Major problems in cancer chemotherapy are toxicity, resistance, and cancer heterogeneity. A new theranostic paradigm has been proposed by the authors. Many million small molecules (SM) are bound to the proteins extracted from a patient's cancer. SM that also bind proteins extracted from normal human tissues are subtracted from the cancer protein bound SM leaving a large array of SM targeting many sites on each of the cancer biomarkers. Targeting many more than the conventional 1 – 4 cancer biomarkers will (...) reduce development of tumor resistance. After several cycles of selection and counter selection, DNA codes appended to the SM will be PCR amplified to provide templates for restricted libraries of the SM to improve selectivity and sensitivity. The large array of selected and counter selected SM assures that many of the compounds in the array will penetrate the cell membrane and bind to intracellular targets, low tumor resistance, low background for imaging, low therapeutic toxicity, and targeting of the diverse biomarkers present in the heterogeneous mixture of cells in primary and metastatic cancer. Theranostic use of radiolabeled SM binding many sites on many, not necessarily critical, biomarkers provides high cancer cell killing. Experiments to provide proof of principle of this novel concept suggested by the authors. -/- . (shrink)

What are the forces shaping the future of international green politics? This book provides an objective account of the basis of green arguments and their social and political implications. It offers a clear overview of the most pressing environmental threats.

What role have experiments played, and should they play, in physics? How does one come to believe rationally in experimental results? The Neglect of Experiment attempts to provide answers to both of these questions. Professor Franklin's approach combines the detailed study of four episodes in the history of twentieth century physics with an examination of some of the philosophical issues involved. The episodes are the discovery of parity nonconservation in the 1950s; the nondiscovery of parity nonconservation in the 1930s, when (...) the results of experiments indicated, at least in retrospect, the symmetry violation, but the significance of those results was not realized; the discovery and acceptance of CP symmetry; and Millikan's oil-drop experiment. Franklin examines the various roles that experiment plays, including its role in deciding between competing theories, confirming theories, and calling fo new theories. The author argues that one can provide a philosophical justification for these roles. He contends that if experiment plays such important roles, then one must have good reason to believe in experimental results. He then deals with deveral problems concerning such reslults, including the epistemology of experiment, how one comes to believe rationally in experimental results, the question of the influence of theoretical presuppositions on results, and the problem of scientific fruad. This original and important contribution to the study of the philosophy of experimental science is an outgrowth of many years of research. Franklin brings to this work more than a decade of experience as an experimental high-energy physicist, along with his significant contributions to the history and philosophy of science. (shrink)

