions between primary psychopathy, secondary psychopathy and impulsivity, only secondary psychopathy was significantly related to risky IGT performance, and this effect was not moderated by the other variables. This finding supports the growing literature suggesting that secondary psychopathy is a better predictor of decision-making problems than the primary psychopathic personality traits of lack of empathy and remorselessness. (shrink)

One rationale policy-makers sometimes give for declining to fund a service or intervention is on the grounds that it would be ‘unaffordable’, which is to say, that the total cost of providing the service or intervention for all eligible recipients would exceed the budget limit. But does the mere fact that a service or intervention is unaffordable present a reason not to fund it? Thus far, the philosophical literature has remained largely silent on this issue. However, in this article, we (...) consider this kind of thinking in depth. Albeit with certain important caveats, we argue that the use of affordability criteria in matters of public financing commits what Parfit might have called a ‘mistake in moral mathematics’. First, it fails to abide by what we term a principle of ‘non-perfectionism’ in moral action: the mere fact that it is practically impossible for you to do all the good that you have reason to do does not present a reason not to do whatever good you can do. And second, when used as a means of arbitrating between which services to fund, affordability criteria can lead to a kind of ‘numerical discrimination’. Various attendant issues around fairness and lotteries are also discussed. (shrink)

Titles and abstracts for the Pitt-London Workshop in the Philosophy of Biology and Neuroscience: September 2001.

This article is an introduction to two other articles in this issue, Catherine Maxwell’s ‘Teaching 19th-century aesthetic prose’ and Kirsteen Anderson’s ‘The whole learner: the role of imagination in developing disciplinary learning’. It highlights the significance of the courses described in Maxwell’s and Anderson’s accounts by discussing how the writing tasks that they engage students in contribute to the development of disciplinary understanding, and how, whilst eschewing reliance on the conventional schooled essay, they enable students to develop writing that (...) is essayistic. It points to the potential that reinvisaging disciplinary writing has for curriculum and assessment design. (shrink)

The “revised edition” of the book Allen first published with the University of Minnesota Press in 1983 makes a number of slight changes to the original. In the Preface Allen says that he corrected some typographical errors in the translation of the dialogue and in the 200-plus-page “analysis” now called a “comment.” He or his new editors also added and subtracted a few of the subheadings in the comment, to which he has added two pages on the anachronistic character of (...) the contemporary “thirdman” debate. Unfortunately, Allen did not take the opportunity offered by the reissue of his book—as part of a series of new translations of the dialogues—to respond to three other book-length studies of the Parmenides that appeared after the initial publication of his own, by Constance Meinwald, Mitchell Miller, and Kenneth Sayre. (shrink)

Traditionally, attempts at resolving the problem of accounting for the possibility of human freedom against the background of determinism have assumed that the options available are to: endorse determinism and deny human freedom, deny determinism in order to make room for human freedom, or find a compatibilist reconciliation. Commonly, the problem is addressed from an 'externalist' perspective. In the dissertation, the issue is refocused upon the positions of 'internalists' such as Frankfurt, Watson, Taylor, and Wolf. Their compatibilist approaches emphasize the (...) importance of first person, psychological characteristics of agents as the salient determinants of human freedom. But each of these internalist approaches are found to be wanting. Consequently, the dissertation considers an alternative internalist view, that of Spinoza. I examine in detail Spinoza's concept of freedom, as it emerges from his overall metaphysical system, and note that his compatibilism not only affirms determinism, but further holds that a certain kind of necessity is a prerequisite to any coherent account of freedom. I then proceed to show that, by comparison with the views of the aforementioned contemporary compatibilists, only Spinoza's concept of freedom can account for a 'developmental' view of human nature, one which depicts the self as engaged in a process of liberation from the sort of psychological determinism which feeds upon ignorance. (shrink)

Robust stakeholder engagement in health research requires broad communicative integration, not only of patients but also other stakeholders such as health system leaders, clinicians, and researcher...

