The sequencing of the human genome has opened the way for using bioinformatics to identify sets of genes controlled by specific regulatory signals. Here, we review the unexpected diversity of DNA response elements mediating transcriptional regulation by estrogen receptors (ERs), which control the broad physiological effects of estrogens. Consensus palindromic estrogen response elements are found in only a few known estrogen target genes, whereas most responsive genes contain only low‐affinity half palindromes, which may also control regulation by other nuclear receptors. (...) ERs can also regulate gene expression in the absence of direct interaction with DNA, via protein–protein interactions with other transcription factors or by modulating the activity of upstream signaling components, thereby significantly expanding the repertoire of estrogen‐responsive genes. These diverse mechanisms of action must be taken into account in screening for potential estrogen‐responsive sequences in the genome or in regulatory regions of target genes identified by expression profiling. BioEssays 24:244–254, 2002. © 2002 Wiley Periodicals, Inc.; DOI 10.1002/bies.10066. (shrink)

Climate change has become one of the most pressing problems that can threaten the existence and development of humans around the globe. Almost all climate scientists have agreed that climate change is happening and is caused mainly by greenhouse gas emissions induced by anthropogenic activities. However, some groups still deny this fact or do not believe that climate change results from human activities. This article examines climate change denialism and its skeptical arguments, as well as the roles of scientists and (...) science communication in addressing the issues. Through this article, we call for the active participation of scientists in science communication activities with the public, the initiation of new science communication sectors specified for climate change, and more attention to social sciences and humanities in addressing climate change issues. (shrink)

Reid’s dilemma concludes that, whether the idea associated with a denied proposition is lively or faint, Hume is committed to saying that it is either believed or merely conceived. In neither case would there be denial. If so, then Hume cannot give an adequate account of denial. I consider and reject Powell’s suggestion that Hume could have advanced a “Content Contrary” account of denial that avoids Reid’s dilemma. However, not only would a Humean Content Contrary account be viciously circular, textual (...) evidence suggests that Hume did not hold such an account. I then argue that Govier’s distinction between force and vivacity cannot help Hume. Not only did Hume fail to recognize this distinction, we can advance a variant of Reid’s dilemma even if we distinguish force from vivacity. (shrink)

In his recent work, Dretske offers a new account of what it is for a mental state, in particular, a sensory experience, to be conscious. According to Dretske’sproposal, subject S’s experience of object O is conscious if and only if it makes S aware of O. This proposal is argued to be open to only two serious interpretations. The first takes it to mean that S’s experience of O is conscious if and only if it constitutes S’s awareness of O, (...) whereas the second takes it to mean that S’s experience of O is conscious if and only if it causes S’s awareness of O. It is argued that neither is a plausible way to understand the nature of state consciousness, because the constitutive interpretation implausibly denies the existence of unconscious veridical experiences, whereas the causal interpretation implausibly casts S’s veridical experience of O, rather than O or a certain external event involving O, as the relevant cause of S’s awareness of O. (shrink)

Jack Spencer has recently argued for the striking thesis that, possibly, an agent is able to do the impossible—that is, perform an action that is metaphysically impossible for that person to perform. Spencer bases his argument on (Simple G), a case in which it is impossible for an agent G to perform some action but, according to Spencer, G is still intuitively able to perform that action. I reply that we would have to give up at least four action-theoretical principles (...) if we accept that G is able to do the impossible. We may be best off retaining the principles and thus rejecting Spencer's intuition that G is able to do the impossible. I then consider an argument for the claim that G is able to do the impossible that goes through the Snapshot Principle. I, however, deny that any true variant of the Snapshot Principle shows that G is able to do the impossible. Moreover, the counterexample to the Snapshot Principle that I develop also suggests that G is unable to do the impossible in (Simple G). The most natural explanation for why an agent is unable to perform some action in this counterexample extends to (Simple G). Next, I develop three error theories for why we might initially share Spencer's intuition that G is able to do the impossible in (Simple G). Finally, I consider a couple other "G-cases" of Spencer's and find them all wanting. Perhaps we are unable to do the impossible. (shrink)