Past research has found that skin colouration, particularly facial redness, influences the perceived health and emotional state of target individuals. In the current work, we explore several extensions of this past research. In Experiment 1, we manipulated facial redness incrementally on neutral and angry faces and had participants rate each face for anger and health. Different red effects emerged, as perceived anger increased in a linear manner as facial redness increased. Health ratings instead showed a curvilinear trend, as both extreme (...) paleness and redness were rated as less healthy than moderate levels of red. Experiment 2 replicated and extended these findings by manipulating the masculinity of both angry and neutral faces that varied in redness. The results found the effect of red on perceived anger and health was moderated by masculine face structure. Collectively, these results show that facial redness has context dependent effects that vary based on facial expression, appearance, and differentially impact ratings of emotional states and health. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:What is Fantasy?Brian Laetz and Joshua J. JohnstonWizards, elves, dragons, and trolls—this is certainly the stuff of fantasy, populating the fictions of such giants as Tolkien, no less than the juvenilia of many aspiring writers. However, it is much easier to identify typical elements of fantasy, than it is to understand the category of fantasy itself. There can be little doubt that, in practice, the genre is pretty well (...) defined, concretely manifesting itself in the shelves reserved for it in video shops and bookstores. But stating why a work belongs on these shelves, rather than those in the near vicinity, such as horror and science fiction, or those more remote, like plain old fiction, presents a real challenge. Certainly, a mere few feet could separate fantasy from the other shelves, but the conceptual distance those feet represent appears great indeed. What, if anything, distinguishes this genre from other categories of mass art. In other words, what is fantasy?To begin, fantasy is a transmedia genre, since there are fantasy novels and movies, for instance, as is illustrated by J. R. R. Tolkien's Lord of the Rings saga and its recent cinematic adaptation. It is interesting to note that fantasy includes works from other media as well, such as paintings, which often accompany fantasy narratives, like Frank Frazetta's recognizable illustrations for Robert E. Howard's Conan the Barbarian stories. Forms of entertainment are also affiliated with the genre, such as role-playing games, like Dungeons and Dragons, though one might balk at considering such things even forms of mass art? Nonetheless, despite the variety of media and entertainments associated with fantasy, [End Page 161] narratives occupy a fundamental place within the genre. For paintings, drawings, and the like are only recognizably fantastic given some narrative background that tells us what wizards, trolls, and dragons look like.1 Plausibly, it is what allows us to see that a drawing depicts an elf, for example, rather than a child with odd pointy ears. Thus, even if some works of fantasy are, strictly speaking, non-narrative, fantastic narratives remain fundamental, since these other works would not be classified as fantasy without them. This warrants initially setting aside things like fantasy games and paintings to focus on narratives. What, precisely, makes a narrative fantastic?First, fantastic narratives are essentially fictional. For regardless of how one ultimately understands the nature of fiction, the notion of true fantasy seems patently incoherent, quite unlike, say, true crime. And it must be stressed that this point should be compatible with any theory of fiction. Second, the sort of things that can make a work fantastic, like wizards and dragons, must be prominent in the work—they cannot be minor details. For example, had there been a two-minute scene in Spartacus in which someone cast a spell, the scene would have been fantastic, but ultimately the movie would not be classified any differently; you would still find it on the drama shelf. Moreover, this condition is not peculiar to fantasy.2 For instance, no one who has suffered through a Steven Seagal film would seriously classify it as romance or even action-romance, simply because it has a minor romantic subplot. Fantasy is no different from any other genre in this regard: whatever features define a genre must be prominent in a work in order for it to belong to the relevant genre. Third, the sort of content that can make a work fantastic must not solely be viewed as symbols for things that are not fantastic. In other words, these elements cannot just be taken as allegorical.3 This alone would seem to disqualify George Orwell's Animal Farm from the genre, since most read the intelligent animals as merely symbols portraying various factions in communist Russia. It should be noted that the actual intentions of the author probably matter little here. For example, even if scholars discovered that Tolkien merely intended the Middle Earth saga as an elaborate allegory, it would remain fantasy; few would be tempted to move the books to another shelf. Fourth, the relevant content must not solely be mocked or lampooned within the work.4 This is necessary... (shrink)

This book is a fresh examination of Thucydides' treatment of Alcibiades in his History of the Peloponnesian War, Alcibiades' significance in the History, and his relation to Thucydides' political themes.

When do descriptive regularities become prescriptive norms? We examined children's and adults' use of group regularities to make prescriptive judgments, employing novel groups that engaged in morally neutral behaviors. Participants were introduced to conforming or non-conforming individuals. Children negatively evaluated non-conformity, with negative evaluations declining with age. These effects were replicable across competitive and cooperative intergroup contexts and stemmed from reasoning about group regularities rather than reasoning about individual regularities. These data provide new insights into children's group concepts and have (...) important implications for understanding the development of stereotyping and norm enforcement. (shrink)

This is a primer on Steven James Bartlett's book CRITIQUE OF IMPURE REASON: HORIZONS OF POSSIBILITY AND MEANING. ●●●●● -/- Some books are long and complex. The Critique of Impure Reason is such a book. It is long enough and complex enough so that it may be a service to some readers to offer a primer to introduce and partially summarize the book’s objectives and method. Here, the author of Critique of Impure Reason: Horizons of Possibility and Meaning provides (...) such a guide, a vade mecum to accompany a reader should he or she embark on a study of the long and complex work. ●●●●● -/- The book is available in a printed edition, ISBN 978-0-578-88646-6, from online booksellers such as Barnes & Noble, Amazon, and through independent bookstores. The book is also available as an eBook, DOI: 10.5281/zenodo.5458352, through Zenodo, PhilSci, PhilPapers, HAL, and other online archives. (shrink)

