Rifamycin is a clinically useful macrolide antibiotic produced by the gram positive bacterium. Amycolatopsis mediterranei. This antibiotic is primarily used against Mycobacterium tuberculosis and Mycobacterium leprae, causative agents of tuberculosis and leprosy, respectively. In these bacteria, rifamycin treatment specifically inhibits the initiation of RNA synthesis by binding to β‐subunit of RNA polymerase. Apart from its activity against the bacteria, rifamycin has also been reported to inhibit reverse transcriptase (RT) of certain RNA viruses. Recently, rifamycin derivatives have been dis‐covered that are (...) effective against Mycobacterium avium, which is associated with the AIDS complex. Consequently, the importance of and demand for rifamycin has increased tremendously, the world over. In this article, recent trends in rifamycin research and accessability of recombinant DNA techniques to increase rifamycin production are reviewed. (shrink)

Trika philosophy or Kashmir Śaivism is one of the major nondual philosophical systems of India where both esoteric and exoteric practices are included systematically and scientifically. The two aspects of manifestation viśvamaya, the immanent and viśvottīrṇa the transcendental covers this entire philosophical system as a unique all-inclusive and very practical. In this process of manifestation in Trika philosophy ‘māyā’ plays an important role both from an ontological and epistemological point of view. Furthermore ‘māyā’ clearly stands as a foremost part with (...) the point of view of a knower (pramātā). So, māyā is a quite notable concept, unlike other Indian philosophical traditions. Apart from this, it gives utmost support to artistic creations, i.e. both artist and aesthete, and because of that reason Pratyabhijñā darśan has a strong influence on Indian literary theory. This paper is an attempt to expound the major dimensions of ‘māyā’ in different levels. (shrink)

We present a framework for analyzing black hole backreaction from the point of view of quantum open systems using influence functional formalism. We focus on the model of a black hole described by a radially perturbed quasi-static metric and Hawking radiation by a conformally coupled massless quantum scalar field. It is shown that the closed-time-path (CTP) effective action yields a non-local dissipation term as well as a stochastic noise term in the equation of motion, the Einstein–Langevin equation. Once the thermal (...) Green's function in a Schwarzschild background becomes available to the required accuracy, the strategy described here can be applied to obtain concrete results on backreaction. We also present an alternative derivation of the CTP effective action in terms of the Bogolyubov coefficients, thus making a connection with the interpretation of the noise term as measuring the difference in particle production in alternative histories. (shrink)

This article will examine the role of imperial maps, Christian mission, shared memories and collective consciousness in the formation of Mizo identity. Arguing that imperial maps, supposedly based upon objective European science, were meant to suit specific purposes and were laden with deeper agendas, this article will maintain that other aspiring maps also depicted conflicting claims to territory and overlooked specific details rather than giving factual descriptions. This article will look at how borders and boundaries thus constructed have actual impacts (...) upon the people, places and spaces they divide and include. It will particularly deal with the aspirations of the Mizo Christians who embraced Christianity during the colonial period, and how they are ‘in India’ but often feel ‘not of India’, and will interrogate the Biblical and historical dimensions of their mental maps. (shrink)

Among those who have worked for uplifting the poor, Mahatma Gandhi occupies a unique place. Although his reform efforts received ample financial support from well-off benefactors, Gandhi’s personal life exemplified ideals of voluntary poverty and renouncement. On Martha Nussbaum’s account of stoicism, Gandhi’s voluntary renouncement may imply morally unacceptable reasoning regarding nonviolence and the plight of the poor. Nussbaum argues that the stoic disparagement of external things of fortune implies that they cannot coherently oppose external harms such as torture or (...) rape as unjust. Furthermore, on Nussbaum’s account, stoic flexibility regarding the duty to render material aid provides insufficient ethical grounds for relieving the injustice of poverty. Applying Nussbaum’s critique of stoicism to Gandhi, I ask if Gandhi’s personal-life renouncement of external things exposes his philosophy to vulnerabilities that Nussbaum finds in the stoics. I then respond to the critique. With the stoics, Gandhi does deny that states of simple living are genuinely bad; therefore, pursuing ethical life means seeking some states of poverty. Nevertheless, based on Gandhian values of freedom, equality, sustainability, service, and character, there are coherent ethical grounds in Gandhian thought for pursuing nonviolence (with its proscription of external harms) while fighting global poverty (with attention to material needs). I explicate a Gandhian view of social uplift that vitally connects individual character to social well-being. I also illuminate a Gandhian model of poverty eradication that reveals deficiencies in a model of poverty eradication that depends solely on the value of external things of fortune. (shrink)

Articles on the philosophy of history and historiography.

