It is clear enough that utilitarianism contributed to the softening of many penal systems in the world by arguing that very cruel punishments should be excluded every time a less cruel one would be just as effective. But does utilitarianism as such oppose the death penalty ? It is well known that Beccaria and Bentham criticized capital punishment on utilitarian grounds. But the fact that John Stuart Mill held a speech in favour of the death penalty at the House of (...) Commons in 1868 suggests that there is no necessity for a utilitarian thinker to oppose it. Otherwise, it would be possible to claim that John Stuart Mill betrayed, so to speak, the principle of utility by defending such a punishment. But nothing, it seems, allows us to say so. On the contrary, we would like to suggest that Mill’s disagreement with Bentham and Beccaria originates from his own empirical judgement on the following question : is death penalty the most cruel punishment for murder ? In other words, whether we like it or not, there is no way we can hold that Mill was less faithful than Beccaria and Bentham to the principle of utility when supporting the death penalty. (shrink)

Dans The Subjection of Women (1869), Mill fait bien plus que prôner l’égalité civique des hommes et des femmes : il entreprend une véritable révolution épistémologique pour déconstruire les représentations naturalisantes du caractère féminin. S’il compare d’abord la condition des femmes à celle des esclaves, c’est pour ensuite l’en distinguer, car la persistance de l’inégalité des sexes est en contradiction avec les principes juridiques des sociétés modernes. Il est donc attentif à la situation singulière du problème de l’assujettissement des femmes (...) : il ne s’agit pas de chercher à faire une « révolution sociale au nom d’un droit abstrait », mais de déraciner les préjugés qui expliquent la permanence archaïque de l’inégalité des sexes. C’est l’occasion d’une réflexion sur la construction de la domination patriarcale comme habitude sociale, par l’influence de l’éducation sur le caractère féminin. (shrink)

John Stuart Mill est passé à la postérité pour deux de ses écrits emblématiques : De la liberté et De l’assujettissement des femmes. Moins connus sont ses discours au Parlement britannique et devant des associations féministes, mais non moins importants. En effet, on oublie bien souvent que JS Mill était non seulement un fonctionnaire de l’administration coloniale, mais aussi un philosophe, un homme politique et un militant. Les textes présentés par Benoît Basse permettent de mettre en lumièr...

Deux assomptions ont été faites au sujet du refus du Pape Pie XII à aller au-delà de condamnations génériques de l'Holocauste Nazi. 1. La politique était dictée par peur de représailles contre les Catholiques et les Juifs. 2. La peur de représailles contre les Juifs était essentiellement une excuse pour ne rien faire ou rester au niveau de condamnations génériques. Mais les organisations juives elles-mêmes ont souvent cité la peur de représailles contre les Juifs comme la raison d'une restrainte dans (...) les déclarations publiques. Bien que la peur des représailles fut un élément formatif de la politique diplomatique du Vatican, la politique n'est pas venue de la peur, comme on peut le voir de l'histoire de condamnations génériques en d'autres contextes de guerre où les atrocités furent en jeu, entre autres en Arménie sous Benoît XV, en Espagne et Abyssinie sous Pie XI, de même qu'en Pologne et en Russie sous Pie XII. Deux fois Benoît XV fit un appel direct au Sultan de Turquie, mentionnant les Arménians spécifiquement trois fois, parlant de «souffrances indicibles», mais sans mentionner des noms personnels, des noms de lieu, des dates, des batailles. Bien que la condamnation resta générique, Benoît XV est considéré un héro national Arménien. Pendant la guerre civile en Espagne les républicains «incontrôlables» ont assassiné plus de cinq mille prêtres, moines et séminaristes pendant les trois premiers mois de la guerre et à la fin de. (shrink)

