The precarious rights of senior citizens, especially those who are highly educated and who are expected to counsel and guide the younger generations, has stimulated the creation internationally of advocacy associations and opinion leader groups. The strength of these groups, however, varies from country to country. In some countries, they are supported and are the focus of intense interest; in others, they are practically ignored. For this is reason we believe that the creation of a network of all these associations (...) is essential. The proposed network would act as a support for the already-existing policies of the United Nations’ High Commission for Human Rights, of independent experts, and of the Global Alliance for the Rights of Older People. All three have long ago recommended the creation of a recognized instrument for uniting presently scattered efforts. The proposed network, therefore, will seek to promote the international exchange of relevant expertise, and it will reinforce the commitments and actions that single countries are currently taking to meet these objectives. For example, informative public events can be organised to promote particular support initiatives and to provide an opportunity for new members of the network to be presented. The network will promote health for senior citizens, disease prevention, senior mobility, safe free time for seniors, alimentary education, protection against new risks and dangers, as well as equity in the services necessary for seniors to adopt new information and communication technologies. In the case of retired academic members, the network will promote equality with respect to continuing use of digital technologies (particularly email), continuing access to research libraries, and the guaranteed ability for seniors to fund their own research programs and to deliver free seminars. (shrink)

Aspiration by Agnes Callard locates standing assumptions in the theory of rationality, moral psychology and autonomy that preclude the possibility of working to acquire new values. The book also explains what changes need to be made if we are to make room for this form of agency, which I call aspiration.

A lively debate in the literature on moral progress concerns the role of practical reasoning: Does it enable or subvert moral progress? Rationalists believe that moral reasoning enables moral progress, because it helps enhance objectivity in thinking, overcome unruly sentiments, and open our minds to new possibilities. By contrast, skeptics argue that moral reasoning subverts moral progress. Citing growing empirical research on bias, they show that objectivity is an illusion and that moral reasoning merely rationalizes pre-existing biased moral norms. In (...) this article, I argue that both the rationalists and the skeptics fail to understand fully the role of practical reasoning by focusing exclusively on moral reasoning to the neglect of social reasoning. In the first half of the article, I argue against the skeptics by vindicating moral reasoning. I identify a Democratic Model of moral reasoning which is reliable and effective in overcoming bias. In the second part of the article, I argue against the rationalists. Drawing on a paradigmatic case of moral progress, i.e., the British abolition of the slave trade, I illustrate that moral reasoning, even when sound, is insufficient to motivate progressive action. The explanation for this puzzling phenomenon is not that the moral norm against cruelty is inert, as skeptics might suggest. Rather, it is that the moral norm against cruelty was overridden by the social norm of slavery which was tied to the British joint commitments to freedom and national honour. The debate between rationalists and skeptics centers around the moral rationality of human action, failing to recognize that human action is in fact primarily about social rationality. I defend a joint commitment account of social rationality, and offer a novel Communitarian Model of social reasoning which follows the logic of social rationality to revise social norms. I defend the reliability and efficacy of the Communitarian Model of social reasoning by applying it to the abolitionist social movement to show how Britons gave fellow Britons social reasons grounded in their joint commitments to freedom and national honour to end slavery. (shrink)

We study the process of observation (measurement), within the framework of a “perspectival” (“relational,” “relative state”) version of the modal interpretation of quantum mechanics. We show that if we assume certain features of discreteness and determinism in the operation of the measuring device (which could be a part of the observer's nerve system), this gives rise to classical characteristics of the observed properties, in the first place to spatial localization. We investigate to what extent semi-classical behavior of the object system (...) itself (as opposed to the observational system) is needed for the emergence of classicality. Decoherence is an essential element in the mechanism of observation that we assume, but it turns out that in our approach no environment-induced decoherence on the level of the object system is required for the emergence of classical properties. (shrink)

