This article demonstrates that our more sophisticated theories of law lead us to a point where we are no longer able to distinguish law from culture, or society, or the market, or politics or anything of the sort. Not only are the various terms inextricably intertwined (something that other thinkers have observed) but we are no longer in a position to articulate any relations between these various terms at all. It is with this latter realization that the dedifferentiation problem (...) kicks in. Because the various terms cannot be disentangled, we find ourselves in the odd position where there is nothing of any positive character to be said about their relations. Each is already the other and, thus, they can have no relation. This is rather bad news for the ways in which we have traditionally conceived theories of law—indeed any theory that gets off the ground by distinguishing law from a discrete something else (which, on first glance, would seem to include all legal theory). (shrink)

Transposable elements (TEs) have emerged as important factors in establishing the cell type‐specific gene regulatory networks and evolutionary novelty of embryonic and placental development. Recently, studies on the role of TEs and their dysregulation in cancers have shed light on the transcriptional, transpositional, and regulatory activity of TEs, revealing that the activation of developmental transcriptional programs by TEs may have a role in the dedifferentiation of cancer cells to the progenitor‐like cell states. This essay reviews the recent evidence of (...) the cis‐regulatory TEs (henceforth crTE) in normal development and malignancy as well as the key transcription factors and regulatory pathways that are implicated in both cell states, and presents existing gaps remaining to be studied, limitations of current technologies, and therapeutic possibilities. (shrink)

Cellular dedifferentiation is an important developmental response to perturbations in morphogenesis. In the cellular slime mold Dictyostelium discoideum this process gives cells the flexibility, when multicellular development is disrupted, to respond to nutrients and reinitiate vegetative growth. Recent studies in D. discoideum described by Soll and colleagues(1) show that genes previously thought to be expressed only during spore germination are also expressed during induced dedifferentiation, suggesting that similar molecular mechanisms are involved in these two developmental processes. It should (...) now be possible to determine whether the developmental programs that control dedifferentiation during spore germination also control conversion of cell types in the multicellular organism. (shrink)

The aim of this paper is to argue in favor of the idea that it is possible not only to give a special place to reason in our life and in society, but also to offer an integrative rational framework, in in which human ends and goals find their rational expression. The text has three parts. The first describes Alfred Schutz's practical-hermeneutical approach to law and normativity, while making room for a subjective practice of reason. The second proposes to reveal, (...) through the description of knowledge in the world of ordinary life, a form of rationality which offers us practical but consistent ways of making a decision. Ultimately, the third aims at the practical-hermeneutical reconstruction of the law, in order to integrate into the core of legal reasoning references to ends and purposes without prejudicing the objectivity of the reasoning itself. The study aims to make a contribution to the problem of dedifferentiation and positivism of practice in the modern world. Le but de ce papier est d’argumenter en la faveur de l’idée qu’il est possible non seulement de donner une place particulière à la raison dans notre vie et dans la société, mais aussi d’offrir un cadre rationnel intégratif, dans lequel les fins et buts humains trouvent leur expression rationnelle. Le texte comporte trois parties. La première décrit l’approche pratique-herméneutique d’Alfred Schutz à l’égard de la loi et de la normativité, tout en faisant place à une pratique subjective de la raison. La deuxième se propose de dévoiler, à travers la description de la connaissance dans le monde de la vie ordinaire, une forme de rationalité qui nous offre des voies pratiques mais consistantes de prendre une décision. En fin de compte, la troisième vise la reconstruction pratique-herméneutique de la loi, afin d’intégrer dans le noyau du raisonnement légal des références à des fins et buts sans porter préjudice à l’objectivité du raisonnement lui-même. L’étude veut apporter une contribution au problème de la dédifférenciation et du positivisme pratique dans le monde moderne. (shrink)

The clonal evolution model and the cancer stem cell model are two independent models of cancers, yet recent data shows intersections between the two models. This article explores the impacts of the CSC model on the CE model. I show that CSC restriction, which depends on CSC frequency in cancer cell populations and on the probability of dedifferentiation of cancer non-stem cells into CSCs, can favor or impede some patterns of evolution and some processes of evolution. Taking CSC restriction (...) into account for the CE model thus has implications for the way in which we understand the patterns and processes of evolution, and can also provide new leads for therapeutic interventions. (shrink)

