The sequencing of the human genome has opened the way for using bioinformatics to identify sets of genes controlled by specific regulatory signals. Here, we review the unexpected diversity of DNA response elements mediating transcriptional regulation by estrogen receptors (ERs), which control the broad physiological effects of estrogens. Consensus palindromic estrogen response elements are found in only a few known estrogen target genes, whereas most responsive genes contain only low‐affinity half palindromes, which may also control regulation by other nuclear receptors. (...) ERs can also regulate gene expression in the absence of direct interaction with DNA, via protein–protein interactions with other transcription factors or by modulating the activity of upstream signaling components, thereby significantly expanding the repertoire of estrogen‐responsive genes. These diverse mechanisms of action must be taken into account in screening for potential estrogen‐responsive sequences in the genome or in regulatory regions of target genes identified by expression profiling. BioEssays 24:244–254, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10066. (shrink)

Un ouvrage sur le temps et un ouvrage collectif, deux raisons qui dissuaderaient peut-être de se plonger dans la lecture de Temps de travail, travail du temps qu’éditent Sylvie Monchatre et Bernard Woehl aux Éditions de la Sorbonne. On aurait tort, car on se priverait alors d’une réflexion lentement mûrie au fil d’un séminaire de deux ans qui a réuni des spécialistes confirmés des difficiles questions que posent les rapports du travail aux temps. Spécialistes rarement réunis et qu’une journée..

The physical sciences include highly developed fields that investigate intensities in the form of intensive quantities like speeds, temperatures, pressures and altitudes. Some contemporary readers of Deleuze interested in the physical sciences at times attribute to Deleuze a common, contemporary scientific concept of intensive magnitude. These readings identify Deleuze's philosophical conception of intensity with an existing scientific conception of intensity. The essay argues that Deleuze does not in fact lift a conception of intensity from the physical sciences to embed it (...) as the fundamental term in his differential ontology. (shrink)

This paper describes the construction method of a legal application ontology. This method is based on the merging of micro-ontologies built from European community directives. The terminae construction method from texts enhanced by an alignment process with a core legal ontology is used for building micro-ontologies. A merging process allows constructing the legal ontology.

Nietzsche and Foucault have given us the idea of conducting a philosophical genealogy of a practice that varies across history. Foucault's work also implies that we can view some abstraction as a practice. These points jointly imply that we can conduct a genealogy of “abstractive practices.” Indeed, a good deal of Foucault's work can be understood as exactly this sort of investigation. But a genealogy of abstractive practice raises a difficult methodological problem. This is the problem of how to determine (...) which definitions of abstraction to use, from amongst the various theoretical accounts of abstraction that we find in the history of thought, to craft our genealogy of abstractive practices. In other words, what will count as an abstractive practice for the purpose of conducting such a genealogy will depend on what we identify as abstraction. This article seeks to expose this problem to demonstrate the methodological difficulties that must be confronted in order to steer a path between ignoring the historical-epistemological limits to the kinds of abstraction we can employ at any given present, on the one hand, and having our sensitivity to these limits halt our historical-philosophical reflections on abstraction as a historical practice, on the other. (shrink)

Demonstrates the dramatic interplay of elements that comprise the concepts of norm, bisexuality, and development.

La thématique des questions d’un point de vue diachronique est l’objet de cet article. Dans un premier temps, est proposé un tour d’horizon des questions ouvertes et fermées depuis le vieil anglais avant de nous intéresser à l’apparition et à l’évolution des pronoms relatifs en wh-. L’auxiliaire do est brièvement discuté. Sont ensuite analysés les syntagmes nominaux thématisés et les prédications existentielles, puis les questions tags ainsi que la grammaticalisation des questions fermées.

From Beauvoir's account in The Second Sex of the upbringing or formation of girls, the chapter extracts her feminist existentialist analysis of the physical and moral orthopedics of girls so as to compare it to Foucault's historical account in Discipline and Punish of the various forms of discipline that have taken children as objects.

