AimPatients with high myopia reportedly exhibit changes in functional brain activity, but the mechanism underlying such changes is unclear. This study was conducted to observe differences in dynamic spontaneous brain activity between patients with HM and healthy controls via dynamic regional homogeneity analysis.MethodsResting-state functional magnetic resonance imaging scans were performed on 82 patients with HM and 59 HCs who were closely matched for age, sex, and weight. The dReHo approach was used to assess local dynamic activity in the human brain. (...) The association between mean dReHo signal values and clinical symptoms in distinct brain areas in patients with HM was determined via correlation analysis.ResultsIn the left fusiform gyrus, right inferior temporal gyrus, right Rolandic operculum, right postcentral gyrus, and right precentral gyrus, dReHo values were significantly greater in patients with HM than in HCs.ConclusionPatients with HM have distinct functional changes in various brain regions that mainly include the L-FG, R-ITG, R-ROL, R-PoCG, and R-PreCG. These findings constitute important evidence for the roles of brain networks in the pathophysiological mechanisms of HM and may aid in the diagnosis of HM. (shrink)

AimResting state functional magnetic resonance imaging was used to analyze changes in functional connectivity within various brain networks and functional network connectivity among various brain regions in patients with high myopia.Methodsrs-fMRI was used to scan 82 patients with HM and 59 healthy control volunteers matched for age, sex, and education level. Fourteen resting state networks were extracted, of which 11 were positive. Then, the FCs and FNCs of RSNs in HM patients were examined by independent component analysis.ResultsCompared with the HC (...) group, FC in visual network 1, dorsal attention network, auditory network 2, visual network 3, and sensorimotor network significantly increased in the HM group. FC in default mode network 1 significantly decreased. Furthermore, some brain regions in default mode network 2, default mode network 3, auditory network 1, executive control network, and significance network increased while others decreased. FNC analysis also showed that the network connection between the default mode network and cerebellar network was enhanced in the HM group.ConclusionCompared with HCs, HM patients showed neural activity dysfunction within and between specific brain networks, particularly in the DMN and CER. Thus, HM patients may have deficits in visual, cognitive, and motor balance functions. (shrink)

Objectives: Autism spectrum disorder (ASD) is a juvenile onset neurodevelopmental disorder with social impairment and stereotyped behavior as the main symptoms. Unaffected relatives may also exhibit similar ASD features due to genetic factors. Although previous studies have demonstrated atypical brain morphological features as well as task-state brain function abnormalities in unaffected parents with ASD children, it remains unclear the pattern of brain function in the resting state.Methods: A total of 42 unaffected parents of ASD children (pASD) and 39 age-, sex-, (...) and handedness-matched controls were enrolled. Multiple resting-state fMRI (rsfMRI) analyzing methods were applied, including amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), degree centrality (DC), and functional connectivity (FC), to reveal the functional abnormalities of unaffected parents in ASD-related brain regions. Spearman Rho correlation analysis between imaging metric values and the severity of ASD traits were evaluated as well.Results: ALFF, ReHo, and DC methods all revealed abnormal brain regions in the pASD group, such as the left medial orbitofrontal cortex (mOFC) and rectal gyrus (ROI-1), bilateral supplementary motor area (ROI-2), right caudate nucleus head and right amygdala/para-hippocampal gyrus (ROI-3). FC decreasing was observed between ROI-1 and right anterior cingulate cortex (ACC), ROI-2, and bilateral precuneus. FC enhancing was observed between ROI-3 and right anterior cerebellar lobe, left medial temporal gyrus, left superior temporal gyrus, left medial frontal gyrus, left precentral gyrus, right postcentral gyrus in pASD. In addition, ALFF values in ROI-1, DC values in ROI-3 were positively correlated with AQ scores in pASD (ρ1 = 0.298, P1 = 0.007; ρ2 = 0.220, P2 = 0.040), while FC values between ROI-1 and right ACC were negatively correlated with AQ scores (ρ3 = −0.334, P3 = 0.002).Conclusion: rsfMRI metrics could be used as biomarkers to reveal the underlying neurobiological feature of ASD for unaffected parents. (shrink)

Science in the views of philosophy and culture.

本书在界定价值与价值观基本范畴的基础上,详尽地分析了我国青年与西方青年在人生、政治、经济、道德、审美、爱情、职业等各方面价值观的现实状况、历史传统与演变趋势,为我国青年全面了解西方、了解世界提供了独特 的视角,并在剥离出西方青年价值观的合理内核的基础上,为构建我国青年的科学价值观指明了方向。本书在我国国际交往日益广泛、即将加入WTO的时代背景下出版有着特别的意义。.