In the atavistic model of cancer progression, tumor cell dedifferentiation is interpreted as a reversion to phylogenetically earlier capabilities. The more recently evolved capabilities are compromised first during cancer progression. This suggests a therapeutic strategy for targeting cancer: design challenges to cancer that can only be met by the recently evolved capabilities no longer functional in cancer cells. We describe several examples of this target‐the‐weakness strategy. Our most detailed example involves the immune system. The absence of adaptive immunity in (...) immunosuppressed tumor environments is an irreversible weakness of cancer that can be exploited by creating a challenge that only the presence of adaptive immunity can meet. This leaves tumor cells more vulnerable than healthy tissue to pathogenic attack. Such a target‐the‐weakness therapeutic strategy has broad applications, and contrasts with current therapies that target the main strength of cancer: cell proliferation. (shrink)

This chapter presents an account of Merleau-Ponty’s interpretation of the body schema as an operative intentionality that is not only opposed to, but also complexly intermingled with, the representation-like grasp of the world and one’s own body, or the body image. The chapter reconstructs Merleau-Ponty’s position primarily based on his preparatory notes for his 1953 lecture ‘The Sensible World and the World of Expression’. Here, Merleau-Ponty elaborates his earlier efforts to show that the body schema is a perceptual ground against (...) which the perceived world stands out as a complex of perceptual figures. The chapter clarifies how Merleau-Ponty’s renewed interpretation of the figure-ground structure makes it possible for him to describe the relationship between body schema and perceptual (body) image as a strictly systematic phenomenon. Subsequently, the chapter shows how Merleau-Ponty understands apraxia, sleep, and perceptual orientation as examples of dedifferentiation and subtler differentiation of the body-schematic system. The last section clarifies how such body-schematic differentiating processes give rise to relatively independent superstructures of vision and symbolic cognition which constitute our body image. It, moreover, explains how, according to Merleau-Ponty, the cognitive superstructures always need to be supported by praxic operative intentionality to maintain their full sense, even though, in some cases, they have the power to compensate for praxic deficiencies. (shrink)

From the point of view of a dynamic morphology, form is not only the result of process(es) — it is process. This process may be analyzed in terms of two pairs of fundamental processes: growth and decay, differentiation and dedifferentiation. Each of these processes can be analyzed in terms of various modalities (parameters) and submodalities. This paper deals with those of growth (see Table 1). For the purpose of systematits and phylogenetic reconstruction the modalities and submodalities can be considered (...) dynamic characters that have states. Each state of such a dynamic character is a more detailed process, hence not static. For example, determinate growth represents a state of the dynamic character (or modality) of growth duration.The processes of Table 1 can be applied to the whole plant kingdom (although in certain cases only some processes of the whole set may be applicable). Thus, the diversity of plant form is seen as a diversity of process combinations. From this point of view, change in form implies change in the process combination(s). Questions that arise are, for example, the following: Which process combinations actually occur? Which of these are the most frequent? How and why have process combinations changed during ontogeny and phylogeny? (shrink)

Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1– 3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4– 7. By contrast, chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8– 10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; it (...) is therefore challenging to induce human pluripotent stem cells by chemical reprogramming. Here we demonstrate, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells that exhibit key features of embryonic stem cells. The whole chemical reprogramming trajectory analysis delineated the induction of the intermediate plastic state at the early stage, during which chemical-induced dedifferentiation occurred, and this process was similar to the dedifferentiation process that occurs in axolotl limb regeneration. Moreover, we identified the JNK pathway as a major barrier to chemical reprogramming, the inhibition of which was indispensable for inducing cell plasticity and a regeneration-like program by suppressing pro-inflammatory pathways. Our chemical approach provides a platform for the generation and application of human pluripotent stem cells in biomedicine. This study lays foundations for developing regenerative therapeutic strategies that use well-defined chemicals to change cell fates in humans. (shrink)

At the time of the disintegration of “actually existing socialism” in the 1990s, it appeared that the inexorable flux of globalization was going to consume the nation-state. However, recent years have witnessed the increasing role of the states in both the Global North and South. The relationship between the state and capital is a frequently traversed subject, but what needs further illumination is the persistence of “many states” and its relation to capitalism as both a national and global formation. While (...) globalization of capital suggests a movement from multiplicity toward a dehistoricized abstraction, a global state has never been actualized. This implies that, unlike capital, the state cannot be dehistoricized or dedifferentiated; therefore, the only way to think about the state is to observe concrete, multiple states. In view of this difference and drawing on Nicos Poulantzas’s and Kōjin Karatani’s inquiries into the states system, this article examines the multi-state system as an internal and external limit to Marxist thought. (shrink)

