The natural source for new pancreatic beta cells is an important issue both for understanding the pathogenesis of diabetes, and for possibly curing diabetes by increasing the number of beta cells. Dor et al.1 investigated beta‐cell renewal and regeneration by genetic lineage analysis in mice during physiological growth and after partial pancreatectomy. The data conclusively showed that beta‐cell replication was the only source for new beta cells without contributions from stem cells or other non‐beta cells. This underlines the capacity for (...) beta‐cell self‐renewal and casts doubt that other cell types are able to generate new beta cells in the intact pancreas. BioEssays 26:1156–1159, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

Das Buch befasst sich mit bislang unbekannten Kontexten von Theodor W. Adornos Kritik der Psychoanalyse, darunter vor allem die versuchte „Arisierung“ durch die Neoanalyse im Göring-Institut der NS-Zeit. Wolfgang Bock nimmt dazu einen wichtigen Ausgangspunkt von Adornos Aufsatz „Die revidierte Psychoanalyse“, der 1952 in der Psyche veröffentlicht wird. Der Autor zeigt anhand einer genauen Lektüre eins bislang unveröffentlichten englischen Vortragsmanuskripts von 1946, dass Adornos sich zusammen mit den zur Emigration gezwungenen jüdischen Analytikern vor allem gegen die Zurichtung der freudschen (...) Triebtheorie durch Karen Horney richtet, gegen die er auch in Amerika argumentiert. Er steht damit keinesfalls allein da. Diese Motive werden von Adorno allerdings ab 1950 in Deutschland nicht mehr offen aufgenommen, da er sich mangels anderer Alternativen nun verstärkt um ein Auskommen mit den ehemaligen Nazis bemüht. Wolfgang Bock, der auch der bislang kaum erfolgte Aufarbeitung dieses faschistischen Erbes in der Psychologie im Nachkriegsdeutschland nachgeht, kann zeigen, dass diese Momente weiterhin in Adornos späterer Fassung der Psychoanalyse wirksam bleiben. Vor diesem Hintergrund unterzieht er so gut wie alle Texte Adornos zur Psychoanalyse einer gründlichen Revision, darunter auch kaum bekannte Forschungsprojekte. Es zeigt sich, dass Adorno in den englischen Texten sehr viel offener argumentiert und damit paradoxerweise späteren Kritikern näher ist, als diese annehmen: Das Bild seines Umgangs mit der Psychoanalyse muss von nun an gründlich revidiert werden. Das Buch veröffentlicht zum ersten Mal den englischen Vortragstext Adornos von 1946 und bietet u.a. eine neue deutsche Übersetzung. (shrink)

Previous studies show evidence of double standards in terms of individuals being more tolerant of questionable consumer practices than of similar business practices. However, whether these double standards are necessarily due to the fact that one party is a business company while the other is a consumer was not addressed. The results of our two experimental studies, conducted among 277 (Study 1) and 264 (Study 2) participants from a Western European country by means of an anonymous self-administered online survey, demonstrate (...) that the respondents were not only harsher in their judgments of unethical business (vs. consumer) behavior, but also harsher in their judgments of unethical behavior by prosperous (vs. non-prosperous) consumers and prosperous (vs. non-prosperous) business companies (Study 1). Further, they were also less tolerant of unethical behavior by consumers (vs. one's best friend) and business companies with which they have a less than good (vs. a good) relationship (Study 2). These results indicate that double standards are due to differences in perceived wealth between subjects and in the individual's relationship with subjects. These two factors imply that double standards are not strictly reserved to consumer-business relations, but might also be used in business-business and consumer-consumer relations. Further, these results indicate that companies need to be aware of the fact that good financial figures may backfire as they might lead individuals to be more critical of a company's deceptive practices. Moreover, these findings point to the importance of businesses investing resources-and to keep investing resources-in developing a good relationship with stakeholders as these good relationships lead to stakeholders being less prone to make moral condemnations. (shrink)