John Harsanyi has offered an argument grounded in Bayesian decision theory that purports to show that John Rawls's original position analysis leads directly to utilitarian conclusions. After explaining why a prominent Rawlsian line of response to Harsanyi's argument fails, I argue that a seemingly innocuous Bayesian rationality assumption, the continuity axiom, is at the heart of a fundamental disagreement between Harsanyi and Rawls. The most natural way for a Rawlsian to respond to Harsanyi's line of analysis, I argue, is to (...) reject continuity. I then argue that this Rawlsian response fails as a defence of the difference principle, and I raise some concerns about whether it makes sense to posit the discontinuities needed to support the other elements of Rawls's view, although I suggest that Rawls may be able to invoke discontinuity to vindicate part of his first principle of justice. (shrink)

The idea of nirvana is alluring but elusive for non-specialists and specialists alike. Offering his own interpretation of key texts, Steven Collins explains the idea in a new, accessible way - as a concept, as an image, and as an element in the process of narrating both linear and cyclical time. Exploring nirvana from literary and philosophical perspectives, he argues that it has a specific role: to provide 'the sense of an ending' in both the systematic and the narrative (...) thought of the Pali imaginaire. Translations from a number of texts, including some dealing with past and future Buddhas, enable the reader to access source material directly. This book will be essential reading for students of Buddhism, but will also have much to teach anyone concerned with Asia and its religions, or indeed anyone with an interest in the ideas of eternal life or timelessness. (shrink)

The civil rights movement has broken away from its religious roots which once provided it firm support and, indeed, it has become a threat to those roots. In fact, the past thirty years evidence two civil rights movements. The original civil rights movement promoted equal opportunity and presupposed a constrained vision of human possibilities compatible with Christianity, The revised civil rights agenda, which had replaced it by 1971, promoted preferential policies dubbed "affirmative action" based on an unconstrained vision incompatible with (...) both Christianity and the American founding. The most visible threat to religious liberty is the expansion of civil rights protections to include homosexuals despite the overwhelming rejection of homosexuality as a lifestyle by the majority of Americans, including Christians. (shrink)

The literature on the politics of science and on science policy is dominated by information about large and highly industrialized countries. For example, models of the different forms of science policy administration and management tend to derive from French, U.S., and British exemplars. Yet in the mid-1990s there is a growing number of small nations, all of which are seeking to harness research communities to the cause of socioeconomic development, while still extracting "value for money" from science budgets. This article (...) uses the case study approach—focusing on the political economy of the politics of science in the Irish Republic, chiefly since the 1950s-to analyze the problems faced by science policy agencies and the scientific community in small nations. The study offers analogies and possible insights into the politics of research policy in other small nations ; it also aims to throw light on emerging research policy trends even in bigger countries as the "bargain" between the funders and the performers of research becomes more and more explicit and increasingly subject to economic justifications. (shrink)

We present an investigation of the ways in which speakers' subjective perspectives are likely to affect the meaning of gradable adjectives like tall or heavy. We present the results of a study showing that people tend to use themselves as a yardstick when ascribing these adjectives to human figures of varied measurements: subjects' height and weight requirements for applying tall and heavy are found to be positively correlated with their personal measurements. We draw more general lessons regarding the definition of (...) subjectivity and the ways in which a standard of comparison and a significant deviation from that standard are specified. (shrink)

