The modern biomedical research laboratory is increasingly defined by dynamic social material conditions requiring researchers to traverse multiple shifting cognitive ecologies within day-to-day practice. Although the complexity of biomedical research is well known, the mechanisms by which the social and material organisation of this space is negotiated has yet to be fully considered. Integrating insights from Material Engagement Theory and Enactive Cognition with observations undertaken within a biomedical research laboratory, this paper develops an understanding of how actors are (...) able to respond to the dynamically changing world that is enacted with and around them. (shrink)

Summary As soon as he was appointed Minister of Public Instruction in 1863, Victor Duruy embarked on a major reform of French education. One of his most important initiatives was the creation of a new secondary curriculum designed to prepare for careers in industry, trade, and agriculture. Edme Fremy, professor at the Muséum d'histoire naturelle, took the opportunity of proposing a course of instruction in practical chemistry that would be offered at the Muséum for young men intending to work in (...) industry. Duruy approved the proposal, and funds were immediately made available. In contrast, Charles-Adolphe Wurtz, who led an internationally recognized research laboratory in organic chemistry in the Paris Faculty of Medicine, had difficulty in securing either administrative recognition or financial support. This article draws on the correspondence that Fremy and Wurtz exchanged with Duruy and senior officials in the Ministry between 1863 and 1869 to bring out the significance of the divergent ministerial responses to the two laboratories. (shrink)

Laboratory safety regulations have been traditionally viewed by its learners and practitioners as a matter of law and policy, which simply requires compliance. A compliance mindset tends be passive and dissociates individuals (or even institutions) from the important reasons and principles underlying the safety rules and regulations, leading to disinterestedness and disdain. I posit that laboratory safety regulations would need to be crafted, presented and taught in a manner that is coupled to, or at least with an emphasis (...) on, research ethics. Learners and practitioners of laboratory safety must be led to fully grasp the ethical underpinnings of the rules and regulations, however perceivably cumbersome or inconvenient the latter may seem. In extended definitions beyond the classical fabrication, falsification and plagiarism, laboratory safety violation (LSV) should indeed be considered a form of research misconduct (RM). A full appreciation of the ethical principles underlying laboratory safety regulations would intuitively make LSVs morally impermissible, and as such defiance would be morally unacceptable. Importantly, LSVs framed as moral transgressions would be equally applied to all perpetrators in terms of culpability regardless of one’s endowment and power status. LSV perpetrators should thus also be punishable in accordance with the federal or institutional laws or bylaws of research ethics and integrity. Pedagogical and content modifications to laboratory safety education to adequately reflect a research ethics emphasis, as well as promotion of epistemic acuity in this regard, would be desirable. (shrink)

The work of Julian Herman Lewis helps to expose the underlying racial organization of laboratory normality in early twentieth-century medicine. In the 1920s and 1930s, Lewis launched a critique of prevailing racial theory, as he established an academic career in pathology at the University of Chicago. As one of the small number of black research physicians at the time, Lewis met barriers to his work that eventually derailed his career. Although his research fell short of its goals, his (...) work continues to provide a key insight into medical laboratory standards as they became institutionalized in Lewis’s field of clinical pathology. By avoiding attributions of race and following prevailing practices of racial exclusion, medical laboratories quietly reasserted social norms in the formation of laboratory normality. An examination of Lewis’s critiques and his research sharpens questions about the development of the concept of “normal” in the human sciences and a related tendency in twentieth-century medicine to conflate difference with pathology. (shrink)

The article examines the need to increase an education toward the development of complex thinking in urban areas where there is a considerable amount of social unrest. The school often fails to bridge the gap between educator/education and learner and this happens in particular when it comes to kids ‘disadvantaged’. The P4C is a pedagogical method that can heal this divide, inter alia, through its dialogic practice. The practice of philosophy can became a way to bridge the sense of fragmentation (...) that the learner feels during his school track when he is having to do with a series of parceled knowledge, because it facilitate the cognitive access to them. The risk to which the student meets with the traditional education, as Freire says, is to undermine the faculty to make aware and to problematize his learning process. To built complex thinking opens the possibility of a 360-degree access to the real and increases the development of critical, creative and caring cognitive spheres. The P4C methodology application should be widespread in many school settings possible, but not only. The article continues with a brief description of some non-formal educational services offered to minors in situations of social disadvantage in Naples, focusing in particular on the Territorial Educational Laboratories. In one of these, L’Officina dei Sogni, an organization working in the territory of the 1st Municipality of the city, I carried out from October 2010 to June 2011 a P4C laboratory with children between 8 and 12 years old, driven by the reflection that this educational methodology can improve on cognitive skills in children and adolescents who are living in situations of high social problems and difficulties at school, in order to reduce for them the risk of social exclusion. The success encountered by the laboratory has had a positive effect also on the other daily Territorial Educational Laboratories activities. The aim of this article is to demonstrate that the use of this philosophical practice is not only possible but necessary in the educational fields that attend in urban areas where there is a strong presence of social problems. (shrink)