Existing accounts of Foucault’s archaeological methodology have not (a) contextualized the concept properly within the intellectual field of its emergence and (b) explained why it is called ‘archaeology’ and not simply ‘history’. Foucault contributed to the field of ‘history of systems of thought’ in France around 1960 by broadening its scope from the study of scientific and philosophical systems into systems of ‘knowledge’ in a wider sense. For Foucault, the term ‘archaeology’ provided a response to new methodological questions arising from (...) this initiative. Archaeological methodology had already been developed into a distinct comparative approach for the study of linguistic and cultural systems, notably by Dumézil. Foucault redevised archaeological methodology for the post-Hegelian tradition of studying ‘problems’ prevalent in the history of systems of thought. The article thus furnishes the groundwork for a ‘sociological archaeology’ or ‘problem analysis’ that is not particularly dependent on Foucault as a social theorist of power. (shrink)

Methodological inspiration from the discipline of archaeology can spur new developments of logic of inquiry in social research beyond contemporary debates among empiricist, rationalist, and pragmatist positions with their corresponding modes of inference: induction, deduction, and abduction. Archaeological methodology pursues comparison not in terms of similarities and differences among cases but through the juxtaposition of heterogeneous yet coexisting finds. On this basis, it pursues inferences by what I call ‘conduction’ about the relationship among finds, understood as their conditions of coexistence. (...) Archaeological methodology will prove especially useful to studies that face uncertainty about the constituting relationships of a phenomenon, surprising coexistences, or a need to transgress established disciplinary or social demarcations. On this background, I particularly discuss the usefulness of archaeological methodology for the broad literature on problems, problematization, issues, and concerns building on the works of Dewey, Callon, and Foucault. (shrink)

'The Philosophy of Forgiveness, Volume III: Forgiveness in World Religions' is a collection of essays that explores the philosophy of forgiveness in different religions, including Judaism, Christianity, Islam, Hinduism, Buddhism and Confucianism. Each chapter scours one of these religions for insights on the concept of forgiveness, asking questions such as whether forgiveness is a virtue, whether it is conditional, whether God has standing to forgive, and whether it is permissible not to forgive some extreme wrongs. In some of the chapters, (...) the concept of forgiveness in one religion is compared with that in another. In other chapters, the ideas of different traditions within a religion are compared and contrasted. Also, some chapters compare a religious concept to the views of a philosophical figure, such as Aristotle, Kant, or Derrida. The contributors to the volume come from various cultural and religious backgrounds and from different disciplines, such as philosophy, religious studies, and psychology. The collection is written for scholars, graduate students, and upper-division undergraduate students interested in forgiveness or comparative religious philosophy. (shrink)

In a letter of 1932, Karl Popper described _Die beiden Grundprobleme der Erkenntnistheorie – The Two Fundamental Problems of the Theory of Knowledge_ – as ‘…a child of crises, above all of …the crisis of physics.’ Finally available in English, it is a major contribution to the philosophy of science, epistemology and twentieth century philosophy generally. The two fundamental problems of knowledge that lie at the centre of the book are the problem of induction, that although we are able to (...) observe only a limited number of particular events, science nevertheless advances unrestricted universal statements; and the problem of demarcation, which asks for a separating line between empirical science and non-science. Popper seeks to solve these two basic problems with his celebrated theory of falsifiability, arguing that the inferences made in science are not inductive but deductive; science does not start with observations and proceed to generalise them but with problems, which it attacks with bold conjectures. _The Two Fundamental Problems of the Theory of Knowledge_ is essential reading for anyone interested in Karl Popper, in the history and philosophy of science, and in the methods and theories of science itself. (shrink)

Patient requests for “inappropriate” medical treatment based on religious beliefs should have special standing. Nevertheless, not all such requests should be honored, because some are morally disturbing. The trouble lies in deciding which ones count. This paper proposes criteria that would qualify a religious belief as medically valid to help physicians decide which requests to respect. The four conditions suggested are that the belief is shared by a community, is deeply held, would pass the test of a religious interpreter and (...) does not harm others. (shrink)

