The rearrangement or permutation of protein substructures is an important mode of divergence. Recent work1 explored one possible underlying mechanism called permutation‐by‐duplication, which produces special forms of motif rearrangements called circular permutations. Permutation‐by‐duplication, involving gene duplication, fusion and truncation, can produce fully functional intermediate proteins1 and thus represents a feasible mechanism of protein evolution. In spite of this, circular permutations are relatively rare and we discuss possible reasons for their existence. BioEssays 28: 973–978, 2006. © 2006 Wiley Periodicals, Inc.

In this volume, Veronica Roberts Ogle offers a new reading of Augustine's political thought as it is presented in City of God. Focusing on the relationship between politics and the earthly city, she argues that a precise understanding of Augustine's vision can only be reached through a careful consideration of the work's rhetorical strategy and sacramental worldview. Ogle draws on Christian theology and political thought, moral philosophy, and semiotic theory to make her argument. Laying out Augustine's understanding of the (...) earthly city, she proceeds by tracing out his rhetorical strategy and concludes by articulating his sacramental vision and the place of politics within it. Ogle thus suggests a new way of determining the status of politics in Augustine's thought. Her study clarifies seemingly contradictory passages in his text, highlights the nuance of his position, and captures the unity of his vision as presented in City of God. (shrink)

Marc Crépon es director de investigación en el Centre National de la Recherche Scientifique y director del Departamento de Filosofía de l’École normale supérieure de París. Entre sus publicaciones se encuentran: La culture de la peur, I. Démocratie, identité, sécurité ; La culture de la peur, II. La guerre des civilisations ; Le consentement meurtrier ; La vocation de l’écriture ; La gauche c’est quand?.

This dissertation is the first comprehensive study of human freedom in the philosophy of Pierre Gassendi, a 17th century natural scientist, Catholic priest, and one of the founders of Early Modern philosophy. The key postulate of this dissertation is that the epistemology of probabilism, which represents Gassendi's skeptical stance toward the possibility of certain knowledge, is also the foundation of human freedom: the uncertain and merely probable nature of all our knowledge serves as a guarantee of the multiplicity of options (...) open to us, and thereby ensures freedom. ;The first part of the dissertation investigates the sources on which Gassendi drew to elaborate his notion of freedom. The main sources are Aristotle's ethical theory and discussion of necessity, chance, and choice, as well as the Epicureans' theory of freedom. In conjunction with the latter, I consider the possibility that Gassendi conceives of the human mind---the seat of freedom---as corporeal, and thereby capable of generating autonomous developments on the basis of the natural motions of its atoms. ;The second part is devoted to studying Gassendi's epistemology of probabilism as the foundation of freedom. I look at the process of judgment that underlies choice, and consider the various manifestations of the freedom of indifference in the process of acquiring knowledge or preparing for a practical decision. I also look at the roles of the will and the intellect throughout these activities. ;The third part looks at theological issues in Gassendi's philosophy that relate to human freedom: divine concurrence with created beings, divine providence, and the limitations that faith imposes on the scope of our inquiry. ;The fourth and final part presents a study of Gassendi's ethics from the perspective of freedom. I investigate the role of temperament, passions, and opinions in human behaviour, and study the role of freedom in shaping these factors. I also consider the concept of pleasure as the central motive of human actions, and its various manifestations in Gassendi's ethics. (shrink)

The aim of this study was to explore the existence of moral distress among nurses in Lilongwe District of Malawi. Qualitative research was conducted in selected health institutions of Lilongwe District in Malawi to assess knowledge and causes of moral distress among nurses and coping mechanisms and sources of support that are used by morally distressed nurses. Data were collected from a purposive sample of 20 nurses through in-depth interviews using a semi-structured interview guide. Thematic analysis of qualitative data was (...) used. The results show that nurses, irrespective of age, work experience and tribe, experienced moral distress related to patient/nursing care. The major distressing factors were inadequate resources and lack of respect from patients, guardians, peers and bosses. Nurses desire teamwork and ethics committees in their health institutions as a means of controlling and preventing moral distress. There is a need for creation of awareness for nurses to recognize and manage moral distress, thus optimizing their ability to provide quality and uncompromised nursing care. (shrink)