This paper investigates how reports concerning a given country’s prospects affect investment decisions in two stylized, artificial organizational settings. We designed a role-game laboratory experiment, where subjects were asked to make investment decisions for two types of fictitious companies from the same country. We found that when available reports included positive country prospects, subjects strategized more on investments regardless of the characteristics of their organization. When reports included negative prospects, however, certain organizational peculiarities influenced the subjects’ interpretations, with (...) decision-makers opting for more prudent plans when managing a more traditional company. Cognitive maps of decision makers showed that subjects considered investment strategies as a means to fulfil a company’s role expectations regarding appropriate decisions. Notwithstanding all caveats due to the artificial and simplified nature of our experimental setting, our findings indicate the need for more research on the effect of reports and prospect analysis on strategic decisions of companies, especially when business prospects are uncertain. (shrink)

The relentless informational variability in the field of natural sciences, today's need for the training of highly competent, versatile, apologetic future specialists, as well as the low motivation of psychology students to teach natural disciplines, was established by us in the process of their questioning, require the search for new, non-standard solutions in the organization of natural science training of future psychologists in institutions of higher education. We believe that one of the effective ways to solve this problem is (...) the organization of the educational process with the natural scientific training of future psychologists in higher education institutions based on innovation and heuristic. To organize the educational process from the natural science training of future psychologists on the basis of innovation and eurestiality, there is a need to determine such ultra-innovation pedagogical technologies and teaching methods that will meet the requirements of the time, contribute to the formation of psychology students' motivation to study natural sciences and improve the quality and the effectiveness of natural science training. We have characterized pedagogical technologies, namely: coworking technology, barcamp technology, workshop technology, SMART technology, BYOD technology and such innovative methods as: lecture-visualization, video lecture, debates, round table, electronic brain assault, a laboratory experiment and a design-role-playing game, which, in our opinion, will contribute to the implementation of the educational process with the natural science training of future psychologists in higher education institutions based on innovation and heuristic. (shrink)

The organization of cutting-edge HEP laboratories has evolved in the intersection of academia, state agencies, and industry. Exponentially ever-larger and more complex knowledge-intensive operations, the laboratories have often faced the challenges of, and required organizational solutions similar to, those identified by a cluster of diverse theories falling under the larger heading of organization theory. The cluster has either shaped or accounted for the organization of industry and state administration. The theories also apply to HEP laboratories, as they (...) have gradually and uniquely hybridized their principles and solutions. Yet scholarship has virtually ignored this linkage and has almost exclusively focused on the laboratories’ presumably unique egalitarian organizational aspects. Guided by the principles developed in the organization theory cluster, we identify the basic organizational features of HEP laboratories in relation to their pursuit of narrow and broad epistemic goals. We also provide a set of criteria and methods for assessing the efficiency of the identified organizational features in achieving such goals. (shrink)

We suggest that the framework proposed by Vigil is useful in laboratory contexts but might come up short for in vivo social interactions. Emotions result from cost-benefits trade-offs but are not solely generated at the individual level to establish emotional social spheres. In organizational contexts, emotion expression can be a constitutive part of a professional activity, and observed sex differences might vanish.

This book is a state-of-the-art review on the Physics of Emergence. Foreword v Gregory J. Chaitin Preface vii Ignazio Licata Emergence and Computation at the Edge of Classical and Quantum Systems 1 Ignazio Licata Gauge Generalized Principle for Complex Systems 27 Germano Resconi Undoing Quantum Measurement: Novel Twists to the Physical Account of Time 61 Avshalom C. Elitzur and Shahar Dolev Process Physics: Quantum Theories as Models of Complexity 77 Kirsty Kitto A Cross-disciplinary Framework for the Description of Contextually Mediated (...) Change 109 Liane Gabora and Diederik Aerts Quantum-like Probabilistic Models Outside Physics 135 Andrei Khrennikov Phase Transitions in Biological Matter 165 Eliano Pessa Microcosm to Macrocosm via the Notion of a Sheaf (Observers in Terms of t-topos) 229 Goro Kato The Dissipative Quantum Model of Brain and Laboratory Observations 233 Walter J. Freeman and Giuseppe Vitiello Supersymmetric Methods in the Traveling Variable: Inside Neurons and at the Brain Scale 253 H.C. Rosu, O. Cornejo-Perez, and J.E. Perez-Terrazas Turing Systems: A General Model for Complex Patterns in Nature 267 R.A. Barrio Primordial Evolution in the Finitary Process Soup 297 Olof Gornerup and James P. Crutchfield Emergence of Universe from a Quantum Network 313 Paola A. Zizzi Occam's Razor Revisited: Simplicity vs. Complexity in Biology 327 Joseph P. Zbilut Order in the Nothing: Autopoiesis and the Organizational Characterization of the Living 339 Leonardo Bich and Luisa Damiano Anticipation in Biological and Cognitive Systems: The Need for a Physical Theory of Biological Organization 371 Graziano Terenzi How Uncertain is Uncertainty? 389 Tibor Vamos Archetypes, Causal Description and Creativity in Natural World 405 Leonardo Chiatti . (shrink)

