Receptors on cytotoxic T lymphocytes and natural killer cells play well‐established roles in the immunological response and share a common ligand in the form of MHC‐I. We discuss how a variety of MHC‐I receptors are also expressed on myelomonocytic cells such as macrophages and dendritic cells. Since myelomonocytic MHC‐I receptors recognise a broad range of alleles and MHC‐I structures, we propose that their task is to discern expression levels and folding forms of MHC. We describe a model in which these (...) recognition events would regulate bidirectional cross talk between cells of innate and adaptive immune systems to organise an ongoing combined immune response. We discuss how such a model is supported by recent literature and might function in a variety of contexts, including immunoregulation during pregnancy. Our model also offers an alternative explanation of immune dysregulation rather than autoimmunity during HLA‐B27‐associated spondyloarthropathies and addresses a number of conundrums in this field. BioEssays 27: 542–550, 2005. © 2005 Wiley periodicals, Inc. (shrink)

Introduction. Whatever its underlying causes, even the description of the phenomenon of thought insertion, of the content of the delusion, presents difficulty. It may seem that the best hope of a description comes from a broadly cognitivist approach to the mind which construes content-laden mental states as internal mental representations within what is literally an inner space: the space of the brain or nervous system. Such an approach objectifies thoughts in a way which might seem to hold out the prospect (...) of describing the ''alienated'' relation to one's own thoughts that seems to be present in thought insertion.1 Method. Firstly, I examine the general structure of cognitivist accounts of intentional or content-laden mental states. I raise the general difficulty of explaining how free-standing, and thus world-independent, inner states can still have bearing on the outer world. Secondly, I briefly examine Frith's model for explaining thought insertion and other passivity phenomena by postulating a failure of an internal monitoring mechanism of inner states. I question what account can be given of non-pathological cases and raise two specific objects. Results. Cognitivist accounts of the mind face a general, and possibly insuperable, challenge: explaining the intentionality of mental states in non-intentional, non- question-begging terms. There have so far been no satisfactory solutions. Cognitivist accounts of passivity phenomena in terms of a failure of internal monitoring face two objections. Firstly, accounting for non-pathological cases generates an infinite regress. Secondly, no account can be given of the paradoxical nature of utterances of the form of Moore's paradox: ''it is raining but I do not believe it''. Conclusions. A cognitivist approach presents an alienated account of thought in normal, non-pathological cases and is no help in accounting for thought insertion. (shrink)

A modest proposal concerning laws, counterfactuals, and explanations - - Why be Humean? -- Suggestions from physics for deep metaphysics -- On the passing of time -- Causation, counterfactuals, and the third factor -- The whole ball of wax -- Epilogue : a remark on the method of metaphysics.

Increasing evidence from psychology and neuroscience suggests that emotion plays an important and sometimes critical role in moral judgment and moral behavior. At the same time, there is increasing psychological and neuroscientific evidence that brain regions critical in emotional and moral capacity are impaired in psychopaths. We ask how the criminal law should accommodate these two streams of research, in light of a new normative and legal account of the criminal responsibility of psychopaths.

Elements of Mind provides a unique introduction to the main problems and debates in contemporary philosophy of mind. Author Tim Crane opposes those currently popular conceptions of the mind that divide mental phenomena into two very different kinds (the intentional and the qualitative) and proposes instead a challenging and unified theory of all the phenomena of mind. In light of this theory, Crane engages students with the central problems of the philosophy of mind--the mind-body problem, the problem of intentionality (or (...) mental representation), the problem of consciousness, and the problem of perception--and attempts to find solutions to these problems. A fresh and engaging exploration of the main issues in the philosophy of mind, Elements of Mind is easily accessible to students with no background in the subject. (shrink)