This article discusses some possibilities for a critical interpretation of Niklas Luhmann’s systems theory. On the one hand, this theory could provide a sophisticated new sociological account of well-known modern social pathologies, such as alienation and reification; on the other, it could be considered a crypto-normative model for the reciprocal mediation between system and environment in which neither blind tautologies nor colonizations would take place. I argue that as a normative model this theoretical matrix seems to resonate with aspects of (...) Adorno’s negative dialectics between subject and object and that the involuntary promise it contains could be fully realized only under other social conditions. The article also presents a preliminary critique of neoliberalism reconceptualized in systems theoretical terms as a dedifferentiation machinery that aims at establishing the primacy of economic rationality and the formation of ‘industries’ in different social spheres. (shrink)

The concept of positional information is applied to a large amount of data obtained previously in experiments on developing and regenerating amphibian limbs. Only the proximo-distal axis of the limb is considered. It is shown that the concept provides a simple, unitary hypothesis which satisfactorily accounts for the experimental data, and may moreover suggest meaningful new approaches. It is suggested that the boundaries of the bipolar limb system lie in the girdle skeleton and at the distal end of the limb, (...) respectively, and that it is the apical epidermis of the growing or regenerating limb which defines the distal boundary conditions. A relatively stable gradient of positional information is assumed to be set up in the mesoderm . It is further shown that the differentiated limb retains its positional information and upon amputation imparts it to the base of the blastema. To explain an apparent discrepancy between the developing and the regenerating limb, it is proposed that dedifferentiation of mesodermal limb tissues upon amputation entails a change of positional value in the mesenchyme. Consequently, the amputation level does not once and for all specify the positional value at the proximal end of a mass of blastemal mesenchyme, particularly when the mesenchyme is transplanted in such a way that its linear size decreases or increases. (shrink)

In this paper the authors give a survey of biological phenomena , for which the term ‘differentiation’, used in the widest sense, has a meaningful application. The last chapter deals with some general aspects of differentiation and connected phenomena, such as polarity, symmetry, loss of potencies, dedifferentiation, redifferentiation, adifferentiation, regulation and integration.To prevent this article becoming too voluminous, the authors had to refrain from extending the treatment of differentiation to non-living matter and to human society.

Concerning artistic research, the state of affairs is still one of delusions and confusions. The reason for this is the pluralization and dedifferentiation of rationality pushed forward by the postmodern period. The way out of it is the way of differentiations. Thus, it seems helpful, first, to remember what we already have in philosophical aesthetics, namely four basic models of art and knowledge. The question, then, is whether artistic research fits into these models. To my mind, it does – (...) though in a new way. Secondly, it is helpful to have a short sober sociological look at the situation. Finally, we have to ask the question about the kind of research that is at stake in artistic research. Here, the meaning of non-propositional knowledge and Kant’s idea of an as-if-knowledge is useful. All in all, artistic research still fails in giving a sufficient explanation of itself. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Empirical Questions Deserve Empirical AnswersColin MartindaleWhat is wrong with the current state of humanistic literary studies? On the theoretical level, we find various types of postmodernism, none of which makes much sense. On the other hand, there are approaches such as Marxism, Feminism, and the New Historicism. One can at least understand the contentions of such theorists, but these contentions are generally quite implausible. If poetry were an effective (...) means of maintaining the status quo or of oppressing anyone, one wonders why this was never noticed by politicians or generals. Now that the fact has been “discovered,” one wonders why it is not put to use by the power elite. What has led literary theory to stray onto such strange grounds? I believe that the faulty methods used by many literary theorists offer us at least part of an answer.Humanistic critics have no reasonable way of deciding among alternative answers if theorists happen to ask a question that is answerable—i.e., if they propose an empirical investigation. Their only method is one of producing examples and trying to persuade the reader. 1 Can a scientific approach provide something better? Certainly it can. First, the scientist does not pose unanswerable questions. Second, science provides methods for resolving disputes, for answering questions that are answerable. These methods are the scientific apparatus of counting, measuring, experimenting, and so on. Humanistic inquiry is simply not as effective as scientific inquiry. If a question is meaningful, it is by definition an empirical question. Science is the only method to us available for answering such questions. Humanism has no decision-making methods, no objective methods of choosing amongst competing hypotheses. [End Page 347]To paraphrase Plato, literary critics hypothesize many fine things but know nothing of how to test them. Science already has the methods. We merely need to apply them. To give an example from my own research, Raymond and a number of other literary scholars tried to say that across the course of the nineteenth century, the content of French poetry became more primary process (Freud), dedifferentiated (Werner), associative (Wundt), or mythic (Cassirer) in its content. 2 Unless one can translate Raymond’s comments into these theoretical terms, it is difficult to understand what in the world he is talking about, let alone to test his contention. Because literary critics usually make up their psychology as they go along, it is difficult to understand what they say. Because they have only a proof-by-example method, it is difficult to believe what they say. If we do make the translation and develop a metric to measure the degree to which poetic content is primary process, we can test Raymond’s hypothesis and find out if it is correct. 3 We can not only find out if it is correct. We can fit curves to the data, compute rates of change, relate rates of change to other variables, and so on. One cannot fit curves to what Lotman aptly called “literary chit-chat.” 4 Without such an objective measure of primary process content, one would no doubt assert that twentieth-century poetry is even more mythic in its content, because the poets themselves have said so. 5 In fact, the metric confirms Plato’s warning that poets lie.Some literary theorists, of course, do things that are at least close to science. Numbers would be of great help to such theorists if only as mnemonic devices. Given that people cannot hold more than about seven things in mind at once, the task of sorting out and comparing hundreds of texts is very difficult unless some counting is done. 6 Humanists can count, but they seem not to realize the value of this ability. Lévi-Strauss and the structuralists were doing what might be called zero-degree science. 7 It is reasonable to segment texts and look for regularities. It is not reasonable to look for regularities before one has determined the reliability of the segmentations: that is, before one has determined whether people agree as to how to segment texts. To compute a reliability coefficient, one has to use numbers, and one has to know the formula. Humanists don’t... (shrink)