Like previous educational technologies, artificial intelligence in education threatens to disrupt the status quo, with proponents highlighting the potential for efficiency and democratization, and skeptics warning of industrialization and alienation. However, unlike frequently discussed applications of AI in autonomous vehicles, military and cybersecurity concerns, and healthcare, AI’s impacts on education policy and practice have not yet captured the public’s attention. This paper, therefore, evaluates the status of AIEd, with special attention to intelligent tutoring systems and anthropomorphized artificial educational agents. I (...) discuss AIEd’s purported capacities, including the abilities to simulate teachers, provide robust student differentiation, and even foster socio-emotional engagement. Next, to situate developmental pathways for AIEd going forward, I contrast sociotechnical possibilities and risks through two idealized futures. Finally, I consider a recent proposal to use peer review as a gatekeeping strategy to prevent harmful research. This proposal serves as a jumping off point for recommendations to AIEd stakeholders towards improving their engagement with socially responsible research and implementation of AI in educational systems. (shrink)

This article focuses on the history of the customs laboratories in the United States between the 1870s and the 1930s, focusing especially on the decades up to World War I. It pays attention to the various dimensions of these laboratories, in particular the context of their creation. The first customs laboratory was established in New York in 1878, and over the subsequent years, similar laboratories were set up across the country. The evolution of this network was influenced by factors (...) such as the increasing specialization of these spaces, their geographic distribution, and changes in their organization and scope. The article also explores the types of imported merchandise analyzed in these labs; the roles of their staff, especially customs chemists, both within and outside these laboratories; their impact on the circulation of goods and in generating revenue from taxation; and the main challenges faced by customs chemists in adapting and standardizing their work. After discussing the necessity of customs laboratories in the United States, the article examines their progressive specialization, with a detailed study of the customs laboratory in New York. This laboratory was the largest and most significant due to its location and longevity. Finally, the paper considers the relationship between customs labs and the law, and how these spaces adapted to new challenges during the first third of the twentieth century. (shrink)

Both the organization and recruiter provide signals to candidates that ultimately affect organizational attraction. Ethics is an important area that communicates vital information to candidates. Drawing on social identity theory, signaling theory, and person–organization fit, this study finds that ethical signals during the recruitment process do affect applicant attraction. Additionally, two important moderators, self-importance of moral identity and firm performance were examined. Using a robust laboratory study, this research found results generally consistent with the hypothesized relationships.

In The Logic of Life, François Jacob reconstructed the history of heredity from the seventeenth century to the present, emphasizing the role of physics in the development of biology. Quantum mechanics provided questions, methods, and techniques to molecular biologists. In the 1960s, physics also provided the organizational model. Jacob worked on the creation of the European Molecular Biology Laboratory, on the model of CERN (European Organization for Nuclear Research). I argue that reflection on the relation between molecular biology (...) and physics played a part in the making of The Logic of Life. Between the mid-1960s and the early 1970s, Jacob focused on relations between the “genealogy” of his molecular biology work and the development of physics at scientific, institutional, and historical levels. He thus brought molecular biology to the attention of a larger public, following the history of the Institut Pasteur, whose public mission had to be reaffirmed to grant its survival. With The Logic of Life, Jacob became an influential intellectual who engaged with scholars in human sciences. He promoted his view of the development of molecular biology as a model for a possible new discipline: bioanthropology. (shrink)

What does unethical behavior look like in everyday professional practice, and how might it become the accepted norm? Examinations of unethical behavior often focus on failures of individual morality or on psychological blind spots, yet unethical behaviors are generated and performed through social interactions across professional practices rather than by individual actors alone. This shifts the focus of behavioral ethics research beyond the laboratory exploring motivation and cognition and into the organizations and professions where unethical behavior is motivated, justified, (...) enabled and supported in specific social contexts. For instance, when pharmaceutical firms fund academic research, how do the funding arrangements intersect with individual behaviors that are typical in academic research? In turn, how do academic-industry interactions affect scientific norms, particularly those involving compliance with rules, regulations, and ethical codes of conduct? A social organization approach to ethics allows us not only to examine ethics in practice, but also to tease apart unethical behaviors that might operate on an unreflective level and become accepted as “just the way it is.”. (shrink)

In this article we examine periods of silence during introspective reports produced during an experimental laboratory procedure. Drawing from conversation analytic research and Sacks’s observations on silences, we argue that silences are a significant resource by which introspective accounts may be designed for the institutional requirements of the experimental setting. We identify the normative features of silence, and sketch some of the pragmatic or performative functions facilitated by silence. We conclude by considering our findings for the more general use (...) of introspective data in the study of consciousness and cognate disciplines. (shrink)