What is Life? This is the question asked by Denis Noble in this very personal and at times deeply lyrical book. Noble is a renowned physiologist and systems biologist, and he argues that the genome is not life itself: to understand what life is, we must view it at a variety of different levels, all interacting with each other in a complex web. It is that emergent web, full of feedback between levels, from the gene to the wider environment, (...) that is life. (shrink)

In evolutionary biology changes in population structure are explained by citing trait fitness distribution. I distinguish three interpretations of fitness explanations—the Two‐Factor Model, the Single‐Factor Model, and the Statistical Interpretation—and argue for the last of these. These interpretations differ in their degrees of causal commitment. The first two hold that trait fitness distribution causes population change. Trait fitness explanations, according to these interpretations, are causal explanations. The last maintains that trait fitness distribution correlates with population change but does not cause (...) it. My defense of the Statistical Interpretation relies on a distinctive feature of causation. Causes conform to the Sure Thing Principle. Trait fitness distributions, I argue, do not. *Received July 2009; revised October 2009. †To contact the author, please write to: Department of Philosophy/Institute for the History, Philosophy of Science and Technology, University of Toronto, Victoria College, 91 Charles Street West, Toronto, ON M5S 1K7, Canada; e‐mail: denis.walsh@utoronto.ca. (shrink)

What is Life? To answer this question, Denis Noble argues that we must look beyond the gene's eye view. For modern 'systems biology' considers life on a variety of levels, as an intricate web of feedback between gene, cell, organ, body, and environment. He shows how it is both a biologically rigorous and richly rewarding way of understanding life.

"The main conclusion of this essay is that it is plausible to conclude that corporations are capable of exhibiting intentionality, and as a result that they may be properly understood as moral agents" (p. 281).

Aesthetic theoriesmayclaim universality, but they are normally conditioned by the aesthetic issues and debates of their own times. Plato and Aristo- tle were motivated both to account for the Greek arts of their day and to connect aesthetics to their general metaphysics and theories of value. Closer to our time, asNo¨el Carroll observes, the theories of Clive Bell and R.G. Collingwood can be viewed as “defenses of emerging avant-garde practices— neoimpressionism, on the one hand, and the mod- ernist poetics of (...) Joyce, Stein, and Eliot on the other.”1 Susanne Langer can be read as provid- ing a justification for modern dance, while the ini- tial version of George Dickie’s institutional the- ory “requires something like the presupposition that Dada is a central form of artistic practice” in order to gain intuitive appeal. The. (shrink)

Over the course of human history, the sciences, and biology in particular, have often been manipulated to cause immense human suffering. For example, biology has been used to justify eugenic programs, forced sterilization, human experimentation, and death camps—all in an attempt to support notions of racial superiority. By investigating the past, the contributors to _Biology and Ideology from Descartes to Dawkins_ hope to better prepare us to discern ideological abuse of science when it occurs in the future. Denis R. (...) Alexander and Ronald L. Numbers bring together fourteen experts to examine the varied ways science has been used and abused for nonscientific purposes from the fifteenth century to the present day. Featuring an essay on eugenics from Edward J. Larson and an examination of the progress of evolution by Michael J. Ruse, _Biology and Ideology_ examines uses both benign and sinister, ultimately reminding us that ideological extrapolation continues today. An accessible survey, this collection will enlighten historians of science, their students, practicing scientists, and anyone interested in the relationship between science and culture. (shrink)

Libertarian theories of the normative core of the corporation hold in common the view that is the responsibility of publicity held corporations to return profits to shareholders within the bounds of certain moral side-constraints. Side-constraints may be either weak (grounded in the rules of the game) or strong (grounded in rights). This essay considers libertarian arguments regarding the normative core of the corporation in the context of global capitalism and in the light of actual corporate behavior. First, it is argued (...) the weak side-constraints view is conceptually incoherent when applied in a global context. Second, it is argued that proponents of the libertarian strong side-constraints view lack an adequate theory of rights. Third, both the weak side-constraints view and the strong side-constraints view are shown to be unsatisfactory insofar as they fail to adequately address the coercive power of corporations. The main conclusion of this essay is that a viable libertarian theory of the corporation has yet to be articulated. (shrink)