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Between Deleuze and DerridaMary Beth MaderPaul Patton and John Protevi, editors. Between Deleuze and Derrida. New York: Continuum, 2003. Pp. ix + 207. Cloth, $105.00. Paper, $29.95.One of the many provisions of Gilles Deleuze's prodigious philosophical invention, Difference and Repetition, is an ontological account of how invention is actual. That book itself is an instance of that of which it offers an account. An element of this account (...) is the notion of an intensive system. The intensive system is proposed as a way in which novelty and movement come about. It requires as its basic constituents two heterogeneous organized series which are put into communication through their differences, producing a resonance internal to the system which then yields a novel forced movement. Several of the essays in Between Deleuze and Derrida so put the work of Gilles Deleuze and Jacques Derrida into communication as to themselves amount to intensive systems: movement and novelty emerge in our grasp of the separate oeuvres of the two philosophers.Essays by Daniel W. Smith and Leonard Lawlor tackle in detail the task of comparative explication. Since Deleuze and Derrida treat many of the same philosophical topics, often employing identical terms, these clear cases for their divergences and similarities are especially useful. Smith's historical situation of Deleuze and Derrida relative to the thought of Duns Scotus, Spinoza, Kant and Nietzsche is exemplary. Dense with connections, Lawlor's decisive expositions pursue the implications of his interpretative distinctions rigorously to their ends, tracing the divergent constructions of the two thinkers to a common source in the notion of a simulacrum. Smith and Lawlor themselves part company, however, over the issue of whether Derrida and Deleuze are best characterized as philosophers of immanence or transcendence. Paul Patton crafts a sophisticated cross-reading of their shared vision of philosophy as a "utopian vocation," without homogenizing the differing voices they hear in this call or its unshared ontology.Branka Arsiæ's imaginative contribution on the topic of passive events and Melville's Bartleby is enlightening even without mention of Deleuze's notion of static ordinal genesis. The essays of John Protevi and Tamsin Lorraine are also rich in philosophical imagination. Protevi's extension of Derrida's aporias of the gift and friendship to an "aporia of love" illuminates Derrida's own evolution while refusing a version of undecidability that remains in static indecision. His discussion of Deleuze and Guattari's notion of the girl, with its isotropic implications for sexuality per se, is one of the best in print. Lorraine displays the novelty of Deleuze and Derrida's post-Heideggerian thought on the temporality of sense and the limits of representation in readings of Alice in Wonderland and Hamlet that clarify by example some of the more forbiddingly elaborate proposals in the philosophy of time that these thinkers offer.Arkady Plotnitsky's chapter addresses the crucial questions of Deleuze's and Derrida's relations to various sub-fields of mathematics and happily considers Derrida, with his deployment of a notion of undecidability, as a legatee of Gödel. It is confusing, however, that this stimulating essay treats Deleuze's and Derrida's invocations of algebra, geometry and topology by means of the "tropes" of "algebra, geometry and topology." This is especially puzzling in the case of Deleuze, whose use of mathematics in Difference and Repetition is avowedly not metaphorical. Further, although algebra is said to be the prime instrument of Plotnitsky's analysis, it turns out that "the general quasi-algebraic inscriptive structure or operation" (111; my italics) is most fundamental to that analysis. For this reason, it would be preferable to locate in both Deleuze and Derrida a post-structuralist concern with structure itself, making "algebra" another in the Derridean syntagmatic chain of names for a descendent of "structure."The book does contain some disappointing stretches. Eric Alliez's chapter does not read well despite its reliable translation. Alphonso Lingis's ruminations of a blithely bewildered Western roamer ("you" and then "me") on his "detour into exoticism" thanks to the "willing" concupiscence of an Asian female bed-mate ("she" and never "you" or "me") make one regret the era of easy... (shrink)