The `fact' of pluralism in science is nosurprise. Yet, if science is representing andexplaining the structure of the oneworld, why is there such a diversity ofrepresentations and explanations in somedomains? In this paper I consider severalphilosophical accounts of scientific pluralismthat explain the persistence of bothcompetitive and compatible alternatives. PaulSherman's `Levels of Analysis' account suggeststhat in biology competition betweenexplanations can be partitioned by the type ofquestion being investigated. I argue that thisaccount does not locate competition andcompatibility correctly. I then defend anintegrative (...) model for understanding pluralism. This view is based on taking seriously both thecomplexity and contingency of biologicalorganization and the idealized character ofbiological models. On this view, explanationbecomes, among other things, the location forthe integration of diverse models. I explicatemy argument by an analysis of explanations ofdivision of labor in social insects. (shrink)

A commonly raised criticism against celebrity culture is that it celebrates people who become famous without any connection to their skills, talents or achievements. A culture in which people become famous simply for being famous is criticized for being shallow and inauthentic. In this paper we offer a defence of celebrity by arguing against this criticism. We begin by outlining what we call the Talent Argument: celebrity is a negative cultural phenomenon because it creates and sustains fame without any connection (...) to the accomplishments that arise from an expression of talent or skill. By appealing to the metaphysics of talent and skill, we argue against the Talent Argument and propose that being a celebrity requires the skills that are necessary to acquire and maintain one’s status as a celebrity. A celebrity is more likely to be talented and successful in their expression of these skills, and even celebrities who are ‘famous for being famous’ will often display talents and skills that give rise to their fame. This means that those who critique celebrity culture should not do so by appealing to the Talent Argument. We show how our account of celebrity, talent and skill works to reject both the strong version of the Talent Argument, as well as a weaker and more plausible version of the argument we call the Valuable Talents argument. We conclude by noting that our analysis has demonstrated the need to explore more closely the kinds of skills that are necessary to cultivate celebrity status. This allows for a more nuanced understanding of what a celebrity is, and the values that are attached to celebrity culture. (shrink)

Elaborates the author’s conception of plasticity by proposing a new way of thinking through Heidegger’s writings on change.

This book is one of the most important recent books on Hegel, a philosopher who has had a crucial impact on the shape of continental philosophy. Published here in English for the first time, it includes a substantial preface by Jacques Derrida in which he explores the themes and conclusions of Malabou's book. _The Future of Hegel: Plasticity, Temporality and Dialectic_ restores Hegel's rich and complex concepts of time and temporality to contemporary philosophy. It examines his concept of time, relating (...) it to perennial topics in philosophy such as substance, accident and the identity of the subject. Catherine Malabou's also contrasts her account of Hegelian temporality with the interpretation given by Heidegger in _Being and Time_, arguing that it is the concept of 'plasticity' that best describes Hegel's theory of temporality. The future is understood not simply as a moment in time, but as something malleable and constantly open to change through our interpretation. The book also develops Hegel's preoccupation with the history of Greek thought and Christianity and explores the role of theology in his thought. Essential reading for those interested in Hegel and contemporary continental philosophy, _The Future of Hegel _is also fascinating to those interested in the ideas of Heidegger and Derrida. (shrink)

I argue that models enable us to understand reality in ways that we would be unable to do if we restricted ourselves to the unvarnished truth. The point is not just that the features that a model skirts can permissibly be neglected. They ought to be neglected. Too much information occludes patterns that figure in an understanding of the phenomena. The regularities a model reveals are real and informative. But many of them show up only under idealizing assumptions.

La question du sujet est ici abordée à partir de l´enseignement de Lacan à partir d´exemple clinique d´enfants suivis dans un cadre institutionnel relevant de l´Aide sociale à l´enfance. On tente d´y démontrer la vacuité du concept de sujet philosophique ou psychologique quant il s´agit de se repérer sur une éthique de la jouissance, d´un sujet de l´inconscient qui se soutient du phallus, d´une séparation du fantasme maternel, d´un abandon dans le réel, de l´effet-sujet attendu de la mise en place (...) d´un suivi psychanalytique. (shrink)

Some theories of personal identity allow some variation in what it takes for a person to survive from context to context; and sometimes this is determined by the desires of person-stages or the practices of communities.This leads to problems for decision making in contexts where what is chosen will affect personal identity.‘Temporal Phase Pluralism’ solves such problems by allowing that there can be a plurality of persons constituted by a sequence of person stages. This illuminates difficult decision making problems when (...) persons have to choose between different life-altering choices. (shrink)