A sophisticated and original introduction to the philosophy of quantum mechanics from one of the world’s leading philosophers of physics In this book, Tim Maudlin, one of the world’s leading philosophers of physics, offers a sophisticated, original introduction to the philosophy of quantum mechanics. The briefest, clearest, and most refined account of his influential approach to the subject, the book will be invaluable to all students of philosophy and physics. Quantum mechanics holds a unique place in the history of physics. (...) It has produced the most accurate predictions of any scientific theory, but, more astonishing, there has never been any agreement about what the theory implies about physical reality. Maudlin argues that the very term “quantum theory” is a misnomer. A proper physical theory should clearly describe what is there and what it does—yet standard textbooks present quantum mechanics as a predictive recipe in search of a physical theory. In contrast, Maudlin explores three proper theories that recover the quantum predictions: the indeterministic wavefunction collapse theory of Ghirardi, Rimini, and Weber; the deterministic particle theory of deBroglie and Bohm; and the conceptually challenging Many Worlds theory of Everett. Each offers a radically different proposal for the nature of physical reality, but Maudlin shows that none of them are what they are generally taken to be. (shrink)

Tim Crane addresses the ancient question of how it is possible to think about what does not exist. He argues that the representation of the non-existent is a pervasive feature of our thought about the world, and that to understand thought's representational power ('intentionality') we need to understand the representation of the non-existent.

This concise book introduces nonphysicists to the core philosophical issues surrounding the nature and structure of space and time, and is also an ideal resource for physicists interested in the conceptual foundations of space-time theory. Tim Maudlin's broad historical overview examines Aristotelian and Newtonian accounts of space and time, and traces how Galileo's conceptions of relativity and space-time led to Einstein's special and general theories of relativity. Maudlin explains special relativity using a geometrical approach, emphasizing intrinsic space-time structure rather than (...) coordinate systems or reference frames. He gives readers enough detail about special relativity to solve concrete physical problems while presenting general relativity in a more qualitative way, with an informative discussion of the geometrization of gravity, the bending of light, and black holes. Additional topics include the Twins Paradox, the physical aspects of the Lorentz-FitzGerald contraction, the constancy of the speed of light, time travel, the direction of time, and more.Introduces nonphysicists to the philosophical foundations of space-time theory Provides a broad historical overview, from Aristotle to Einstein Explains special relativity geometrically, emphasizing the intrinsic structure of space-time Covers the Twins Paradox, Galilean relativity, time travel, and more Requires only basic algebra and no formal knowledge of physics. (shrink)

Preface ix 1 Meaning and the Means to an Understanding of Ends 2 Why Is an Eye? 21 3 Adaptationism and Engineering 39 4 On Five "-Isms" 67 5 Function, Selection, and Explanation 87 6 Deflating Function 119 7 Artifacts and Organisms 139 References 167 Index 177.

In order to know what a belief is, we need to know when it is appropriate to say that two subjects (or the same subject at two different times) believe(s) the same or entertain the same thought. This is not entirely straightforward. Consider for instance1. Tom thinks that he himself is the smartest and Tim believes the same2. In 2001, Bill believed that some action had to be taken to save the rain forest and today he believes the same.What does (...) Tim think? That he, Tim, is the smartest, or that Tom is? And what does Bill believe today? That action had to be taken in 2001 or that it has to be taken now? Both answers are intuitively acceptable. This has to be accounted for somehow.Building on Mark Richard's work on tense, Scott Soames 1 claims that the substitutional interpretation of the quantifiers is unable to account for the intended meaning of such statements as (2) and the validity of some inferences involving them. I will show that his argument is not convincing. Not only does the substitutional interpretation fare no worse than the objectual one, but it seems to be able to avoid a problem which could be seriously damaging for any account of the sameness of thoughts based on the notion of structured proposition. In the first section, I state the problem allegedly raised by tensed belief ascriptions to the substitutional interpretation of the quantifiers. In the second, Soames's argument is shown to be flawed. I also show that the content of the that-clause in (2) is not faithfully represented by any kind of structured proposition. Finally, I show how the substitutional interpretation can handle all such statements as (1) and (2) and the inferences involving them. (shrink)

