Epigenetics – the study of mechanisms that influence and modify gene expression – is providing unique insights into how an individual’s social and physical environment impact the body at a molecular level, particularly in populations that experience stigmatization and trauma. Researchers are employing epigenetic studies to illuminate how epigenetic modifications lead to imbalances in health outcomes for vulnerable populations. However, the investigation of factors that render a population epigenetically vulnerable present particular ethical and methodological challenges. Here we are concerned with (...) demonstrating how, in targeting certain populations for epigenetic research, this research may be pathologizing socio-cultural and medical practices in those populations in a way that increases their vulnerability. Using a case study approach, this article examines three vulnerable populations currently of interest to epigenetic researchers – Indigenous, autistic, and transgender populations – in order to highlight some of the challenges of conducting non-stigmatizing research in epigenetics. (shrink)

The ethics of care has flourished in recent decades yet we remain without a succinct statement of its core theoretical commitment. This book uses the methods of analytic philosophy to argue for a simple care ethical slogan: dependency relationships generate responsibilities. It uses this slogan to unify, specify and justify the wide range of views found within the care ethical literature.

Individuals have various kinds of obligations: keep promises, don’t cause harm, return benefits received from injustices, be partial to loved ones, help the needy and so on. How does this work for group agents? There are two questions here. The first is whether groups can bear the same kinds of obligations as individuals. The second is whether groups’ pro tanto obligations plug into what they all-things-considered ought to do to the same degree that individuals’ pro tanto obligations plug into what (...) they all-things-considered ought to do. We argue for parity on both counts. (shrink)

A standard objection to socioeconomic human rights is that they are not claimable as human rights: their correlative duties are not owed to each human, independently of specific institutional arrangements, in an enforceable manner. I consider recent responses to this ‘claimability objection,’ and argue that none succeeds. There are no human rights to socioeconomic goods. But all is not lost: there are, I suggest, human rights to ‘socioeconomic consideration’. I propose a detailed structure for these rights and their correlative duties, (...) while remaining neutral on substantive moral debates. I argue that socioeconomic-consideration human rights are satisfactorily claimable and sufficiently practical. (shrink)

During the 1970s and 1980s, a team of Automated Theorem Proving researchers at the Argonne National Laboratory near Chicago developed the Automated Reasoning Assistant, or AURA, to assist human users in the search for mathematical proofs. The resulting hybrid humans+AURA system developed the capacity to make novel contributions to pure mathematics by very untraditional means. This essay traces how these unconventional contributions were made and made possible through negotiations between the humans and the AURA at Argonne and the transformation in (...) mathematical intuition they produced. At play in these negotiations were experimental practices, nonhumans, and nonmathematical modes of knowing. This story invites an earnest engagement between historians of mathematics and scholars in the history of science and science studies interested in experimental practice, material culture, and the roles of nonhumans in knowledge making. (shrink)

Herodotus holds an honoured place among the pioneers of Greek epigraphy. We seek in vain for earlier signs of any appreciation of the historical value of inscriptions, and though we may conjecture that the antiquarian interests of some of his contemporaries or near-contemporaries might well have led them in this direction, our view of the beginnings of Greek epigraphical study must be based on Herodotus, whether or not he truly deserves to be regarded as its ρχηγέτηϲ. Apart from its significance (...) in the history of scholarship Herodotus' use of inscriptions may be expected to throw some light on his methods and on his conception of his task. He cites epigraphic evidence throughout his work and in relation to a wide range of topics; if his use of this material suggests any general conclusions, we do not need to allow for the bias of a single source or the effect of peculiar local conditions, as we must when we consider his accounts of individual episodes or areas. We are relatively well placed to assess his procedure. We have a reasonably clear idea of the general appearance of the various scripts concerned , and in this respect enjoy a considerable advantage over the majority of Herodotus' original audience. Three of the inscriptions which he cites have been wholly or partly preserved, and thus provide a simple gauge of his accuracy in reporting such evidence. (shrink)

The Cambridge History of Medieval Philosophy comprises over fifty specially commissioned essays by experts on the philosophy of this period. Starting in the late eighth century, with the renewal of learning some centuries after the fall of the Roman Empire, a sequence of chapters takes the reader through developments in many and varied fields, including logic and language, natural philosophy, ethics, metaphysics, and theology. Close attention is paid to the context of medieval philosophy, with discussions of the rise of the (...) universities and developments in the cultural and linguistic spheres. A striking feature is the continuous coverage of Islamic, Jewish, and Christian material. There are useful biographies of the philosophers, and a comprehensive bibliography. The volumes illuminate a rich and remarkable period in the history of philosophy and will be the authoritative source on medieval philosophy for the next generation of scholars and students alike. (shrink)

In this reply to an article of Toni Erskine's, I argue that coalitions of the willing are moral agents. They can therefore bear responsibility in their own right.