The ecological approach to object pretend play, developed from the ecological perspective, suggests an action- and affordance based perspective to account for pretend object play. Theoretical, as well as empirical reasons, support the view that children in pretense incorporate objects into their play in a resourceful and functionally appropriate way based on the perception of affordances. Therefore, in pretense children are not distorting reality but rather, they are perceiving and acting upon action possibilities. In this paper, we argue for the (...) viability of an ecological theoretical framework to pretend object play which has been traditionally understood as a representational and metarepresentational ability. We discuss the origins and basic assumptions of the ecological approach to pretense. We layout details by presenting a qualitative analysis of a pretend play episode and discuss the results of an experimental study inspired by the ecological assumptions. We discuss pretend object play in the context of ecological work on tool use. We address the relationship between the enactive and the ecological approaches to pretend play, pointing out similarities as well as differences. We conclude that ecological and enactive approaches have shown that it is possible to challenge accepted interpretations and seek explanatory frameworks that could move the field in new directions. (shrink)

Freud, Psychoanalysis and Symbolism offers an innovative general theory of symbolism, derived from Freud's psychoanalytic theory and relocated within mainstream scientific psychology. It is the first systematic investigation of the development of Freud's treatment of symbolism throughout his published works, and discovers in those writings a broad theory which is far superior to the widely accepted, narrow, 'official' view. Agnes Petocz argues that the treatment of symbolism must begin with the identification and clarification of a set of logical constraints and (...) psychological requirements which any general theory of symbolism must respect, and that these requirements have been neglected by existing accounts across a number of disciplines. Her newly proposed 'Freudian broad' theory of symbolism, by contrast, does meet these requirements, but only after it has been rehabilitated within a revised psychoanalytic context, encompassing major changes to our understanding of the concepts of unconscious and repression and the role of language. (shrink)

Objections to the use of historical case studies for philosophical ends fall into two categories. Methodological objections claim that historical accounts and their uses by philosophers are subject to various biases. We argue that these challenges are not special; they also apply to other epistemic practices. Metaphysical objections, on the other hand, claim that historical case studies are intrinsically unsuited to serve as evidence for philosophical claims, even when carefully constructed and used, and so constitute a distinct class of challenge. (...) We show that attention to what makes for a canonical case can address these problems. A case study is canonical with respect to a particular philosophical aim when the features relevant to that aim provide a reasonably complete causal account of the results of the historical process under investigation. We show how to establish canonicity by evaluating relevant contingencies using two prominent examples from the history of science: Eddington’s confirmation of Einstein’s theory of general relativity using his data from the 1919 eclipse and Watson and Crick’s determination of the structure of DNA. (shrink)

This paper seeks to determine the extent to which individuals with borderline personality disorders can be held morally responsible for a particular subset of their actions: disproportionate anger, aggressions and displays of temper. The rationale for focusing on these aspects lies in their widespread acknowledgment in the literature and their plausible primary association with blame directed at BPD patients. BPD individuals are indeed typically perceived as “difficult patients” (Sulzer 2015, Bodner et al. 2011), significantly more so than schizophrenic or depressive (...) patients (Markam 2003). The “responsibility question” for patients with BPD has already been raised (Martin 2010, Zachar & Potter 2009, Bray 2003), but this paper tackles it from a novel perspective. First, I narrow down the category of things for which the responsibility question is specific to individual with BPD. After that, I argue that some of the diagnosis criteria of BPD such as emotional instability or impulsivity might serve as excusing factors targeting the “control condition” on moral responsibility. Second, this paper also considers another widely accepted condition on moral responsibility: the epistemic condition. The view defended in the paper is that the answer to the responsibility question for individuals with BPD, concerning both the control condition and the epistemic condition, hinges on an understanding of their epistemic profile. (shrink)