A considerable body of evidence now documents, beyond reasonable doubt, biological and health risk factors for crime and violence. Nevertheless, intervention and prevention efforts with offenders have avoided biological interventions, in part due to past misuses of biological research and the challenges that biological predispositions to crime raise. This article reviews the empirical literature on two biological intervention approaches, omega-3 supplementation and transcranial direct current stimulation. Emerging research on these relatively benign interventions suggests that increased omega-3 intake through dietary intervention (...) and prefrontal upregulation using non-invasive brain stimulation may show some initial promise in reducing antisocial behavior. The ethical issues related to mandated and offered biological interventions within the criminal justice system are discussed. (shrink)

In this ingenious and powerfully argued book Tim Maudlin sets out a novel account of logic and semantics which allows him to deal with certain notorious paradoxes which have bedevilled philosophical theories of truth. All philosophers interested in logic and language will find this a stimulating read.

Consider the sentence 'This sentence is not true'. It seems that the sentence can be neither true nor not true, on pain of contradiction. Certain notorious paradoxes like this have bedevilled philosophical theories of truth. Tim Maudlin presents an original account of logic and semantics which deals with these paradoxes, and allows him to set out a new theory of truth-values and the norms governing claims about truth. All philosophers interested in logic and language will find Truth and Paradox a (...) stimulating read. (shrink)

What, if anything, is wrong with typological thinking? The question is important, for some evolutionary developmental biologists appear to espouse a form of typology. I isolate four allegations that have been brought against it. They include the claim that typological thinking is mystical; the claim that typological thinking is at odds with the fact of evolution; the claim that typological thinking is committed to an objectionable metaphysical view, which Elliott Sober calls the ‘natural state model’; and finally the view (endorsed (...) by Ron Amundson and Günter Wagner) that typological thinking—and specifically evolutionary developmental biology’s typological thinking—is committed to a peculiar form of causation that does not fit neatly into the causal models endorsed by population genetics. I argue that, properly understood, the typological thinking of evolutionary developmental biology does not run into any of these problems. *Received April 2008; revised August 2009. †To contact the author, please write to: Department of History and Philosophy of Science, University of Cambridge, Free School Lane, CB2 3RH Cambridge, United Kingdom; e‐mail: [email protected]. (shrink)

The rights and wrongs of adaptationism areoften discussed by appeal to what I call theartefact model. Anti-adaptationistscomplain that the use of optimality modelling,reverse engineering and other techniques areindicative of a mistaken and outmoded beliefthat organisms are like well-designedartefacts. Adaptationists (e.g. Dennett 1995)respond with the assertion that viewingorganisms as though they were well designed isa fruitful, perhaps necessary research strategyin evolutionary biology. Anti-adaptationistsare right when they say that techniques likereverse engineering are liable to mislead. This fact does not undermine the artefact (...) modelprecisely because the same techniques misleadus for the same reasons when they are appliedunreflectively to artefacts. Thoseadaptationists who hold only that it isworthwhile to investigate organisms as thoughthey were artefacts and thoseanti-adaptationists who criticise simplisticdesign models have far more in common than thelabels attached to their positions mightsuggest. (shrink)

On the Move presents a rich history of one of the key concepts of modern life: mobility. Increasing mobility has been a constant throughout the modern era, evident in mass car ownership, plane travel, and the rise of the Internet. And typically, people have equated increasing mobility with increasing freedom. However, as Cresswell shows, while mobility has certainly increased in modern times, attempts to control and restrict mobility are just as characteristic of modernity. Through a series of fascinating historical episodes (...) Cresswell shows how mobility and its regulation have been central to the experience of modernity. (shrink)