The second line of the poem in which Archilochus related his fable of the fox and the ape was a source of perplexity to Hellenistic scholars. According to Athenaeus Apollonius Rhodius explained it by reference to the Spartan practice of winding official dispatches round a staff or baton: τι δ λευκ μντι περιειλοντες τν σκυτλην ο Λκωνες γρφον βολοντο ερηκεν κανς πολλνιος διος ν τ περ ρχιλχου. This interpretation evidently failed to satisfy Aristophanes of Byzantium, who wrote a monograph περ (...) τς χνυμνης σκυτλη' view has held the field. (shrink)

It once seemed almost self-evident that the extraordinary progress of Greek astronomy and mathematics in the Hellenistic age were, at least in part, the result of contact with Babylonian and Egyptian culture. But, whatever they may have owed to Babylonia in the exact sciences, there is now a growing consensus that even as early as Eudoxus the Greeks had advanced beyond the point where they might have profited from Egyptian help, and it is not easy to find a solid basis (...) for the widespread Greek belief in the superior wisdom of the Egyptian hierarchy. Yet the preface to the famous Calendar for the Saite nome, P. Hibeh 27, provides circumstantial evidence that one Greek, at least, in the fourth or early third century B.C., found in Egypt an instrument for measuring the time at night which was new to him and which he may well have found impressive in its accuracy. (shrink)

This note is not concerned with the reliability of this information, but with the lexical singularity παλλς, which has won widespread acceptance as an ancient sacral term, though our lexica display an uncommon, and indeed misleading, prudishness as to its meaning: ‘maiden-priestess’ ; ‘bei den Griechen in ägypt. Theben noch als sakraler Ausdruck = παρθνος' ; ‘A Thèbes d'Égypte pour désigner une prêtresse = παρθνος' . Pubescent temple-prostitutes had no place in Hellenic religious life, and it might be thought surprising (...) that there was a Greek word for them; yet Strabo offers the term without explanation or speculation as to derivation or dialectal provenance, apparently confident that it is indeed Greek and not a foreign loan-word. The Greeks who frequented Upper Egypt were not a group of largely homogeneous origin, who might have preserved in quasi-colonial isolation an archaism obsolete elsewhere in the Hellenic world. No such usage is mentioned in ancient discussions of the derivation of Pallas, wide though the etymological net is cast in the attempt to explain Athene's title: see, e.g., sch. Il. 1.199–200 , sch. Od. 1.252, P. Oxy. 2260. (shrink)

Simone de Beauvoir's The Second Sex has been heralded as a canonical text of feminist theory. The book focuses on providing an account of the lived experience of woman that generates a condition of otherness. However, I contend that it falls short of being able to account for the multidimensionality of identity insofar as Beauvoir's argument rests upon the comparison between racial and gendered oppression that is understood through the black–white binary. The result of this framework is the imperceptibility of (...) identities at the crossroads between categories of race and gender. Hence, the goal of this article is to explore the margins of Beauvoir's work in order to decenter the “other” of The Second Sex and make known what is made imperceptible by its architecture, using Latina identity as an interventional guide. I conclude that given the prominence of The Second Sex in feminist theory, this shortcoming must be addressed if feminist theorists are to use it responsibly. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:From Impatience to EmpathyStephanie Pierce and Kavita Shah AroraWe gave J.H. a label the first time we met her, as many often do—“Uncooperative.” She was a patient with autism and intellectual delay who had presented to the emergency department (ED) with vaginal bleeding. After receiving the gynecology consult request from the emergency medicine physicians, we were already mentally formulating our recommendations based on the information they told us over (...) the phone. “Does not cooperate with exam,” “no acute surgical intervention is currently warranted,” and “recommend outpatient follow–up.”When we arrived in her room, she was sitting in the hospital bed surrounded by a protective shield of caregivers from her group home. We introduced ourselves as the gynecology team but it was obvious that J.H. could not communicate verbally. Upon speaking with her caregivers we learned that she had Cowden syndrome, a genetic disease that confers significantly increased risks for several types of cancer including endometrial, thyroid, and breast cancers. J.H. had also been having heavy vaginal bleeding, which was difficult for her caregivers to manage, and this was the reason she was brought into the emergency department. After attempting to gain as much information as we could from the caregivers, we started to perform an abdominal exam, which made J.H. extremely agitated. We quickly stopped the exam and the caregivers helped to calm J.H. We remember our mixture of emotions—bewilderment at the agitation and commotion in the exam room full of people, frustration at not being able to complete our exam fully, and annoyance that this “difficult patient” was taking up our limited time between surgical cases. Thankfully, these knee–jerk reactions were quickly replaced by feelings of concern for the patient and the realization of how frightening an experience this must be for her—being in a strange place with white walls and unfamiliar people, unable to communicate her thoughts.J.H.’s mother, her surrogate decision–maker, was not at the hospital that day but the caregivers told us that she had expressed a strong desire for her daughter to have a prophylactic hysterectomy due to her lifetime risk for developing uterine cancer as well as a permanent solution to the bleeding concerns. What had initially started as a simple ED consult was now turning into a complex question. The ethical and legal dilemma was obvious—whether to perform a major surgery that would irreversibly sterilize a patient who could not consent on her own behalf in order to minimize the potential risk of cancer later in life. While medical management could improve the bleeding and potentially reduce the risk of cancer, frequent exams would be necessary [End Page 19] to ensure that the medication was working and that premalignant changes were not occurring in J.H.’s uterus. However, based on our experience in the emergency department, J.H. would need anesthesia for such exams and it was doubtful the medications would completely normalize her elevated risk of uterine malignancy. We knew that in order to address this question, we would need to see J.H. again along with her mother to have a frank discussion about the risks and benefits of such a decision, and so we made plans to see her in our outpatient clinic.Several days later, J.H., her mother, and the group home caregivers arrived in the office. Anticipating a complex discussion, we had requested a representative from the hospital ethics committee to join us at the visit. We didn’t know what to expect meeting J.H.’s mother for the first time but as we sat in the room talking, it was obvious that she was truly trying to act in her daughter’s best interest. Similarly, it was touching to watch the faces of the caregivers from the group home as they nodded in solidarity with J.H.’s mother, also clearly wanting what was best for her and supporting her mother in this difficult decision. J.H., meanwhile, seemed content to sit silently with us during the discussion, surrounded as she was by people who cared deeply for her well–being.After extensive partnership with the ethics consultants... (shrink)