Agnès Bastit | : La présente contribution s’intéresse au micro-récit évangélique transmis par les Synoptiques et l’Évangile selon Thomas, qui met en scène un conflit pour la soustraction de « biens » à un « Fort » qui les détient. L’étude s’adonne dans un premier temps à une analyse des diverses formes textuelles sous lesquelles cet apologue a initialement circulé, puis à une enquête sur les diverses lectures et utilisations théologiques du thème dans l’oeuvre d’Irénée à la fin du iie (...) siècle et, au-delà, de quelques-uns de ses contemporains ou continuateurs. Du point de vue du panorama de la présence du verset et de l’histoire de son interprétation dans l’Église ancienne, la recherche a tendu à être exhaustive en ce qui concerne les trois premiers siècles, mais reste indicative pour les quatrième et cinquième siècles. La diffusion du récit dans l’Église ancienne est liée à sa fonction kérygmatique : l’économie de la rédemption de l’homme, injustement détenu par le diable, s’y trouve représentée par une action simple et efficace, reliant la vivification ultime de l’homme à sa formation puis captivité initiales, à travers le moment décisif de la libération de l’homme. | : This presentation deals with a microstory — passed down by the Synoptic gospels and the Gospel of Thomas — about a conflict due to the plundering of the “goods” possessed by a “strong one”. Our study begins with an analysis of the different textual forms in which this story circulated initially ; there follows an investigation into the various theological readings and uses of that theme in Irenaeus’s work at the end of the 2nd century, and also in the works of some of his contemporaries or later upholders of his theses. As for the general presence of that verse and the history of its interpretation in the ancient Church, research has been fairly exhaustive with regard to the first three centuries, but it remains only indicative for the 4th and 5th centuries. The propagation of that story in the ancient Church is closely related to its kerygmatic function : a simple, efficacious act sums up the economy of redemption, the rescue of man unjustly kept prisoner by the devil ; thus the story connects the ultimate revitalisation of man to his initial formation and subsequent captivity by recalling the decisive moment of man’s liberation. (shrink)

This article presents a developmental ecological approach to the emergence and development of metaphor in children, based on the ecological psychology tradition following the work of J.J. Gibson, and its extension into developmental research and theory, as developed by E.J. Gibson and others. This framework suggests that a basic compatibility and meaningfulness exists between the knower and the known, based on the direct perception of affordances. To build an ecological understanding of metaphor we need to clarify how this metaphysical ground (...) plays out in acts of knowing that involve metaphor. In this endeavor, it is important to understand the ontogenesis of novel insightful metaphors and the role of perception. Developmental ecological psychology has repeatedly shown that infants can perceive meta-modal invariants that specify persistence of qualities. Early metaphors are consequences of the process in which invariants over naturally occurring kinds are perceived. Thus, novel metaphor production is an act of situated and experience-dependent perceiving and acting in the ecological world of socially shared meanings. Examples from previous experimental and qualitative research are reviewed to substantiate theoretical claims. (shrink)

Standard dual-process models in the action domain postulate that stimulus-driven processes are responsible for suboptimal behavior because they take them to be rigid and automatic and therefore the default. We propose an alternative dual-process model in which goal-directed processes are the default instead. We then transfer the dual- process logic from the action domain to the emotion domain. This reveals that emotional behavior is often attributed to stimulus-driven processes. Our alternative model submits that goal-directed processes could be the primary determinant (...) of emotional behavior instead. We evaluate the type of empirical evidence required for validating our model and we consider implications of our model for behavior change, encouraging strategies focused on the expectancies and values of action outcomes. (shrink)

Many appraisal theories claim that appraisal causes emotion. Critics have rejected this claim because they believe (a) it is incompatible with the claim that appraisal is a part of emotion, (b) it is not empirically supported, (c) it is circular and hence nonempirical, and (d) there are alternative causes. I reply that (a) the causal claim is incompatible with the part claim on some but not all interpretations of the causal claim and the part claim, (b) the lack of empirical (...) support can be remedied, (c) there may even be ways to cope with the circularity problem, and (d) it is unclear to what extent the alternative causes differ from appraisal. (shrink)

BackgroundInformed consent as stipulated in regulatory human research guidelines requires that a volunteer is well-informed about what will happen to them in a trial. However researchers are faced with a challenge of how to ensure that a volunteer agreeing to take part in a clinical trial is truly informed. We conducted a qualitative study among volunteers taking part in two HIV clinical trials in Uganda to find out how they defined informed consent and their perceptions of the trial procedures, study (...) information and interactions with the research team.MethodsBetween January and December 2012, 23 volunteers who had been in the two trials for over 6 months, consented to be interviewed about their experience in the trial three times over a period of nine months. They also took part in focus group discussions. Themes informed by study research questions and emerging findings were used for content analysis.ResultsVolunteers defined the informed consent process in terms of their individual welfare. Only two of the volunteers reported having referred during the trial to the participant information sheets given at the start of the trial. Volunteers remembered the information they had been given at the start of the trial on procedures that involved drawing blood and urine samples but not information about study design and randomisation. Volunteers said that they had understood the purpose of the trial. They said that signing a consent form showed that they had consented to take part in the trial but they also described it as being done to protect the researcher in case a volunteer later experienced side effects.ConclusionVolunteers pay more attention during the consent process to procedures requiring biological tests than to study design issues. Trust built between volunteers and the research team could enhance the successful conduct of clinical trials by allowing for informal discussions to identify and review volunteers’ perceptions. These results point to the need for researchers to view informed consent as a process rather than an event. (shrink)