IntroductionInternational sharing of health data opens the door to the study of the so-called ‘Big Data’, which holds great promise for improving patient-centred care. Failure of recent data sharing initiatives indicates an urgent need to invest in societal trust in researchers and institutions. Key to an informed understanding of such a ‘social license’ is identifying the views patients and the public may hold with regard to data sharing for health research.MethodsWe performed a narrative review of the empirical evidence addressing patients’ (...) and public views and attitudes towards the use of health data for research purposes. The literature databases PubMed, Embase, Scopus and Google Scholar were searched in April 2019 to identify relevant publications. Patients’ and public attitudes were extracted from selected references and thematically categorised.ResultsTwenty-seven papers were included for review, including both qualitative and quantitative studies and systematic reviews. Results suggest widespread—though conditional—support among patients and the public for data sharing for health research. Despite the fact that participants recognise actual or potential benefits of data research, they expressed concerns about breaches of confidentiality and potential abuses of the data. Studies showed agreement on the following conditions: value, privacy, risk minimisation, data security, transparency, control, information, trust, responsibility and accountability.ConclusionsOur results indicate that a social license for data-intensive health research cannot simply be presumed. To strengthen the social license, identified conditions ought to be operationalised in a governance framework that incorporates the diverse patient and public values, needs and interests. (shrink)

Despite the ever increasing collaboration between industry and universities, the previous empirical studies on research integrity and misconduct excluded participants of biomedical industry. Hence, there is a lack of empirical data on how research managers and biomedical researchers active in industry perceive the issues of research integrity and misconduct, and whether or not their perspectives differ from those of researchers and research managers active in universities. If various standards concerning research integrity and misconduct are upheld between industry and universities, this (...) might undermine research collaborations. Therefore we performed a qualitative study by conducting 22 semi-structured interviews in order to investigate and compare the perspectives and attitudes concerning the issues of research integrity and misconduct of research managers and biomedical researchers active in industry and universities. Our study showed clear discrepancies between both groups. Diverse strategies in order to manage research misconduct and to stimulate research integrity were observed. Different definitions of research misconduct were given, indicating that similar actions are judged heterogeneously. There were also differences at an individual level, whether the interviewees were active in industry or universities. Overall, the management of research integrity proves to be a difficult exercise, due to many diverse perspectives on several essential elements connected to research integrity and misconduct. A management policy that is not in line with the vision of the biomedical researchers and research managers is at risk of being inefficient. (shrink)

We regularly intentionally expose ourselves to fictions we take to be likely to elicit in us emotions we generally find unpleasant when prompted by actual states of affairs. This is the so-called “paradox of tragedy”. We contribute to solving the paradox of tragedy by denying that, when fiction-directed, most of these emotions are in themselves unpleasant. We first provide strong evidence that these emotions, such as fear, sadness, or pity, are often enjoyed when fiction-directed. We then advance an explanation of (...) what makes these fiction-directed emotions often not unpleasant, while their reality-directed counterparts are generally so. In the last section, we advance an explanation of what makes fiction-directed emotions often enjoyable, and argue that a complete solution to the paradox of tragedy should be pluralist. (shrink)

Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need (...) to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent. (shrink)

Formalised knowledge systems, including universities and research institutes, are important for contemporary societies. They are, however, also arguably failing humanity when their impact is measured against the level of progress being made in stimulating the societal changes needed to address challenges like climate change. In this research we used a novel futures-oriented and participatory approach that asked what future envisioned knowledge systems might need to look like and how we might get there. Findings suggest that envisioned future systems will need (...) to be much more collaborative, open, diverse, egalitarian, and able to work with values and systemic issues. They will also need to go beyond producing knowledge about our world to generating wisdom about how to act within it. To get to envisioned systems we will need to rapidly scale methodological innovations, connect innovators, and creatively accelerate learning about working with intractable challenges. We will also need to create new funding schemes, a global knowledge commons, and challenge deeply held assumptions. To genuinely be a creative force in supporting longevity of human and non-human life on our planet, the shift in knowledge systems will probably need to be at the scale of the enlightenment and speed of the scientific and technological revolution accompanying the second World War. This will require bold and strategic action from governments, scientists, civic society and sustained transformational intent. (shrink)