In 1484, humanist philosopher and theologian Marsilio Ficino published the first complete Latin translation of Plato's extant works. Students of Plato now had access to the entire range of the dialogues, which revealed to Renaissance audiences the rich ancient landscape of myths, allegories, philosophical arguments, etymologies, fragments of poetry, other works of philosophy, aspects of ancient pagan religious practices, concepts of mathematics and natural philosophy, and the dialogic nature of the Platonic corpus's interlocutors. By and large, Renaissance readers in the (...) Latin West encountered Plato's text through Ficino's translations and interpretation. -/- In Plato's Persona, Denis J.-J. Robichaud provides the first synthetic study of Ficino's interpretation of the Platonic corpus. Robichaud analyzes Plato's works in their original Greek and in Ficino's Latin translations, as well as Ficino's non-Platonic writings and correspondence, in the process uncovering new aspects of Ficino's intellectual work habits. In his letters and works, Ficino self-consciously imitated a Platonic style of prose, in effect devising a persona for himself as a Platonic philosopher. Plato's dialogues are populated with a wealth of literary characters with whom Plato interacts and against whom Plato refines his own philosophies. Reading through Ficino's translations, Robichaud finds that the Renaissance philosopher seeks an understanding of Plato's persona(e) among all the dialogues' interlocutors. In effect, Ficino assumed the role of Plato's Latin spokesperson in the Renaissance. -/- Plato's Persona is grounded in an extensive study of scholarship in Renaissance humanism, classics, philosophy, and intellectual history, and contextualizes Ficino's intellectual achievements within the contemporary Christian orthodox view of Platonism. Ficino was an influential figure in the early Italian Renaissance: the key intermediary between Greek and Latin, and between manuscript and print, giving voice to Plato and access to the ancient frameworks needed to interpret his dialogues. (shrink)

This paper comprises a case study illustrating ethical and practical challenges for a Ugandan hospital-based social worker early in the COVID-19 pandemic, followed by a commentary. The hospital was under-resourced, with staff and patients experiencing lack of information and panic. The social worker, Denis Adia, recounts his responses to new and ethically challenging situations, including persuading Muslim patients to stop fasting for the good of their health; deciding to keep a baby in hospital with parents although this was against (...) the rules; and supporting a stigmatised former patient in the face of intimidation by colleagues. He reflects on the importance of recognising each person’s unique needs and circumstances, seeing this as a vital role for social workers. The case is followed by a commentary from a UK academic (Sarah Banks), who notes the cognitive and emotional effort (‘ethics work’) undertaken by the social worker to: see the ethical aspects of particular situations; take account of patients’ specific needs; ensure they are treated with respect; promote their well-being; and perform as a good social worker. Banks draws attention to the key role of the virtue of courage in pandemic conditions, which involves working with new risks and facing fears with confidence. (shrink)

Spinoza discovered and studied Descartes's philosophy at the school of Van den Enden and then at the University of Leiden. Spinoza is seen as providing metaphysical views of unparalleled audacity, which remain highly exciting and offer a source of inspiration and a source of theoretical models in a wide variety of fields, including neurobiology. The most general of Spinoza's intentions is to expound in accordance with “the prolix Geometric order” what Descartes had left in a more informal one. Spinoza's original (...) distance from Cartesian conceptions, before becoming obvious in the metaphysical views of the Ethics, is already noticeable in the TIE. In metaphysics, the Spinoza‐Descartes relationship is complex, but cannot be said to take the form of an implicit dialogue or a community of inspiration. Descartes's emphasis on the use of free will, the gap between the two authors in matters of moral anthropology is therefore quite limited. (shrink)