Agnes Arber's international reputation is due in part to her exceptional ability to interpret the German tradition of scholarship for the English-speaking world. The Mind and the Eye is an erudite book, revealing its author's familiarity with philosophy from Plato and Aristotle through Aquinas to Kant and Hegel; but it is not dull, because the quiet enthusiasm of the author shines through. In this book she turns from the work of a specialist in one science to those wider questions which (...) any scientist must ask at intervals. What, in short, is the relationship between the eye that sees and the mind that weighs and pronounces? An important feature of this Cambridge Science Classics reissue is the introduction provided by Professor P. R. Bell, who as a Cambridge botany student at the time that Agnes Arber was writing The Natural Philosopby of Plant Form, is uniquely able to set The Mind and the Eye in the context of contemporary biological research. (shrink)

Utilising science and technology to maximize human performance is often an essential feature of military activity. This can often be focused on mission success rather than just the welfare of the individuals involved. This tension has the potential to threaten the autonomy of soldiers and military physicians around the taking or administering of enhancement neurotechnologies (e.g., pills, neural implants, and neuroprostheses). The Hybrid Framework was proposed by academic researchers working in the U.S. context and comprises “rules” for military neuroenhancement (e.g., (...) ensuring transparency and maintaining dignity of the warfighter). Integrating traditional bioethical perspectives with the unique requirements of the military environment, it has been referenced by military/government agencies tasked with writing official ethical frameworks. Our two-part investigation explored the ethical dimensions of military neuroenhancements with military officers – those most likely to be making decisions in this area in the future. In three workshops, structured around the Hybrid Framework, we explored what they thought about the ethical issues of enhancement neurotechnologies. From these findings, we conducted a survey (N = 332) to probe the extent of rule endorsement. Results show high levels of endorsement for a warfighter’s decision-making autonomy, but lower support for the view that enhanced warfighters would pose a danger to society after service. By examining the endorsement of concrete decision-making guidelines, we provide an overview of how military officers might, in practice, resolve tensions between competing values or higher-level principles. Our results suggest that the military context demands a recontextualisation of the relationship between military and civilian ethics. (shrink)

Face à la démarche théologique qui commence à partir de concepts dogmatiques existants, E. Schillebeeckx, en renversant cette démarche du déductif à l'inductif, élabore une théologie basée sur l'herméneutique de l'expérience et de la praxis. Ainsi aborde-t-il la question de l'actualisation de la foi, en montrant la relation dialectique entre la tradition de la foi et le contexte où vivent les croyants. Se situant dans le champ culturel asiatique, Agnès Kim rappelle qu'il y a là un champ d'interprétation façonné tout (...) autrement que celui que le christianisme a connu jadis. Mais ce champ asiatique est également en train d'être modifié par les expériences nouvelles qui critiquent aussi l'ensemble de l'expérience acquise. S'imposent ainsi à elle de doubles contextes existentiels qui la conduisent à poser la question des énoncés dogmatiques en situant cette question au sein de ces contextes, qui sont quelque peu en discontinuité par rapport à l'ancien, et qu'elle considère comme paradigmes du contexte interculturel. In face of the theological approach that begins with existing dogmatic concepts, E. Schillebeeckx, in reversing the approach from the deductive to the inductive, develops a theology based on a hermeneutics of experience and praxis. Thus he approaches the question of the actualization of the faith by showing the dialectical relationship between the tradition of faith and the context in which believers live. Putting herself in the Asian cultural context, Agnès Kim reminds us it is a sphere of interpretation that has been fashioned quite differently from the one experienced by Christianity in the past. But this Asian context is also being modified by new experiences that criticize acquired experience as a whole. Twofold existential contexts thus dominate her approach, leading her to raise the question of dogmatic statements while situating the question in these contexts, which are somewhat discontinuous in relation to the former one and which she considers to be paradigms of the intercultural context. (shrink)

