Cellular reprogramming can manipulate the identity of cells to generate the desired cell types1– 3. The use of cell intrinsic components, including oocyte cytoplasm and transcription factors, can enforce somatic cell reprogramming to pluripotent stem cells4– 7. By contrast, chemical stimulation by exposure to small molecules offers an alternative approach that can manipulate cell fate in a simple and highly controllable manner8– 10. However, human somatic cells are refractory to chemical stimulation owing to their stable epigenome2,11,12 and reduced plasticity13,14; it (...) is therefore challenging to induce human pluripotent stem cells by chemical reprogramming. Here we demonstrate, by creating an intermediate plastic state, the chemical reprogramming of human somatic cells to human chemically induced pluripotent stem cells that exhibit key features of embryonic stem cells. The whole chemical reprogramming trajectory analysis delineated the induction of the intermediate plastic state at the early stage, during which chemical-induced dedifferentiation occurred, and this process was similar to the dedifferentiation process that occurs in axolotl limb regeneration. Moreover, we identified the JNK pathway as a major barrier to chemical reprogramming, the inhibition of which was indispensable for inducing cell plasticity and a regeneration-like program by suppressing pro-inflammatory pathways. Our chemical approach provides a platform for the generation and application of human pluripotent stem cells in biomedicine. This study lays foundations for developing regenerative therapeutic strategies that use well-defined chemicals to change cell fates in humans. (shrink)

This study investigates the social and environmental disclosure practices of socially responsible Chinese listed firms as displayed in their annual reports and corporate social responsibility reports from the perspective of stakeholders. A stakeholder-driven, three-dimensional social and environmental disclosure index that integrates the quantity and two aspects of the quality of disclosure perceived by stakeholders is constructed to assess the social and environmental disclosures in firm annual reports and CSR reports. The study results indicate that stakeholders perceive different disclosure types and (...) disclosure items as important to differing degrees. CSR reports provide more stakeholder-relevant social and environmental disclosure than annual reports. (shrink)

This article is an extension of my previous article, which describes pure knowing as the ability and criteria for making moral judgment.1 Due to apparent contradictions among Wang Yangming's statements, there are controversies over the evaluation and interpretation of Wang's idea of the relation between moral knowledge 2 and moral action. Generally, on the one hand, Wang admits that there are people who commit wrong actions even though they recognize that these actions are wrong. He claims not only that sages (...) possess pure knowing, but also that robbers feel ashamed to be called "robbers" through the working of pure knowing.3 On the other hand, he explicitly states that "There have never... (shrink)

This paper analyzes the relation between shame and a Confucian notion of yi, especially through discussions from Confucius and Mencius. Section one clarifies Mencius’s position that righteousness is both external and internal. Although this idea includes rules, it is primarily something intended by our innate moral feelings. Section two illustrates the point that if one’s action is not right, the feeling of shame spontaneously arises and motivates a self-correction. This section also clarifies the difference between the idea of shame in (...) Max Scheler and in Confucian thought. Section three compares absolute yi with general li as well as the roles that shame and duty play in relation to ren. (shrink)

In this paper, I focus on analyzing the manifestation and significance of respect. I first illustrate the two meanings of jing 敬 and their connection in Confucian classical texts, which is helpful to understand the Confucian phenomenology of respect. The two meanings are seriousness as a mind-state and respect as an intentional feeling. After clarifying this point, I undertake a phenomenological analysis of respect, in order to show that respect helps one to achieve moral pursuit. This analysis takes the Kantian (...) notion of respect as a starting point but further is accomplished by the phenomenology of value and feeling. The respect for duties and affairs, the respect for personhood and dignity, and the respect for the worthy with merit motivate one to take moral actions. For example, respect contributes in taking one’s duties seriously, appreciating human beings’ spiritual values and good tendencies even when they have not been actualized, supporting the worthy to play a role, and emulating the worthy to make a contribution and serve others. In Subsequently, I clarify how respect helps one to achieve religious pursuit in one form of Christianity, in light of Max Scheler’s discussion on humility and reverence. Through revering God one respects others; through serving God and participating in God’s humble spirit one serves others. I elucidate the Confucian classics’ discussions on religious experience, in order to show how respect helps one to achieve religious pursuit in one form of Confucianism, and how it is similar and different from Max Scheler’s clarification. The concrete relation between respect and li 禮 in the Confucian tradition will be treated in another work. (shrink)