Europeans seeking to understand tribal arts face obvious problems of comprehending the histories, values, and ideas of vastly remote cultures. In this respect the issues faced in understanding tribal art (or folk art, primitive art, traditional art, third or fourth-world art — none of these designations is ideal) are not much different from those encountered in trying to comprehend the distant art of “our own” culture, for instance, the art of medieval Europe. But in the case of tribal or so-called (...) primitive art, there are special complications. First, objects of tribal art are sometimes so strange to us that we cannot tell immediately whether they are intended to be works of art (or some local analogue of what we would call art) at all.1An African head-rest I once came across had an odd, extravagant extrusion which made the whole piece reminiscent of Arp. It seemed to my baffled, ignorant eyes to be much more than a mere head-rest, but I couldn’t tell what more it was supposed to be. Maybe that extension on the side of the object had some purely utilitarian function, acting as a handle, or perhaps it was a natural part of the original block of wood, left there merely because it looked nice to the eye of the carver. Though the head-rest seemed beautiful, I still don’t know if I was admiring as an essentially expressive object some simple item of practical use, or something that combined expression and utility. (shrink)

This paper presents a reading of the Tractatus’ remarks on ethics. Drawing on work by Anselm Müller, subsequently developed by Anthony Price, the reading makes of some of Wittgenstein’s most striking and most puzzling early remarks a recognizable and insightful account of ethical experience, while also accommodating the equally striking formal quality of those remarks. The account identifies a distinctive ethical achievement that requires a distance from particular concrete goods that one might pursue and a responsiveness to those goods as (...) a whole—to one’s world as a whole; only through such openness is one open to the abstract objective that is doing what is best; and only through openness to that does one express oneself in, and assume responsibility for, one’s actions. This account allows us to understand why, for example, Wittgenstein connects “absolute or ethical value” with “wonder at the existence of the world” and with “understand[ing] the question about the meaning of life”. But it also makes sense of why that is precisely a question, and why those to whom “the meaning of life … become[s] clear” cannot “say in what this meaning consist[s]”. The responsiveness to a good which ethical subjects distinctively manifest is a responsiveness not to some distinctive and describable state of affairs but to the question of what is best—willing determination of what here and now that is. This account yields a vision of self-expression not as hearkening to some inner voice but as an openness to one’s life as a whole; and this, in turn, opens up a way of approaching the puzzle of Wittgenstein’s insistence that “of [the willing subject] we cannot speak”. I also suggest that we find here one possible sense for Wittgenstein’s famous remark to Ludwig von Ficker that “the point of [the Tractatus] is ethical”, in that openness to the world as a whole—openness to how things are as such and as a whole—emerges as fundamentally a practical, rather than theoretical achievement. (shrink)

The paper presents an interpretation of the thinking behind the early Wittgenstein's "general form of the proposition." It argues that a central role is played by the assumption that all domains of discourse are governed by the same laws of logic. The interpretation is presented partly through a comparison with ideas presented recently by Michael Potter and Peter Sullivan; the paper argues that the above assumption explains more of the key characteristics of the "general form of the proposition" than Potter (...) and Sullivan suppose, including, in particular, its claim that the bases from which all other propositions are derived must be elementary propositions. (shrink)

This is a survey article in which I explore some important recent work on the topic in question, Kant’s formula of the end in itself (or “formula of humanity”). I first provide an overview of the formulation, including what the formula seems roughly to be saying, and what Kant’s main argument for it seems to be. I then call the reader’s attention to a variety of questions one might have about the import of and argument for this formula, alluding to (...) some of the works in which philosophers have recently raised or tried to answer these questions. Then, for the bulk of the paper, I focus my discussion on two issues of contention: the identity of the “end in itself” that the formula refers to, and the relation between the value of the end in itself and the value of other ends. I do not attempt to argue for a particular position of my own regarding these issues. Instead, I explain a number of the more interesting or influential recent attempts to answer these questions, compare these approaches in various ways, draw implications from them, and raise concerns about some of them. I also suggest that an important link connects the question about the identity of the end in itself and the question about the relation between the value of the end in itself in relation to the value of other ends: How one answers these questions commits one to a position on the thorny issue of whether, how, and how fully, autonomy is manifested through empirical (not simply pure) practical reason. (shrink)