本书围绕中国近代历史上新文化运动反孔批儒的议题，从儒学转型的视角，集中探讨了聚焦在康有为、章太炎身上的现代进程转向问题。.

藤原文亮(1963~),1996年加入日本国籍,现为日本九州看护福祉大学副教授.

本書包括兩個主題，前四章是對陽明學派初起時的一些觀察。陽明心學在明代中期出現的意義，是在功名、詩文、程朱理學籠罩之中，高唱身心性命之學，為浮華而形式化的學術環境注入一股清流。然而在陽明所來往的程朱理學 家之中，為己之學已是共同的方向，陽明只是走的更遠而已。徐愛有經世之志，董澐以詩為生涯，錢緒山則從事朱子學，皆在身心性命的關懷下成為陽明弟子。王龍溪早慧脫俗，直承陽明之學而發展其精髓。後六章是關於蕺山學 派的，近年蕺山學派研究的重點包括蕺山身後解釋權之爭，與明清學術轉型等問題。一般認為黃梨洲較得蕺山真意，但多數弟子則傾向朱子學，並影響到蕺山嗣子劉汋對蕺山著作的編輯與刪改。本書認為劉汋從工夫論的立場理解 蕺山，對蕺山著作的整理足以作為客觀研究的依據。對蕺山思想的詮釋，本書本於牟宗三先生「以心著性」說，並略有修正。梨洲融鑄與簡化蕺山思想，而展開經史學術的創造，思想上的貢獻是發展格物說。惲日初同時受到高景 逸與劉蕺山影響，其格物思想的背景是節義與藝術。.

本书共七章,内容包括:舜帝与中华道德统绪,舜帝葬所与舜帝陵庙,舜帝陵祭祀与舜德传承,舜帝与礼乐文明,舜文化的阐释与演进等.

本书着眼于人与文化,运用马克思人学理论和文化类型理论对中国传统走向现代的社会变革和人的存在进行了深入的理论分析,不仅从人的活动及其目的、人的自我及其实现、现代人的自我实现之路三大层在展开对中国现代化过 程的探讨.

“泰初有無”，萬物原初中美之為“大”無名卻有實。大美終而有了一個言說的對象，這位不速之客卻反客為主。從寂寞入喧鬧，在主體之間七嘴八舌中大美難免名實相乖，美名之下往往其實難副。 在“自然人化”過程中感官“人化”發生了美感與藝術創造力，繼之美學與文藝學分別成為獨立的學科，它們的知識合法性以各自認識上的真理性支持。 我們人文家園中這兩片小小田畦。它們緊相毗鄰又以田埂與其他地塊相隔。這就是美學和文藝學以其對象的感性審美形式區別于其他學科對象的形式。 毛崇杰，1939年生于上海。1962年畢業于南京大學地質系，畢業後在中國科學院科學出版社任編輯，1973年調至中國科學院地質研究所。.

本书共七章,内容包括:舜帝与中华道德统绪,舜帝葬所与舜帝陵庙,舜帝陵祭祀与舜德传承,舜帝与礼乐文明,舜文化的阐释与演进等.

中共浙江省委党校学科建设成果资助出版项目 “浙江省科学发展观与浙江发展研究中心”研究成果.

Ben shu wei Xianggang Zhong wen da xue Ya Tai yan jiu suo yan jiu yuan Zheng Hailin bo shi suo zhu, ji jie qi fang xue dong xi fang shi nian suo zhuan xie wen zhi jing cui er cheng, nei rong fen wei si xiang, li shi ren wu, he wen hua ping lun san bu fen. Guan dian zheng que, ke guan gong zheng, fu yu chuang yi.

全书共分为四部分,主要内容包括第一部分文学理论研究;第二部分中国文学与日本文学研究;第三部分日本经典作家作品研究举要;第四部分中日学者对话.

本书分为上下篇,上篇收录作者1982~2001年间写作和发表的有关马克思哲学研究的11篇论文,下篇收录作者1985年到今天写作和发表的有关国外马克思主义哲学研究的16篇论文。.

本书分四编,约40万字,收录了国内美学界数十位知名专家、学者的论文,涉及转型期中国美学理论建构和学科前景、当下美学的问题及其转机、文化资源利用与美学的策略等多方面内容,在多层面分析中国社会文化转型的现 实问题、多视角解读当下语境中中国美学理论课题与建构难点的基础上,围绕如何看待和解决转型期中国美学面临的困境与问题,提出了富有理论深度和学术建设性的意见,集中展示了当前中国美学界对“ 转型期中国美学问题”的思考策略和思考深度.