This study was conducted to investigate the relationship between posttraumatic growth, resilience, positive coping style, and self-efficacy among the primary caregivers of children with developmental disorders in Chongqing, China. A total of 198 primary caregivers aged from 22 to 66 years old, including 155 females and 43 males, were enrolled. The Posttraumatic Growth Inventory, Connor-Davidson Resilience Scale-10, Simplified Coping Style Questionnaire, and General Self-Efficacy Scale were used for data collection. The results found that PTG could be positively predicted by resilience. (...) Positive coping style and self-efficacy mediated the relationship between resilience and PTG. The different levels of PTG were determined by the resident location, monthly income and education of the primary caregivers. The results suggest that it is critical to improve the mental health of the primary caregivers of children with developmental disabilities. Our results also provide a scientific basis for future research. (shrink)

In order to exchange knowledge, humans need to share a common lexicon of words as well as to access the world models underlying that lexicon. What is a natural process for a human turns out to be an extremely hard task for a machine: computers can’t represent knowledge as effectively as humans do, which hampers, for example, meaning disambiguation and communication. Applied ontologies and NLP have been developed to face these challenges. Integrating ontologies with (possibly multilingual) lexical resources is an (...) essential requirement to make human language understandable by machines, and also to enable interoperability and computability across information systems and, ultimately, in the Web. This book explores recent advances in the integration of ontologies and lexical resources, including questions such as building the required infrastructure (e.g., the Semantic Web) and different formalisms, methods and platforms for eliciting, analyzing and encoding knowledge contents (e.g., multimedia, emotions, events, etc.). The contributors look towards next-generation technologies, shifting the focus from the state of the art to the future of Ontologies and Lexical Resources. This work will be of interest to research scientists, graduate students, and professionals in the fields of knowledge engineering, computational linguistics, and semantic technologies. (shrink)

In the Western studies of the texts of Mozi, three distinctive views have surfaced in the past few decades: (1) Mozi is inconsistent because he seems to have been committed to both a Utilitarian standard and a divine command theory; (2) Mozi is a divine command theorist who argues that it is right to benefit the world because it is the will of heaven; and (3) Mozi is a utilitarian thinker who has based morality on the criterion of whether actions (...) benefit the world. In this paper, I will argue that the whole debate about whether Mozi is a divine command theorist or a utilitarian is misguided, because it is based on an incorrect understanding of the fundamental cultural perspective associated with the notion of Tian. An adequate understanding of the notion of Tian will reveal its fundamental difference from the Western notion of heaven. Such an understanding will enable us to put Mozi's moral philosophy in the ancient Chinese perspective in which a tension and potential conflict between 'the will of heaven' and 'the benefit of the world' simply cannot arise. (shrink)

The field of causal learning and reasoning (largely overlooked in the target article) provides an illuminating case study of how the modern Bayesian framework has deepened theoretical understanding, resolved long-standing controversies, and guided development of new and more principled algorithmic models. This progress was guided in large part by the systematic formulation and empirical comparison of multiple alternative Bayesian models.