The live outdoor webcam seems inseparable from the mid-1990s’ popular proliferation of the Internet. Combining a well-known medium, i.e. the photograph, with a new one, i.e. the Internet, the live outdoor webcam seems in the rear-view mirror to have contributed significantly to the popular perception of the Internet as a globally distended and thus “geographical” medium. Moreover, due to its role in the NASA Triana mission, the never-realised flagship of the Clinton–Gore administration’s Digital Earth project, the live webcam seemed to (...) play an important part in the construction of what leading geographers coined a “virtual geography”—the geography of the Internet, and the networked geography—that sought to establish itself as a new field of study during the late 1990s. In order to substantiate for this interpretation, I would like in the first part of this article to identify a number of basic characteristics of the outdoor webcam and, in the second, to analyse and discuss two papers written by leading scholars in the field; papers which have been important in the assessment of the impact of the Internet and geographical information systems (GIS) before the scientific community as well as policy makers within technological innovation and the public sector. (shrink)

From Stoicism to Platonism describes the change in philosophy from around 100 BCE, when monistic Stoicism was the strongest dogmatic school in philosophy, to around 100 CE, when dualistic Platonism began to gain the upper hand - with huge consequences for all later Western philosophy and for Christianity. It is distinguished by querying traditional categories like 'eclecticism' and 'harmonization' as means of describing the period. Instead, it highlights different strategies of 'appropriation' of one school's doctrines by philosophers from the other (...) school, with all philosophers being highly conscious of their own identity. The book also sets out to break down the traditional boundaries between, on the one hand, the study of Greco-Roman philosophy in the period and, on the other hand, that of contemporary Hellenistic Jewish and early Christian writings with a philosophical profile. In these ways, the book opens up an immensely fruitful period in the history of philosophy. (shrink)

In this article, three descriptive models are described and compared in an attempt to discover the minimum number of concepts and relations necessary to an abstract description of social structure. It is argued that a "situational model" which uses the concepts of social time, social space and social role together with the relations of internal structure and external distribution is both adequate to the task and superior to the two other models. The advantages and implications of the situational model are (...) discussed. (shrink)

Historically, as well as more recently, women's emancipation has been seen in two ways: sometimes as the `right to be equal' and sometimes as the `right to be different'. These views have often overlapped and interacted: in a variety of guises they have played an important role in both the development of ideas about women and feminism, and the works of political thinkers by no means primarily concerned with women's liberation. The chapters of this book deal primarily with the meaning (...) and use of these two concepts in the context of gender relations, but also draw attention to their place in the understanding and analysis of other human relationships. (shrink)

This paper engages in an interpretation and critique of Simondon’s approach to technical objects through his concept of alienation. I begin with his argument for why the fundamental source of alienation is “psycho-physical” and explain his critique of politico-economic analyses of alienation. I then explain his proposal for reducing alienation by rethinking work as “technical activity.” I then argue that while Simondon’s analyses of the internal functionality of technical objects provide important contributions to the philosophy of technology, he also overemphasizes (...) the psycho-physical and in turn underestimates the role of politico-economic factors in the ontogenesis of technical objects and production of alienation. Both the psycho-physical and politico-economic, I claim, must be thought together as necessarily interconnected conditions of the ontogenesis of technical objects. On that basis, it becomes possible to engage in philosophical critique of and education about the inner functionality of contemporary technologies and their accompanying risks. (shrink)