Knowledge hiding is known to have negative consequences on organizational performance. The existing literature mainly focuses on the identification of antecedents and consequences of knowledge hiding. The studies pertaining to the top management role in creating a culture that stops concealing knowledge within an organization are limited. To fill that gap, the paper empirically address the knowledge sharing culture and to explore the management support to avoid knowledge hiding culture in an organization. This study based on an empirical (...) study carried out in a United Kingdom-based laboratory within a high-tech global corporation, in which the atmosphere appeared conducive to knowledge sharing, and knowledge transfer appeared voluntary and spontaneous. The paper seeks to address why members of the case organization is reluctant about knowledge hiding among themselves. The study reveals that the management role is important in creating a culture that help discourage employees to withhold knowledge. The paper identifies the actions that top management takes to stop concealing knowledge within an organization. This study has provided several contributions. The findings of the study may be useful to managers and practitioners. For managers, this paper presents some important organizational factors that can be nurtured to avoid a knowledge-hiding culture in the organization. They can also take the management actions of the case organization as lessons to create a culture that encourage their employees to avoid knowledge hiding behavior. (shrink)

SUMMARYEighteenth-century scientific translation was not just a linguistic or intellectual affair. It included numerous material aspects requiring a social organization to marshal the indispensable human and non-human actors. Paratexts and actors' correspondences provide a good observatory to get information about aspects such as shipments and routes, processes of translation and language acquisition, texts acquisition and dissemination.The nature of scientific translation changed in France during the second half of the eighteenth century. Beside solitary translators, it also happened to become a (...) collective enterprise, dedicated to providing abridgements or enriching the learned journals with full translations of the most recent foreign texts. That new trend clearly had a decisive influence on the nature of the scientific press itself. A way to set up science as a social activity in the provincial capital of Dijon, translation required a local and international network for acquiring the linguistic and scientific expertise, along with the original texts, as quickly as possible. Laboratory results and mineralogical observations were used to compare material facts with those described in the original text. By providing a double kind of validation – with both the experiments and the translations – the laboratory thus happened to play a major role in translation. (shrink)

Academic integrity is one of the significant issues facing assessments in higher education. While there are a plethora of papers addressing this problem in certain locales, very little research has been published regarding tertiary institutions in the Caribbean. This paper satisfies this paucity in the literature and present findings which will help benchmark it against other comparable populations. This mixed-methods case study examines first-year students’ perceptions of plagiarism definitions, its seriousness, reasons for plagiarising, and its prevalence in a General Chemistry (...) lab course at a Jamaican university. Quantitative and qualitative data were collected and triangulated using a questionnaire and document analysis to understand the complexity of participants’ views. The results show that students largely define plagiarism as copying portions of text and not citing someone else’s work. While accepting that copying large and small portions of text are serious offences, students are less inclined to perceive copying a picture and self-plagiarism as problematic. Although students believe plagiarism is prevalent, they oppose harsh consequences, citing lack of understanding, course difficulty, time management issues, lack of motivation, and fear of failure as understandable reasons. Institutional recommendations to mitigate this growing concern include implementing strategies that would broaden students’ knowledge of what constitutes plagiarism, employing pedagogic strategies that aim to increase students’ self-efficacy, creating a more supportive academic environment, and reducing participation in plagiaristic behaviour. (shrink)

The ArgumentSociologists of Third World science, who share the dominant assumption in the philosophy of science that the “culture” of specific substantive fields of scientific inquiry is invariant across the globe, have, after a period of blind optimism devoted to building a critical mass of scientists in the developing countries, relapsed into a bleaker mood and see the Third World as a peripheral region lacking in “creativity” in its research programs.Challenging the doctrine of the universality of scientific practice by means (...) of an in situ study of an Indian physics laboratory, an attempt is made to bring to light a particular community's shared ideals of knowledge which animate the everyday practice of its field of study and fashion its choice of problems, style of professional communication, attitudes toward experiment, etc. These local ingredients should not be understood as deficiencies with respect to some arbitrary norm but as what differentiates research practices in different parts of the world. (shrink)

RESUMO Este artigo discute a divisão do trabalho científico entre pesquisadores seniores e juniores em um centro de pesquisa brasileiro de genética humana e médica. Partindo do debate contemporâneo sobre a progressiva imbricação entre ciência e tecnologia - com progressiva fusão entre ambas, que evoca noções como a de tecnociência - é possível verificar, na subárea específica, velocidades crescentes na produção de dados, que pressionam os pesquisadores de maneiras distintas, seja pelo crescente custo das inovações tecnológicas, seja pela necessidade de (...) métodos mais complexos para a análise. Nesse contexto, analiso questões relativas à especialização do trabalho científico, à separação entre concepção e execução, e às transformações correlatas na formação de novos pesquisadores. Parte-se do pressuposto teórico-metodológico de que a atividade científica não pode ser tratada de forma homogênea, existindo configurações distintas de acordo com o espaço disciplinar, a organização institucional e a tradição científica local, entendida enquanto empreendimento historicamente enraizado e social e culturalmente contingente. ABSTRACT The article discusses the division of scientific labour among senior and junior researchers in a Brazilian research center for human and medical genetics. Starting with the contemporary debate on the progressive intertwining of science and technology - with progressive fusion of both, evoking notions such as technoscience - it is possible to verify, in this specific subarea, rising speed in data production that pressure scientists in different manners: through the rising cost of technological innovations and through the necessity for more complex methods of analysis. In this context I analyze issues concerning the specialization of scientific work, the separation between conception and execution as well as correlate changes in the formation of new researchers. The theoretical-methodological pressupposition is that scientific activity cannot be treated in a homogeneous way, and that there exist distinct configurations according to the disciplinary space, the institucional organization and local scientific tradition, understood as a historically rooted and socially and culturally contingent undertaking. (shrink)