European Portuguese (EP) is a language with variable stress, and the main cues for stress are duration and vowel reduction. A previous behavioral study has reported a stress “deafness” effect in EP when vowel quality cues are unavailable. The present study recorded both event-related potentials (ERPs) and behavioral data to examine the stress processing by native EP speakers in the absence of the vowel quality cues. Our behavioral result was consistent with previous research, showing that when vowel reduction is absent (...) EP speakers demonstrated a stress “deafness” effect similar to that found in speakers of languages with fixed stress or without any lexical stress marking. In the ERP task, both the trochaic and iambic conditions yielded mismatch negativity (MMN) and late negativity, suggesting that EP speakers are able to discriminate the two stress patterns without vowel reduction at the pre-attentive stage. Moreover, the ERP and behavioral data revealed compatible results regarding the pattern of stress bias in EP. In the EPR task, the MMN and late negativity components were more negative and span over a larger temporal window in the iambic condition than in the trochaic condition, indicating a higher sensitivity for the iambic stress pattern. In the behavioral task, EP speakers responded more accurately and more quickly to the iambic stress. These results match recent developmental findings in the acquisition of stress, but speak against the dominant view in EP phonological literature which assumes penultimate stress to be the regular stress pattern. In addition, both the ERP and the behavioral data showed that EP speakers’ stress processing was influenced by their working memory (WM) capacity. The participants with high WM capacity outperformed the participants with limited WM capacity in the iambic condition. In sum, our results broaden the current knowledge on stress processing by EP speakers at both the pre-attentive and attentive levels. (shrink)

This paper will investigate the phenomenology of shame with referring to Max Scheler’s description of the phenomenon and to the tradition of Confucianism. Section I explores the conflict between spirit, life and pleasure in the experience of shame. Shame implies a hierarchy of value, and it is felt when there is a conflict among different values and when the agent intends to sacrifice a higher value for a lower one. Shame also takes place when one is treated by others as (...) a mere object or merely as a sensuous being rather than a spiritual being possessing personal dignity. Section II clarifies the problem of destructive shame and humiliation. While genuine shame is indispensable for a person as such, wrongly felt shame is destructive to the cultivation of virtue. Differences between shame and humiliation and how one should treat humiliation will also be reexamined. (shrink)

The main goals of this paper are two. First, it articulates what kinds of knowing pure knowing is in its narrow sense pure knowing as the capacity of moral judgment; pure knowing as moral knowledge and standard. Besides, it analyses pure knowing’s different features through a phenomenological description. All these aspects of pure knowing are tied by moral feeling. Second, this paper addresses two sets of theoretical problems that have been raised in Confucian discourse with respect to pure knowing and (...) Heavenly principle, primarily those that render Wang’s notion of pure knowing to be static recognition toward particular moral issues, or immediate response, which reading cannot really admit the possibilities of extension, reflection, moral cultivation, and reform of institution; and those that understand pure knowing to be merely abstract without concrete content, such as merely being a metaphysical substance. When properly understood, that is, from the perspective of moral emotions, Wang Yangming’s account of pure knowing provides for the possibilities of enhancement and cultivation, while insisting that the content of pure knowing is always accessible to us. (shrink)

How do experiences of shame and guilt shape or reflect the ways in which the vanquished are reconciled (or not) to the new world order established by the victors? Shame and guilt are universal experiences in the emotional landscape of post-war politics, albeit for different reasons and with radically different political effects. An examination of Germany after 1918 and of Japan after 1945 reveals that experiences of shame and guilt may be pivotal for creating conditions of possibility for reconciliation marked (...) by political and moral transformation. This transformative potential of shame and guilt, however, is a double-edged sword. In threatening old identities, values and beliefs, experiences of shame and guilt may provoke defensive, reactionary and violent political responses, and thus may precipitate hideous rather than salutary transformations. Political leadership and political culture are crucial factors in shaping the kind of reconciliation — reactionary or transformative — as well as the specific nature of transformations that experiences of shame and guilt may motivate the vanquished to pursue. (shrink)

A fair amount of recent Xunzi scholarship has focused on the problem of moral transformation. The problem being addressed supposedly arises this way. According to Xunzi, human nature is innately or inherently evil; individuals, nevertheless, can become moral agents capable to embracing and loving moral principles. Unfortunately, Xunzi does not provide any account of how individuals whose characters are inherently evil can transformed into full moral agents. Several scholars have proposed various ways in which Xunzi could address the problems, but (...) all are unsatisfactory for various reasons. In this paper, I will develop my own reading of Xunzi’s moral philosophy. My approach is to put Xunzi in the context of classical Confucianism, a tradition that shaped Xunzi’s thinking on his metaphysical assumption about the world, his reverence for the wisdom of sage kings, and his emphasis on education as the necessary condition for virtue development. (shrink)