One of the first philosophers to relate Indian philosophical thought to Western analytic philosophy, Jaysankar Lal Shaw has been reflecting on analytic themes from Indian philosophy for over 40 years. This collection of his most important writings, introduces his work and presents new ways of using Indian classical thought to approach and understand Western philosophy. By expanding, reinterpreting and reclassifying concepts and views of Indian philosophers, Shaw applies them to the main issues and theories discussed in contemporary philosophy of language (...) and epistemology. Carefully constructed, this volume of his collected writings, shows the parallels Shaw draws between core topics in both traditions, such as proper names, definite descriptions, meaning of a sentence, knowledge, doubt, inference and testimony. It captures how Shaw uses the techniques and concepts of Indian philosophers, especially the followers of the Navya-Nyaya, to address global problems like false belief, higher order knowledge and extraordinary perception. Exploring timeless ideas from Indian thought alongside major issues in contemporary philosophy, Shaw reveals how the two traditions can interact and throw light on each other, providing better solutions to philosophical problems. He has also reflected on modern issues such as freedom, morality and harmony from the classical Indian thought. Featuring a glossary and updates to his writings,The Collected Writings of Jaysankar Lal Shaw: Indian Analytic and Anglophone Philosophy also includes new work by Shaw on the relationship between Indian and analytic philosophy today. (shrink)

The Hon’ble Supreme Court of India, in a landmark judgment, scrapped a draconian law [Section 66 (A)] that gave the police absolute power to put behind bars anybody who was found posting offensive or annoying comments online. This paper aims to examine the take of people on the “Free Speech via Social Media” issue and their attitude towards the way sensitive messages/information are posted, shared and forwarded on social media, especially, Facebook.,The research was carried out on a sample of 200 (...) social media users, all picked up randomly, from five Indian states/Union Territories. Data were collected through a questionnaire, and users were contacted through e-mail. Data collected were analyzed through the Kolmogorov–Smirnov (K-S) Z test.,The findings indicate that hate posts/messages are on the rise, and more and more users are joining in. Besides, prosecution happens only when the aggrieved party is influential or powerful.,The findings of this research give a strong insight into the social media behaviour of users in relation to hate contents/posts. The study establishes the fact that Indian people are in favour of free speech, but with a sense of restraint and responsibility. The work could form the basis for future research on various aspects of hate speech on social media. Researchers could study the trials and prosecutions that have happened over the past few years and whether punishment has acted as a deterrent.,The research is likely to be important for those involved in work on freedom of speech or hate speech through social media. Social networking sites such as Facebook would also get some insights into users’ perception towards free and hate speech mechanism on social media. (shrink)

Soil is fragile and nonrenewable but the most basic of natural resources. It has a capacity to tolerate continuous use but only with proper management. Improper soil management and indiscriminate use of chemicals have contributed to some severe global environmental issues, e.g., volatilization losses and contamination of natural waters by sediments and agricultural fertilizers and pesticides. The increasing substitution of energy for labor and other cultural inputs in agriculture is another issue. Fertilizers and chemicals account for about 25% of the (...) production energy investment in agriculture. An additional 60% is accounted for by machinery, gasoline, electricity, and power-related inputs. Fertilizer additions to cropland are not utilized fully and significant amounts, depending on conditions, are either lost in surface runoff or leached into the ground water. The annual discharge of dissolved solids from agricultural lands to the waterways in the USA is substantial. The increasing use of herbicides in agriculture is a threat to the quality of surface and ground water, although this threat is dependent upon both the chemistry of the compound and the ecosystem in which it is used. Especially within the Third World, development of an environmental ethic and environmental laws have not kept pace with the increase in pesticide use. Above all is the severe and global problem of soil degradation currently occurring at the rate of five to seven million hectares per year. The policy and moral aspects of these issues are discussed. (shrink)

The informed-consent process should be one of meaningful information exchange between researchers and study participants. One of the responsibilities of research ethics committees is to oversee appropriate inf...