In the not too distant past, it was common to treat Hume's skeptical doubts regarding the justification of our beliefs in causal connections—understood as necessary connections between objects or events—as having appeared per conceptionem immaculatam in his post-Cartesian mind. Thanks to recent efforts by scholars in early modern philosophy, however, we are now more informed about the roots of Hume's conclusions in Cartesian thought itself, especially the influence of Malebranche and his arguments for occasionalism. And by the research of historians (...) of Medieval philosophy we are reminded that many aspects of seventeenth-century occasionalism, in turn, have their ancestry in Latin and Arabic thought of the Middle Ages. In this paper I offer a small contribution to the overall project of illuminating the precedents in Medieval philosophy for the theses and arguments in Malebranche that so clearly influenced the most important and influential philosophical analysis of causation ever. There is a tradition here, where the goal is to undermine claims to discover real causal relations or powers in nature. I will concentrate on one particular aspect or tool of that tradition: the negative argument that we can never perceive a sufficiently necessary connection between any two natural objects or events. (shrink)

Written by epidemiologists, ethicists and legal scholars, this book provides an in-depth account of the moral problems that often confront epidemiologists, including both theoretical and practical issues. The first edition has sold almost three thousand copies since it was published in 1996. This edition is fully revised and includes three new chapters: Ethical Issues in Public Health Practice, Ethical Issues in Genetic Epidemiology, and Ethical Issues in International Health Research and Epidemiology. These chapters collectively address important developments of the past (...) decade. Three chapters from the first edition have also been reorganized: Ethicall Optimized Study Deisgns in Epidemiology, Ethical Issues in Epidemiologic Research with Children, and The Ethics of Epidemiologic Research with Older Populations. Instead of standing alone, these chapters have been integrated into chapters on informed consent, confidentiality and privacy protection, and community-based intervention studies. (shrink)

The self-interest paradigm predicts that unethical behavior occurs when such behavior benefits the actor. A recent model of lying behavior, however, predicts that lying behavior results from an individual''s inability to meet conflicting role demands. The need to reconcile the self-interest and role conflict theories prompted the present study, which orthogonally manipulated the benefit from lying and the conflicting role demands. A model integrating the two theories predicts the results, which showed that both elements — self benefit and role conflict (...) — influenced lying, separately and interactively. Additionally, the relative strength of the roles in conflict affected their level of influence. Theoretical and practical implications are discussed. (shrink)

Pre-publication certification through peer review stands in need of philosophical examination. In this paper, philosopher-psychologist Steven James Bartlett recalls the arguments marshalled four hundred years ago by English poet John Milton against restraint of publication by the "gatekeepers of publication," AKA today's peer reviewers.

This is the introduction to Self-reference: Reflections on Reflexivity, edited by Steven James Bartlett and Peter Suber. The introduction identifies and describes a wide range of varieties of self-reference, some which have become important topics of investigation in philosophy, and others which are of significance in other disciplines. /// The anthology is the first published collection of essays to give a sense of depth and breadth of current work on this fascinating and important set of issues. The volume contains (...) 13 essays by well-known authors in this field, written on special invitation for this collection. In addition, the book includes the first general bibliography of works on self-reference, comprising more than 1,200 citations. (shrink)

Thirty years after the publication of Dominique Janicaud’s criticism of what he termed the “theological turn” of phenomenology in France, what is the state of the debate? This paper addresses that question, by examining the phenomenology of revelation in Marion, Lacoste, and others, in turn replying to various arguments that have been advanced against the theological turn and on behalf of methodological atheism. Not only is revelation a viable topic of phenomenological analysis, the attempts to formulate a methodologically atheist phenomenology (...) fail. (shrink)

Sorry that he is no longer here to read it, I consider in this paper Scott Cameron’s discussion of my views questioning the value of the concept of “nature” for environmental philosophy. Scott had suggested, based on arguments from hermeneutics, that although we never have access to a nature independent of our interpretations of it, still the existence of such a nature is necessarily presupposed by all such interpretations. I claim in response that if we replace the (idealist) notion of (...) interpretation by the (materialist) one of practice, that presupposition is no longer necessary: the independence required is built into the notion of practice itself, and need not be seen as a characteristic of the world “outside” of us. (shrink)