Learner control is an important instructional design in video-based learning. This study assessed two conditions: a full learner control where learners direct their learning path, and a hybrid learner control where learners follow the instructor-set path but still enjoy certain aspects of control. Two groups of university students participated in this study by learning statistics through online video courses. The findings show that the full learner control condition attained higher learning performance than the hybrid learner control condition, but spent more (...) time than the latter. The full learner control condition scored higher than the hybrid condition in the difficult sections of video-based learning; but no significant difference was found in the easy section. There was a significant difference between the two conditions in learning agency, but no differences in cognitive load and affective and cognitive engagement. Hierarchical regression analysis indicated differences between the full and the hybrid learner control conditions in the factors predicting overall scores. The findings carry important contributions and implications for the research and practice of instructional designs in online video-based learning such as MOOCs. (shrink)

Let $\Gamma$ be the random bipartite graph, a countable graph with two infinite sides, edges randomly distributed between the sides, but no edges within a side. In this paper, we investigate the reducts of $\Gamma$ that preserve sides. We classify the closed permutation subgroups containing the group $\operatorname {Aut}(\Gamma)^{\ast}$ , where $\operatorname {Aut}(\Gamma)^{\ast}$ is the group of all isomorphisms and anti-isomorphisms of $\Gamma$ preserving the two sides. Our results rely on a combinatorial theorem of Nešetřil and Rödl and a strong (...) finite submodel property for $\Gamma$. (shrink)

With the rapid development of the Internet and smart phone technology, a large number of short videos are shared through social platforms. Therefore, video content analysis is a very important and popular work in machine learning and artificial intelligence currently. However, it is very difficult to analyze all aspects of video content originally produced by large-scale users. How to screen out bad and illegal content from short videos published by a large number of users, select high-quality videos to share with (...) other users, and improve the quality of video on the distribution platform of the entire user is a top priority. Based on this background, this paper focuses on optimizing video auditing to provide basic features for algorithm judgment, supporting original content and increasing the distribution of new content, and strengthening manual intervention combining algorithm recommendation with manual recommendation. Four major aspects of the artificial training algorithm model discuss the optimization effect of artificial intelligence on the algorithm in order to provide some guidance for the sustainable and healthy development of mobile short video. (shrink)

Aiming at the vulnerability of wireless network, this paper proposed a method of WiFi penetration testing based on Kali Linux which is divided into four stages: preparation, information collection, simulation attack, and reporting. By using the methods of monitoring, scanning, capturing, data analysis, password cracking, fake wireless access point spoofing, and other methods, the WiFi network penetration testing with Kali Linux is processed in the simulation environment. The experimental results show that the method of WiFi network penetration testing with Kali (...) Linux has a good effect on improving the security evaluation of WiFi network. (shrink)

Reading comprehension is never considered a simple task in linguists’ views as it requires a full set of linguistic knowledge, such as word decoding, understanding syntactic and morphological structures, and deriving proper meanings from these structures in a given context. Bearing the simple view of reading, the primary goal of this study is to explore whether the split presentation of Chinese splittable compounds influences the recognition of the compounds in second language (L2) Chinese reading comprehension, and how the reading skills, (...) i.e., word decoding and linguistic comprehension, cooperate to complete this reading comprehension task. Splittable compounds (SCs) in Chinese are typically verbs composed of two constituents with limited separability. The separable property of SCs and their vague morpho-syntactic status are supposed to cause difficulties for L2 Chinese learners in recognizing the compounds. Especially for those whose native language manifests lexical integrity, the split presentation of the compounds may invite the L2 Chinese readers to process them with a mechanism different from that for their non-split forms. To the best of our knowledge, the efforts on investigating this issue are insufficient. In this study, 27 Spanish speaking L2 Chinese learners were invited to complete tasks including reading and interpreting 6 selected SCs in the split and non-split forms, rating their familiarities with each SC and reporting the syntactic category of the SCs based on their existing linguistic knowledge. The results, showed that the split presentation of SCs did cause challenges for L2 Chinese learners in recognizing the compounds in the reading process, regardless of their Chinese proficiencies. The L2 Chinese participants performed significantly worse in recognizing split SCs in salient Verb-Object structures than recognizing those in unsalient Verb-Object structures. These findings underscore the importance of linguistic comprehension in L2 Chinese in-text word reading comprehension and suggest words as the basic processing units. (shrink)