Animal welfare scientific literature has accumulated rapidly in recent years, but bias may exist which influences understanding of progress in the field. We conducted a survey of articles related to animal welfare or well being from an electronic database. From 8,541 articles on this topic, we randomly selected 115 articles for detailed review in four funding categories: government; charity and/or scientific association; industry; and educational organization. Ninety articles were evaluated after unsuitable articles were rejected. The welfare states of animals in (...) new treatments, conventional treatments or control groups with no treatment were classified as high, medium or low according to one or more. More articles were published in which the welfare of animals in new treatments was better than that of animals in the conventional or no treatment groups, demonstrating a positive result bias. Failure to publish studies with negative or inconclusive results may lead to other scientists unnecessarily repeating the research. The authors’ assessments of the welfare state of the groups were similarly rated high, medium or low, and it was found that new treatments were rated lower if the research was funded by industry, and higher when funded by charities, with government funding agencies intermediate. These differences were not evident in the Five Freedoms assessment, demonstrating an authors’ assessment bias that appeared to support the funding agencies’ interests. North American funded publications rated the welfare of animals in New treatments higher and those in a Conventional or No Treatment lower, compared with European-funded publications. It is concluded that preliminary evidence was provided of several forms of publication bias in animal welfare science. (shrink)

Written by one of the most influential figures in post-World-War-II social thought, _A Theory of Modernity_ is a comprehensive analysis of the main dynamics of modernity, which discusses the technological, social and political elements of modernism.

In this paper, I characterize visual epistemic representations as concrete two- or three-dimensional tools for conveying information about aspects of their target systems or phenomena of interest. I outline two features of successful visual epistemic representation: that the vehicle of representation contain sufficiently accurate information about the phenomenon of interest for the user’s purpose, and that it convey this information to the user in a manner that makes it readily available to her. I argue that actual epistemic representation may involve (...) tradeoffs between these and is successful to the extent that they are present. (shrink)

Appraisal theories of emotion have two fundamental assumptions: (a) that there are regularities to be discovered between situations and components of emotional episodes, and (b) that the influence of these situations on these components is causally mediated by a mental process called appraisal. Appraisal theories come in different flavors, proposing different to-be-explained phenomena and different underlying mechanisms for the influence of appraisal on the other components.

I present an overview of emotion theories, organised around the question of emotion causation. I argue that theories of emotion causation should ideally address the problems of elicitation, intensity, and differentiation. Each of these problems can be divided into a subquestion that asks about the relation between stimuli and emotions (i.e., the functional level of process description, cf. Marr, 1982) and a subquestion that asks about the mechanism and representations that intervene (i.e., the algorithmic level of process description). The overview (...) reveals that theories of emotion causation sometimes differ with regard to the kind of process that they hold responsible for emotion causation. More precisely, they hold different assumptions regarding the conditions under which the process is supposed to operate (optimal versus suboptimal), the format of the representations involved (propositional versus perceptual), and the object or input of the central process (stimulus versus responses/experience). Further, the overview reveals that theories of emotion causation sometimes differ with regard to the level of process description that they focus on. Finally, the overview brings to light several similarities among the theories discussed. (shrink)

Critics of appraisal theory have difficulty accepting appraisal (with its constructive flavor) as an automatic process, and hence as a potential cause of most emotions. In response, some appraisal theorists have argued that appraisal was never meant as a causal process but as a constituent of emotional experience. Others have argued that appraisal is a causal process, but that it can be either rule-based or associative, and that the associative variant can be automatic. This article first proposes empirically investigating whether (...) rule-based appraisal can also be automatic and then proposes investigating the automatic nature of constructive (instead of rule-based) appraisal because the distinction between rule-based and associative is problematic. Finally, it discusses experiments that support the view that constructive appraisal can be automatic. (shrink)

The paper sketches the historical development from emotion as a mysterious entity and the source of maladaptive behaviour, to emotion as a collection of ingredients and the source of also adaptive behaviour. We argue, however, that the underlying mechanism proposed to take care of this adaptive behaviour is not entirely up for its task. We outline an alternative view that explains so-called emotional behaviour with the same mechanism as non-emotional behaviour, but that is at the same time more likely to (...) produce adaptive behaviour. The phenomena that were initially seen as requiring a separate emotional mechanism to influence and cause behaviour can also be explained by a goal-directed mechanism provided that more goals and other complexities inherent in the goal-directed process are taken into account. (shrink)