The paper examines the relation between Foucault’s account of modern race and racism in the "Society Must Be Defended" lectures and his analysis of the emergence of the modern notion of life and its science in The Order of Things . In "Society Must Be Defended ," Foucault uses the term ‘life’ both with respect to pre-modern and modern political regimes, arguing that in the pre-modern eras there was a particular relation of sovereign power to life and death that differs (...) from the relation to life and death which prevails in the modern era. In The Order of Things , Foucault also discusses the concept of life and the historical emergence of the science of life, biology, in the nineteenth century. For Foucault, modern biological racism is a specifically scientific death sentence. The paper argues that the kind of death at issue in this modern racism must be understood in light of the new evolutionary accounts of life as a transorganismic continuity that emerge in the life sciences. (shrink)

Demosthenes' Philippic cycle conveys a satirical picture of Athenians trapped in a spiral of symbolic activity: to a demos nostalgic for great-power status but loath to energetic intervention, high-sounding resolutions substitute for low-level responses and by their character as official enactments create the illusion of meaningful engagement. This "syndrome" is a rhetorical scare-image subserving a political agenda. At a time when his influence was still limited, Demosthenes found it expedient to exaggerate the cautious approach of the "peace party" into a (...) "knowing-doing gap" in order to move the audience to accept his own hard line on the Macedonian question. (shrink)

Research shows that trained mentors achieve better results than untrained ones. Their training should particularly address their expectations for their future mentoring. Our study involved 190 preservice teachers, potential mentors of ongoing school mentoring for primary and secondary school students of all grades. They were randomly assigned to one of four conditions in a 2-x-2 between-subjects design of mentoring type (traditional mentoring versus e-mentoring) and mentoring context (non-pandemic versus COVID-19 pandemic). Participants assessed mentoring conducted under these four conditions in terms (...) of its appropriateness for achieving four mentoring program targets: learning, key skills, social targets, and problem coping. Participants were also asked to assess the resources available to achieve each program target. Overall, the potential mentors considered the various conditions to be suitable for achieving the four program targets. They were particularly favorable in their assessment of the possibility for the realization of learning targets. Likewise, they assumed that sufficient resources were available to achieve the targets. However, a repeated-measures MANOVA showed that the potential mentors considered more ambitious targets to be possible in traditional mentoring than in e-mentoring and normal (i.e., pre-pandemic) contextual conditions than during the COVID-19 pandemic. In contrast, they estimated the resources available to achieve the targets to be about the same in the four conditions. This indicates a decoupling of mentoring targets from the consideration of the resources needed to achieve them. This assumption was confirmed in correlation analyses and has implications for mentor training. (shrink)

Agamemnon’s death cries elicit an elaborate choral debate structured to track and satirize the movement from interventionist impulse to evasion and inaction, and characterized by procedural terminology, the categories speech/delay/action, and self-conscious reflections on its own deliberative practice. These are familiar themes from later strictures of public discourse, in history and political oratory, and from that perspective the dramatic chorus too may be read as a meta-rhetorical comment on ekklesiastic deliberation where logoi and erga fly out of sync. I argue (...) that the inconclusive debate glances beyond its immediate context and resonates with the extra-textual experiences of Aeschylus’ audience. (shrink)

Wenn die Rede auf den Fortschritt kommt, geht es um die Verbesserung der menschlichen Lebensverhältnisse. Doch die Erfahrungen modernen Gesellschaften mit Tyrannei, Kriegen, Wirtschaftskrisen und Umweltzerstörung haben das Vertrauen in die Überwindung natürlicher Abhängigkeiten und sozialer Über erschüttert. Viele sehen heute im Fortschritt eine bloße Illusion oder einen Mythos. Es scheint mir angesichts der allgegenwärtigen scharfen Kritik an der Fortschrittsidee im zeitgenössischen Denken angebracht, von einer Psychologie des Fortschritts zu sprechen. Damit meine ich nicht das Fühlen und Verhalten, das Fortschritt (...) bedingt oder umgekehrt durch ihn hervorgerufen wird; ich meine die Psychologisierung des Fortschritts: die Annahme, er sei eine reine Kopfsache, etwas Ausgedachtes oder Erhofftes, das sich durch seine Projektion auf historische oder soziale Prozesse zu einer gefahrvollen Erzählung verfestigt. "Psychologisierung des Fortschritts" ist also meine Chiffre für die projektivistische Fortschrittskritik, die ich hier ihrerseits kritisiere und der ich ein kulturalistisches Menschenbild entgegensetze. (shrink)

The doctors -- The patients -- "Misunderstandings".

