The ability to convert human somatic cells into induced pluripotent stem cells (iPSCs) is allowing the production of custom‐tailored cells for drug discovery and for the study of disease phenotypes at the cellular and molecular level. IPSCs have been derived from patients suffering from a large variety of disorders with different severities. In many cases, disease related phenotypes have been observed in iPSCs or their lineage‐specific progeny. Several proof of concept studies have demonstrated that these phenotypes can be reversed in (...) vitro using approved drugs. However, several challenges must be overcome to take full advantage of this technology. Here, we highlight recent advances in the field and discuss the main challenges associated with this technology as it applies to disease modelling. (shrink)

"Most modern philosophers attempt to solve the problem of morality from within the epistemological assumptions that define the dominant cultural perspective of our age. Alan Gewirth's Reason and Morality is a major work in this ongoing enterprise. Gewirth develops, with patience and skill, what he calls a 'modified naturalism' in which morality is derived by logic alone from the concept of action.... I think that the publication of Reason and Morality is a major event in the history of moral (...) philosophy. It develops with great power a new and exciting position in ethical naturalism. No one, regardless of philosophical stance, can read this work without an enlargement of mind. It illuminates morality and agency for all."—E. M. Adams, The Review of Metaphysics "This is a fascinating study of an apparently intractable problem. Gewirth has provided plenty of material for further discussion, and his theory deserves serious consideration. He is always aware of possible rejoinders and argues in a rigorous manner, showing a firm grasp of the current state of moral and political philosophy."—Mind. (shrink)

Cultures around the world have regarded self-fulfillment as the ultimate goal of human striving and as the fundamental test of the goodness of a human life. The ideal has also been criticized, however, as egotistical or as so value-neutral that it fails to distinguish between, for example, self-fulfilled sinners and self-fulfilled saints. Alan Gewirth presents here a systematic and highly original study of self-fulfillment that seeks to overcome these and other arguments and to justify the high place that the (...) ideal has been accorded. He does so by developing an ethical theory that ultimately grounds the value of self-fulfillment in the idea of the dignity of human beings.Gewirth begins by distinguishing two models of self- fulfillment--aspiration-fulfillment and capacity-fulfillment--and shows how each of these contributes to the intrinsic value of human life. He then distinguishes between three types of morality--universalist, particularist, and personalist--and shows how each contributes to the values embodied in self-fulfillment. Building on these ideas, he develops a Odialectical' conception of reason that shows how human rights are central to self-fulfillment. Gewirth also argues that self-fulfillment has a social as well as an individual dimension: that the nature of society and the obstacles that disadvantaged groups face affect strongly the character of the self-fulfillment that persons can achieve.Bold in scope and rigorous in execution, Self-Fulfillment is a powerful new contribution to moral, social, and political philosophy. (shrink)

What is health policy for? In Health and the Good Society, Alan Cribb addresses this question in a way that cuts across disciplinary boundaries. His core argument is that biomedical ethics should draw upon public health values and ethics; specifically, he argues that everybody has some share of responsibility for health, including a responsibility for promoting greater health equality. In the process, Cribb argues for a major rethink of the whole project of health education.

The rise of the field of “ experimental mathematics” poses an apparent challenge to traditional philosophical accounts of mathematics as an a priori, non-empirical endeavor. This paper surveys different attempts to characterize experimental mathematics. One suggestion is that experimental mathematics makes essential use of electronic computers. A second suggestion is that experimental mathematics involves support being gathered for an hypothesis which is inductive rather than deductive. Each of these options turns out to be inadequate, and instead a third suggestion is (...) considered according to which experimental mathematics involves calculating instances of some general hypothesis. The paper concludes with the examination of some philosophical implications of this characterization. (shrink)

One criticism of David Lewis's account of counterfactuals is that it sometimes assigns the wrong truth-value to a counterfactual when both antecedent and consequent happen to be true. Lewis has suggested a possible remedy to this situation, but commentators have found this to be unsatisfactory. I suggest an alternative solution which involves a modification of Lewis's truth conditions, but which confines itself to the resources already present in his account. This modification involves the device of embedding one counterfactual within another. (...) On the revised set of truth conditions, counterfactuals with true components are sometimes true and sometimes false, in a way that is more in keeping with our intuitive judgments about such statements. (shrink)

The authors develop an axiomatic theory of nonexistent objects and and give a formal semantics for the language of the theory.