The introduction of new medical treatments based on invasive technologies has often been surrounded by both hopes and fears. Hope, since a new intervention can create new opportunities either in terms of providing a cure for the disease or impairment at hand; or as alleviation of symptoms. Fear, since an invasive treatment involving implanting a medical device can result in unknown complications such as hardware failure and undesirable medical consequences. However, hopes and fears may also arise due to the cultural (...) embeddedness of technology, where a therapy due to ethical, social, political and religious concerns could be perceived as either a blessing or a threat. While Deep Brain Stimulation (DBS) for treatment resistant depression (TRD) is still in its cradle, it is important to be proactive and try to scrutinize both surfacing hopes and fears. Patients will not benefit if a promising treatment is banned or avoided due to unfounded fears, nor will they benefit if DBS is used without scrutinizing the arguments which call for caution. Hence blind optimism is equally troublesome. We suggest that specificity, both in terms of a detailed account of relevant scientific concerns as well as ethical considerations, could be a way to analyse expressed concerns regarding DBS for TRD. This approach is particularly fruitful when applied to hopes and fears evoked by DBS for TRD, since it can reveal if our comprehension of DBS for TRD suffer from various biases which may remain unnoticed at first glance. We suggest that such biases exist, albeit a further analysis is needed to explore this issue in full. (shrink)

Las tecnologías se insertan en la innovación educativa, dando la posibilidad de incorporar herramientas digitales en los abordajes investigativos. En este escenario Scrivener y Evernote sonherramientas digitales para la escritura académica, permiten insertar notas escritas, notas de voz, resúmenes, documentos, imágenes, citas de autores, audios, links, entre otros. La formulación delproblema parte de la necesidad de incrementar investigaciones en todos los niveles educativos de forma fácil y automatizada. El objetivo de este estudio es reflexionar sobre el aporte significativo que poseen (...) las herramientas virtuales en la escritura académica. La metodología empleada está enmarcada dentro del paradigma cualitativo de tipo no experimental y documental, posee un muestreo probabilístico intencional de 57 fuentes documentales primarias que reúnen artículoscientíficos, libros, fuentes oficiales, informes técnicos, autores y organizaciones que respaldan las teorías de las herramientas digitales para sustentar de forma científica el artículo. La conclusiónradica en que las herramientas Scrivener y Evernote generan un aporte significativo al desarrollo de la escritura académica, logrando contribuir al impulso de la publicación de artículos académicos y científicos que, asociados a las tecnologías de la información y comunicación, promueven el desarrollo de este tipo de comunidades investigativas, para lograr una mayor optimización de recursos intelectuales como un desafío para potenciar la cultura académica. (shrink)

El presente texto se propone explorar las subjetividades, los imaginaros y las sensibilidades del presente que resultan de cambios estructurales como la globalización, la mundialización de la cultura, la resignificación de los Estados y su entorno institucional, los procesos de individualización y de fragmentación social y cultural, la expansión y proliferación de los medios masivos de comunicación y el auge de las nuevas tecnologías de la información. Ante la infinidad de escenas de la vida contemporánea que pueden citarse para dar (...) cuenta de la expresión de lo nuevo cultural, el texto propone analizar una que encarna en lo que llama el fenómeno Cumbio, y que expresa muy elocuentemente uno de los rasgos que asume la escena actual y que tiene que ver con reconocer públicamente a aquellos que hacen de su intimidad un espectáculo. (shrink)

La sensación de la imposibilidad de alcanzar la versión definitiva del pasado resulta en la urgencia a tematizar los discursos que se arrogan su representación. En respuesta a las guerras de los discursos, la filosofía de la historia en el siglo XX examina centralmente el lenguaje en el que se expre..