The main purpose of this article is to bring into relief the difficulties faced by generous interpretations of the Kantian problem of poverty and to propose an alternative interpretation which (a) agrees with some generous interpretations that Kant's juridical treatment of poverty is to be understood by analogy with his juridical treatment of slavery, but which (b) departs from generous interpretations in general by arguing that this analogy is not to be understood in terms of “dependence” as such, but in (...) terms of “depersonification.” More specifically, it argues that what makes slavery and poverty unjust for Kant is not that they entail a human being finding herself (completely) dependent on the choice of another human being, but that they entail a human being being deprived of her juridical personality. The Kantian problem of poverty is ultimately a problem of juridical depersonification, and this problem of juridical depersonification does not arise in all (complete) dependence relations. (shrink)

Hart's and Kelsen's respective outlooks on the concept of normativity not only differ by the way they explain this concept but also, more importantly, in what they seek to achieve when endeavouring to account for the normative dimension of law. By examining Hart's and Kelsen's models in the light of Korsgaard's understanding of the “normativity problem,” my aim is to emphasise not only their contrasted perspectives, but also the common limit they impose on their theories by dismissing as inappropriate any (...) question regarding the emergence of legal normativity. On the basis of my previous arguments, I shall explain why I deem Raz's analysis of the contrast between Hart's and Kelsen's conceptions of normativity to be misleading. (shrink)

Marx’s polemic against Proudhon represents a crucial stage in the development of his dialectical method and his conception of history and progress. The critique of Proudhon demonstrates Marx’s hostility towards the very teleological account of social change of which he has himself been accused. In order to redress this imbalance, the break with Proudhon is presented here as a result of Marx’s rejection of the speculative Hegelian dialectic. This rejection is an exercise in self-criticism that is highly relevant to our (...) understanding of Marxian theory in general. (shrink)

Some studies report that the sport context increases the risk of exposure to sexual violence for athletes. In contrast, others indicate a protective effect of sport participation against sexual violence, particularly among varsity athletes. Studies of sexual violence towards varsity athletes are limited by their failure to include control groups and various known risk factors such as age, graduate level, gender and sexual identity, disability status, international and Indigenous student status, and childhood sexual abuse. The purpose of the present study (...) is to fill in these gaps to determine whether varsity athletes are at greater risk than non-athletes of sexual violence towards them or whether, on the contrary, involvement in a varsity sport is coherent with the Sport Protection Hypothesis. Data for this article come from the ESSIMU study, a broad survey of students, professors, and other employees at six francophone universities regarding sexual violence on university campuses. A total of 6,485 students with complete data on sexual violence, athlete status, and gender were included in the study. From this total, 267 participants identified themselves as varsity athletes. Data were analyzed using a series of logistic regressions on each form of violence using athlete status as a predictor and characteristics associated with sexual violence victimization or distinguishing between varsity athletes and non-athletes as confounding variables. When considering all confounding variables in the regression analyses on four yearly incidence rates of sexual violence, the results revealed that being a varsity athlete did not significantly increase the risk of exposure to sexual violence at university. All considered other variables were more significant predictors of the past year’s risk of sexual violence victimization than athlete status was. (shrink)

The 2008 crisis has revived debates on the relevance of laissez-faire, and thus on the role of the State in a modern economy. This volume offers a new exploration of the writings of Keynes and Friedman on this topic, highlighting not only the clear points of opposition between them, but also the places in which their concerns where shared. This volume argues that the parallel currently made with the 1929 financial crisis and the way the latter turned into the Great (...) Depression sheds new light on the proper economic policy to be conducted in both the short- and the long-run in a monetary economy. In light of the recent revival in appreciation for Keynes’ ideas, Rivot investigates what both Keynes and Friedman had to say on key issues, including their respective interpretations of both the 1929 crisis and the Great Depression, their advocacy of the proper employment policy, and the theoretical underpinnings of the latter. The book asks which lessons should be learnt from the Thirties? And what is the relevance of Keynes’ and Friedman’s respective pleas for today? (shrink)