Research suggests that although many elementary teachers integrate social studies with the language arts, this instruction tends to be poorly designed with little emphasis on social studies learning. This study examined an instructional method rarely used as a form of integration at the primary-grade level—interactive read-alouds of informational text—in order to determine the degree that this intervention might simultaneously build kindergarten students’ knowledge of economic concepts and content literacy in low-SES settings. As evidenced by students’ responses during one-on-one assessments before (...) and following the interactive read-alouds, students made statistically significant learning gains in both social studies and content literacy. Implications of the findings and areas for further research are discussed. (shrink)

Nicolai Hartmann describes how artistic objects arise through the interplay between a material foreground and immaterial background. In this paper, I show how the layered structure also prevents the modal imbalance inherent in artistic objects from violating the intermodal laws of the real. The real law of intermodal implication specifies that real possibility cannot extend beyond real necessity. I begin by explicating the real intermodal laws and describing how they give the real sphere its characteristic narrowness and determinateness. Hartmann describes (...) artistic objects as entailing a possibility that extends beyond real necessity. This intermodal imbalance does not, however, threaten the hegemony of the real intermodal laws, because only its foreground layer is fully situated within the real sphere of being. Its background layer has components that belong to the ideal sphere governed by the ideal modes. For the ideal modes, the law of intermodal implication only holds in one direction so that what is necessary must be actual and what is actual must be possible. Since this relation of implication is not reciprocal for the ideal modes, ideal possibility implies neither ideal actuality nor ideal necessity. (shrink)

On a Humean account, a person's reasons for action are determined by her desires---in the broadest sense of 'desires', that is, noncognitive pro-attitudes. In four essays, I defend this account against several prominent objections. The first essay addresses the concern that the Humean cannot account for rationalizing reasons . The next three essays concern justifying reasons : reasons for action that are more fully normative than those that merely make action intelligible. Instrumental reasons, prudential reasons, and intrinsic reasons are three (...) different sorts of reasons to which an agent can appeal in justifying her action. ;Each essay focuses on a specific attack against the Humean account. In the second essay I argue that the normatively of instrumental reasons is brute ; and that, contrary to the received view, this is compatible with Humeanism. In the third essay I consider prudential reasons and defend the Humean claim that all and only present concerns provide normative reasons for action. In the final essay I address the fundamental question considerations of deliberative relevance: what makes certain desires and considerations relevant to a specific decision-making context, that is, what puts them among a person's present active reasons. ;In addition to defending a broadly Humean account of practical reasons, I am concerned to expand the components of a plausible form of Humeanism. Specifically, I argue that desires alone are not always sufficient to ground an agent's reasons, and that affective states are sometimes also necessary. I call this view "thick Humeanism". In essays one and four especially, I urge that a central place be given to affective states in determining practical reasons. I also invoke recent studies in cognitive psychology to support my claims about the role of the emotions in practical deliberation. (shrink)