The present paper attempts to highlight the strategy of regional specialisation for technological innovation in R&D laboratories. The paper makes a proposition that regional specialisation should be recognised as a strategic initiative for technology development in R&D laboratories. The rationale for this strategic initiative has been substantiated with the help of illustrations from the cases of technology development efforts taken up in different laboratories in the country under the Council of Scientific and Industrial Research (CSIR), India. In this direction, CSIR (...) and other centres of excellence have played a pioneering role in the development of various industrial clusters and artisan concentrations in different parts of the country. The implications of adoption or otherwise of this strategy initiative for technological innovation in R&D laboratories have been discussed. (shrink)

A recent Organisation for Economic Co-Operation and Development survey demonstrated that an internationalization of genetic laboratory services currently emerged from the rarity of certain genetic abnormalities and from the small of laboratories performing specialized testing. When DNA samples cross national boundaries for genetic testing services to be performed in another country, the heterogeneity of national legal frameworks raises important questions regarding quality of genetic services available internationally.Some aspects of the genetic laboratories’ services are abundantly discussed by the literature, among (...) which most prominent are quality control standards and patients rights. Firstly, a 2003 study identified key distinctions between the different legal frameworks for genetic services. While some countries impose exhaustive regulatory requirements, others favor guidelines for good practices. Moreover, proficiency assessment, clinical validity, retention of laboratory records and test reports are not dealt with uniformly. (shrink)

Recent research and theory highlights the distinctive features of shame vs. guilt, as well as the important implications of that distinction for typical and atypical behaviour regulation. Briefly, shame is characterised by withdrawal and hiding from judgemental others, and guilt by making amends–repairing and confessing. The present study was aimed at determining whether a shame-relevant and a guilt-relevant pattern of responses to a standard violation could be distinguished in toddlers.Two-year-old children participated in a play session, during which a mishap occurred (...) that the children appeared to have caused. Based upon whether or not children avoided the experimenter (E) after the mishap, they were dichotomised into a shame-relevant group of subjects (Avoiders) who avoid E after the mishap, are slow to make reparation, and are slow to tell E about the mishap; and a guilt-relevant group (Amenders) showing the opposite pattern. All guilt-relevant behaviours were greater for Amenders than Avoiders, and all but one shame-relevant behaviour was greater for Avoiders than for Amenders, suggesting coherence in the organisation of responses. Moreover, convergent evidence from a maternal report questionnaire indicated that in non-laboratory settings as well, Amenders manifested greater guilt relative to shame than did Avoiders. Further research is needed to determine developmental antecedents and consequences of the Avoider/Amender dichotomy. (shrink)

Our daily lives unfold continuously, yet our memories are organised into distinct events, situated in a specific context of space and time, and chunked when this context changes (at event boundaries). Previous research showed that this process, termed event segmentation, enhances object-context binding but impairs temporal order memory. Physiologically, peaks in pupil dilation index event segmentation, similar to emotion-induced bursts of autonomic arousal. Emotional arousal also modulates object-context binding and temporal order memory. Yet, these two critical factors have not been (...) systematically studied together. To address this gap, we ran a behavioural experiment using a paradigm validated to study event segmentation and extended it with emotion manipulation. During encoding, we sequentially presented greyscale objects embedded in coloured frames (colour changes defining events), with a neutral or aversive sound. During retrieval, we tested participants’ memory of temporal order memory and object-colour binding. We found opposite effects of emotion and event segmentation on episodic memory. While event segmentation enhanced object-context binding, emotion impaired it. On the contrary, event segmentation impaired temporal order memory, but emotion enhanced it. These findings increase our understanding of episodic memory organisation in laboratory settings, and potentially in real life with perceptual changes and emotion fluctuations constantly interacting. (shrink)

Summary The rhetorical uses of discovery and invention stories are legion, but of particular concern in this paper are those that are deployed for economic or commercial reasons, especially in claiming intellectual property rights, usually in the form of patents. The case of stories about Dr Irving Langmuir (1881–1957) of the General Electric Research Laboratory, who won the Nobel Prize for Chemistry in 1932 and was the first industry-based laureate from the United States, is examined. Langmuir won the prize (...) for his ‘outstanding discoveries and inventions within the field of surface chemistry’, which also happened to underlie the virtual monopoly that General Electric gained in the supply of electric light. Langmuir was the inspiration for the stereotypically absent-minded and disinterested character of Dr Felix Hoenikker in Kurt Vonnegut's novel, Cat's Cradle (1963). My case study focuses on this and other representations of Langmuir as a discoverer, especially those generated by the General Electric Company, and explores the utility of these representations for Langmuir himself, and for his employer, in corporate PR, in ongoing struggles over patents, and in the post-war organisation of R&D. It is argued that, while the era of corporate research produced new collective modes of discovery and invention their description in heroic, individualistic terms long continued, and for good reason. (shrink)