In seinen Vorlesungen über die Ästhetik hat Hegel einen der wichtigsten und wirkmächtigsten Beiträge zur Ästhetik und Philosophie der Kunst entwickelt. Von der systematischen Klärung der Idee des Schönen über die geschichtliche Unterscheidung der symbolischen, klassischen und romantischen Kunstform bis hin zur Darstellung der einzelnen Künste (Architektur, Skulptur, Malerei, Musik, Poesie) werden alle relevanten Aspekte entfaltet und miteinander vernetzt. Eindrucksvoll ist nicht nur Hegels plastischer Zugriff auf die Fülle konkreten Materials. Bedeutsam ist vor allem sein kulturphilosophischer Ansatz, der die Kunst (...) auf dem Rang des "absoluten Geistes" als zentrales Medium menschlicher Selbstverständigung begreift. Die vieldiskutierte These vom "Ende der Kunst" in der Moderne hängt damit direkt zusammen. Hegel hat seine vier Berliner Ästhetik-Kollegien nicht selbst publiziert. Dieser Kommentarband orientiert sich an der Edition des Hegel-Schülers H.G. Hotho und zieht ergänzend die Nachschriften, insbes. des letzten Kollegs von 1828/29 hinzu. In dieser Form wird Hegels Ästhetik auf dem aktuellen Forschungsstand für ein breites philosophisches und kulturwissenschaftliches Interessenfeld erschlossen. Mit Beiträgen von B. Collenberg-Plotnikov, N. Hebing, G. Hindrichs, S. Houlgate, W. Jaeschke, R. Pippin, B. Sandkaulen, U. Seeberg, M. Seel, A. Speight u. J. Stolzenberg. (shrink)

The contemporaries of Friedrich Heinrich Jacobi (1743-1819) openly acknowledged his towering importance. Both Fichte and Hegel praised him in the same breath with Kant as having launched the philosophical revolution they sought to complete. Yet for more than a century, misrepresentations of Jacobi's thought have stood in the way of a proper appreciation of his insights. In her study of this long-neglected German philosopher, internationally-renowned Jacobi expert Birgit Sandkaulen interprets his philosophical writings in their intellectual context. Originally published in German (...) and translated into English for the first time, this is a major contribution to reading the life, work, and legacy of Jacobi. The biographical chapter on Jacobi's life as a public intellectual was written specifically for this English edition. Offering new perspectives on Fichte, Schelling, and Hegel, Sandkaulen focuses on Jacobi's specific conception of practical realism. This conception, the source of Jacobi's famous defense of faith and human freedom, matches his critique of the German Idealists: the post-Kantian systems of German Idealism were bound to fail. Sandkaulen shows us that long before 20th-century philosophers took up this line of thought, indeed at the very origin of the epoch-making developments of classical German philosophy, Jacobi articulated a practical, ethical, personal realism that is as philosophically appealing and relevant today as it was in its time"--Publisher's description. (shrink)

Why the DNA‐containing organelles, chloroplasts, and mitochondria, are inherited maternally is a long standing and unsolved question. However, recent years have seen a paradigm shift, in that the absoluteness of uniparental inheritance is increasingly questioned. Here, we review the field and propose a unifying model for organelle inheritance. We argue that the predominance of the maternal mode is a result of higher mutational load in the paternal gamete. Uniparental inheritance evolved from relaxed organelle inheritance patterns because it avoids the spread (...) of selfish cytoplasmic elements. However, on evolutionary timescales, uniparentally inherited organelles are susceptible to mutational meltdown (Muller's ratchet). To prevent this, fall‐back to relaxed inheritance patterns occurs, allowing low levels of sexual organelle recombination. Since sexual organelle recombination is insufficient to mitigate the effects of selfish cytoplasmic elements, various mechanisms for uniparental inheritance then evolve again independently. Organelle inheritance must therefore be seen as an evolutionary unstable trait, with a strong general bias to the uniparental, maternal, mode. (shrink)