Paul Boghossian has pointed out a ’circularity problem’ for dispositionalist theories of meaning: as a result of the holistic character of belief fixation, one cannot identify someone’s meaning such and such with facts of the form S is disposed to utter P under conditions C, without C involving the semantic and intentional notions that such a theory was to explain. Alex Miller has recently suggested an ’ultra‐sophisticated dispositionalism’ (modelled on David Lewis’s well known version of functionlism) and has argued that (...) this version of dispositionalism escapes Boghossian’s ’circularity problem’. Miller argues, nonetheless, that another of Boghossian’s criticisms of dispositionalism, ’the infinity problem’ still applies to this ’ultra‐sophisticated dispositionalism’: C will still draw upon a potential infinity of mediating background clusters of belief. The present paper argues that the feature that ’the infinity problem’ presents as problematic is a feature of a host of familiar explanations. Our fundamental difficulty in this area is not our inability to understand how a more general model can be applied to a particular domain (the intentional understood as dispositional) but our failure to understand that general model itself (dispositional explanation). (shrink)

The aim of this article is to analyse and to reconsider the role of theologians in the public sphere, especially within ethic commissions or committees. First, the author discusses origin and structures of the so-called bioethical paradigm. Then, he compares some theoretical models of how this challenge might be met: theological deduction of ethics, autonomy of ethics, and >re-theologisation decentration< or reformulation, and creative reconstruction.

Je souhaiterais revenir sur une représentation qui nous est à tous familière : celle d’après laquelle, au vrai départ de la modernité, l’on trouverait l’œuvre de Descartes, et plus précisément, dans cette œuvre, la constitution, l’activité et la mise en scène d’un moi. Ce mot lui-même, « la modernité », désignerait en somme un nouvel âge de la subjectivité, un âge de la subjectivité proprement dite, et cette subjectivité serait, par excellence, la subjectivité cartésienne.

Cholak, Goncharov, Khoussainov, and Shore [1] showed that for each k > 0 there is a computably categorical structure whose expansion by a constant has computable dimension k. We show that the same is true with k replaced by ω. Our proof uses a version of Goncharov's method of left and right operations.

We show that for every c.e. degree a > 0 there exists an intrinsically c.e. relation on the domain of a computable structure whose degree spectrum is {0, a}. This result can be extended in two directions. First we show that for every uniformly c.e. collection of sets S there exists an intrinsically c.e. relation on the domain of a computable structure whose degree spectrum is the set of degrees of elements of S. Then we show that if α ∈ (...) ω∪{ω } then for any α-c.e. degree a > 0 there exists an intrinsically α-c.e. relation on the domain of a computable structure whose degree spectrum is {0, a}. All of these results also hold for m-degree spectra of relations. (shrink)

There has been increasing interest over the last few decades in the study of the effective content of Mathematics. One field whose effective content has been the subject of a large body of work, dating back at least to the early 1960s, is model theory. Several different notions of effectiveness of model-theoretic structures have been investigated. This communication is concerned withcomputablestructures, that is, structures with computable domains whose constants, functions, and relations are uniformly computable.In model theory, we identify isomorphic structures. (...) From the point of view of computable model theory, however, two isomorphic structures might be very different. For example, under the standard ordering of ω the success or relation is computable, but it is not hard to construct a computable linear ordering of type ω in which the successor relation is not computable. In fact, for every computably enumerable degree a, we can construct a computable linear ordering of type ω in which the successor relation has degree a. It is also possible to build two isomorphic computable groups, only one of which has a computable center, or two isomorphic Boolean algebras, only one of which has a computable set of atoms. Thus, for the purposes of computable model theory, studying structures up to isomorphism is not enough. (shrink)

Psychological individualism is motivated by two taxonomic principles: (i) that psychological states are individuated by their causal powers, and (ii) that causal powers supervene upon intrinsic physiological state. I distinguish two interpretations of individualism--the 'orthodox' and the 'alternative'--each of which is consistent with these motivating principles. I argue that the alternative interpretation is legitimately individualistic on the grounds that it accurately reflects the actual taxonomic practices of bona fide individualistic sciences. The classification of homeobox genes in developmental genetics provides an (...) illustration. When applied to the taxonomy of psychological kinds, alternative individualism has some surprising consequences. In particular, externalist taxonomies of thought are consistent with the alternative interpretation, and hence consistent with individualism. I conclude, on this basis, that the individualism/externalism dispute which has long preoccupied philosophy of psychology is an empty one. (shrink)