The α‐actinins are an ancient family of actin‐binding proteins that play structural and regulatory roles in cytoskeletal organisation and muscle contraction. α‐actinin‐3 is the most‐highly specialised of the four mammalian α‐actinins, with its expression restricted largely to fast glycolytic fibres in skeletal muscle. Intriguingly, a significant proportion (∼18%) of the human population is totally deficient in α‐actinin‐3 due to homozygosity for a premature stop codon polymorphism (R577X) in the ACTN3 gene. Recent work in our laboratory has revealed a strong (...) association between R577X genotype and performance in a variety of athletic endeavours. We are currently exploring the function and evolutionary history of the ACTN3 gene and other α‐actinin family members. The α‐actinin family provides a fascinating case study in molecular evolution, illustrating phenomena such as functional redundancy in duplicate genes, the evolution of protein function, and the action of natural selection during recent human evolution. BioEssays 26:786–795, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The origin of chordates and the consequent genesis of vertebrates were major events in natural history. The amphioxus (lancelet) is now recognised as the closest extant relative to the stem chordate and is the only living invertebrate that retains a vertebrate‐like development and body plan through its lifespan, despite more than 500 million years of independent evolution from the stem vertebrate. The inspiring data coming from its recently sequenced genome confirms that amphioxus has a prototypical chordate genome with respect to (...) gene content and structure, and even chromosomal organisation. Pushed by joint efforts of amphioxus researchers, amphioxus is now entering a new era, namely its maturation as a laboratory model, through the availability of a large amount of molecular data and the advent of experimental manipulation of the embryo. These two facts may well serve to illuminate the hidden secrets of the genetic changes that generated, among other vertebrates, ourselves. (shrink)

With rapid changes in urban living today, peoples’ behavioural patterns and spatial practices undergo a constant process of adaptation and negotiation. Using “house” as a laboratory and everyday life and spatial relations of residents as a framework of analysis, the paper examines the spatial planning concepts in traditional and contemporary Iranian architecture and the associated socio-cultural practices. Discussions are drawn upon from a pilot study conducted in the city of Kerman, to investigate ways in which contemporary housing solutions can (...) better cater to the continually changing socio-cultural lifestyles of residents. Data collection for the study involved a series of participatory workshops and employed creative visual research methods, participant observation and semi structured interviews to examine the interlacing of everyday socio-spatial relations and changing perception of identity, belonging, socio-cultural and religious values and conflict. The inferences from the study showcases the emerging social and cultural needs and practices of people manifested through the complex relationship between residents, the places in which they live, and its spatial planning and organisation. For a better understanding of this complex relationship, the paper argues the need for resituating spatiality as a socio-cultural paradigm. (shrink)

Development of a vaccine for schistosomiasis, a parasitic disease currently affecting over 200 million people worldwide, has been targeted as a priority by the World Health Organisation. Research demonstrating the ability of humans to acquire natural immunity to schistosome infection, together with the successful use of attenuated vaccines in animals both under laboratory and field conditions, suggest that development of a human vaccine is feasible. Attenuated vaccines for schistosomiasis are considered neither safe nor practicable for human use, however, and (...) therefore other approaches must be considered. This review examines progress currently being undertaken in a number of different areas towards achieving the goal of a safe and effective human vaccine for schistosomiasis. (shrink)

During the 1870s animal morphologists and embryologists at Cambridge University came to dominate British zoology, quickly establishing an international reputation. Earlier accounts of the Cambridge school have portrayed this success as short-lived, and attributed the school's failure to a more general movement within the life sciences away from museum-based description, towards laboratory-based experiment. More recent work has shown that the shift in the life sciences to experimental work was locally contingent and highly varied, often drawing on and incorporating aspects (...) of museum work. Thus in order to understand the more general changes, studies of particular sites are needed. Here I examine the organisation of teaching at Cambridge, both in terms of the spaces in which it was taught and the ways in which teaching and examining were organised, to bring out the complexities of the 'revolt from morphology' and to show in more detail the institutional aspects that intertwined with intellectual change. Francis Maitland Balfour, as head of the Cambridge school, was able to make use of family connections and his own personal wealth to promote morphology. His successor lacked these resources, and one competition within the natural sciences at Cambridge intensified, morphology was unable to compete properly. (shrink)

Emotional openness is characterised by a capacity to tolerate threatening self-relevant material and an interest towards new emotional situations. We investigated how specific networks of memories could be an important contributing factor to emotional openness. At Phase 1, participants completed measures of personality traits and emotional intelligence, described a self-defining memory, provided other memories associated with it, and rated the valence of each of their memories. A score assessing the complexity of this memory network, comprising the number of memories reported (...) and their valence diversity, was created. Two weeks later, in laboratory, participants watched an anxiety-inducing film and took part in an interview assessing their emotional openness to the film. They completed a cognitive task before and after the film to measure ego depletion. Controlling for traits and emotional intelligence, memory network complexity was positively associated with emotional openness and negatively with ego depletion. The mental organisation of self-defining memories thus appears to be a critical factor contributing to emotional openness. (shrink)