BackgroundAs the range of therapeutic options in the field of oncology increases, so too does the strain on health care budgets. The imbalance between what is medically possible and financially feasible is frequently rendered as an issue of tragic choices, giving rise to public controversies around health care rationing.Main bodyWe analyse the Norwegian media discourse on expensive cancer drugs and identify four underlying premises: (1) Cancer drugs are de facto expensive, and one does not and should not question why. (2) (...) Cancer drugs have an indubitable efficacy. (3) Any lifetime gained for a cancer patient is an absolute good, and (4) cancer patients and doctors own the truth about cancer. Applying a principle-based approach, we argue that these premises should be challenged on moral grounds. Within the Norwegian public discourse, however, the premises largely remain unchallenged due to what we find to be unjustified claims of moral superiority. We therefore explore alternative framings of the issue of expensive cancer drugs and discuss their potential to escape the predicament of tragic choices.ConclusionsIn a media discourse that has seemingly stagnated, awareness of the framings within it is necessary in order to challenge the current tragic choices predicament the discourse finds itself in. In order to allow for a discourse not solely concerned with the issue of tragic choices, the premises that underlie it must be subjected to critical examination. As the field of oncology advances rapidly, we depend on a discussion of its opportunities and challenges that is meaningful, and that soberly addresses the future of cancer care—both its potential and its limits. (shrink)

Eric Crégheur, Jeffery Aubin, Alice Fanguet, Gavin McDowell, Louis Painchaud, Paul-Hubert Poirier, Simon St-Arnault-Chiasson, Philippe Therrien, Benoît Tissot et Yann Vadnais.

What role does non-genetic inheritance play in evolution? In recent work we have independently and collectively argued that the existence and scope of non-genetic inheritance systems, including epigenetic inheritance, niche construction/ecological inheritance, and cultural inheritance—alongside certain other theory revisions—necessitates an extension to the neo-Darwinian Modern Synthesis (MS) in the form of an Extended Evolutionary Synthesis (EES). However, this argument has been challenged on the grounds that non-genetic inheritance systems are exclusively proximate mechanisms that serve the ultimate function of calibrating organisms (...) to stochastic environments. In this paper we defend our claims, pointing out that critics of the EES (1) conflate non-genetic inheritance with early 20th-century notions of soft inheritance; (2) misunderstand the nature of the EES in relation to the MS; (3) confuse individual phenotypic plasticity with trans-generational non-genetic inheritance; (4) fail to address the extensive theoretical and empirical literature which shows that non-genetic inheritance can generate novel targets for selection, create new genetic equilibria that would not exist in the absence of non-genetic inheritance, and generate phenotypic variation that is independent of genetic variation; (5) artificially limit ultimate explanations for traits to gene-based selection, which is unsatisfactory for phenotypic traits that originate and spread via non-genetic inheritance systems; and (6) fail to provide an explanation for biological organization. We conclude by noting ways in which we feel that an overly gene-centric theory of evolution is hindering progress in biology and other sciences. (shrink)

Les réseaux personnels sont des ensembles de relations interpersonnelles dans lesquelles les personnes sont engagées. Toutes les études sur ces réseaux montrent l’existence de variations dans leur taille et leur composition selon les indicateurs de hiérarchie sociale, le niveau d’études, la profession ou le revenu. Ces variations peuvent être interprétées comme des « inégalités relationnelles » dans la mesure où les relations sont des ressources essentielles pour de nombreux aspects de la vie sociale. Ces ressources jouent un rôle particulièrement important (...) pour les personnes âgées lorsqu’elles sont confrontées aux diverses difficultés liées au vieillissement. À partir d’une étude sur les parcours et les réseaux de 342 personnes de soixante ans et plus, cet article évalue l’évolution de ces inégalités relationnelles selon différents types de contenus relationnels associés aux questions sur les relations. Au-delà de ces variations, les inégalités tendent à s’accroître avec l’âge, notamment entre les personnes les moins diplômées et les autres, ce qui fait apparaître des temporalités différentes du « vieillissement relationnel ». (shrink)

The grand duchy of Luxembourg is a showcase example for the constructed nature of national identities. This book explores this construction process from the nineteenth to the twenty-first century, focusing on representations of the past, space and language.