Voice mismatch between conjuncts is impossible in the gapping construction. Some recent studies explained this effect by analyzing gapping as involving the ellipsis of a category at least as large as VoiceP. One prediction this analysis makes is that mismatch of any head structurally lower than Voice should not be possible in gapping. In this study, through a series of acceptability judgment experiments examining argument structure mismatches in gapping, we provide empirical observations that challenge this prediction.

This study examines the relationship between corporate social responsibility, a central ethical concern, and firm total risk, a central business concern, using a large US dataset spanning 1991 to 2015. It includes considerations for the recent financial crisis to establish whether firm engagement in specific CSR dimensions decrease or increase firm risk. The findings demonstrate the impact of CSR engagement is different, depending on the specific CSR dimension in question, and the relationship between each of the seven CSR dimensions and (...) total risk is time varying. Our empirical evidence suggests that firms should prioritize different CSR dimensions as an integral part of their CSR strategies and strategic management and change the priority in different market conditions. (shrink)

To clarify the relationship between higher vocational students’ liking of teachers and their learning engagement, based on the theory of social exchange, 1,279 vocational students in the Yangtze River Delta and the Pearl River Delta in China are used as the research objects. From the perspective of students and teachers, SPSS and AMOS are used to conduct a two-stage linear regression analysis. The results show that students’ liking of their teachers has a positive effect on learning engagement; liking positively affects (...) students’ psychological empowerment; liking of teachers indirectly influences learning engagement through psychological empowerment; teacher’s support positively moderates the indirect relationship between liking of teachers and learning engagement through psychological empowerment. This study attempts to provide practical guidance for college students to provide learning engagement. (shrink)

The article analyzes the works of Chinese artists of various historical eras who used a stylistic and thematic direction with the image of a plum blossom. The artists' appeal to images of nature to convey feelings and experiences contributed to the emergence of this image and its formation as a symbol of steadfastness and inflexibility of character. Thus, the subject of the proposed study is Chinese painting, the object is the formation of such a common motif as a plum blossom. (...) The purpose of this publication is to determine the main types of images of this image in Chinese traditional painting in the time interval from the VI century to the end of the XIV century — the most fruitful period of its formation and development. Plum blossom is of greater importance in the development of traditional landscape painting in China. For almost a millennium, the interpretation, compositional solution, as well as the technique of depicting this image have changed. The author's contribution to the development of the problem is a comprehensive analysis of images of plum blossoms in landscape paintings by Chinese artists of various historical eras, as well as the characteristics of the process of evolution and the features of the embodiment of this image. The paper traces the origins of this plot in the art works of Chinese artists, analyzes the processes of change and development of images, and characterizes the specifics of its external expression and internal content. (shrink)

This chapter discusses the reception of The Classic of Filial Piety (Xiaojing孝經) from medieval to late imperial China. Based on the records found in Scripta Sinica database, we see the way in which female biographies indicate the increasing importance of The Classic of Filial Piety in female education during late imperial China. Male biographies, however, demonstrate the opposite trend. I suggest this phenomenon does not reflect the decline in its male readership, but rather a change in the status of the (...) book. I then discuss how the text played a significant role in political culture before medieval period and became mainly a primer after Southern Song. The marginalization of the text in political and elite circles caused it to figure less prominently in male biographies. In addition, this chapter also discusses certain aspects related to The Classic of Filial Piety and female education, as well as the revival of the study of the Canon during the late Ming and how the book regained its political importance by the support of the Qing state. (shrink)

