The ability to convert human somatic cells into induced pluripotent stem cells (iPSCs) is allowing the production of custom‐tailored cells for drug discovery and for the study of disease phenotypes at the cellular and molecular level. IPSCs have been derived from patients suffering from a large variety of disorders with different severities. In many cases, disease related phenotypes have been observed in iPSCs or their lineage‐specific progeny. Several proof of concept studies have demonstrated that these phenotypes can be reversed in (...) vitro using approved drugs. However, several challenges must be overcome to take full advantage of this technology. Here, we highlight recent advances in the field and discuss the main challenges associated with this technology as it applies to disease modelling. (shrink)

Bilder spielen in allen Schulfächern immer schon eine zentrale Rolle. Die intellektuellen Energien, die in den Bildungs- und Erziehungswissenschaften aufgewendet werden, um Fragen des Einsatzes von Bildern zu beantworten, wirken daher beachtlich. Eingeklammert bleiben dabei bisher jedoch Phänomene der Unsichtbarkeit, obwohl sie grundlegend für alles Bildliche sind. Denn sie gehören zu jener Dimension, die wir als "latent" bezeichnen. Eine Auseinandersetzung mit den Funktionen von Bildern in Lehrkontexten kann deshalb nur erfolgreich sein, wenn die philosophischen Debatten über "Latenz", die zwischen dem (...) Zeitalter der Aufklärung und dem frühen 21. Jahrhundert stattgefunden haben, Eingang in die bildungswissenschaftliche Theoriebildung finden. (shrink)

This study addresses the social aspect of the duty of pilgrimage through the documentation method based on sociological perspective. The aim of this paper is to determine the social gains of people through the pilgrimage. Religion is an phenomenon that people need in every aspect of their daily life. Because religion is one of the phenomenon that deeply affect the individual and society. The pilgrimage, which is one of the sociological expressions of religion, and maintains its existence in the form (...) of creed, worship and religious community, is instrumental in strengthening and consolidating the faith and feeling the feelings of brotherhood. For instance; spiritual fundamentals of integration are based on Quran by means of worships such as salaat, fasting and alms with the pilgrimage as well as the messages serving as guidance for socio-cultural integration. In accordance with this, worships, with its psychological effects, lead people to attain social aspects such as brotherhood, solidarity, protecting each other, enduring and overcoming distresses together, accomplishing societal sharing by meeting on the common ground of benefaction in the establishment and subsistence of the Islamic community. The pilgrimage, on that sense, is required to have its principal qualification once more in where the historical, social, political and economic issues of the Islamic world are discussed and solutions addressing such issues are delivered accordingly. Therefore, the pilgrimage is not expected to only affects the individuals, families, groups but also regulates the national and transnational lives of societies. (shrink)

Miguel Angel Muñoz brings together in this book several inteviews he made over more than two decades in England, France, Spain and Mexico. These conversations complete and close a cycle, not of creation, but of the exercise of conversing with multiple creators: poets, historians, anthropologists and novelists. These are works that he believes coincide in an identical aesthetic conviction: they insist on concern not only for creativity but also for the complex social and cultural history that we live in the (...) world of yesterday and today. (shrink)

ObjectivesTo examine implicit and explicit attitudes toward gay men and lesbian women among heterosexual undergraduate and graduate psychology and nursing students.MethodsImplicit attitudes were measured via the Implicit Association Test and explicit attitudes via the Attitudes Toward Lesbian Women and Gay questionnaire.Main resultsAll groups held negative implicit attitudes toward gay men and lesbian women. Among undergraduates, nursing students reported holding more negative explicit attitudes toward gay men and lesbian women than psychology students.ConclusionThe curricula in both nursing and psychology studies need to (...) address the medical and paramedical needs and issues of sexual minorities. (shrink)

In a world of glossy corporate social responsibility reports, the shallowness of the actual CSR results may well be its counterpart. We claim that the possible gaps between aspirations and implementations are due to the company's overrating abilities to deal with the irrational and complex moral world of business. Many academic approaches aim to lift business ethics up to a higher level by enhancing competences but will fail because they are too rationalistic and generalistic to match the pluralistic and situational (...) practice constituted by the mosaic of values and set of constraints. This is demonstrated by describing and analyzing the CSR development of the multinational caterer Sodexo and in particular its Dutch branch. We explain what they do and why they are not successful. We present a new tool named Ethical Room for Maneuver that centers experiences and concrete situations in a playground of inquiry and experiment to enhance abilities to operate in themoral world and to meliorate business and society with more effectiveness. (shrink)

The main purpose of this article is to bring Ragin’s recent methodological contributions, which build on ideas borrowed from fuzzy logic, to the attention of management scholars. To demonstrate the possible use of the techniques developed by Ragin in management research, three specific examples for their likely applications are presented: the replications of Porter’s diamond framework for Turkey, Greece and Canada. The article concludes that Ragin’s systematic techniques prove helpful in making explicit the process of comparing qualitative evidence derived from (...) case study research, and thus they deserve greater attention in the management literature. (shrink)