This essay reads Alice’s Adventures in Wonderland (1865) alongside influential mid-century Victorian psychology studies—paying special attention to those that Carroll owned—in order to trace the divergence of Carroll’s literary representations of the “dream child” from its prevailing medical association with mental illness. The goals of this study are threefold: to trace the medico-historical links between dream-states and childhood, to investigate the medical reasons behind the pathologization of dream-states, and to understand how Alice’s Adventures in Wonderland contributed to Victorian interpretations of (...) the child’s mind. (shrink)

Theory in Africa, Africa in Theory explores the place of Africa in archaeological theory, and the place of theory in African archaeology. The centrality of African models in reconstructions is explored, focusing on materiality and agency in the past. The differences between how African models are used in western theoretical discourse and the use of that theory within Africa are also highlighted, as a means to explore the nature of theory itself. Thus, this dual purposed volume is a timely intervention (...) into archaeological theory, deconstructing the taken-for-granted foundations of the ways we approach the past. (shrink)

The Middle Ages saw a great flourishing of philosophy. Now, to help students and researchers make sense of the gargantuan—and, often, dauntingly complex—body of literature on the main traditions of thinking that stem from the Greek heritage of late antiquity, this new four-volume collection is the latest addition to Routledge’s acclaimed Critical Concepts in Philosophy series. Christina Van Dyke of Calvin College, USA, and an editor of the Cambridge History of Medieval Philosophy, has carefully assembled classic contributions, as well (...) as more recent work, to create a one-stop ‘mini library’ of the best and most influential scholarship. -/- With a comprehensive index and a useful synoptic introduction newly written by the editor, Medieval Philosophy will be welcomed as an indispensable resource for reference and research. (shrink)

This book is an investigation into metaphysics: its aims, scope, methodology and practice. Dyke argues that metaphysics should take itself to be concerned with investigating the fundamental nature of reality, and suggests that the ontological significance of language has been grossly exaggerated in the pursuit of that aim.

In this paper, I draw attention to the phenomenon of warranted epistemic blame in order to pose a challenge for most forms of epistemic instrumentalism, which is the view that all of the demands of epistemic normativity are requirements of instrumental rationality. Because of the way in which the instrumentalist takes the force of one’s epistemic reasons to derive from one’s own individually held ends, the instrumentalist faces unique difficulties in explaining our standing to blame one another for violations of (...) epistemic norms. In many cases, it is unclear why, according to the instrumentalist, we might be entitled to others’ adherence to epistemic norms at all. This is a serious problem. The upshot is that theorists of epistemic normativity should be prepared reject most forms of epistemic instrumentalism. (shrink)

Medieval philosophy is primarily associated today with university-based disputations and the authorities cited in those disputations. In their own time, however, scholastic debates were recognized as just one part of wide-ranging philosophical and theological discussions. A Hidden Wisdom breaks new ground by drawing attention to another crucial component of these conversations: the Christian contemplative tradition. The thirteenth–fifteenth centuries in particular saw a dramatic increase in the production and consumption of mystical and contemplative literature in the ‘Christian West’, by laypeople as (...) well as religious scholars, women as well as men. A Hidden Wisdom focuses on five topics of particular interest to both scholastics and contemplatives in this period—namely, self-knowledge, reason and its limits, love and the will, persons, and immortality and the afterlife. This focus centers on the (often overlooked) contributions of medieval women and demonstrates that when we reunite scholasticism with its contemplative counterpart, we gain not only a more accurate understanding of the scope of medieval Christian philosophy and theology but also an increased awareness of a deeply practical tradition that builds up as well as tears down, generates as well as deconstructs. The book’s treatment of topics and figures is meant to be representative rather than exhaustive—a tasting menu rather than a comprehensive study. The choice of topics offers a series of ‘hooks’ for philosophers to connect their own interests to issues central to medieval contemplative philosophy, while also providing medievalists in other disciplines a fresh lens through which to view these texts. (shrink)

Are epistemic reasons merely a species of instrumental practical reasons, making epistemic rationality a specialized form of instrumental practical rationality? Or are epistemic reasons importantly different in kind? Despite the attractions of the former view, Kelly (2003) argues quite compellingly that epistemic rationality cannot be merely a matter of taking effective means to one’s epistemic ends. I argue here that Kelly’s objections can be sidestepped if we understand epistemic reasons as instrumental reasons that arise in light of the aims held (...) by social collectives of which we are members, rather than being fixed by our own individual goals. This social version of epistemic instrumentalism would not be subject to counterexamples that point to the failure of individual people to possess desires or goals that would account for all of the epistemic reasons we find it natural to attribute to them. I conclude by comparing the proposed view to the alternative version of instrumentalism defended by Kornblith (1993). I argue that the social view I sketch here has one noteworthy advantage. It better accounts for the intuitive distinctness of our practical and epistemic reasons for belief in cases where flouting epistemic norms would better help us to achieve our own individual goals. (shrink)