When physicist Alan Sokal recently submitted an article to the postmodernist journal Social Text, the periodical's editors were happy to publish it--for here was a respected scientist offering support for the journal's view that science is a subjective, socially constructed discipline. But as Sokal himself soon revealed in Lingua Franca magazine, the essay was a spectacular hoax--filled with scientific gibberish anyone with a basic knowledge of physics should have caught--and the academic world suddenly awoke to the vast gap that (...) has opened between the scientific community and their mould-be critics. But the truth is that not only postmodern critics but Americans in general have a weak grasp on scientific principles and facts. In Connected Knowledge, physicist Alan Cromer offers a way to bridge the chasm, with a lively, lucid account of scientific thinking and a provocative new agenda for American education. Science, Cromer argues, is anything but common sense: It requires a particular habit of mind that does not come naturally. For example, something as simple as buoyancy can only be explained through Archimedes' principle--that a body in a fluid is subject to an upward force equal to the weight of fluid it displaces--yet few scientists could arrive at this ancient concept by trial and error. School children, however, are often given a ball and a tank of water, and asked to explain buoyancy any way they can. Today's de emphasis on teaching pupils necessary facts and principles, he argues, "far from empowering them, makes them slaves of their own subjective opinions." This movement in education, known as Constructivism, has close ties to postmodern critics (such as the editors of Social Text) who question the objectivity of science, and with it the existence of an objective reality. Cromer offers a ringing defense of the knowability of the world, both as an objective reality and as a finite landscape of discovery. The advance of scientific knowledge, he argues, is not unlike the mapping of the continents; at this point, we have found them all. He shows how the advent of quantum mechanics, rather than making knowledge less certain, actually offers a more precise understanding of the behavior of atoms and electrons. Turning from philosophy to education, he argues that instead of allowing students to flounder, however creatively, schools should follow a progressive curriculum that returns theoretical knowledge to the classroom. Connected Knowledge, however, goes much farther. As a discipline that insists upon connecting theory with measurable reality, physical science offers a new direction for reforming the social sciences. Cromer also shows how some of the hottest issues in public policy--including the debates over special education and group variations in I.Q., can be resolved through clear, hard headed thinking. For example, he argues for use of the G.E.D. as a national educational standard, with a new "politics of intelligence" to guide the distribution of school resources. Always forthright and articulate, Alan Cromer offers a startling new vision for integrating science, philosophy, and education. (shrink)

This paper discusses comparison classes—sets that relativize the interpretation of gradable adjectives, often specified with for-clauses as in John is smart for a linguist. Such a discussion ultimately lends support to the thesis that scales, degrees, measure functions, and linear orders are grammatically derived from more basic relations between individuals. Three accounts of comparison classes are compared and evaluated. The first proposes that such classes serve as an argument to a function that determines a standard of comparison. The second maintains (...) that these classes restrict the domain of a measure function used to map entities to degrees. The third proposes that these classes limit the kind of individuals that participate in a binary relation; this relation is then used in the construction of a scale and a measure function. It is this third account that is most consistent with the empirical data. It can explain how comparison classes fix a standard of comparison, induce presuppositions concerning the comparative subjects, and induce incommensurability in comparative constructions. (shrink)

Free marketeers claim that theirs is the only economic mechanism which respects and furthers human freedom. Socialism, they say, has been thoroughly discredited. Most libertarians treat the state in anything other than its minimal, 'nightwatchman' form as a repressive embodiment of evil. Some reject the state altogether. But is the 'free market idea' a rationally defensible belief? Or do its proponents fail to examine the philosophical roots of their so-called freedom? Anti-libertarianism takes a sceptical look at the conceptual tenets of (...) free market politics. Alan Haworth argues that libertarianism is little more than an unfounded, quasi-religious statement of faith: a market romance. Moreover, libertarianism is exposed as profoundly antithetical to the very freedom which it purports to advance. This controversial book is for anyone interested in the cultural and political impact of free market policies on the modern world. It will be invaluable to students and specialists of political and economic theory, social science and philosophy. (shrink)

An analysis of the collective engagement with the disease known as Alzheimer’s and the dementia reputed of it reveals recourse to a socially standardized formula that attributes causal agency to the brain in the absence of clinching knowledge. I propose that what Baudrillard calls the model of molecular idealism stipulates such a neurological view of determinism in order to provide caregivers with reassurance in the face of the perplexing character of dementia and the depressing reactions to mortality that it brings (...) to the surface. (shrink)

'In this book, Alan Roland has presented the challenge of Asian cultures to psychoanalytic theory and practice more forcefully than ever before. The book is full of new ideas and fascinating anecdotes and case material from Roland's clinical work and that of others. His proposals to revise psychoanalysis for the treatment of Indian and Japanese patients should initiate a debate of fundamental significance.' - Robert A. LeVine, Harvard University.