Dans son inventaire des « lieux théologiques », Melchior Cano ne faisait aucune place à l’expérience spirituelle, les « spirituels » ne paraissant même pas comme théologiens… La frontière qui, relayant une distinction paisible, s’était élevée entre théologie et spiritualité, sur la base d’une évolution de la théologie vers une scientificité et sous l’effet des interrogations du nominalisme, semble être devenue poreuse, sinon avoir disparu. De fait, la théologie contemporaine pense l’expérience croyante. La question pourrait se formuler ainsi : où (...) et comment peut se faire la prise en charge théologique de la vie spirituelle, du capital chrétien d’expérience spirituelle ? Est-ce par une discipline propre, la théologie spirituelle ? Qu’est-ce qui la caractériserait ? Pour réfléchir ainsi au devenir de la théologie spirituelle, on commencera par observer, avec quelques exemples d’élaborations théologiques significatives, comment la théologie contemporaine prend en compte la dimension expérientielle de la foi chrétienne. Mais prendre en compte cette part constitutive d’expérience, est-ce pour autant prendre en charge l’expérience spirituelle ? Si oui, une théologie spirituelle n’aurait plus de raison d’être ; si non, quelle est la vocation d’une telle théologie ?In his inventory of “theological loci”, Melchior Cano did not at all include spiritual experience and “spirituals” do not even appear in his listing as theologians… Following after a period of peaceful distinction, the border that has arisen between theology and spirituality - on the basis of an evolution of theology towards scientificity and under the influence of the questions raised by nominalism – seems now to have become porous, if not to have altogether vanished. In fact, contemporary theology reflects on believing experience. We could put the question this way: where and how can theology take charge of spiritual life, valorizing the Christian capital of spiritual experience ? Is it through a specific discipline, spiritual theology? What would characterize it ? In order to think through the way spiritual theology is developing, we shall begin by observing, thanks to a few examples of significant theological texts, how contemporary theology takes into account the experiential dimension of Christian faith. However, is taking into account this constitutive part of experience the same as taking charge of spiritual experience ? If so, a spiritual theology would no longer have a raison d’être; if not, what then is the task of such a theology ? (shrink)

Érotiques, le titre du dossier du numéro 31 de Clio HFS peut intriguer. D’emblée, disons qu’il ne s’agit pas d’un adjectif qui caractériserait les femmes et les hommes dont il sera question dans ce numéro, comme d’autres titres de la revue pourraient le suggérer. Pas davantage celles et ceux qui y ont contribué. Il ne dénote pas non plus le ton des articles du dossier qui reste, on le déplorera peut-être, d’autant plus marqué par l’austérité universitaire que le sujet paraît (...) ne pas l’être. En... (shrink)

This book offers a 'genealogical' explanation of law's normativity. The term 'genealogical' conveys a commitment to a non-metaphysical type of enquiry. While it explains how law, as a normative phenomenon, comes about, it does not seek to ground law's normativity in anything but the context of social interaction giving rise to it. Legal normativity is brought about on a daily basis. Whether in revolutionary circumstances or in the quotidian need for judges, lawmakers or citizens to balance law's demands with those (...) of morality or prudence, our ability to bind ourselves through law ultimately depends on our capacity to articulate a better way of living together, and to commit ourselves to it. These efforts of assessment and articulation depend, in turn, on our conception of normative agency. Assert the need to trace the truth of ethical judgments to some independent moral 'facts' conditioning their objectivity, and you will get a different understanding of what it is we are doing when we dispute law's authority in the name of moral values. Tracing the truth of moral judgements back to our own social practices not only affects the nature of disagreement; it also dramatically increases our responsibility when, as lawmakers, judges, or citizens we 'take the law into our own hands' and confront it with our moral expectations. (shrink)