Emotions are a natural vector for acting together with others and are witnessed in human behaviour, perception and body functions. For this reason, studies of human-to-human interaction, such as multi-person motor synchronisation, are a perfect setting to disentangle the linkage of emotion with socio-motor interaction. And yet, the majority of joint action studies aiming at understanding the impact of emotions on multi-person performance resort to enacted emotions, the ones that are emulated based on the previous experience of such emotions, and (...) almost exclusively focus on dyadic interaction. In addition, tasks chosen to study emotion in joint action are frequently characterised by a reduced number of physical dimensions to gain experimental control and subsequent facilitation in data analysis. Therefore, it is not clear how naturalistically induced emotions diffuse in more ecological interactions with other people and how emotions affect the process of interpersonal synchronisation. Here, we show that positive and negative emotions differently alter spontaneous human synchronous behaviour during a multi-person improvisation task. The study involved 39 participants organised in triads who self-reported liking improvisational activities. The task involved producing improvisational movements with the right hand. Participants were emotionally induced by manipulated social feedback involving a personal ranking score. Three-dimensional spatio-temporal data and cardiac activity were extracted and transformed into oscillatory signals to compute behavioural and physiological synchrony. Our results demonstrate that individuals induced with positive emotions, as opposed to negative emotions or a neutral state, maintained behavioural synchrony with other group members for a longer period of time. These findings contribute to the emerging shift of neuroscience of emotion and affective sciences towards the environment of social significance where emotions appear the most—in interaction with others. Our study showcases a method of quantification of synchrony in an improvisational and interactive task based on a well-established Kuramoto model. (shrink)

Taking regular walks when living with Parkinson’s disease has beneficial effects on movement and quality of life. Yet, patients usually show reduced physical activity compared to healthy older adults. Using auditory stimulation such as music can facilitate walking but patients vary significantly in their response. An individualized approach adapting musical tempo to patients’ gait cadence, and capitalizing on these individual differences, is likely to provide a rewarding experience, increasing motivation for walk-in PD. We aim to evaluate the observance, safety, tolerance, (...) usability, and enjoyment of a new smartphone application. It was coupled with wearable sensors and delivered individualized musical stimulation for gait auto-rehabilitation at home. Forty-five patients with PD underwent a 1-month, outdoor, uncontrolled gait rehabilitation program, using the BeatWalk application. The music tempo was being aligned in real-time to patients’ gait cadence in a way that could foster an increase up to +10% of their spontaneous cadence. Open-label evaluation was based on BeatWalk use measures, questionnaires, and a six-minute walk test. Patients used the application 78.8% of the prescribed duration and enjoyed it throughout the program. The application was considered “easy to use” by 75% of the patients. Pain, fatigue, and falls did not increase. Fear of falling decreased and quality of life improved. After the program, patients improved their gait parameters in the six-minute walk test without musical stimulation. BeatWalk is an easy to use, safe, and enjoyable musical application for individualized gait rehabilitation in PD. It increases “walk for exercise” duration thanks to high observance.Clinical Trial Registration: ClinicalTrials.gov Identifier: NCT02647242. (shrink)

We investigate the role of continuous reductions and continuous relativization in the context of higher randomness. We define a higher analogue of Turing reducibility and show that it interacts well with higher randomness, for example with respect to van Lambalgen’s theorem and the Miller–Yu/Levin theorem. We study lowness for continuous relativization of randomness, and show the equivalence of the higher analogues of the different characterizations of lowness for Martin-Löf randomness. We also characterize computing higher [Formula: see text]-trivial sets by higher (...) random sequences. We give a separation between higher notions of randomness, in particular between higher weak 2-randomness and [Formula: see text]-randomness. To do so we investigate classes of functions computable from Kleene’s [Formula: see text] based on strong forms of the higher limit lemma. (shrink)

Deep learning and other black-box models are becoming more and more popular today. Despite their high performance, they may not be accepted ethically or legally because of their lack of explainability. This paper presents the increasing number of legal requirements on machine learning model interpretability and explainability in the context of private and public decision making. It then explains how those legal requirements can be implemented into machine-learning models and concludes with a call for more inter-disciplinary research on explainability.