In the operating theater, the micro-politics of practice, such as interpersonal communications, are central to patient safety and are intimately tied with values as well as knowledge and skills. Team communication is a shared and distributed work activity. In an era of "professionalism," that must now encompass "interprofessionalism," a virtue ethics framework is often invoked to inform practice choices, with reference to phronesis or practical wisdom. However, such a framework is typically cast in individualistic terms as a character trait, rather (...) than in terms of a distributed quality that may be constituted through intentionally collaborative practice, or is an emerging property of a complex, adaptive system. A virtue ethics approach is a necessary but not sufficient condition for a collaborative bioethics within the operating theater. There is also an ecological imperative - the patient's entry into the household (oikos) of the operating theater invokes the need for "hospitality" as a form of ethical practice. (shrink)

‘Fascinating’, ‘brilliant’, ‘oddly moving’, ‘a warm human picture’ – this biography was enthusiastically received when it came out in 1957. And no wonder. It is not only the lively story of a distinguished man but a lucid account of his work and its significance. The author, who was himself a philosopher and journalist, has followed the bright thread of Russell’s personality with affectionate insight, from the three-day-old baby who looked about him ‘in a very energetic way’, and the boy who (...) jibbed at taking Euclid on trust, through the many turns of his life, to the undimmed octogenarian, still questioning and still deeply concerned. The subject is a great one and the biographer has matched it. (shrink)

: In earlier work, Bernard R. Goldstein and the present author have introduced a procedural rule for historical inquiry, which requires that one take pains to establish the credibility of any citation of ancient thought by later writers in antiquity through a process of verification. In this paper, I shall apply what I call the Rule of Ancient Citations to Simplicius' interpretation of Aristotle's remarks in Meta L. 8, which is the primary point of departure for the modern understanding of (...) Greek planetary theory. I first sketch several lines of argument that lead me to conclude that Simplicius' interpretation should not be accepted because it assumes a concern with planetary phenomena unknown to the Greeks before the late 2nd and early 1st centuries BC. Then, after showing that there is a fairly well defined range of readings of Aristotle's remarks more in keeping with what we actually know of astronomy in the 5th and 4th centuries BC, I conclude that neither Aristotle's report about the Eudoxan and Callippan accounts of the celestial motions nor Simplicius' interpretation of this report is a good starting point for our understanding of early Greek planetary theory. (shrink)

The fundamental causal concept in Chisholm's theory of agency is that of causally contributing to, a generic concept covering both event-causal contributors and agent-causal contributors. Chisholm's elucidation of agent-causation is explored and defended against objections. It is then argued that Chisholm's ontology, in particular in its treatment of the concept of an evert, generates difficulties for his theory of agency oi which two are explored: that it is hard to reconcile with Chisholm's own apparent analysis of the distinction between intentional (...) and unintentional actions; and that it entails that every causal contributing has an infinite set of causal contributors, which is in conflict with the principle that any set of nonredundant conditions that are jointly sufficient for the occurrence of an event are so by the nature of things, and not by virtue of some further event. (shrink)

Let φ be a monadic second order sentence about a finite structure from a class K which is closed under disjoint unions and has components. Compton has conjectured that if the number of n element structures has appropriate asymptotics, then unlabelled (labelled) asymptotic probabilities ν(φ) (μ(φ) respectively) for φ always exist. By applying generating series methods to count finite models, and a tailor made Tauberian lemma, this conjecture is proved under a mild additional condition on the asymptotics of the number (...) of single component K-structures. Prominent among examples covered, are structures consisting of a single unary function (or partial function) and a fixed number of unary predicates. (shrink)

This book, first published in 1978, is a radical approach to the philosophical distinction between Being and beings, in which the life of Socrates is used as the metaphor for the theoretical life, in contrast to the continuous historical interest in that life as an object for biographical reconstruction and description. Professor Blum's main concern is to develop a story that coordinates stages of the theoretical life to practices which exemplify man's ideal relationship with language.

This article examines the role of dissection in the teaching of secondary biology and environmental science, within the context of the development of attitudes toward animals. Retrospective data concerning their experience in high school with dissection for 191 undergraduate education students are described, and their reported use of alternatives to invasive animal study are evaluated in relation to specific educational objectives in secondary science. It was found that most students were required to perform dissections, that many but not most experienced (...) negative and stable emotional reactions, and that teachers employed limited alternatives to dissection in their classes. The implications of this for secondary science teaching and for teacher education are discussed. (shrink)

This paper aims to elucidate the meanings of the concept of modernity, highlighting its contradictory core and the theoretical and practical implications of this contradiction. To this end, we turn to the works of the German philosopher Immanuel Kant (1724-1804), as a paradigmatic intellectual expression of modernity, insofar as the author highlights notions that seem central to understanding the specificity of his time, which are brought together in his reflections on history and human progress, in the context of the enlightenment (...) that is struggling to become effective. We believe it is possible to extract from these reflections an idea of utopia which, although it needs to be cleansed of certain idealistic excesses, ends up representing a perspective that dialogues with Critical Theory, notably with Theodor Adorno (1903-1969). Although he demonstrates the bankruptcy and limits of the philosophical categories that authors such as Kant used to think about modernity, he doesn't discard the concepts in question, but rather puts them under tension, ultimately aiming to unveil the prospects for emancipation from the administered world, which, in the final analysis, have always been present at the heart of modern thought. (shrink)