At the outset of an ethnographic inquiry, we navigated national and international resources to search for theoretical and practical guidance on obtaining parents and children’s informed consent/assent. While much theoretical guidance debating ethical issues to children’s participation in research was found, a paucity of published papers offering practical guidance on assent processes and/or visual representations of child assent forms and information sheets was discovered. The purpose of this article is to describe our experiences, both theoretically and practically, of negotiating the (...) process of obtaining informed consent and assent with parents and children for a non-therapeutic qualitative research study. We hope this article instigates a platform for others to explicate their experience and contributes to the construction of a coherent body of knowledge which will clearly delineate important elements that must be considered when negotiating children’s agreement to participate in research. (shrink)

many symbols. We define o, as the probability that an arbitrary machine be circular and we prove that o, is a random number that goes beyond..

Background: Nurses are expected to provide comprehensive, holistic and ethically accepted care according to their code of ethics and practice. However, in Malawi, this is not always the case. This article analyses moral competence concept using the Walker and Avant's strategy of concept analysis. Objective: The aim of this article is to analyse moral competence concept in relation to nursing practice and determine defining attributes, antecedents and consequences of moral competence in nursing practice. Method: Analysis of moral competence concept was (...) done using Walker and Avant's strategy of concept analysis. Results: Deductive analysis was used to find the defining attributes of moral competence, which were kindness, compassion, caring, critical thinking, ethical decision making ability, problem solving, responsibility, discipline, accountability, communication, solidarity, honesty, and respect for human values, dignity and rights. The identified antecedents were personal, cultural and religious values; nursing ethics training, environment and guidance. The consequences of moral competence are team work spirit, effective communication, improved performance and positive attitudes in providing nursing care. Conclusion: Moral competence can therefore be used as a tool to improve care in nursing practice to meet patients' problems and needs and consequently increase public's satisfaction in Malawi. (shrink)

This paper aims to investigate whether and in what respects the conceptions of the body and of agency that Judith Butler develops in Bodies That Matter are useful contributions to feminist theory. The discussion focuses on the clarification and critical assessment of the arguments Butler presents to refute the charges of linguistic monism and determinism.

Background: Ethical competence in nursing practice helps clinical nurses to think critically, analyse issues, make ethical decisions, solve ethical problems and behave ethically in their daily work. Thus, ethical competence contributes to the promotion of high-quality care. However, studies on ethical competence in Malawi are scanty. Objectives: The aim of this study was to explore ethical competence among clinical nurses in selected hospitals in Malawi. Methodology: A cross-sectional survey was conducted in four selected hospitals in Malawi with a sample of (...) 271 clinical nurses. Data were collected using self-administered questionnaires, which included a Moral Competence Scale for Home Care Nurses. Descriptive statistics and logistic regression were computed for the dataset using STATA version 12.0. Ethical consideration: The study protocol complied with all ethical requirements and was approved by the College of Medicine Research Ethics Committee under the University of Malawi. Results: The clinical nurses in Malawi are ethically competent. However, there is a significantly high number (p 0.05). Three determinants of high ethical competence level (strong will, judgement skills and recognition of discrepancy of intention) were identified through a reduced model after stepwise logistic regression analysis. Furthermore, results show that indicators of ethical competence include caring, confidentiality and observance of nurses dressing code. The study has also confirmed that the Moral Competence Scale for Home Care Nurses is a reliable tool to assess ethical competence in low-resource settings. Conclusion: The majority of nurses who completed the survey had low ethical competence. However, clinical nurses with high ethical competence level are required to competently manage complex ethical challenges in health facilities. Strategies for enhancing ethical competence such as continuing ethics education, establishment of ethics committees and provision of supportive supervision are recommended to enable nurses in Malawi attain a high level of ethical competence. (shrink)

