We reply to the Ioannidis's paper "Effectiveness of antidepressants; an evidence based myth constructed from a thousand controlled trials." We disagree that antidepressants have no greater efficacy than placebo. We present the efficacy from hundreds of trials in terms of the percentage of patients with a substantial clinical response (a 50% improvement or more symptomatic reduction). This meta-analysis finds that 42-70% of depressed patients improve with drug and 21%-39% improve with placebo. The response benefit of antidepressant treatment is 33%-11% greater (...) than placebo. Ioannidis argues that it would be vanishingly smaller because systematic biasing in these clinical trials would reduce the drug-placebo difference to zero. Ioannidis' argument that antidepressants have no benefit is eroded by his failures of logic because he does not present any evidence that there are a large number of studies where placebo is substantially more effective than drug. (To reduce to zero, one would also have to show that some of the unpublished studies find placebo better than drug and have substantial systematic or methodological bias). We also present the empirical evidence showing that these methodological concerns generally have the opposite effect of what Ioannidis argues, supporting our contention that the measured efficacy of antidepressants likely underestimates true efficacy.Our most important criticism is Ioannidis’ basic underlying argument about antidepressants that if the existing evidence is imperfect and methods can be criticized, then this proves that antidepressant are not efficacious. He presents no credible evidence that antidepressants have zero effect size. Valid arguments can point out difficulties with the data but do not prove that a given drug had no efficacy. Indeed better evidence might prove it was more efficacious that originally found.We find no empirical or ethical reason why psychiatrists should not try to help depressed patients with drugs and/or with psychotherapeutic/behavioral treatments given evidence of efficacy even though our treatment knowledge has limitations. The immense suffering of patients with major depression leads to ethical, moral, professional and legal obligations to treat patients with the best available tools at our disposal, while diligently and actively monitoring for adverse effects and actively revising treatment components as necessary. (shrink)

I argue that difference-making should be a crucial element for evaluating the quality of evidence for mechanisms, especially with respect to the robustness of mechanisms, and that it should take central stage when it comes to the general role played by mechanisms in establishing causal claims in medicine. The difference- making of mechanisms should provide additional compelling reasons to accept the gist of Russo-Williamson thesis and include mechanisms in the protocols for Evidence- Based Medicine (EBM), as the EBM+ research group (...) has been advocating. (shrink)

In this paper I offer an anti-Humean critique to Williamson and Russo’s approach to medical mechanisms. I focus on one of the specific claims made by Williamson and Russo, namely the claim that micro-structural ‘mechanisms’ provide evidence for the stability across populations of causal relationships ascertained at the (macro-) level of (test) populations. This claim is grounded in the epistemic account of causality developed by Williamson, an account which—while not relying exclusively on mechanistic evidence for justifying causal judgements—appeals nevertheless to (...) mechanisms, and rejects their anti-Humean interpretation in terms of capacities, powers, potencies, etc. By using (and expanding on) Cartwright’s basic critique against Humean mechanisms, I suggest that, in order to move beyond the level of plausibility, Williamson and Russo’s position is in need of a clarification as to the occurent reading of the components, functioning and interferences of mechanisms. Relatedly, as concerns Williamson’s epistemic account of causation, I argue that this account is in need of a more straightforward answer as to what truth-makers its causal claims should have. (shrink)

Volume 19, Issue 10, October 2019, Page 90-92.