The following dissertation shows how German Literature negotiates the relationship between language and the visual arts, particularly in Romantic narratives. In contrast with authors of the Enlightenment, the Romantics tend to deny specificity to visual experience and in so doing dedifferentiate visual experience from the textual. ;The initial, methodological, chapter explicates perceptual models informed by the interplay of the philosophical approaches of Kant and Wittgenstein with the psychoanalytic discourse of Freud. In Chapter Two, I turn to Lessing's Laokoon Uder uber (...) die Grenzen der Malerei und Poesie , in which he divides the arts into pictoral and linguistic signs. While the boundary between the two appears quite clear in Laokoon, his play Emilia Galotti reveals Lessing's anxiety that the difference cannot be so easily maintained. ;The subsequent chapter explores the representation of the visual arts in Tieck's Franz Sternbalds Wanderungen . After a discussion of Wackenroder's Herzensergiessungen eines kunstliebenden Klosterbruders , 1 turn to Tieck's novel about a young student of Albrecht Durer. The novel responds to the ostensible binary between language and the visual arts by transmuting the distinction into one between readable landscape paintings and phantasmatic images that guide the protagonist. ;As another example of this Romantic viewpoint, I analyze Brentano's Godwi oder das steinerne Bild der Mutter . Here I use the distinction between symbol and allegory to point out the ways in which the text turns the difference between the arts into one between rhetorical figures. A similar manifestation of the problem occurs in Eichendorff's Das Marmorbild , discussed in Chapter Five. The novella follows the same lines as Lessing's Laokoon, thematizing the materiality of its eponymous marble statue. My final chapter concerns Kleist's model of visual perception, which is closely bound to his theology in his tales "Die heilige Cacilie" and "Der Findling" . ;Writing Images interprets the role of visuality in German Romantic literature in order to understand an unresolved problematic of late eighteenth and early nineteenth-century thought for those who would too quickly either differentiate between or conflate the visual and the written. (shrink)

Regeneration capabilities are found in most or all animals. Whether regeneration is part of the development of an animal or a distinct phenomenon independent of development is a debatable question. If we consider regeneration as a process belonging to development, similarly to embryogenesis or metamorphosis, the existence of regenerative capabilities in adults can be seen as an argument in favor of the theory that development continues throughout the life of animals. Here I perform a comparative analysis of regeneration versus “classical” (...) developmental processes in animals in order to determine to what extent these processes are inclusive or distinct. I identify the existence of regeneration-specific processes, i.e., processes that occur during the regeneration, but not the initial development, of a given structure. In addition, I find that seemingly similar processes acting during development and regeneration may have differential molecular and cellular bases. I thus conclude that there are significant differences between regeneration processes in adult animals and developmental processes occurring during earlier phases of the life cycle. The existence of regenerative capabilities in adult animals can therefore not be used as an argument in favor of the idea that development spans the whole life. (shrink)