In [4], Kunen used iterated ultrapowers to show that ifUis a normalκ-complete nontrivial ultrafilter on a cardinalκthenL[U], the class of sets constructive fromU, has only the ultrafilterU∩L[U] and this ultrafilter depends only onκ. In this paper we extend Kunen's methods to arbitrary sequencesUof ultrafilters and obtain generalizations of these results. In particular we answer Problem 1 of Kunen and Paris [5] which asks whether the number of ultrafilters onκcan be intermediate between 1 and 22κ. If there is a normalκ-complete ultrafilterUonκsuch (...) that {α <κ: α is measurable} ∈Uthen there is an inner model with exactly two normal ultrafilters onκ, and ifκis super-compact then there are inner models havingκ+ +,κ+or any cardinal less than or equal toκnormal ultrafilters.These methods also show that several properties ofLwhich had been shown to hold forL[U] also hold forL[U]: using an idea of Silver we show that inL[U] the generalized continuum hypothesis is true, there is a Souslin tree, and there is awell-ordering of the reals. In addition we generalize a result of Kunen to characterize the countaby complete ultrafilters ofL[U]. (shrink)

Using measures developed by Singhapakdi et al. (1996, Journal of Business ethics 15, 1131–1140) the perceived importance of ethics and social responsibility (PRESOR) is measured among MBA students in the United States, Malaysia and Ukraine revealing a stockholder view and two stakeholder views. Relativism and Idealism are also measured. The scores of MBA students are compared among each other and with those of the U.S. managers who were part of the original study. Managers'' scores tend to be significantly higher on (...) the Stockholder and Stakeholder II views, and much lower on Relativism than the MBA students. The Malaysian MBA students scored higher than did the American MBA students on Relativism, Idealism and the Stockholder view. The Ukrainian MBA students'' scores on the three PRESOR factors are generally similar to those of the American MBAs, while they had the highest scores of any group on the Relativism scale. Overall, the patterns of responses, as much as the significant differences on specific scales, support the notion that culture, however defined, affects both values and ethics. Several directions for future research are identified.''. (shrink)

Human beings are epistemically interdependent. Much of what we know and much of what we need to know we glean from others. Being a gregarious bunch, we are prone to venturing opinions whether they are warranted or not. This makes information transfer a tricky business. What we want from others is not just information, but reliable information. When we seek information, we are in the position of enquirers not examiners. We ask someone whether p because we do not ourselves already (...) know whether p. So we cannot check our informant’s bona fides by seeing whether she is speaking the truth about p. We need grounds for trust. In What’s the Point of Knowledge? Michael Hannon maintains that this is the predicament that underlies the concept of knowledge. The we here is comprehensive. Evidently, every language has a word for knowledge. This, Hannon suggests, indicates that the concept of knowledge satisfies a universal human need. A goal, if not the goal, of epistemology is to identify that need and ascertain how it is satisfied. Following Craig, Hannon argues that the point of knowledge is to enable us to identify good – that is, suitably reliable – informants. Let us call this the information transfer view. (shrink)

Since mitochondrial replacement techniques were developed and clinically introduced in the United Kingdom, there has been much discussion of whether these lead to children borne of three parents. In the UK, the regulation of MRT has dealt with this by stipulating that egg donors for the purposes of MRT are not genetic parents even though they contribute mitochondrial DNA to offspring. In this paper, I examine the way that the Human Fertilisation and Embryology Act in the UK manages the question (...) of parentage. I argue that the Act breaks the link typically made between genetic causation and genetic parenthood by redefining genetic causation solely in terms of nuclear genetics. Along with this, mtDNA is construed as a kind of supplement to the nuclear family. Drawing on the account of the supplement developed by Jacques Derrida, I argue that mtDNA and the women who donate it are seen as both essential to establishing the nuclear family but also exterior to and insignificant for it. (shrink)

Talents often play a significant role in our personal and social lives. For example, our talents may shape the choices we make and the goods that we value, making them central to the creation of a meaningful life. Differences in the level of talents also affect how social institutions are structured, and how social goods and resources are distributed. Despite their normative importance, it is surprising that talents have not yet received substantial philosophical analysis in their own right. As a (...) result, the current literature is rife with conceptual ambiguity: a talent is referred to as all of a skill, potential, ability, capacity, endowment, and a natural gift. In response to this confusion, in this paper I develop an account of what a talent is, based on the debate concerning the metaphysics of ability and dispositions. I argue for a position that I call ‘talent dispositionalism’: S has a talent for skill A in circumstances C iff S has the general disposition to excellently develop and maintain A when, in circumstances C, she tries to excellently develop and maintain A. On this account, a talent is not the skill itself, but a general iterated ability for the excellent development and up-keep of a particular skill, constituted by an agent’s dispositional properties. I defend the account against four objections usually levelled against traditional dispositionalist theories of ability, and highlight some ways the account may influence debates in other areas of philosophical inquiry. (shrink)