This article aims to establish that literature is an ideal laboratory for undertaking some phenomenological experimentations, even when not explicitly intended by the author. By considering three works that all tell the story of one man gone far away from his country and isolated in a mysterious, fascinating and closed place, we propose to study the complex relations that weave between space and time and between landscape and consciousness, and to deduce from it their phenomenological impact. We attempt to (...) show that space localization and organisation influence and even modify the behaviour and the personality of humans, and induce a new relation to temporality: the mountain arouses boredom, the desert prepares the expectation and the shore brings the facing of one’s fate. (shrink)

To explain social learning without invoking the cognitively complex concept of imitation, many learning mechanisms have been proposed. Borrowing an idea used routinely in cognitive psychology, we argue that most of these alternatives can be subsumed under a single process, priming, in which input increases the activation of stored internal representations. Imitation itself has generally been seen as a This has diverted much research towards the all-or-none question of whether an animal can imitate, with disappointingly inconclusive results. In the great (...) apes, however, voluntary, learned behaviour is organized hierarchically. This means that imitation can occur at various levels, of which we single out two clearly distinct ones: the a rather detailed and linear specification of sequential acts, and the a broader description of subroutine structure and the hierarchical layout of a behavioural Program level imitation is a high-level, constructive mechanism, adapted for the efficient learning of complex skills and thus not evident in the simple manipulations used to test for imitation in the laboratory. As examples, we describe the food-preparation techniques of wild mountain gorillas and the imitative behaviour of orangutans undergoing to the wild. Representing and manipulating relations between objects seems to be one basic building block in their hierarchical programs. There is evidence that great apes suffer from a stricter capacity limit than humans in the hierarchical depth of planning. We re-interpret some chimpanzee behaviour previously described as and suggest that all great apes may be able to imitate at the program level. Action level imitation is seldom observed in great ape skill learning, and may have a largely social role, even in humans. (shrink)

Institutions in France are not yet well prepared to respond to allegations of scientific misconduct. Following a serious allegation in late 1997. INSERM,* the primary organization for medical and health-related research in France, began to reflect on this subject, aided by scientists and jurists. The conclusions have resulted in establishing a procedure to be followed in cases of alleged misconduct, and also in reinforcing the application of good laboratory practices within each laboratory. Guidelines for authorship practices and (...) scientific assessment must also be considered. Even though each institution must remain responsible for responding to allegations of scientific misconduct within its doors, INSERM would like to see national, European, and international co-ordination about the methods of such response. (shrink)

What comprises ‘data’ varies from one institution to another based on the information which is deemed important by individual institutions. To effectively and efficiently produce, collect, and retain data, an organization develops specific defining characteristics of data to meet its informational needs. Procedures to maintain and retain knowledge among laboratory members and principal investigators will allow for improved efficiency of data collection. Optimization of communication, maintenance of inventories, record keeping, and updating relevant training programs are all critical to (...) supporting the quality and integrity of a particular organization’s data. Concurrent revisions to such procedures will ensure that the definition of data as well as the means by which it is collected and maintained remain appropriate to the needs of the individual organization. (shrink)

The size and organization of the brain are determined by the activity of progenitor cells early in development. Key mechanisms regulating progenitor cell biology involve miRNAs. These small noncoding RNA molecules bind mRNAs with high specificity, controlling their abundance and expression. The role of miRNAs in brain development has been studied extensively, but their involvement at early stages remained unknown until recently. Here, recent findings showing the important role of miRNAs in the earliest phases of brain development are reviewed, (...) and it is discussed how loss of specific miRNAs leads to pathological conditions, particularly adult and pediatric brain tumors. Let‐7 miRNA downregulation and the initiation of embryonal tumors with multilayered rosettes (ETMR), a novel link recently discovered by the laboratory, are focused upon. Finally, it is discussed how miRNAs may be used for the diagnosis and therapeutic treatment of pediatric brain tumors, with the hope of improving the prognosis of these devastating diseases. (shrink)

Nick Hopwood, Simon Schaffer and Jim Secord, “Seriality and scientific objects in the nineteenth century”, History of Science, xlviii. Series represent much that was new and significant in the sciences between the French Revolution and the First World War. From periodical publication to the cinema, tabulation to industrialized screening, series feature in major innovations in scientific communication and the organization of laboratories, clinics, libraries, museums and field - XIXe siècle – Nouvel article.