Deep brain stimulation (DBS) is a developing technology. New generations of DBS technology are already in the pipeline, yet this particular fact has been largely ignored among ethicists interested in DBS. Focusing only on ethical concerns raised by the current DBS technology is, albeit necessary, not sufficient. Since current bioethical concerns raised by a specific technology could be quite different from the concerns it will raise a couple of years ahead, an ethical analysis should be sensitive to such alterations, or (...) it could end up with results that soon become dated. The goal of this analysis is to address these changing bioethical concerns, to think ahead on upcoming and future DBS concerns both in terms of a changing technology and changing moral attitudes. By employing the distinction between inherent and noninherent bioethical concerns we identify and make explicit the particular limits and potentials for change within each category, respectively, including how present and upcoming bioethical concerns regarding DBS emerge and become obsolete. Many of the currently identified ethical problems with DBS, such as stimulation-induced mania, are a result of suboptimal technology. These challenges could be addressed by technical advances, while for instance perceptions of an altered body image caused by the mere awareness of having an implant may not. Other concerns will not emerge until the technology has become sophisticated enough for new uses to be realized, such as concerns on DBS for enhancement purposes. As a part of the present analysis, concerns regarding authenticity are used as an example. (shrink)

Humans are social animals that rely on different ways to interact with each other. The COVID-19 pandemic strongly changed our communication strategies. Because of the importance of direct contact for our species, we predict that immediately after the forced social isolation, people were more prone to engage in direct rather than in virtual interactions, thus showing a lower mimicry response in the use of smartphones. In a non-longitudinal study, we collected behavioral data under naturalistic contexts and directly compared the data (...) of the mimicry response gathered immediately following the Italian lockdown (May–September 2020) with those gathered one year later (May–October 2021). Contrary to our expectations, the mimicry response in the use of smartphones was higher immediately after the lockdown than a year later. Probably the large use of these devices during the lockdown translated into a greater sensitivity to be affected by others’ smartphone manipulation. Indeed, social isolation modified, at least in the short term, the ways we interact with others by making us more prone to engage in “virtual” social interactions. The bright side of the coin unveiled by our findings is that the effect seems to diminish over time. The large behavioral dataset analyzed here (1,608 events; 248 people) also revealed that the mimicry response in the use of smartphones was higher between familiar subjects than between strangers. In this view, mimicry in manipulating smartphones can be considered an example of joint action that fosters behavioral synchrony between individuals that, in the long-term, can translate into the formation of social bonding. (shrink)

Los Manuscritos de Bernau representan una obra clave para quien busca entender la teoría del tiempo husserliana. Tanto los intérpretes sobre el tema, como el propio Husserl indican que estos escritos constituyen su obra maestra. Pero la indiscutible relevancia de estos manuscritos no quita la dificultad que implica dar cuenta de una lectura consistente del texto. Nuestra intención aquí consistirá en evaluar la relación que pueda establecerse entre esta obra y los Análisis sobre las síntesis pasivas. La idea que guiará (...) el trabajo será que la labor experimental encarada por Husserl entre 1917 y 1918 provocó, en el contexto del estudio de la temporalidad, el descubrimiento de nociones centrales que luego serían profundizadas bajo el tópico de la asociación. En particular, analizaremos las transformaciones que se presentan en la noción de protención y las descripciones de la modificación retencional.The Bernau Manuscripts represents a crucial work to understand the Husserlian theory of time. The interpreters of the subject, as much as Husserl himself, point out that this studies are a master piece. But the unquestionable relevance of Bernau does not minimize the implied difficulty to achieve a consistent interpretation of the text. Our intention here is to determine the relation between this text and The Analysis Concerning Passive Synthesis. The main idea of this paper will be that the experimental work performed by Husserl between 1917-1918 leads to, in the context of time studies, the discovery of key notions. The developpment of this notions will be accomplished under the topic of association. Particularly, we will analize the transformations the notion of protension presents and the descriptions of retentional modification. (shrink)