The association of celebrity worship with mental health concerns has been extensively studied in the past two decades. However, there is a lack of research on basic demographic characteristics that can potentially alter the link between celebrity admiration and different aspects of mental health. The present study investigates the possible moderating role of gender, age, and opposite/same-gender celebrity selection on the association of celebrity worship with general well-being, self-esteem and perceived daytime sleepiness. A total of 1763 Hungarian adults completed an (...) online survey focusing on attitudes and behaviors relating to celebrities and mental well-being. The moderation analysis showed that the negative association between celebrity worship and self-esteem was slightly stronger for women than for men, and the association between celebrity worship and perceived daytime sleepiness was slightly stronger for younger individuals than for older ones. Although both gender and age were particularly weak moderators, these results draw the attention to some potential individual differences when interpreting links between celebrity worship and different aspects of mental health. (shrink)

Agnes Heller conversó con la Redacción de Areté el 24 de abril de 2003, durante una visita a la Universidad Católica para dictar la Lección Inaugural del Año Académico de la Facultad de Letras y Ciencias Humanas. En la conversación estuvieron presentes los profesores Pepi Patrón, Fidel Tubino y Miguel Giusti.

Many views define the concept of automaticity in terms of a number of features, but they differ with regard to the features they put most emphasis on, as well as with regard to the coherence they assume among the features. One contemporary account is the gradual and decompositional view, which proposes to investigate each automaticity feature separately and determine the degree to which it is present. In this chapter, we engage in a detailed analysis of the most important features in (...) order to examine whether they can indeed be regarded as gradual, and whether they can be conceptually and logically separated. (shrink)

Summary This article examines the life and thought of Thomas Balogh and Nicholas Kaldor, two Hungarian-born British economists, to suggest how the personal background and émigré status of these economists changed their view of the British economy and the economic policy recommendations they put forward as high-profile government advisers in the post-1945 period. This article combines research on inter-war intellectual migration and the history of British economics and economic policy making after the Second World War. It shows how the large (...) scale migration of Central European intellectuals to the English-speaking countries affected the academic, intellectual and cultural lives of the host countries; it also suggests how economics, a relatively young social science discipline, has been crucially enriched by the contributions of exiles from old Europe, and how the mainstream paradigm of modern economics, the so-called neoclassical synthesis, was the result of the cross-fertilisation of ideas facilitated by the physical movement of academics and thinkers. (shrink)

Source: Author: Agnes F. Montalbo The aim of this study was to measure the exhaustion, cynicism and professional efficacy that would determine an individual’s level of burnout. A convenient sample of employees was obtained from different call centers in Metro Manila. The results indicated a high level of exhaustion for the age group of 18-29 years old and for the female respondents. More than half of the respondents were high in cynicism and those who reported a low professional efficacy were (...) mostly females. Age showed a significant relationship with exhaustion and cynicism while tenure at present job showed a significant relationship with professional efficacy. Results implied that working in a call center may lead to employee burnout especially for females and those who are new in their job. ]]>. (shrink)

Background The involvement of pregnant women in vaccine clinical trials presents unique challenges for the informed consent process. We explored the expectations and experiences of the pregnant women, spouses/partners, health workers and stakeholders of the consent process during a Group B Streptococcus maternal vaccine trial. Methods We interviewed 56 participants including pregnant women taking part in the trial, women not in the trial, health workers handling the trial procedures, spouses, and community stakeholders. We conducted 13 in-depth interviews and focus group (...) discussions with 23 women in the trial, in-depth interviews with 5 spouses, and 5 women not in the trial, key informant interviews with 5 health workers and 5 other stakeholders were undertaken. Results Decision-making by a pregnant woman to join a trial was done in consultation with spouse, parents, siblings, or trusted health workers. Written study information was appreciated by all but they suggested the use of audio and visual presentation to enhance understanding. Women stressed the need to ensure that their male partners received study information before their pregnant partners joined a clinical trial. Confidentiality in research was emphasised differently by individual participants; while some emphasised it for self, others were keen to protect their family members from being exposed, for allowing them to be involved in research. However, others wanted their community participation to be acknowledged. Conclusion We found that pregnant women make decisions to join a clinical trial after consulting with close family. Our findings suggest the need for an information strategy which informs not only the pregnant woman, but also her family about the research she is invited to engage in. (shrink)