The debate about the use of robots in the care of older adults has often been dominated by either overly optimistic visions (coming particularly from Japan), in which robots are seamlessly incorporated into society thereby enhancing quality of life for everyone; or by extremely pessimistic scenarios that paint such a future as horrifying. We reject this dichotomy and argue for a more differentiated ethical evaluation of the possibilities and risks involved with the use of social robots. In a critical discussion (...) surrounding the capabilities approach to the ethical evaluation of quality of life, we develop an ethical framework that is more appropriate to the situation of the oldest old. We urge employment of a context-dependent approach to the ethical evaluation of new technologies in the care and therapy of older adults, and using the example of the robotic seal Paro, we show how this can be accomplished in a sensible and practical way. (shrink)

This article studies the role of entrepreneurship in business ethics and promotes a resource-based ethics. The need for and usefulness of this form of ethics emerge from an analysis of contemporary business ethics that appears to be inefficacious and from a moral business practice formed out of the relationship between the veal calf industry of the VanDrie Group and the Dutch Society for the Protection of Animals in their development and implementation of a Welfare Hallmark for calves. Both organizations created (...) jointly a new meat segment in the market by trust-building and partnership. The relationship shows a remodeling of capabilities of both organizations in the light of co-creation of values. The VanDrie Group established an effectuation of moral goals by being socially sensitive and resource-minded. The DSPA created openings for dialogue by being pragmatic in its ideals. Philosophically, this article sketches a resource-based ethics with Deweyan concepts as end-in-view and transactionality of means and ends. Both organizations show in their entrepreneurship the ability to create, what is called "Room for Maneuver" by exploring, socializing, individualizing, and growing. By maneuvering they set off a form of co-evolution between business and ethics. This article demonstrates what actual moral entrepreneurship can do in bringing about moral change by combining effectively social, policy, norm, and economic related values. (shrink)

Includes 2 texts: Lucio Anneo Seneca, by Juan Fernando Ortega Muñoz, and Andaluces universales, by Francisco García Bazán.

Various aspects of the relationship between ethical climate types and organizational commitment have been examined, although a relationship with the concept of bullying, which may be very detrimental to an organization, has not attracted significant attention. This study contributes to the existing research by taking the effects of bullying behaviour into consideration. The aim of this study is to explore the effects of bullying behaviour upon the relationship between ethical climate types and organizational commitment. It will be noted that work-related (...) bullying behaviour significantly mediated the relationship between instrumentality climate and two of the dimensions of organizational commitment. Significant relationships between ethical climate dimensions and organizational commitment can also be detected. By emphasizing a required ethical climate dimension for organizations this study therefore presents in outline a partial strategy to reduce bullying behaviour and to increase organizational commitment. (shrink)

Building blocks are practical materials for playing, learning, and working at kindergartens, schools, universities, and companies. This study explores the historical implications of particular sets of building blocks in the interdisciplinary consolidation and transformation of techniques, materials, discourses, and subjects.

¿Qué relación existe entre el cine y la filosofía, entre la narración y el pensamiento, entre la imagen y el concepto? ¿Qué tipo de conocimiento puede ofrecer el cine? ¿Qué quiere el cine de la filosofía? ¿Y la filosofía del cine? ¿Puede hacerse filosofía a través del cine o toda la filosofía que se hace es siempre una proyección de filosofía que no tiene nada que ver con el cine ni con las películas? ¿Puede el cine hacer algo más que (...) ilustrar ideas filosóficas previas? ¿Pueden los cineastas transmitir con sus películas ideas filosóficas originales? ¿Existe un pensamiento cinematográfico que se resiste a ser traducido al lenguaje conceptual? ¿Qué han dicho los filósofos sobre el cine? (shrink)

"El pensador vagabundo. Estudios sobre Walter Benjamin", de varios autores, más que un libro es un homenaje a la obra de este gran pensador nominado como uno de los más valiosos e influyentes escritores de la humanidad. Walter Benjamin dejó por escrito miles de páginas que trataban de todo lo posible, hablando desde su infancia hasta el cambio que produjo la fotografía en el mundo artístico. Estos textos tienen el propósito de acercar al lector a este magnífico mundo del pensamiento (...) de Walter Benjamin. Los autores van entrelazando las ideas de este filósofo con sus seguidores más lucidos del ámbito de las humanidades, y así construyen un collage de la obra de Walter Benjamin, que por un lado nos acerca a su comprensión de los conceptos básicos, como por ejemplo, el de la historia y, en cambio, por otro establecen semejanzas entre sus escritos y el arte de Andy Warhol o Roberto Bolaño. (shrink)

No tenim temps per a res. La família, els amics, l’esport o altres dèries sempre queden en un segon pla. També el cultiu del pensament, que suposadament és una de les coses que identifica més i millor la nostra espècie, resta a l’espera. La pressa ens aclapara. En aquest context precipitat necessitem temps per descobrir el temps. Un oasi de pensament que comencem a explorar gràcies a parar atenció aquí i allà: ressenyem les observacions resultants, plantegem sengles qüestions estimulants i (...) esmolem el senderi amb l’exercici compartit d’enraonar, altrament conegut com a diàleg. No en va Ramon Llull augurava taxatiu que: “Pensar per un mateix és l’únic projecte a la vida”. (shrink)