While previous writing on the philosophy of sport has tended to see sport as a kind of testing ground for philosophical theories devised to deal with other kinds of problems—of ethics, aesthetics, or logical categorization—here Steven Connor offers a new philosophical understanding of sport in its own terms. In order to define what sport essentially is and means, Connor presents a complete grammar of sport, isolating and describing its essential elements, including the characteristic spaces of sport, the nature of (...) sporting time, the importance of sporting objects like bats and balls, the methods of movement in sport, the role of rules and chance, and what it really means to cheat and to win. Defined as games that involve bodily exertion and exhaustion, sports simultaneously require constraint and the ability to overcome it. Sport, argues Connor, is a fundamental feature of modern humans. It is shown to be one of the most powerful ways in which we negotiate the relationship between the human and natural worlds. Encompassing a huge range of different sports, and enlisting the help of Hegel, Freud, Wittgenstein, Heidegger, Adorno, Sartre, Ayer, Deleuze, and Serres, _A Philosophy of Sport _will inform, surprise, and delight thoughtful athletes and sporty philosophers alike. (shrink)

By the end of World War II, religion appeared to be on the decline throughout the United States and Europe. Recent world events had cast doubt on the relevance of religious belief, and modernizing trends made religious rituals look out of place. It was in this atmosphere that the careers of Scholem, Eliade, and Corbin--the twentieth century's legendary scholars in the respective fields of Judaism, History of Religions, and Islam--converged and ultimately revolutionized how people thought about religion. Between 1949 and (...) 1978, all three lectured to Carl Jung's famous Eranos circle in Ascona, Switzerland, where each in his own way came to identify the symbolism of mystical experience as a central element of his monotheistic tradition. In this, the first book ever to compare the paths taken by these thinkers, Steven Wasserstrom explores how they overturned traditional approaches to studying religion by de-emphasizing law, ritual, and social history and by extolling the role of myth and mysticism. The most controversial aspect of their theory of religion, Wasserstrom argues, is that it minimized the binding character of moral law associated with monotheism.The author focuses on the lectures delivered by Scholem, Eliade, and Corbin to the Eranos participants, but also shows how these scholars generated broader interest in their ideas through radio talks, poetry, novels, short stories, autobiographies, and interviews. He analyzes their conception of religion from a broadly integrated, comparative perspective, sets their distinctive thinking into historical and intellectual context, and interprets the striking success of their approaches. (shrink)

In this paper, I argue that Arnauld’s conception of God is more radical than scholars have been willing to allow. It is not the case that, for Arnauld, God acts for reasons, with His will guided by wisdom (much as the God of Malebranche and Leibniz acts), albeit by a wisdom impenetrable to us. Arnauld’s objections to Malebranche are directed not only at the claim that God’s wisdom is transparent to human reason, but at the whole distinction between will and (...) wisdom in God, even if that wisdom were “hidden.” Arnauld’s God, in fact, approaches the extreme voluntarist God of Descartes, and thus transcends practical rational agency altogether. (shrink)

Molinism entails that God cannot actualize just any possible world because God has no control over what counterfactuals of freedom (CFs) are true. This fact confronts the Molinist with a dilemma. If God has a plan for the course of history logically antecedent to his cognizance of the true CFs, then God would have been implausibly lucky if any actualizable world corresponded to his plan. If, on the other hand, God did not have a plan for the course of history (...) antecedent to his cognizance of the true CFs, then Molinism is incommensurate with a meticulous view of providence. (shrink)

[A Polish translation of Steven James Bartlett, “Phenomenology of the Implicit,” Dialectica: Revue international de philosophie de la connaissance, Vol. 29, Nos. 2-3, 1975, pp. 173-188.] -/- This paper marks a juncture between the author’s studies in phenomenology and the transition he made to a study of what he has called a “metalogic of reference.” Published in 1974 in Polish translation, followed by its publication in English in 1975, “Phenomenology of the Implicit” describes the author’s “translation schema” that permits (...) certain of the central goals of Husserlian transcendental philosophy to be transposed to a framework that studies the preconditions of valid reference. The result of this translation was the development of the author’s “de-projective” approach to phenomenology, which he later dissociated from phenomenology in the form of a pure metalogic of reference. (shrink)