Just like other experts, members of the professions develop their craft thanks to a deep internalisation of both complex cognitive structures and a mix of habits and intuitive understandings. These non-cognitive aspects of expertise can be what distinguishes the merely competent from the truly brilliant. Yet habits can also be what makes us blind to important features of the world we inhabit. In the life of a professional, these features include the vulnerability of those seeking her services, which in turn (...) grounds the professional's particular ethical responsibility. This book develops an in-depth account of habit to understand its impact upon the way moral decisions are made in a professional context. Its central thesis is the following: what most often stands in the way of a professional meeting her ethical responsibility is not so much stupidity (or character defects) but rather the deleterious aspects of habituation. This book calls for renewed attention to be paid to habits and their relationship to ethical agency. Mostly neglected in moral and legal theory, such an inquiry not only conditions an adequate understanding of the risks inherent in a legal system's institutional structure. It is also essential if we are to come to grips with the challenges raised by the professions' growing reliance upon automated systems."--Publisher description. (shrink)

This paper addresses the issue of the dynamic enforcement of a constraint in an argumentation system. The system consists in (1) an argumentation framework, made up, notably, of a set of arguments...

The aim of this article is to revisit the work of the French philosopher Julia Kristeva and ask what place we might give her conceptual framework today. I will focus on one key aspect of Kristeva’s work, sexual difference, as that which ties most, if not all, aspects of Kristeva’s work. I am hoping to present a concise, yet wide-ranging view on Kristeva’s critical contribution to the fields of politics and ethics. My objective will be threefold. First, I will present (...) the main lines of Kristeva’s theory on sexual difference; this presentation will also outline her political critique of equality and diversity in the domains of gender and sexuality. Kristeva believes that contemporary politics invested in suppressing inequality through the promotion of diversity will in the long term not only prove unsuccessful, but also create more exclusion. Secondly, I will point out the main objections raised against her theories and show how her critics come to their conclusions. Objectors to Kristeva’s sexual difference theory are mostly concerned with the manner in which she associates marginality and unintelligibility. They see little value in her theory, because, on the one hand, it relegates marginal groups to a world beyond social viability, and, on the other, because it effectively disables advancements in equality politics. Finally, I hope to provide the reader with a useful counter-critique to Kristeva’s detractors that will show why their views are partly founded on a misreading of her ethical framework and a desire to translate her work into a more pragmatic and user-friendly tool. I will argue that Kristeva’s work is best apprehended as a variant of psychoanalytic ethics and that to engage with its rhetoric is to capture the full weight of Kristeva’s contribution to politics and intellectual engagement. (shrink)

Le présent article s’interroge sur l’action citoyenne et plus particulièrement sur ce qui peut pousser des personnes, qui ont toujours vécu dans un « anonymat politique », à se lancer dans une action publique qui interpelle les gouvernements. L’auteure prend pour point de départ la conception selon laquelle des préoccupations vécues dans la vie quotidienne sont à l’origine d’une prise de conscience quant à un problème qui concerne ce que les acteurs identifient comme des biens communs. Elle illustre sa thèse (...) à partir d’une étude menée auprès d’un comité de citoyens qui s’est formé dans la foulée de la mobilisation contre le gaz de schiste au Québec en 2010. (shrink)

Au volant de son taxi, Mori sillonne New York, la ville où il s’est installé après avoir vécu dans plusieurs autres pays, et qu’il aime et n’aime pas. Arrêté par les agents de contrôle de l’immigration clandestine, il est renvoyé en Afrique après un séjour en détention. Contre la frontière et ses cruautés, le récit, traversé par la pensée de Deleuze, de Derrida et de Tierno Bokar, suggère que seule la mise en œuvre d’une poétique de l’hospitalité peut redonner sens (...) à nos vies, redonner au parcours de chacun, migrants et sédentaires, le statut d’une histoire. (shrink)