This paper presents a puzzle or antinomy about the role of properties in causation. In theories of properties, a distinction is often made between determinable properties, like red, and their determinates, like scarlet (see Armstrong 1978, volume II). Sometimes determinable properties are cited in causal explanations, as when we say that someone stopped at the traffic light because it was red. If we accept that properties can be among the relata of causation, then it can be argued that there are (...) good reasons for allowing that some of these are determinable properties. On the other hand, there are strong arguments in the metaphysics of properties to treat properties as sparse in David Lewis’s (1983) sense. But then it seems that we only need to believe in the most determinate properties: particular shades of colour, specific masses, lengths and so on. And if we also agree with Lewis that sparse properties are ‘the ones relevant to causal powers’ (1983: 13) it seems we must conclude that if properties are relevant to causation at all, then all of these are determinate properties. I call this ‘the antinomy of determinable causation’. On the one hand, we have a good argument for the claim that determinable properties can be causes, if any properties are. I call this the Thesis. But on the other hand, we have a good argument for the claim that only the most determinate properties can be causes, if any properties are. I call this the Antithesis. Clearly, we need to reject either the Thesis or the.. (shrink)

How can we determine an acceptable level of risk? Should these decisions be made by experts, or by the people they affect? How should safety and security be balanced against other goods, such as liberty? This is the first collection to examine the philosophical dimensions of these pressing practical problems. Leading scholars exploring the full range of philosophical implications of risk, including: risk and ethics risk and rationality risk and scientific expertise risk and lay knowledge the objectivity of risk assessment (...) risk and the precautionary principle risk and terror. With contributions from Carl F. Cranor, Sven Ove Hansson, Martin Kusch, Tim Lewens, D.H. Mellor, Adam Morton, Stephen Perry, Martin Peterson, Alan Ryan, Per Sandin, Cass R. Sunstein and Jonathan Wolff; this collection is essential reading, not only for philosophers and researchers in legal, economic and environmental studies, but for those seeking to gain a better understanding of the decisions we must make as concerned citizens. (shrink)

Nissen and Bullemer's serial reaction time task has proven to be a useful model task for exploring implicit sequence learning. Neuropsychological research indicates that SRT learning may depend on the integrity of the basal ganglia, but not on medial temporal and diencephalic structures that are crucial for explicit learning. Recent neuroimaging research demonstrates that motor cortical areas , prefrontal, and parietal cortex also may be involved. This paper reviews this neuropsychological and neuroimaging research, but finds it lacking specific links between (...) structure and function. In order to promote better functional hypotheses, the second part of the paper examines the function of these brain areas from a broader perspective. Neuroimaging and neuropsychological research with human subjects, as well as neurophysiological and lesion research with animals, suggests a number component operations that these brain mechanisms may contribute to learning in the SRT task. (shrink)

Human development is a matter of complex interactions between nutritional regimes, genes, educational regimes and other diverse developmental resources. I argue that there is no ethically salient difference between the contributions made to development by genes and the contributions made by these other resources. Since we think nutrition and schooling should be included in the calculus of distributive justice, we should include at least some genes in this calculus too. What is more, under the right circumstances genetic engineering may become (...) a useful tool for the distribution of developmental resources. This said, attention to the parity of genetic and environmental causation can also help to articulate the legitimate suspicions many groups have of genetic engineering. (shrink)

Simmels Buch gehört zu den Werken, die durch die Simmel-Gesamtausgabe, in deren Rahmen die Philosophie des Geldes 1989 erschien, erst wieder nachdrücklich in der Diskussion einer Theorie der Kultur um 1900 und darüber hinaus Berücksichtigung gefunden haben. Vormals v. a. als Soziologe bzw. unter Sozialwissenschaftlern bekannt, hat Simmel seitdem einen Ruf als Philosoph erhalten, der in Wiederaufnahme eines für ihn zeitgenössischen Streites in stellvertretend geführten Debatten erneut gegen das Pejorativum eines bloßen bzw. vulgären, jedenfalls potentiell gefährlichen Relativismus verteidigt wird.