Research on patients with damage to ventromedial frontal cortices suggests a key role for emotions in practical decision making. This field of investigation is often associated with Antonio Damasio’s Somatic Marker Hypothesis—a putative account of the mechanism through which autonomic tags guide decision making in typical individuals. Here we discuss two questionable assumptions—or ‘myths’—surrounding the direction and interpretation of this research. First, it is often assumed that there is a single somatic marker hypothesis. As others have noted, however, Damasio’s ‘hypothesis’ (...) admits of multiple interpretations (Dunn et al. [2006]; Colombetti [2008]). Our analysis builds upon this point by characterizing decision making as a multi-stage process and identifying the various potential roles for somatic markers. The second myth is that the available evidence suggests a role for somatic markers in the core stages of decision making, that is, during the generation, deliberation, or evaluation of candidate options. On the contrary, we suggest that somatic markers most likely have a peripheral role, in the recognition of decision points, or in the motivation of action. This conclusion is based on an examination of the past twenty-five years of research conducted by Damasio and colleagues, focusing in particular on some early experiments that have been largely neglected by the critical literature. 1 Introduction2 What is the Somatic Marker Model?3 Multiple Somatic Marker Hypotheses3.1 Are somatic markers necessary for practical decision making?3.2 Speed, accuracy, or both?3.3 At which of the five stages of decision making are somatic markers engaged?4 Anecdotal Evidence Suggests a Peripheral Role for Somatic Markers4.1 Chronic indecisiveness4.2 Extreme impulsiveness4.3 Enhanced decision making in the lab4.4 Lack of motivation. 5 Early Experiments Suggest that VMF Damage Leaves Core Processes Intact5.1 The evocative images study5.2 Five problem solving tasks6 Recent Experiments Fail to Discriminate among Alternate Versions of SMH7 Conclusion. (shrink)

I am focusing here on the main counterarguments that were raised against a thesis I put forward in my article “Nietzsche, the Overhuman, and Transhumanism” (2009), namely that significant similarities can be found on a fundamental level between the concept of the posthuman, as put forward by some transhumanists, and Nietzsche’s concept of the overhuman. The articles with the counterarguments were published in the recent “Nietzsche and European Posthumanisms” issue of The Journal of Evolution and Technology (January-July 2010). As several (...) commentators referred to identical issues, I decided that it would be appropriate not to respond to each of the articles individually, but to focus on the central arguments and to deal with the counterarguments mentioned in the various replies. I am concerned with each topic in a separate section. The sections are entitled as follows: 1. Technology and evolution; 2. Overcoming nihilism; 3. Politics and liberalism; 4. Utilitarianism or virtue ethics?; 5. The good Life; 6. Creativity and the will to power; 7. Immortality and longevity; 8. Logocentrism; 9. The Third Reich. When dealing with the various topics, I am not merely responding to counterarguments; I also raise questions concerning transhumanism and put forward my own views concerning some of the questions I am dealing with. (shrink)

On the basis of an earlier contribution to the philosophy of computer science by Amnon Eden, this essay discusses to what extent Eden’s ‘paradigms’ of computer science can be transferred or applied to software engineering. This discussion implies an analysis of how software engineering and computer science are related to each other. The essay concludes that software engineering can neither be fully subsumed by computer science, nor vice versa. Consequently, also the philosophies of computer science and software engineering—though related to (...) each other—are not identical branches of a general philosophy of science. This also implies that not all of Eden’s earlier arguments can be directly mapped from the domain of computer science into the domain of software science. After the discussion of this main topic, the essay also points to some further problems and open issues for future studies in the philosophy of software science and engineering. (shrink)

Let us by ‘first-order beliefs’ mean beliefs about the world, such as the belief that it will rain tomorrow, and by ‘second-order beliefs’ let us mean beliefs about the reliability of first-order, belief-forming processes. In formal epistemology, coherence has been studied, with much ingenuity and precision, for sets of first-order beliefs. However, to the best of our knowledge, sets including second-order beliefs have not yet received serious attention in that literature. In informal epistemology, by contrast, sets of the latter kind (...) play an important role in some respectable coherence theories of knowledge and justification. In this paper, we extend the formal treatment of coherence to second-order beliefs. Our main conclusion is that while extending the framework to second-order beliefs sheds doubt on the generality of the notorious impossibility results for coherentism, another problem crops up that might be no less damaging to the coherentist project: facts of coherence turn out to be epistemically accessible only to agents who have a good deal of insight into matters external to their own belief states. (shrink)