When is it a good time to think about time? The answer provided by this essay is that there is no time like the present, especially the crazy, tense present of the year 2020. In this year four distinct scales of temporality have collided in a prolonged period of crisis and uncertainty: (1) the onset of a global pandemic that devastated the world economy and killed over a million people, the worst public health disaster since the Spanish flu of 1918; (...) (2) a political crisis featuring the rise of authoritarian governments around the world that threatened to overturn two centuries of efforts to secure stable representative democracies, centered in the rise of a would-be tyrant and demagogue in the US; (3) an explosive social movement centered in the endemic condition of systemic racism in the US; (4) a global environmental crisis that threatens the stability of the planetary ecological system as a sustainable habitat for thousands of species, including the human. Quarantined in monkish isolation by the pandemic, the author has engaged in a set of reflections on these convergent time scales. Instead of the classic (and unanswerable) philosophical question “What is time?” this essay reflects on the ways we picture time in metaphors, figures, personifications, and diagrams. In an anachronistic gathering of images of time from ancient and modern sources, the essay attempts to replace the ontology of time with an iconology that may provide some useful tools for finding our way through this epochal crisis. (shrink)

In the last decade, the organization of pharmaceutical research on neglected tropical diseases has undergone transformative change. In a context of perceived “market failure,” the development of new medicines is increasingly handled by public-private partnerships. This shift toward hybrid organizational models depends on a particular form of exchange: the sharing of proprietary assets in general and of intellectual property rights in particular. This article explores the paradoxical role of private property in this new configuration of global health research and development. (...) Rather than a tool to block potential competitors, proprietary assets function as a lever to attract others into risky collaborative ventures; instead of demarcating public and private domains, the sharing of property rights is used to increase the porosity of that boundary. This reimagination of the value of property is connected to the peculiar timescape of global health drug development, a promissory orientation to the future that takes its clearest form in the centrality of “virtual” business models and the proliferation of strategies of deferral. Drawing on the anthropological literature on inalienable possessions, we reconsider property’s traditional exclusionary role and discuss the possibility that the new pharmaceutical “commons” proclaimed by contemporary global health partnerships might be the precursor of future enclosures. (shrink)

Many population axiologies avoid the Repugnant Conclusion by endorsing Superiority: some number of great lives is better than any number of mediocre lives. But as Nebel shows, RC follows from the Intrapersonal Repugnant Conclusion: a guaranteed mediocre life is better than a sufficiently small probability of a great life. This result is concerning because IRC is plausible. Recently, Kosonen has argued that IRC can be true while RC is false if small probabilities are discounted to zero. This article details the (...) unique problems created by combining Superiority with discounting. The resultant view, Superiority Discounting, avoids the Repugnant Conclusion only at the cost of the Preposterous Conclusion: near-certain hell for arbitrarily many people is better than near-certain heaven for arbitrarily many people. (shrink)

Local food systems are growing, and little is known about how the constellation of farms and markets change over time. We trace the evolution of two local food systems over six years, including a dataset of over 2690 market connections between 1520 locations. Longitudinal social network analysis reveals how the architecture, actor network centrality, magnitude, and spatiality of these supply chains shifted during the 2012–2018 time period. Our findings demonstrate that, despite growth in the number of farmers’ markets, grocery stores, (...) farms and restaurants in both counties, each local food system also experienced high turnover rates. Over 80% of the market connections changed during the study period. Farms, farmers’ markets, and grocery stores showed a 40–50% ‘survival’ rate, indicating their role in sustaining local food systems over longer time periods. Other actors, such as restaurants, had a much higher turnover rate within the network. Both food systems became more close-knit and consolidated as the center of gravity for both local food systems pulled away from urban areas toward rural farmland. Evidence of both growth and decay within local food systems provides a new understanding of the social networks behind local food markets. (shrink)