Early in the COVID-19 pandemic there was widespread concern that healthcare systems would be overwhelmed, and specifically, that there would be insufficient critical care capacity in terms of beds, ventilators or staff to care for patients. In the UK, this was avoided by a threefold approach involving widespread, rapid expansion of critical care capacity, reduction of healthcare demand from non-COVID-19 sources by temporarily pausing much of normal healthcare delivery, and by governmental and societal responses that reduced demand through national lockdown. (...) Despite high-level documents designed to help manage limited critical care capacity, none provided sufficient operational direction to enable use at the bedside in situations requiring triage. We present and describe the development of a structured process for fair allocation of critical care resources in the setting of insufficient capacity. The document combines a wide variety of factors known to impact on outcome from critical illness, integrated with broad-based clinical judgement to enable structured, explicit, transparent decision-making founded on robust ethical principles. It aims to improve communication and allocate resources fairly, while avoiding triage decisions based on a single disease, comorbidity, patient age or degree of frailty. It is designed to support and document decision-making. The document has not been needed to date, nor adopted as hospital policy. However, as the pandemic evolves, the resumption of necessary non-COVID-19 healthcare and economic activity mean capacity issues and the potential need for triage may yet return. The document is presented as a starting point for stakeholder feedback and discussion. (shrink)

This paper discusses a role playing ethics case suitable for business students in which participants must balance shareholder and stakeholder concerns. Students take on the role of operations manager and are challenged to consider the effects of their choices on the local society as they balance the demands of stockholders, employees, and family when the concerns of the groups come into conflict. The exercise helps students understand the need to consider the ethicalcomponents of business decisions and the difficulties of handling (...) values in conflict. Students learn more about their own values through playing the role of manager. Suggested discussion questions are provided. This note also reviews some of the extant literature on the goals of stakeholder versus shareholder wealth and the role of ethics, and it discusses areas of common ground between the stakeholder/shareholder theories. (shrink)

Valuation is portrayed here as a dynamic and interactive process, not a static notion linked to willingness to pay. Valuation through economic measures can be built upon by creating trusting and legitimising procedures of stakeholder negotiation and mediation. This is a familiar practice in the US, but it is only beginning to be recognised as an environmental management tool in the UK. The introduction of strategic environmental and landuse appraisal plans for shorelines, estuaries, river catchments and rural landscapes, combined with (...) the mobilisation of protest around landuse proposals that are not seemingly justified on the basis of 'need' suggest that a more legitimate participatory form of democracy is required to reveal valuation through consensual negotiation. (shrink)

On Classical Theism, God is ontologically distinct from the physical universe which He has created; He needn't have created any universe at all; and He could exist even if the universe didn't. By contrast, the universe couldn't have existed if God didn't and it needs God to sustain it in existence from moment to moment. Classical Theism is thus committed to the universe not being identical to God. I shall argue that Classical Theism is committed to seeing the universe as (...) God's body . It follows that it is also committed to the falsity of theories which identify people with their bodies or state that of necessity people depend on their bodies for their continued existence. (shrink)

This paper constitutes a suggested route through the well-trodden minefield that is Mill's proof of Utilitarianism. A deductive course—tramping gamely straight across from an egoistic psychological hedonism to a disinterested ethical hedonism—would seemingly be the most hazardous route across the terrain. Thus, it has become standard policy amongst guides to advise readers of Utilitarianism that this is a route which Mill neither needs nor attempts to take. I shall argue that in travelling down this route one can avoid the dangers (...) with which it is usually associated and I shall tentatively suggest that one may find oneself following Mill's footsteps in doing so. (shrink)

In this paper, I argue that if the libertarian free will defence were seen to fail because determinism were seen to be true, then another solution to the problem of evil would present itself. I start by arguing that one cannot, by consideration of agents' choices between morally indifferent options, reach any conclusion as to these agents' moral qualities. If certain forms of consequentialism were false, determinism true, and if there were a God who chose to create this universe, then (...) His choice would have been between such options. Consideration of the general nature of the universe God putatively chose to create would not then license any conclusion as His moral qualities. (shrink)