A tissue is a geometrical, space-filling, random cellular network; it remains in this steady state while individual cells divide. Cell division is a local, elementary topological transformation which establishes statistical equilibrium of the structure. We describe the physical conditions to maintain stationary the epidermis (of mammals or of the cucumber), in spite of the fact that cells constantly divide and die. Specifically, we study the statistical equilibrium of the basal layer, a corrugated surface filled with cells, constituting a two-dimensional topological (...) froth. Cells divide and detach from the basal layer, and these two topological transformations are responsible for the stationary state of the epidermis. The topological froth is capable of responding rapidly and locally to external constraints, and is a good illustration of the plasticity of random cellular networks.Statistical equilibrium is controlled by entropy, both as a measure of disorder and as information, and is characterized by observable relations between average cell shapes and sizes. The technique can be applied to any random cellular network in dynamical equilibrium. Mitosis as the dominating topological transformation and the fact that the distribution of cell shapes is very narrow are the only inputs specific to biology. (shrink)

Background Making appropriate end-of-life decisions in the intensive care unit (ICU) requires shared interprofessional decision-making. Thus, a decision-making climate that values the contributions of all team members, addresses diverse opinions and seeks consensus among team members is necessary. Little is known about religion’s influence on ethical decision-making climates. Therefore, this study aimed to examine the association between religious belief and ethical decision-making climates. Methods The study was a cross-sectional analytical observation study as a part of the prospective observational DISPROPRICUS study. (...) A total of 2,275 nurses and 717 physicians from 68 ICUs representing 12 countries in Europe and the US participated. All participants were asked which religion (if any) they belonged to and how important their religion (if any) was for their professional attitude towards end-of-life care. Perceptions of ethical decision-making climates were evaluated using a validated, 35-item self-assessment questionnaire that evaluates seven factors. Using cluster analysis, ICUs were categorised into four ethical decision-making climates: good, average (with nurses’ involvement at the end of life), average (without nurses’ involvement at the end of life) and poor. Results Of the 2,992 participants, 453 (15%) were religious (had religious convictions and found them important or very important for their attitude towards end-of-life care). The remaining 2,539 were non-religious (i.e. had religious convictions but assessed that they were not important for their attitude towards end-of-life care). When adjusting for country and ICU, the overall perception of the four ethical climates was associated with religious beliefs, with non-religious healthcare providers having more positive perceptions of the ethical climates compared to religious healthcare providers (p < 0.01). Within good climates, non-religious healthcare providers rated leadership by physicians (p < 0.01), interdisciplinary reflection (p = 0.049) and active decision-making by physicians (p = 0.02) as more positive compared to religious participants. In poor climates, religious healthcare providers had a more positive perception of the active involvement of nurses (p = 0.01). Within the other climates, no differences were found. Conclusions Overall perceptions of ethical decision-making climates were associated with religious beliefs, with non-religious healthcare providers generally having a more positive perception of the ethical climates than religious healthcare providers. (shrink)

Mucoidy and cytotoxicity arise from two independent modifications of the phenotype of the bacterium Pseudomonas aeruginosa that contribute to the mortality and morbidity of cystic fibrosis. We show that, even though the transcriptional regulatory networks controlling both processes are quite different from a molecular or mechanistic point of view, they may be identical from a dynamic point of view: epigenesis may in both cases be the cause of the acquisition of these new phenotypes. This was highlighted by the identity of (...) formal graphs modelling these networks. A mathematical framework based on formal methods from computer science was defined and implemented with a software environment. It allows an easy and rigorous validation and certification of these models and of the experimental methods that can be proposed to falsify or validate the underlying hypothesis. (shrink)

Contra Jackendoff, we argue that within the parallel architecture framework, the generality of language does not require a rich conceptual structure. To show this, we put forward a delegation model of specialization. We find Jackendoff's alternative, the subdivision model, insufficiently supported. In particular, the computational consequences of his representational notion of modularity need to be clarified.

The aim of this article was to provide experimental evidence that classical dissociation between levels of consciousness associated with memory retrieval can be explained in terms of task dependency and distinctiveness of traces. In our study phase, we manipulated the level of isolation of the memory trace by means of an isolation paradigm . We then tested these two types of isolation in a series of tasks of increasing complexity: a lexical decision task, a recognition task, and a free recall (...) task. The main result of this study was that distinctiveness effects were observed as a function of the type of isolation and the nature of the task. We concluded that trace distinctiveness improves subsequent access to the trace, while the level of trace distinctiveness also appears to determine the possibility of conscious or explicit retrieval. (shrink)