„Substances capable of self-reproduction“ as cellular targets of chemical carcinogens.In the course of studies on chemical carcinogenesis, which included animal experiments with a carcinogenic azo dye and a mathematical analysis of the observed effects, Hermann Druckrey and Karl Küpfmüller showed in 1948 that carcinogens induce heritable changes by targeting cellular „substances capable of self-reproduction“. The authors did not discuss the chemical nature of these substances which remained unclear for a long time thereafter. It was not until 1964 that deoxyribonucleic acid (...) (DNA) was recognized, by Peter Brookes and Philip Lawley, as a target for the genotoxic action of chemical carcinogens. In retrospect, the results of Druckrey and Küpfmüller gave an early, indirect and until now not considered hint to an important role of DNA (the „substance“) malfunction in the development of cancer, since DNA is the only molecule capable of self-reproduction.The results are now appreciated in light of the scientific knowledge available at the time. (shrink)

BackgroundOperation room (OR) planning is a complex process, especially in large hospitals with high rates of unplanned emergency procedures. Postponing elective surgery in order to provide capacity for emergency operations is inevitable at times. Elderly patients, residents of nursing homes, women, patients with low socioeconomic status and ethnic minorities are at risk for undertreatment in other contexts, as suggested by reports in the medical literature. We hypothesized that specific patient groups could be at higher risk for having their elective surgery (...) rescheduled for non-medical reasons.MethodsIn this single center, prospective observational trial, we analysed 2519 patients undergoing elective surgery from October 2018 to May 2019. A 14-item questionnaire was handed out to illicit patient details. Additional characteristics were collected using electronic patient records. Information on the timely performance of the scheduled surgery was obtained using the OR’s patient data management system. 6.45% of all planned procedures analysed were postponed. Association of specific variables with postponement rates were analysed using the Mann–Whitney U test and Fisher's exact test/χ2-test.ResultsSignificantly higher rates of postponing elective surgery were found in elderly patients. No significant differences in postponing rates were found for the variables gender, nationality (Germany, EU, non-EU), native language, professional medical background and level of education. Significantly lower rescheduling rates were found in patients with ties to hospital staff and in patients with a private health insurer.ConclusionsElderly patients, retirees and nursing home residents seem to be at higher risk for having their elective surgery rescheduled. However, owing to the study design, causality could not be proven. Our findings raise concern about possible undertreatment of these patient groups and provide data on short-term postponement of elective surgery.Trial registration DRKS00015836. Retrospectively registered. (shrink)

Over the years, artificial neural networks have been applied successfully in many areas including IT security. Yet, neural networks can only process continuous input data. This is particularly challenging for security-related, non-continuous data like system calls of an operating system. This work focuses on five different options to preprocess sequences of system calls so that they can be processed by neural networks. These input options are based on one-hot encodings and learning word2vec, GloVe or fastText representations of system calls. As (...) an additional option, we analyse if mapping system calls to their respective kernel modules is an adequate generalization step for replacing system calls or enhancing system call data with additional information regarding their context. When performing such preprocessing steps it is important to ensure that no relevant information is lost during the process. The overall objective of system call analysis in the context of IT security is to categorize a sequence of them as benign or malicious behavior. Therefore, this scenario is used to evaluate different system call representations in a classification task. Results indicate that a broader range of attacks can be detected when enriching system call representations with corresponding kernel module information. Prior learning of embeddings does not achieve significant improvements. This work is an extension of the work by Wunderlich et al. [1] published in Advances in Intelligent Systems and Computing. (shrink)

Falk Wunderlich präsentiert einen grundlegend neuen Ansatz zum Verständnis der Kant'schen Bewusstseinstheorie. Im ersten Teil bietet er eine detaillierte Rekonstruktion der bewusstseinstheoretischen Diskussionen des 18. Jahrhunderts. Im Mittelpunkt steht dabei die Rekonstruktion des Geflechts von Diskussionen, in dessen Kontext sich Kants Überlegungen bewegen. Auf diese zeitgenössischen Debatten werden im zweiten Teil Kants bewusstseinstheoretische Ansätze bezogen. Der Autor vertritt die These, dass Kant die zeitgenössischen Standardansichten über Bewusstsein, Apperzeption und Selbstbewusstsein entgegen dem Anschein nur einschränkt modifiziert und ihre begrifflichen Grundlagen (...) beibehält. Schließlich wird vor dem Hintergrund dieser Kontextualisierung eine alternative Interpretation der transzendentalen Deduktion entwickelt. (shrink)

The general notions of object- and metalanguage are discussed and as a special case of this relation an arbitrary first order language with an infinite model is expanded by a predicate symbol T0 which is interpreted as truth predicate for . Then the expanded language is again augmented by a new truth predicate T1 for the whole language plus T0. This process is iterated into the transfinite to obtain the Tarskian hierarchy of languages. It is shown that there are natural (...) points for stopping this process. The sets which become definable in suitable hierarchies are investigated, so that the relevance of the Tarskian hierarchy to some subjects of philosophy of mathematics are clarified. (shrink)