School achievement and failure have become growing political and social concerns due to the negative consequences of school failure for individuals and society. The inclusive educational movement, which calls for equal access, permanence, participation, and promotion of all students worldwide, poses many challenges for schools and school systems. As a public policy strategy, some countries have provided additional funds for incorporating non-teaching professionals such as school psychologists and social workers in regular K-12 schools. However, there is lack of research on (...) the effects of these psychosocial professionals on student outcomes. This national multilevel study explored the effect of psychologists (n= 8,469) and social workers (n= 3,524) on indicators of eighth-grade (n= 147,531) and 10th-grade (n= 106,347) students' academic achievement and dropout in Chile. A multilevel secondary analysis was performed using national records of non-teaching professionals working as school staff members, achievement scores on the national SIMCE test, and dropout rates based on official records. Results showed that after controlling for individual and school variables known to affect achievement and dropout, schools with psychologists and social workers working as staff members had lower short- and long-term dropout rates. The presence and higher number of school psychologists per school was positively associated with higher math achievement, with a reduced effect in low-SES schools. Lower-SES schools with more social workers had higher math scores. These results support policies that increase funding for school psychologists and social workers, since their incorporation partly explains better school achievement and less school failure when controlling for individual and school characteristics, but emphasize the need to further explore the mechanisms through which school achievement and failure are developed with the support of psychologists and social workers in schools. We discuss the need to regulate the type of prevention and intervention strategies from a whole-school, evidence-based approach, as well as to incorporate psychosocial training modules and comprehensive guidelines as part of professional training programs and as certified requisites for working in schools. (shrink)

Throughout the 1990-ies Nussbaum, in collaboration with others, has elaborated and argued for a list of human capabilities which specifies necessary conditions of human flourishing. The capabilities approach has been enormously influential in putting issues of global development and justice, and especially justice for women, on the philosophical and political agenda. Moreover, many international agencies and institutions, including the United Nations Development Program, have started to make use of this approach. Despite of its obvious good intentions the approach deserves more (...) serious critical attention from philosophers than it has received until now. In my paper I take up some fundamental problems with Nussbaum’s philosophical framework. I will argue that Nussbaum’s conception of human nature is still (implicitly) Cartesian and, more in particular, that her conception of reason is outdated. It raises problems with respect to the question of universal values, the possibility of which Nussbaum defends by reference to the faculty of reason. (shrink)

Ethical clinical practice requires cultural competency. In the United States, Hispanics report stronger attitudinal barriers to drug abuse treatment than any other racial/ethnic group. Hispanics report feeling that drug abuse treatment providers do not understand their unique cultural needs and are unfamiliar with their experiences of discrimination and immigration. Using this case study to explore broader ethical and policy issues, this study investigates the extent to which US universities train counselors to address the culturally specific needs of Hispanic patients and (...) how this is reflected in practice in Los Angeles County. Based on a content analysis of the required courses, syllabi, and course descriptions at 30 universities related to culture/race/racism/ethnicity/diversity at the undergraduate and graduate levels on the addiction therapist track, and thematic analysis of eight in-depth interviews with counselors working in outpatient rehabilitation centers in Los Angeles, I argue that cultural competency education for drug abuse counselors is too surface level and infrequent to adequately prepare students for a career in addiction counseling for Hispanic clients. Significant changes must be made to how cultural diversity is valued and prioritized in the field of psychology to provide better care for Hispanic people with a substance use disorder and fulfill the moral obligation to eliminate this health disparity. Although this study focuses on counselors in Los Angeles, these findings are relevant for professionals and healthcare systems across the United States and beyond who seek to provide equitable and effective care for Hispanic patients. (shrink)

The presence of stigmatizing language in the electronic health record (EHR) has been used to measure implicit biases that underlie health inequities. The purpose of this study was to identify the presence of stigmatizing language in the clinical notes of pregnant people during the birth admission. We conducted a qualitative analysis on N = 1117 birth admission EHR notes from two urban hospitals in 2017. We identified stigmatizing language categories, such as Disapproval (39.3%), Questioning patient credibility (37.7%), Difficult patient (21.3%), (...) Stereotyping (1.6%), and Unilateral decisions (1.6%) in 61 notes (5.4%). We also defined a new stigmatizing language category indicating Power/privilege. This was present in 37 notes (3.3%) and signaled approval of social status, upholding a hierarchy of bias. The stigmatizing language was most frequently identified in birth admission triage notes (16%) and least frequently in social work initial assessments (13.7%). We found that clinicians from various disciplines recorded stigmatizing language in the medical records of birthing people. This language was used to question birthing people's credibility and convey disapproval of decision‐making abilities for themselves or their newborns. We reported a Power/privilege language bias in the inconsistent documentation of traits considered favorable for patient outcomes (e.g., employment status). Future work on stigmatizing language may inform tailored interventions to improve perinatal outcomes for all birthing people and their families. (shrink)