Formal systems are standardly envisaged in terms of a grammar specifying well-formed formulae together with a set of axioms and rules. Derivations are ordered lists of formulae each of which is either an axiom or is generated from earlier items on the list by means of the rules of the system; the theorems of a formal system are simply those formulae for which there are derivations. Here we outline a set of alternative and explicitly visual ways of envisaging and analyzing (...) at least simple formal systems using fractal patterns of infinite depth. Progressively deeper dimensions of such a fractal can be used to map increasingly complex wffs or increasingly complex 'value spaces', with tautologies, contradictions, and various forms of contingency coded in terms of color. This and related approaches, it turns out, offer not only visually immediate and geometrically intriguing representations of formal systems as a whole but also promising formal links (1) between standard systems and classical patterns in fractal geometry, (2) between quite different kinds of value spaces in classical and infinite-valued logics, and (3) between cellular automata and logic. It is hoped that pattern analysis of this kind may open possibilities for a geometrical approach to further questions within logic and metalogic. (shrink)

In _Apparaître: Essai de philosophie phénoménologique_, Denis Seron proposes a phenomenological approach to intentionality as a positive contribution to the contemporary debate in the philosophy of mind.

La révision imminente de la loi bioéthique ouvre un moment où tout est possible. Ecrit par un juriste universitaire spécialisé dans les questions médicales et impliqué dans la pratique quasi quotidienne de l'éthique clinique depuis des années, cet essai éclaire l'urgence éthique qu'imposent certaines situations humaines souvent dramatiques. Face aux questions si complexes qu'elles soulèvent, il convie à abandonner le manteau du péremptoire et à endosser la responsabilité du faire réfléchir. Fin de vie, assistance médicale à la procréation, gestation pour (...) autrui animent le débat public et la controverse. Mais interruptions volontaires de grossesse par exemple pour raisons psychosociales, ou contraception définitive, sont plus méconnues. La volonté est de les sortir de l'obscurité où éthiquement elles se meurent. Le ton de cet essai ne se veut pas revendicatif mais résolument tourné vers la réalité des situations, la confrontation des arguments et les propositions concrètes. (shrink)

The holistic view of the Universe is a very promising approach. The necessity of such a view is shown by the teaching of Carl Friedrich von Weizsäcker, a German physicist and philosopher. If we accept Panpsychism as the best alternative to Materialism and Dualism, we should take the holistic view seriously. Panpsychism and Holism combined lead to the Idea of Cosmopsychism. If we consider the Universe as a holistic Quantum System, we should ask, what causes the collapse of its wavefunction? (...) I offer four possible answers and I tend to divine consciousness, which brings the collapse of the wavefunction of our Universe. (shrink)

In the ten dense chapters of his new book, John Finnis examines and sometimes amends what he takes to be the key moral, legal, social and political doctrines of Thomas Aquinas. Finnis correctly stresses that neither ethics nor politics, in the Arstotelian tradition to which Aquinas belonged, are theoretical sciences. They are ‘practical’ or action‐guiding sciences. Since societal order originates in free choice, it is subject to moral norms. The latter are more firmly grounded by Aquinas than Aristotle because the (...) former unlike the latter has an explicit and coherent account of universal or exceptionless moral principles.Finnis natural law ethics derives from a set of self‐evident precepts that focus practical reason on the pursuit and protection of basic human goods. Finnis expanding list of the latter now include marriage. Finnis equates – implausibly, in my view – attaining the ensemble of basic human goods with Aquina's notion of beatitudo imperfecta or this‐worldly happiness.Throughout the book, Finnis' exegesis of Aquinas is slanted towards bolstering Finnis' own Thomist philosophical ethics. Accordingly, Thomistic historical scholarship, which carefully traced Aquinas' biblical and patristic sources and which locate Aquinas' theological ethics within the conditions of his own life and times, has little weight in Finnis' interpretation. Overall, Finnis shows little concern for the internal logic of the Summa theologiae and, consequently, he does not adequately clarify how Aquinas' own ethics, according to its proper principles, can be both integrally theological and rational without thereby becoming a philosophical ethics. (shrink)