Critics of reliability theories of epistemic justificationoften claim that the `generality problem' is an insurmountabledifficulty for such theories. The generality problem is theproblem of specifying the level of generality at which abelief-forming process is to be described for the purposeof assessing its reliability. This problem is not asintractable as it seems. There are illuminating solutionsto analogous problems in the ethics literature. Reliabilistsought to attend to utilitarian approaches to choices betweeninfinite utility streams; they also ought to attend towelfarist approaches to social (...) choice situations that donot demand full aggregation of individual welfares.These analogies suggest that the traditional `single number'approach to reliability is misguided. I argue that a newapproach – the `vector reliability' approach – is preferable.Vector reliability theories associate target beliefs withreliability vectors – that is, structured collections ofreliability numbers – and construct criteria of epistemicjustification that appeal to these vectors. The bulk of thetheoretical labor involved in a reliability account of epistemicjustification is thus transferred from picking a uniquereliability number to constructing a plausible criterionof epistemic justification. (shrink)

The paper focuses on Priestley’s complex views on the essence of God in connection with his materialism, elaborated in the Disquisitions Relating to Matter and Spirit (1777/ 1782). This issue is crucial if one wishes to get a clear idea of what Priestley’s materialism amounts to; whether it is mainly a thesis about the material grounds of the human mind (“psychological materialism”), or a more far-reaching one about what kind of substances exist in the world (a version of “ontological materialism”). (...) The claim that God may be material allows for the most radical version of ontological materialism according to which everything in the world is material, without altogether denying that God exists. In fact, Priestley considers and partially defends at least three different views on the potential materiality of God: (1) an agnostic stance that is his official view, (2) materialism about God based on his own theory of matter, and (3) “gross” materialism about God. The aim of the paper is to analyze these three views, in particular concerning what kind of materialism they support and whether they can contribute to the consistent Christian materialism Priestley envisaged. (shrink)

On the one hand, the concept of truth is a major research subject in analytic philosophy. On the other hand, mathematical logicians have developed sophisticated logical theories of truth and the paradoxes. Recent developments in logical theories of the semantical paradoxes are highly relevant for philosophical research on the notion of truth. And conversely, philosophical guidance is necessary for the development of logical theories of truth and the paradoxes. From this perspective, this volume intends to reflect and promote deeper interaction (...) and collaboration between philosophers and logicians investigating the concept of truth than has existed so far.Aside from an extended introductory overview of recent work in the theory of truth, the volume consists of articles by leading philosophers and logicians on subjects and debates that are situated on the interface between logical and philosophical theories of truth. The volume is intended for graduate students in philosophy and in logic who want an introduction to contemporary research in this area, as well as for professional philosophers and logicians. (shrink)

The paper puts Kant’s second paralogism in the first edition of his Critique of Pure Reason into the context of eighteenth century debates on materialism. In the second paralogism, Kant argues that neither dualism nor materialism about the human mind can be established, while focusing on a received anti-materialist argument that he dubs the “Achilles argument”. The Achilles argument that Kant ultimately rejects is based on the assumption that the unity of thought requires a unified substratum and thus an immaterial (...) soul. I argue (1) that the second paralogism is not a paralogism formally but (2) nonetheless provides an illuminating discussion of the shortcomings of the Achilles argument. In doing so, I attempt to identify the contemporary background for Kant’s reconstruction of this argument. (shrink)

The proof-theoretic results on axiomatic theories oftruth obtained by different authors in recent years are surveyed.In particular, the theories of truth are related to subsystems ofsecond-order analysis. On the basis of these results, thesuitability of axiomatic theories of truth for ontologicalreduction is evaluated.

Emotion expressions of outgroup members inform judgements and prompt affective responses in observers, shaping intergroup relations. However, in the context of political group conflicts, emotions are not always directly observed in face-to-face interactions. Instead, they are frequently linguistically ascribed to particular actors or groups. Examples of such emotion ascriptions are found, among others, in media reports and political campaign messaging. For instance, anger and fear are frequently evoked in connection with and ascribed to right-wing populist groups. Yet not much is (...) known about the specific effects that ascriptions of discrete emotions to outgroups can have on intergroup relations. With this pre-registered study, we contribute to bridging this gap by analysing the effects of ascriptions of anger and fear to a right-wing populist outgroup. In an online survey experiment, administered to a sample of the German general population (N = 3500), we manipulated the emotions ascribed to these outgroups using brief vignettes. Our findings suggest that ascriptions of anger to right-wing populist outgroups increase reactive anger in observers, whereas ascriptions of fear reduce anger as well as contempt towards populists. Effects of ascribed emotions on stereotype content and action tendencies could not be identified. (shrink)

Two of the distinctive ethical issues that arise for computer users (as opposed to computer programmers) have to do with the file formats that are used to encode information and the licensing terms for computer software. With respect to both issues, most professional philosophers do not recognize the burdens that they impose on others. Once one recognizes these burdens, a very simple argument demands changes in the behavior of the typical computer user: some of the ways we use computers gratuitously (...) impose significant burdens on others; it is wrong to impose significant burdens on others gratuitously; some of the ways we use computers are unethical. (shrink)