The paper discusses the role of tense and time from a cross-linguistic perspective by comparing English and Mandarin. Multiple translations of the same literary piece are used to test the correspondence between the tense, the perfective aspect and temporal adverbials. In English, tense marking is found to work with at least two language-specific stylistic means, clause interpolation and inversion, to create a mixed narrative viewpoint. In Mandarin, neither the perfective aspect nor temporal adverbials, i.e., constructions that invoke time, are systematically (...) used across the renditions, which shows the Mandarin system’s overall indifference to time in managing viewpoint in discourse. The Mandarin renditions, in addition to an overall indifference to time, feature consistent and frequent use of reduplication as the system’s distinctive viewpoint strategy. The paper concludes with a discussion of the cognitive consequence of a language using an obligatory marking system to piggyback the function of viewpointing narratives. (shrink)

Modern philosophers tends to regard morality as intrinsically universalist, embracing universal norms that apply formally to each moral agent qua moral agent, independent of particularities such as familial relationships or membership in a specific community. At the same time, however, most of us think (and certainly act as if) those particularist properties play a significant and legitimate role in our moral lives. Accordingly, determining the proper relationship of these two spheres of the moral life is of great importance, but a (...) fully successful resolution of this tension remains lacking. I believe Dietrich von Hildebrand’s work on love, and specifically his development of the idea of Eigenleben (Subjectivity) in The Nature of Love, offers a fruitful way forward. In this paper I begin by laying out some of the chief features of the universalist character of modern moral theory in both Kantianism and consequentialism. I then articulate some of the ways in which von Hildebrand’s understanding of Eigenleben offers us genuine insights towards articulating a substantive account of the proper relationship of the universal demands of morality and the particularist demands of my own life. Specifically, von Hildebrand’s critique of extreme altruism shows that moral agents cannot be properly understood according to merely formal properties like rationality, because each person’s particular Eigenleben is the only real grounds for moral agency. Von Hildebrand develops a critique of depersonalized universalism similar to Bernard Williams’ later criticisms of Kantian moral thought, while offering a positive account that is in many ways more compelling. Ultimately, von Hildebrand allows us to see that a genuine Subjectivity is the necessary grounds for the possibility of love, including and especially the love of God, which serves as the basis for a genuine morality based on objective values. Building on this insight we can begin to articulate an account of the moral life grounded in answering the call of God that can do justice to both our universalist and particularist intuitions. (shrink)

This study compares the estimated grammar school effect in different regression models, and explains why previous evidence of the effetiveness of grammar school is mixed. Like most studies of school effectiveness evaluation, previous research on grammar school effect usually applies regression to control for confounding between-school factors and determines whether attending grammar schools is associated with an academic benefit. While this value-added approach is very feasible and widely adopted, there is usually substantial variation in the evidence produced when statistical choices (...) differ. Applying the national data with more than 149,000 pupils, the study presents the sensitivity of grammar school effectiveness when baseline variables, outcome variables, and regression techniques differ. The findings will help researchers understand the mixed evidence of the effectiveness of grammar schools so far, and the unsettled debate on grammar schools nationally. While inconsistent estimations due to passive design is a common trait in school effectiveness evaluation studies, grammar schools’ effectiveness might be even more sensitive to statistical choices due to their special student intakes. Interpreting the variation between different statistical models, the findings caution researchers in dealing with the evidence in grammar school effectiveness and call for stronger designs as well as more carefully selected explanatory variables. (shrink)

The aim of this study is to use a commognitive responsibility framework to visualize responsibility shift in collaborative problem solving during computer-supported one-to-one tutoring. Commognitive responsibility shift means that individuals’ cognitive responsibility shift can be reflected by the discourse in communication. For our sample, we chose a 15-year-old Chinese boy and his mathematics teacher with 6 years of teaching experience, both of whom have experienced computer-supported learning and teaching mathematics, respectively. We collected four tutoring videos online, and a 45-min interview (...) video from the teacher. We found that the third type of commognitive responsibility shift in both the teacher’s and student’s CPS behavior online is not only teacher–student comparison but also alternating-led, which includes teacher–student-led and student–teacher-led. (shrink)