A key characteristic of an animal's nervous system is that it can respond to brief environmental stimuli with lasting changes in its structure and function. These changes are triggered by specific patterns of neuronal electrical activity and are manifested as changes in the strength and patterns of synaptic connectivity between activated neurons. The biochemical mechanisms that control these changes are unclear, but cytoplasmic rises in Ca2+ levels may play a critical role, especially in regulating neuronal gene expression for making activity‐induced (...) synaptic changes permanent. Recently, two reports have explored the spatial features by which activity‐induced rises in Ca2+ levels activate transcription factors and gene expression(1,2). The reports suggest that Ca2+ influx acts both locally at the synapse and distantly within the nucleus to regulate transcription factors and gene expression. The results also show that regulatory elements within genes can respond differentially, depending on spatial differences in intracellular Ca2+ rises. These reports suggest new spatial mechanisms by which Ca2+‐dependent gene expression could contribute to activity‐dependent synaptic changes. (shrink)

One of the more difficult tasks that Clerselier faced in bringing out his 1664 edition of the Traité de l'homme was securing the illustrations, eventually composed by La Forge and Gutschoven. After considering the chronology of this frustrating process, which is interesting in its own right, I will examine the illustrations themselves, comparing them with Schuyl’s illustrations for his 1662 Latin edition, and especially in the light of what Clerselier says were the intended purpose of such illustrations.

Spinoza resolves the tension between reason and revelation by granting reason complete authority and autonomy in all philosophical and natural matters, and by denying revelation any claims to knowledge. Despite this dramatic partisanship, he attempts to make this solution attractive to believers by creating a hermeneutic that allows a limited claim to knowledge for revelation. This article attempts to explain how he arrived at this strategy and why he believed it would succeed.

ONE OF THE MOST VEXING AND PERSISTENT ISSUES among students of Spinoza’s Tractatus Theologico-Politicus is the question of the work’s intended audience. Determining the audience of the TTP is critical not only for judging the work’s tone but also for assessing its purpose and scope. Despite the importance of this issue, Spinoza offers little help in resolving the question of his intended audience. Indeed, after outlining the argument of the work in the preface, he playfully dodges the question of audience.

Husserl’s concept of an “historical apriori” is marked by a tension: It simultaneously departs from, and develops his long-standing commitment to philosophy as transcendental phenomenology. This paper looks at some reasons for this tension in the context of Husserl’s attempt to determine philosophy as a “tradition” in The Origin of Geometry. Husserl is convinced that philosophy is a scientific tradition, and the historical apriori serves in the analysis of the conditions that define a distinctively scientific “handing down.” The key here (...) is a kind of writing—mathematics—thanks to which the participants in the tradition can be certain that they are in essential connection with the “original” idealities of that tradition. But Husserl’s discovery about the individual philosopher’s relation to the philosophical tradition—namely, that it is always mediated by a kind of “poetic invention”—undermines his conviction that philosophy can be a scientific tradition. This is Husserl’s “existentialism.”. (shrink)

This study examines the moral and ethical arguments presented by public relations practitioners in online debate on the appropriateness of representing the tobacco industry or tobacco interests. It is a descriptive and inferential analysis of 21 e-mail messages posted during a 14-month debate on the PRForum, an online newsgroup for public relations professionals, applying Kohlberg's cognitive-development theory of moralization. Debate focused on the right of an organization to promote a legal product versus a practitioner's obligation to protect the welfare of (...) society. Intensity of disagreement, and the inability to achieve consensus, suggests that personal ethical baselines are subjective, that practitioner perceptions of right or wrong are injluenced by their level of cognitive and moral development, and that codes of behavior of professional organizations are too ambiguous to use in dealing with complex ethical issues. (shrink)