This article introduces a new model of the relationship between growth and learning and tests a set of hypotheses related to the development of adult competency using time allocation, anthropometric, and experimental task performance data collected between 1992 and 1997 in a multiethnic community in the Okavango Delta, Botswana. Building on seminal work in life history theory by Hawkes, Blurton Jones and associates, and Kaplan and associates, the punctuated development model presented here incorporates the effects of both growth and learning (...) constraints on age-specific task performance. In addition, the payoff to investment in two forms of embodied capital, growth-based and learning-based, are examined in relation to features of the socioecology, including subsistence economy and family composition.The three main findings are:The development of adult competency in specific tasks entails a steplike relationship between growth- and experience-based forms of embodied capital in the ontogeny of ability acquisition.There is a trade-off between the acquisition of experience-based embodied capital in the form of skills and knowledge and immediate productivity among children. Time allocation to these alternatives is primarily determined by the short- and long-term costs and benefits to parents of investment in children’s embodied capital.The availability of laborers and the overall labor requirements of the household are major determinants of investment in alternate forms of embodied capital and resulting variation in children’s time allocation. The value of children’s labor to their parents is dependent upon the opportunity costs to engaging in other activities not only for the child in question but also for potential substitute laborers.These results have important implications for our understanding of the role of growth and learning in the evolution of the human juvenile period, as well as for our understanding of cross-cultural variation in child growth and development and patterns of work and play. (shrink)

This second volume in the series "Studies in Hellenistic Civilization", published for the Danish Research Council for the Humanities, offers a comprehensive analysis of the Stoic theory of Oikeiosis.

At the top of his ethical system Aristotle placed, as the supreme value, eudai- monia (happiness). But what does this really mean? ...

In this article Troels Norager discusses the subject of sacrifice in the context of Kierkegaard's Works of Love and Fear and Trembling. The first section argues that contrary to contemporary attempts to turn Kierkegaard into a phenomenologist of love, Kierkegaard should be regarded as a radical Christian thinker who (partly for biographical reasons) deliberately emphasized the necessity of being willing to sacrifice one's most precious love object. The second part deals with Abraham's dilemma in Genesis 22 and argues, critically (...) surveying the intriguing interpretation proposed by Ingolf Dalferth, that no credible solution to this deeply troubling story is to be found. In the final section the author ponders the contemporary significance of Abraham's sacrifice and briefly points to insights from eminent political philosophers like Rawls and Habermas. This leads to the conclusion that theology should finally be taking leave of Abraham by rejecting Abraham as the 'Father of faith' and as a paradigm to be emulated. Instead, theologians and philosophers of religion are called upon to embrace our post-secular modernity without surrendering to the demands of authoritarian religion. (shrink)

Conventional gender analysis of development policy does not adequately explain the slow progress towards gender equality. Our research analyses the gender discourses embedded in agricultural and rural development policies in Myanmar and Nepal. We find that both countries focus on increasing women’s participation in development activities as a core gender equality policy objective. This creates a binary categorisation of participating versus non-participating women and identifies women as responsible for improving their position. At the same time, gender (in)equality is defined exclusively (...) as a women’s concern. Such discourses, as constitutive practices, produce specific knowledge about rural women and new subjectivities that prescribe and govern them solely as subjects of development. Our research suggests that such a limited discursive practice invisiblises gendered power relations and structural and institutional issues, ultimately slowing progress towards gender equality. We demonstrate the importance of studying policy as discourse, beyond the effectiveness of policies or mainstreaming tools, and call for empirical evidence on the impact of these discourses on women’s subjectivities and lived experiences. (shrink)

This paper investigates the compatibility of Hegel’s analyses of the mechanization of work in industrial society with Hegel’s notion of freedom as rational self-determination. Work as such is for Hegel a crucial moment on the way to a more complete realization of human freedom, but, as I maintain with Adorno, the technological developments of the last two centuries raise the question of whether the nature of work itself has changed since the industrial revolution. In his Jena lectures, Hegel recognized significant (...) problems that the mechanization of work poses for human freedom that—on my assessment—his later, mature thought does not sufficiently address. One finds, however, a more comprehensive depiction of the same worries that Hegel mentioned in his Jena lectures in Adorno’s critique of the dominant forms of labor in contemporary society and his understanding of technological rationality, which according to Adorno, dominates the contemporary world. I suggest, furthermore, that juxtaposing Hegel’s and Adorno’s thoughts on technology and the mechanization of work reveals Adorno’s philosophy of technology to be an extension, rather than a critique, of the spirit of Hegel’s own philosophical project as immanent critique of the necessary entailments of any given concept. (shrink)