How does science create knowledge? Epistemic cultures, shaped by affinity, necessity, and historical coincidence, determine how we know what we know. In this book, Karin Knorr Cetina compares two of the most important and intriguing epistemic cultures of our day, those in high energy physics and molecular biology. Her work highlights the diversity of these cultures of knowing and, in its depiction of their differences--in the meaning of the empirical, the enactment of object relations, and the fashioning of social relations--challenges (...) the accepted view of a unified science. By many accounts, contemporary Western societies are becoming "knowledge societies"--which run on expert processes and expert systems epitomized by science and structured into all areas of social life. By looking at epistemic cultures in two sample cases, this book addresses pressing questions about how such expert systems and processes work, what principles inform their cognitive and procedural orientations, and whether their organization, structures, and operations can be extended to other forms of social order. The first ethnographic study to systematically compare two different scientific laboratory cultures, this book sharpens our focus on epistemic cultures as the basis of the knowledge society. (shrink)

The temporal structure of behavior contains a rich source of information about its dynamic organization, origins, and development. Today, advances in sensing and data storage allow researchers to collect multiple dimensions of behavioral data at a fine temporal scale both in and out of the laboratory, leading to the curation of massive multimodal corpora of behavior. However, along with these new opportunities come new challenges. Theories are often underspecified as to the exact nature of these unfolding interactions, and (...) psychologists have limited ready-to-use methods and training for quantifying structures and patterns in behavioral time series. In this paper, we will introduce four techniques to interpret and analyze high-density multi-modal behavior data, namely, to: (1) visualize the raw time series, (2) describe the overall distributional structure of temporal events (Burstiness calculation), (3) characterize the nonlinear dynamics over multiple timescales with Chromatic and Anisotropic Cross-Recurrence Quantification Analysis (CRQA), (4) and quantify the directional relations among a set of interdependent multimodal behavioral variables with Granger Causality. Each technique is introduced in a module with conceptual background, sample data drawn from empirical studies and ready-to-use Matlab scripts. The code modules showcase each technique’s application with detailed documentation to allow more advanced users to adapt them to their own datasets. Additionally, to make our modules more accessible to beginner programmers, we provide a “Programming Basics” module that introduces common functions for working with behavioral timeseries data in Matlab. Together, the materials provide a practical introduction to a range of analyses that psychologists can use to discover temporal structure in high-density behavioral data. (shrink)

Abstract. This essay discusses the deep perceptual and social changes that the advanced applications of biotechnology could bring in the West. It examines the probable collapse of a fundamental perceptual bipolarity on which the Western mind and social mobilization have been based since its inception in the West: Athens--Jerusalem. This collapse will quite possibly radically reshape Western perceptions of self and nature and will remodel established constellations and modes of social mobilization and social organization. The radical collapse of the (...) preceding established feature of Western modernity is due to take place in the field of biotechnology, since the latter promises to produce a deliverable perfection of flesh and an equally corporeal personal bliss. I call this promise ``eutopia,'' an actual and tangible utopia-- ``a laboratory on the hill.''. (shrink)

We contrast reactive and endogenously active perspectives on brain activity. Both have been pursued continuously in neurophysiology laboratories since the early 20thcentury, but the endogenous perspective has received relatively little attention until recently. One of the many successes of the reactive perspective was the identification, in the second half of the 20th century, of the distinctive contributions of different brain regions involved in visual processing. The recent prominence of the endogenous perspective is due to new findings of ongoing oscillatory activity (...) in the brain at a wide range of time scales, exploiting such techniques as single-cell recording, EEG, and fMRI. We recount some of the evidence pointing to ways in which this endogenous activity is relevant to cognition and behavior. Our major objective is to consider certain implications of the contrast between the reactive and endogenous perspectives. In particular, we relate these perspectives to two different characterizations of explanation in the new mechanistic philosophy of science. In a basic mechanistic explanation, the operations of a mechanism are characterized qualitatively and as functioning sequentially until a terminating condition is realized. In contrast, a dynamic mechanistic explanation allows for non-sequential organization and emphasizes quantitative modeling of the mechanisms's behavior. For example, with appropriate parameter values a set of differential equations can be used to demonstrate ongoing oscillations in a system organized with feedback loops. We conclude that the basic conception of mechanistic explanation is adequate for reactive accounts of brain activity, but dynamical accounts are required to explain sustained, endogenous activity. (shrink)

This paper first queries what type of concept of emergence, if any, could be connected with the different chemical activities subsumed under the label ‘quantum chemistry’. In line with Roald Hoffmann, we propose a ‘rotation to research laboratory’ in order to point out how practitioners hold a molecular whole, its parts, and the surroundings together within their various methods when exploring chemical transformation. We then identify some requisite contents that a concept of emergence must incorporate in order to be (...) coherent from the standpoint of the scientific practices involved. In this respect, we finally propose a relational form of emergence which pays attention to the constitutive role of the modes of intervention and to the co-definition of the levels of organization. No metaphysical distinction between the higher and basic levels of organization is supposed, but only a plurality of modes of access. Moreover, these modes of access are not construed as mere ways of revealing intrinsic patterns of organization but, on the contrary, are considered to be active elements on which the constitution of those patterns depends. What is at stake in this paper is therefore not an ontological form of emergence but an agnostic one which fits what chemists do in their daily work. (shrink)