Introduction. Non-institutional humanities, philosophical practice, and informal education are “a family like” phenomena that are outside the social institution of science and education and are adjacent to socio-cultural activities and social work. The purpose of the article is to outline the contours of the informal educational creative industry in the postmodern society, which combines non-institutional humanities, philosophical practice, and informal education. Methods. The author uses the methods of autobiographical reflection, comparative analysis, empirical observation and analysis of the primary sources of (...) non-institutional humanities. Scientific novelty of the research. The transition to nonmaterial work of the postmodern era is the reason for the relevance of the area under study. The growing demand of a contemporary for such issues as the meaning of life, happiness, the growth of the precariat, the ousting of philosophy from formal education constitute a new social reality that determines the novelty of the research in the informal educational creative industry. Results. The author classifies non-institutional humanities according to the spheres of its existence and the strategies of subject genesis presented in the teachings. The concept of dedifferentiation is considered as an explanation of the area under study in postmodernism. The specificity of the philosophical approach in the work of a practicing philosopher is considered. Conclusions. The author connects the prospects of the informal educational creative industry with institutionalization in the way of leisure, entertainment, and other personal services. The author makes conclusions about the differences between formal and informal education, and indicates the risks and opportunities for the development of the informal philosophical sector. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Kennedy Institute of Ethics Journal 12.3 (2002) 305-323 [Access article in PDF] Scope Note 41 Bioethics and Cloning, Part I Susan Cartier Poland and Laura Jane Bishop This is Part One of a two part Scope Note on Bioethics and Cloning. Part Two will be published in the December 2002 issue of the Kennedy Institute of Ethics Journal and as a separate reprint. Contents For Parts 1 And 2 (...) Part 1Part 2I.History of the ScienceI.Ethical PerspectivesII.Historical CommentaryII.Religious PerspectivesIII.Animal WelfareIII.Fiction and FilmIV.Laws and Legal Literature"Clone" is a collective noun (I, Stewart 1997, p. 771). A collective noun names a group and is composed of individual members, such as "herd" or "flock." Derived from the Greek kl¯on for twig or slip, "clone" was first used in biology to describe the aggregate of asexually produced progeny of an individual, either naturally occurring or man-made; the definition later expanded to mean a group of genetically identical members who originate from a single ancestor. Thus, a clone is a group that results from the process of asexual reproduction.In nature, cloning occurs either by parthenogenesis (reproduction without fertilization) or by fission (embryo splitting). In a pioneering experiment in 1952, Robert Briggs and Thomas J. King (I, 1952), cancer researchers at the Institute for Cancer Research (today part of the Fox Chase Cancer Center) in Philadelphia, demonstrated on frogs another method of cloning by transplanting nuclei into enucleated cells, a technique called "nuclear transplantation," which John B. Gurdon and colleagues (I, 1958, 1975) used to create clones of frogs.Then, in the late 1970s and early 1980s, two back-to-back frauds in cloning occurred. First, the cloning of a human described by American science journalist David Rorvik in the 1978 book In His Image was called a hoax by a court in [End Page 305] 1982. Second, the cloning of three mice, announced by German wunderkind Karl Illmensee to scientific circles in 1979 (and to the public in 1981), could not be proven to be true, according to convincing evidence by McGrath and Solter (I) published in 1984.With their pronouncement that mammalian cloning was impossible, McGrath and Solter essentially stopped cloning research and funding for such biological research. So by the mid-1980s, instead of further investigating cloning, developmental biologists studied embryology related to in vitro fertilization, while molecular biologists studied recombinant DNA under the newly relaxed NIH guidelines. These two strands of scientific investigation came together in the work of Ian Wilmut, who created in vitro embryos using nuclear transplantation to reproduce genetically engineered cattle. Wilmut was seeking a way to increase the successful birth rate when, in the 1990s, he produced identical twin sheep, Megan and Morag, cloned from an embryonic cell, followed by another sheep, Dolly, cloned from an adult cell. The birth of a mammal from an embryo whose genetic material came from an adult cell firmly re-established the possibility of cloning from adults. Prior to Dolly's birth, scientists believed that adult cells lost the ability to dedifferentiate—i.e., to become unspecialized—and so could not direct the development of an embryo through to birth.The 1997 announcement of Dolly's birth initiated the present widespread discussion of cloning. Because of its potentially vast applications across human health, medicine, agriculture, and business/economics, cloning raises a host of issues including those concerning: genetics and genetic engineering, patenting, animal rights and/or animal welfare (especially for transgenic, research, or cloned animals), organ transplantation, reproduction, eugenics, pharmacology (drug production using transgenic animals), research practices, informed consent, stem cell research, women's rights, children's rights, parental rights and responsibilities, and theology and philosophy. It fosters questions about the meaning and purpose of life, the limits of human powers to intervene in research and therapy, and what it means to be human or animal. In addition, environmentalists and organic farmers raise concerns about the effect of novel animals and plants on the environment, while nutritionists and the lay public wonder... (shrink)