ABSTRACTLate Enlightenment German materialism has hardly attracted any scholarly attention in the past, in spite of the fact that there were quite a few exponents of it. In this paper, I identify the philosophically most important ones and examine to what extent they were connected with each other. In fact, there are local concentrations of materialists at universities and academic circles in Göttingen, Halle, and Gießen. I then discuss the spectrum of materialist positions held by them, from empiricist naturalism in (...) the case of Michael Hißmann to emergentism and Spinozism in the case of Karl von Knoblauch. Finally, I examine how German materialists conceived of the nature of soul and its immortality. It turns out that most of them were mortalists, with the exception of August Wilhelm Hupel, and some of them also endorsed Socinianism. (shrink)

At the centre of the traditional discussion of truth is the question of how truth is defined. Recent research, especially with the development of deflationist accounts of truth, has tended to take truth as an undefined primitive notion governed by axioms, while the liar paradox and cognate paradoxes pose problems for certain seemingly natural axioms for truth. In this book, Volker Halbach examines the most important axiomatizations of truth, explores their properties and shows how the logical results impinge on (...) the philosophical topics related to truth. In particular, he shows that the discussion on topics such as deflationism about truth depends on the solution of the paradoxes. His book is an invaluable survey of the logical background to the philosophical discussion of truth, and will be indispensable reading for any graduate or professional philosopher in theories of truth. (shrink)

Theological and secular concepts ofstewardship evolved markedly in the 20thcentury. During this period of evolution, theAmerican Country Life Association through itschurch, academic, farm organization, andgovernmental affiliations, served as a bridgingand bonding agent in developing the stewardshipidea. As in any evolutionary process, thestewardship concept was subjected to a broadarray of influences and characterized bynotable highlights such as the Lynn Smithcritique of the Judaeo-Christian ethic, theman-in-nature statement of Douglas John Hall,and the environmental concerns of ecologistsand philosophers of the post-Rachel Carson era.Some gains (...) have been made in understanding theplace of humans in nature, but the stewardshipidea continues as work in process. (shrink)

We gratefully thank Filipa Matos Wunderlich for the permission to republish this text, which was first published in a shorter version in KOHT ja PAIK/PLACE and LOCATION Studies in Environmental Aesthetics and Semiotics VI, 2008.: Temporality is a fundamental characteristic of urban places. An attribute of nature, people and space, place-temporality consolidates and emerges out of their dynamic relationship in urban space. Temporality is place-specific and a result of compounds - Urbanisme – Nouvel article.

It is a commonplace that in the development of modern logic towards its actual shape at least two directions or traditions have to be distinguished. These traditions may be called, following the mo...

Liberalism believes that individuals are endowed a priori with reason or at least agency and it is up to that reason and agency to make choices, commitments and so on. Communitarianism criticizes liberalism’s explicit and deliberate neglect of the self and insists that we attain a self and identity only through the effective recognition of significant others. However, personal autonomy does not seem to be a default position, neither reason nor community is going to provide it inevitably. Therefore, it is (...) so important to go beyond the liberal–communitarian divide. This article is analysing various proposals in this direction, asks about the place of communities and the individual in times of populism and the pandemic and provides a global perspective on the liberal–communitarian debate. (shrink)

Agrarianism in America assumes manyforms, in part because of the varied sources ofruralistic values, some evolving from times beforenationhood. Views expressed are sometimes anti-city,other times pro-rural. The Jeffersonian perspective isrevealed in three forms, two by historians, one by aphilosopher. They agree that Jefferson was animportant figure in America's land system, but theydiffer markedly in their uses of Jeffersonian valuesabout agriculture, land, and rural life. The essayconcludes with a basis for “new agrarianism” basedmore on land than agriculture as enterprise.

Using a contextual method the specific development of logic between c. 1830 and 1930 is explained. A characteristic mark of this period is the decomposition of the complex traditional philosophical omnibus discipline logic into new philosophical subdisciplines and separate disciplines such as psychology, epistemology, philosophy of science, and formal logic. In the 19th century a growing foundational need in mathematics provoked the emergence of a structural view on mathematics and the reformulation of logic for mathematical means. As a result formallogic (...) was taken over by mathematics in the beginning of the 20th century as is shown by sketching the German example. (shrink)

The hierarchy of conceptual categories involves a level of abstraction called the basic level. This is the level at which the subjects are fastest at identifying category members, at which conceptual priming most easily obtains, at which information is most easily remembered over time, and at which a single mental image can reflect the entire category. Basic-level categories tend to be the first ones acquired by young children, and also tend to be expressed by the simplest words. Various approaches have (...) been developed to deal especially with verbs, which, as the basis of grammatical clauses, are more structured than nouns. Generative semantics explored the idea that the inherent structure of verbs conforms to the syntactic structure of sentences, and therefore should be studied by means of complex paraphrases. (shrink)