From a national U.S. sample of senior academic biochemists, ninety-four indicated that they personally knew of an incident of scientific wrongdoing. Among these individuals, less formal actions against an offending individual were endorsed when either actions were believed to have the potential to publicly embarrass the offending individual, or the actions might adversely affect the professional career of the whistleblower. These relationships remain significant after controlling for professional status, career age, and current level of formal departmental administrative responsibility. Study limitations (...) and implications are discussed. (shrink)

A pigeon has been conditioned to peck at red objects and has also been conditioned to peck at triangular objects. The pigeon is now presented with a red triangle and pecks. In virtue of which of the object's properties did the pigeon peck? I argue that the disjunctive property "red or triangular" best answers this question and that this in turn gives us reason to admit such disjunctive properties to our ontology. I also show how the criterion for causal efficacy (...) that I employ, expressed in terms of counterfactual conditionals, works to preclude spurious disjunctive properties from counting as efficacious. (shrink)

New Perspectives on Aristotle'sDe caelo (Leiden) 139-161. Machamer, PK (1978) " Aristotle on Natural Place and Motion" Isis 69: 377-387. ...

: The Hellenistic reception of Babylonian horoscopic astrology gave rise to the question of what the planets really do and whether astrology is a science. This question in turn became one of defining the Greco-Latin science of astronomy, a project that took Aristotle's views as a starting-point. Thus, I concentrate on one aspect of the various definitions of astronomy proposed in Hellenistic times, their demarcation of astronomy and physical theory. I explicate the account offered by Geminus and its subordination of (...) astronomy to arguments made in physical theory about what really is the case. I then show how Ptolemy treats the same topic but maintains that this science is sufficient on its own to determine the realia it studies. In this way, I identify two moments in an obvious process of intellectual change that had profound consequences for the history of astronomy and cosmology over the next 1500 years. My hope is that this will advance our understanding of the reception of horoscopic astrology in Hellenistic times and also serve to locate Ptolemy more fully in his intellectual context. (shrink)

The rapid development of biobanks internationally reflects the considerable expectations attached to the exploitation of genetics knowledge. However, establishing consent and legitimacy for the new generation of biobanks is not without its challenges because they tend to be prospective in nature, involving the collection of DNA, personal medical and lifestyle data generally held over a very long period of time for unspecified research purposes. Thus far, biobanks have tended to be established ahead of wide-ranging debate about their broad implications. Making (...) specific reference to the 'engagement' processes employed by UK Biobank during its establishment phase, this article focuses on the politics of 'public engagement'. It examines the context of arguments for 'public engagement', drawing attention to how particular approaches to 'engagement' within biobank projects may serve to limit debate on substantive questions arising from their development. Unless biobanks' 'engagements' substantially involve publics in deliberations about their development, it is argued, publics are likely to become distrustful of projects and perhaps resist other similar population-based health initiatives in the future. (shrink)

The book contends that the digression ending Simplicius’ In de caelo 2.12 is not a proper history of early Greek planetary theory, but a creative atempt to show that to accept Ptolemy’s planetary hypotheses one need not repudiate Aristotle’s argument that the cosmos is eternal.

The views on race expressed by Hume in a footnote appended to his essay ‘Of National Characters’ seem so egregiously misguided that the suspicion has developed among some commentators that his fundamental philosophical outlook may be inextricably intertwined with a host of deeply pejorative racist assumptions that serve to encourage a pervasive pattern of exploitative and oppressive actions directed against people of colour. This paper, in contrast, argues that predominant thrust of Hume’s account of human nature is towards emphasizing the (...) psychological similarities manifest by all healthy human beings, irrespective of biological sex or alleged racial affiliations: from Hume’s perspective, white Europeans and people of colour are separated by much less than they have in common. It is, moreover, Hume’s acknowledgement of the characteristics that all human beings have in common that motivates his forceful criticisms of the practice of chattel slavery. Basing his judgement on his appreciation of our shared humanity, Hume condemns slavery as a practice that cannot be reconciled with any legitimate set of moral sentiments. (shrink)

In his A Theory of Justice, John Rawls suggests that a society's notion of justice informs its distribution of rights, obligations, and goods. For him, "justice as fairness" ensures that the principles dictating this distribution be agreed upon fairly. I will argue that there is no exact parallel in the Chinese tradition to what Rawls is calling "justice as fairness." Instead, we see serving a similar purpose an emphasis on the regulation of harmonious processes within the body of society. This (...) can be seen in the use of the Chinese word zhi (ÖÎ) to refer both to governing and to healing. In this sense, Chinese ideas about justice seem to come closer to Plato than to Rawls. (shrink)