The surplus of impulses is a key category in Gehlen’s anthropobiology to understand the process of hominisation and humanisation. From the dedifferentiation of human instincts and the primitivisation of man’s anatomy, to the role of experience, institutions, and speech, the surplus of impulses is a source that flows between the inner and the outer, by feeding the action circle that whether translates in activity or is redirected inwards in order to become a movement of volitional constitution. The ambivalence in (...) which Gehlen deals with this function of freedom gives rise to a pessimistic and sacrificial idea of man. However, he posits certain basic elements of a hedonistic theory of speech from which we can better understand the stabilizing task of language as cornerstone of institutions. (shrink)

Embryonic and adult field do not exhibit the same properties because they are formed by cell populations whose activities cannot be compared in all respects. Dominant cells are not distributed in the same manner; the same mechanisms are not involved for remodelling of the field, especially after an amputation.In adult organisms, cell equilibrium is disturbed a first time by elimination of differentiated tissues which provokes dedifferentiation and proliferation, and a second time by healing, which restores cell equilibrium of a (...) distal end. Undifferentiated cells begin to differentiate immediately after their production and they reform the missing levels, following a sequence either basipetal or basifugal according to the place of their production . The differentiating regenerate temporarily exhibits embryonic field properties in various experimental conditions which suppress the dominance of the stump or supplies additional undifferentiated material. (shrink)

Many nuclear proteins have been found recently to interact with short conserved sequences which are involved in regulating the transcription of various genes. Nuclear transcription factors may be arbitrarily subdivided into two groups, ubiquitous and tissue‐specific. The transcription of one gene is usually regulated by several factors which interact with different sequences located either in the promoter region of the gene or outside it. The appearance or disappearance of transcription factors for some genes corresponds to certain phases of cell differentiation (...) or dedifferentiation and even to individual stages of the cell cycle. (shrink)

Contemporary French philosopher Michel Serres has out-of-the-rut thoughts about many things, including media. This article focuses on his understanding of the genealogy of media, the notion of exo-Darwinism, and his forward-looking attitude toward new technologies. An alternative, counterintuitive take on human nature is revealed as the discussion proceeds. This article also touches upon what is irreplaceable about humans in an age when artificial intelligence is rapidly evolving.

An immanent criticism of family criticism. Beyond the concept of authoritarian family, typical of the Frankfurt School particularly in order to grasp the sources of totalitarianism, the article considers that modern family system dedifferentiation is the objective process of its abolition at the present moment. This in two different ways: with the massive return of old family systems as clans and tribes, and through feminist and gay power revendications. The final suggestion is a social individualism in order to support (...) without trauma the current family perishing. (shrink)

In attempting to achieve some form of mapping between consciousness and cognition, I distinguish between a weak and a strong version of the hypothesis, indicating a change in mode of thinking of a metaphoric-symbolic nature . The weak version would claim that metaphors, symbols, analogies and images are used in an attempt to depict the experience, which is not easily translatable into words. The strong version would claim that metaphoric thinking is one of the hallmarks of the experience, and is (...) used both in an attempt to depict the experience and also to convey to the reader, and possibly to induce in the reader, some of the qualities of that experience. My discussion of these two options is preceded by some comments on problems inherent in studying altered or alternate states of consciousness. I also discuss the relationships among physiognomic perception, cognitive dedifferentiation, and symbolic cognition. (shrink)