This work explores issues in Gandhi scholarship, political theory, and religion. By applying core aspects of Gandhian philosophy to the present age it shows a harmony between commonly taken to be disparate aspects of social life that should interest anyone concerned about the future prospects for liberalism.

Like the dominant moral philosophers in the Western tradition, Mahatma Gandhi reaches moral conclusions that emphasize universality, impartiality, and detachment. This is in apparent contrast to feminist philosophers who have put forth a scheme for reaching moral conclusions that gives centrality to feeling, experience, and interdependence. In the following, I show that Gandhi shares significant agreement with feminists in spite of the kinds of moral conclusions he reaches. The crucial difference between Gandhi and the feminist critics lies in how the (...) distinctiveness of the other is understood. For Gandhi, I show, that the distinctiveness of others which evokes our affection is significant only in so far as it is a starting point that aides us in reaching the highest form of moral concern—a kind of agape (unselfish love for all). (shrink)

During these five war years science has proclaimed and demonstrated its role as Hercules. It has employed as its loudspeaker the bursting bomb, and as its courier the swift vehicle. Its blows have been instantly lethal.Next, science has shown its skill as the fabricator of useable goods. And, lastly the giant has revealed some of its mild and even compassionate moods as the binder of man's mortal wounds and the healer of his fevers and mental abberations.

This theoretical paper takes an agency-theoretic approach to questions of corporate social responsibility (CSR). A comparison of various extant frameworks focusses on how CSR agency emerges in complex multi-agent and multi-sector stakeholder networks. The discussion considers the respective capabilities and relevance of these frameworks – culminating in an integrative CSR practice model. A short literature review of the evolution of CSR since the 1950’s provides the backdrop for understanding multi-agent cross-sectoral stakeholder coalitions as a strategic determinant of today’s organizational behavior. (...) The paper turns to Werhane’s coupling of moral imagination and systems thinking and forging stakeholder coalitions in problem contexts that were traditionally deemed intractable by for-profit organizations. However, it identifies the problem that the systems approach treats macro-agents (organizations, stakeholders) as given (“black-boxed”) and shies away from more radically re-imagining the possibilities of reassembling agency from the bottom up. Actor Network Theory (ANT) provides such a method, which strictly commits to treating organizational behavior as a product of technological, human and environmental micro-processes. ANT, however, is lacking a genuine moral deliberative stance in designing complex CSR coalitions. In an attempt to capitalize on the respective strengths of these frameworks (Systems thinking and ANT) the paper tends to a recent iterative series of “situational transactive” models that are rooted in the US pragmatist tradition and seek to capture intelligent planning processes in complex problematic contexts. The contribution proposes a new CSR practice model, which assigns specific roles to the theoretical contributions of ANT, system thinking and pragmatism in complex deliberation processes. This model can be industry-tested in a future study. (shrink)

Category theory has become central to certain aspects of theoretical physics. Bain has recently argued that this has significance for ontic structural realism. We argue against this claim. In so doing, we uncover two pervasive forms of category-theoretic generalization. We call these ‘generalization by duality’ and ‘generalization by categorifying physical processes’. We describe in detail how these arise, and explain their significance using detailed examples. We show that their significance is two-fold: the articulation of high-level physical concepts, and the generation (...) of new models. 1 Introduction2 Categories and Structuralism 2.1 Categories: abstract and concrete 2.2 Structuralism: simple and ontic3 Bain’s Two Strategies 3.1 A first strategy for defending Objectless 3.2 A second strategy for defending Objectless4 Two Forms of Categorical Generalization 4.1 Generalization by duality 4.2 Generalization by categorification 4.3 The role of category theory in physics5 Conclusion. (shrink)

What do our studies of Gandhi tell us about the current crisis of health and politics in the US? The crisis intersects growing realization of the disproportionate impact of the pandemic on poor communities of color with general resistance to policing tactics and policies that are widely considered exercises of systemic racism. One significant response to this situation has been the “defund the police” movement, pressing for systemic institutional change in policing. However, for us, defund is not so much about (...) weakening the state sector. Instead, it is about strengthening community participation in planning decisions about how public funds might be reallocated, not to pay for more tactical gear for cops but more social workers, community investments, and so on. (shrink)