Sometimes we engage in a pursuit before we can fully access its value. When we embark upon, for example, the project of coming to appreciate classical music, we make a foray into a new domain of value. The chapter introduces a new kind of reason—a proleptic reason—to rationalize such large-scale transformative pursuits. The proleptic reasoner is aware of the defect in her appreciation of some value, and feels the need to improve. It is explained that the work done by proleptic (...) reasons cannot be done by more familiar kinds of reasons. The implications of proleptic rationality for reasons-internalism are considered. Internalists hold that what I have reason to do can be arrived at by a procedurally rational extrapolation from my current desires. However, because the act of learning some new form of valuation cannot be analyzed as satisfying the values one already has, proleptic reasons are not internal. (shrink)

Gliomas can display marked changes in the concentrations of energy metabolism molecules such as creatine (Cr), phosphocreatine (PCr) and lactate, as measured using magnetic resonance spectroscopy (MRS). Moreover, the BOLD (blood oxygen level dependent) contrast enhancement in functional magnetic resonance imaging (fMRI) can be reduced or missing within or near gliomas, while neural activity is not significantly reduced (so-called neurovascular decoupling), so that the location of functionally eloquent areas using fMRI can be erroneous. In this paper, we adapt a previously (...) developed model of the coupling between neural activation, energy metabolism and hemodynamics, by including the venous dilatation Balloon model of Buxton and Frank. We show that decreasing the cerebral blood flow (CBF) baseline value, or the CBF increase fraction, results in a decrease of the BOLD signal and an increase of the lactate peak during a sustained activation. Baseline lactate and PCr levels are not significantly affected by CBF baseline reduction, but are altered even by a moderate decrease of mitochondrial respiration. Decreasing the total Cr and PCr concentration reduces the BOLD signal after the initial overshoot. In conclusion, we suggest that the coupled use of BOLD fMRI and MRS could contribute to a better understanding of the neurovascular and metabolic decoupling in gliomas. (shrink)

Straipsnyje aptariami Vilniaus miesto policijos 2010 ir 2011 m. registruotų įvykių geografinių tyrimų, atliktų Vilniaus universitete 2011–2012 m., rezultatai. Apie šimtą tūkstančių įvykių per metus buvo lokalizuoti pagal nurodytus jų adresus ir klasifikuoti pagal veikos pobūdį. ArcGIS 10 programinės įrangos įrankiais atlikta bendra ir skirtingų tipų įvykių pasiskirstymo laike analizė rodo, kad daugiausia įvykių mieste įvyksta pirmojoje tamsaus paros meto pusėje. Tik vagystės ir plėšimai daugiausia vyksta dieną. Sudaryti apibendrinti labai tikslūs įvykių tankio žemėlapiai atskleidžia įvykių koncentraciją miesto centre ir (...) daugiabučių namų rajonuose, dažnai aplink prekybos ir pramogų centrus. 2010 ir 2011 m. įvykių tankio branduoliai lokalizuoti vienodai, nors 2011 m. įvykių tankis branduoliuose pastebimai didesnis. Vagysčių ir plėšimų procentinė dalis pasiskirsčiusi kitaip nei bendras įvykių tankis: ji didžiausia Šnipiškių, Verkių ir Žvėryno seniūnijose. Smurtiniai nusikaltimai didžiausią dalį sudaro Panerių ir Rasų seniūnijose. Įvykių žemėlapiai geriau atskleidžia bendras ir atskirų tipų nusikalstamumo tendencijas, padeda stebėti jų pokyčius ir planuoti prevencijos priemones. Jie viešai skelbiami Lietuvos erdvinės informacijos portale www.geoportal.lt. (shrink)

L’ouvrage de Florence Weber, Le sang, le nom, le quotidien : une sociologie de la parenté pratique, s’inscrit dans une démarche ambitieuse, en croisant deux ensembles d’analyses généralement séparés : d’une part, les travaux sur le care et la prise en charge familiale des personnes dépendantes, enfants, malades et vieillards (domaine des spécialistes des politiques sociales et de la santé, économistes, sociologues et politistes) et, d’autre part, les analyses portant sur les transformations c...