In this article three viewpoints on the relation of body and language are discussed: the poststructuralist viewpoint of Judith Butler, the phenomenological viewpoint of Maurice Merleau-Ponty and the postmodernist viewpoint of Jean-François Lyotard. The reason juxtaposing for these three accounts is twofold. First, the topic requires a combination of post-structuralist and phenomenological insights, and second, the accounts are supplementary. Butler's account raises questions that can be answered with the help of Merleau-Ponty's work. Lyotard's anthropology of the inhuman offers a perspective (...) of finitude that is missing in the other two. The aim of the article is to outline the necessary ingredients of an adequate conception of the speaking embodied subject. (shrink)

Este artículo representa el primer paso para demostrar que la akrasia[1] proporciona la característica estructural subyacente en los juicios de culpabilidad o responsabilidad ética y jurídica por actos negligentes; el trabajo explica el fenómeno de la akrasia y compara las concepciones clásicas y contemporáneas de este fenómeno. Argumentamos que actuamos inadvertidamente porque actuamos acráticamente, lo que se explica en términos de un compromiso defectuoso específico del razonamiento práctico por parte del agente ejecutor, es decir, una falta de integración entre el (...) carácter y el pensamiento que debe entenderse como una falla para habitar la perspectiva deliberativa-aspiracional. (shrink)

Este artículo da cuenta de una entrevista realizada a doce profesores que ejercen docencia en un programa de Pedagogía en Inglés de una universidad chilena, que busca identificar los géneros que solicitan leer y escribir a los estudiantes durante su formación de pregrado, y las principales dificultades detectadas en ambas habilidades. Mediante análisis de contenido se pudo identificar una variedad de géneros en lecturas asignadas, no así en escritura, en donde tanto la práctica como la enseñanza explícita de los géneros (...) apareció limitada. Las principales debilidades declaradas incluyen conocimiento limitado de vocabulario en L1 y L2, falta de hábitos y estrategias de lectura y escritura, y dificultad para expresar ideas en forma escrita. Esta información es relevante para la planificación de actividades de lecto-escritura que ayuden a estos profesores en formación a superar los problemas identificados. (shrink)

O objetivo deste artigo é apresentar uma argumentação sobre a possibilidade de se pensar a justiça como uma experiência do i m possível. Parte-se da distinção derridiana entre justiça e direito. Essa distinção trará algumas implicações no que tradicionalmente é entendido como ética. Partindo do jogo ou da différance marcada entre a presença/ausência, pretende-se estabelecer um ponto de diálogo entre Derrida e Levinas. O ponto de aproximação é a questão do terceiro na relação do face a face. Nesse sentido, problematiza-se (...) se a desconstrução pode ser adotada como um possível modo filosófico que fundamente a compreensão da justiça. (shrink)

Abstract:Brain–computer interfaces (BCIs) can enable communication for persons in severe paralysis including locked-in syndrome (LIS); that is, being unable to move or speak while aware. In cases of complete loss of muscle control, termed “complete locked-in syndrome,” a BCI may be the only viable solution to restore communication. However, a widespread ignorance regarding quality of life in LIS, current BCIs, and their potential as an assistive technology for persons in LIS, needlessly causes a harmful situation for this cohort. In addition (...) to their medical condition, these persons also face social barriers often perceived as more impairing than their physical condition. Through social exclusion, stigmatization, and frequently being underestimated in their abilities, these persons are being locked out in addition to being locked-in. In this article, we (1) show how persons in LIS are being locked out, including how key issues addressed in the existing literature on ethics, LIS, and BCIs for communication, such as autonomy, quality of life, and advance directives, may reinforce these confinements; (2) show how these practices violate the United Nations Convention on the Rights of Persons with Disabilities, and suggest that we have a moral responsibility to prevent and stop this exclusion; and (3) discuss the role of BCIs for communication as one means to this end and suggest that a novel approach to BCI research is necessary to acknowledge the moral responsibility toward the end users and avoid violating the human rights of persons in LIS. (shrink)