Bellʼs 1964 theorem causes a severe problem for the notion that correlations require explanation, encapsulated in Reichenbachʼs principle of common cause. Despite being a hallmark of scientific thought, dropping the principle has been widely regarded as much less bitter medicine than the perceived alternative—dropping relativistic causality. Recently, however, some authors have proposed that modified forms of Reichenbachʼs principle could be maintained even with relativistic causality. Here we break down Reichenbachʼs principle into two independent assumptions—the principle of common cause proper and (...) factorization of probabilities. We show how Bellʼs theorem can be derived from these two assumptions plus relativistic causality and the law of total probability for actual events, and we review proposals to drop each of these assumptions in light of the theorem. In particular, we show that the non-commutative common causes of Hofer-Szabó and Vecsernyés fail to have an analogue of the notion that the common causes can explain the observed correlations. Moreover, we show that their definition can be satisfied trivially by any quantum product state for any quantum correlations. We also discuss how the conditional states approach of Leifer and Spekkens fares in this regard. (shrink)

Reviving the Invisible Hand is an uncompromising call for a global return to a classical liberal economic order, free of interference from governments and international organizations. Arguing for a revival of the invisible hand of free international trade and global capital, eminent economist Deepak Lal vigorously defends the view that statist attempts to ameliorate the impact of markets threaten global economic progress and stability. And in an unusual move, he not only defends globalization economically, but also answers the cultural and (...) moral objections of antiglobalizers. Taking a broad cross-cultural and interdisciplinary approach, Lal argues that there are two groups opposed to globalization: cultural nationalists who oppose not capitalism but Westernization, and "new dirigistes" who oppose not Westernization but capitalism. In response, Lal contends that capitalism doesn't have to lead to Westernization, as the examples of Japan, China, and India show, and that "new dirigiste" complaints have more to do with the demoralization of their societies than with the capitalist instruments of prosperity. Lal bases his case on a historical account of the rise of capitalism and globalization in the first two liberal international economic orders: the nineteenth-century British, and the post-World War II American. Arguing that the "new dirigisme" is the thin edge of a wedge that could return the world to excessive economic intervention by states and international organizations, Lal does not shrink from controversial stands such as advocating the abolishment of these organizations and defending the existence of child labor in the Third World. (shrink)

The book highlights the concept of ontology, relationship between language and ontology, the distinction between ontology and reality, the role of linguistic philosophers in dealing with ontology etc. Apart from these, the eminent scholars address themselves with the ontology behind the value of valuation, exclusion and discrimination, inter-religious dialogue, Indian theories of language, values in cinema, poetic language etc.

Language is always directed to Reality whatever its nature may be. The valuable articles incorporated in this book examine the following questions in particular:? What is relation between Language and Reality??What are different dimensions of Reality? Can all types of Reality be expressed through language??Can the relation between Language and Reality be explained as internal or external??Can meaning of Language be equated with its existence?All the contributors of this Volume have discussed at length, the relation between Language and Reality from (...) the Eastern as well as Western perspectives. This volume is the result of intensive and matured thinking of the scholars working in this field for a longer period of time. (shrink)

After decades of service to The Acorn, editor Barry Gan--who received the journal from founding editor Ha Poong Kim--has passed the responsibility along. We are happy to announce that the editorial and business office of The Acorn has found a new home at the Department of Philosophy and Religious Studies of Texas State University. For more than a decade, The Acorn has been affiliated with a society that we have recently renamed the Gandhi, King, Chavez, Addams Society (GKCAS). The new (...) name adds Cesar Chavez and Jane Addams to the short list of role models that the society seeks to honor through scholarly study, but the short list is not intended to be exclusive. As a result of reorganization and transition we are adopting a new subtitle of the journal as follows, The Acorn: Philosophical Studies in Pacifism and Nonviolence. (shrink)

v. 1. Role of Vedanta as universal religion -- v. 2. Role of Vedanta as science of self-reliazation.