In this paper, I examine the question of the scope of justice, in a not unusual distributive, egalitarian, and universalistic framework. Part I outlines some central features of the egalitarian theory of justice I am proposing. According to such a conception, justice is – at least prima facie – immediately universal, and therefore global. It does not morally recognize any judicial boundaries or limits. Part II examines whether, even from a universalistic perspective, there are moral or pragmatic grounds for rejecting (...) or limiting the global scope of justice. In particular, I scrutinize five universalistic objections: (1) the principle of “moral division of labor”; (2) the connection between cooperation and distributive justice; (3) the primacy of democracy; (4) the dangers of a world state; and (5) political‐pragmatic reasons. I intend to show that these objections cannot undermine the strong normative claims of global justice. At the most, political‐pragmatic reasons speak in favor of initially striving for somewhat less, in order to receive more general backing. (shrink)

Topic of the paper is Q-logic – a logic of agency in its temporal and modal context. Q-logic may be considered as a basal logic of agency since the most important stit-operators discussed in the literature can be defined or axiomatized easily within its semantical and syntactical framework. Its basic agent dependent operator, the Q-operator (also known as Δ- or cstit-operator), which has been discussed independently by F. v. Kutschera and B. F. Chellas, is investigated here in respect of its (...) relation to other temporal and modal operators. The main result of the paper, then, is a completeness result for a calculus of Q-logic with respect to a semantics defined on the tree-approach to agency as introduced and developed by, among others, F. v. Kutschera and N. D. Belnap. (shrink)

This systematic review identified and evaluated instruments measuring patients' perceptions of patient‐centred nursing care. Of 2629 studies reviewed, 12 were eligible for inclusion. Four instruments were reported: The Individualized Care Scale, the Client‐Centred Care Questionnaire, the Oncology patients' Perceptions of the Quality of Nursing Care Scale and the Smoliner scale. These instruments cover themes addressing patient participation and the clinician–patient relationship. Instruments were shown to have satisfactory psychometric properties, although not all were adequately assessed. More research is needed regarding test–retest (...) reliability, convergent and discriminant validity, validity with known groups and structural validity using confirmatory factor analysis. (shrink)

The article aims to put on the table the ongoing works of the United Nations Organization and others like World Trade Organization being focused in their current and future challenges to build an effective and useful Multilateral Trading System. Apart from achievements and reforms undertaken, further ones - based on another approach: considering the diversity principle - are proposed in order to reach equitable and fair trading negotiations outcomes in benefits of all members.

For 50 years, Star Trek has been an inspiration to its fans around the world, helping them to dream of a better future. This inspiration has entered our culture and helped to shape much of the technology of the early 21st Century. The contributors to this volume are researchers and teachers in a wide variety of disciplines; from Astrophysics to Ethnology, from English and History to Medicine and Video Games, and from American Studies to the study of Collective Computing Systems. (...) What the authors have in common is that some version of Star Trek has inspired them, not only in their dreams of what may be, but in the ways in which they work - and teach others to work - here in the real world. Introduced with references to Star Trek films and television shows, and illustrated with original cartoons, each of the 15 chapters included in this volume provides insights into research and teaching in this range of academic fields. (shrink)

Is there any good reason to believe in Nietzsche's metaphysics even thought he himself claims that it is not "the truth" in correspondence with the world? According to Danto, Nietzsche's metaphysics is only valid for Nietzsche himself. However, this answer does not take into consideration Nietzsche's claim for the general superiority of his philosophy. Nietzsche's view seems inconsistent: on the one hand, he claimed all perspectives are equally false in respect to "the truth," but on the other, he regarded his (...) view as superior. This book explains in which respect Nietzshe justifies his claims, that Nietzsche's position is not inconsistent, and why consistency is important for him. (shrink)

This article discusses the influence that Schopenhauer’s thought had on Mihai Eminescu’s work with reference to the idea of “pessimism.” It also considers Schopenhauer’s influence on Romanian philosophy and literature at the end of the nineteenth century. We shall examine Eminescu’s alleged “Schopenhauerian pessimism,” considering firstly “pessimism” as a part of Eminescu’s “myth.” Secondly, we shall cover the critical reception of Eminescu’s “Schopenhauerian pessimism,” discussing the existing literary and philosophical scholarship. Finding that there are issues for debate regarding Schopenhauer’s alleged (...) influence upon Eminescu, we argue that Eminescu’s “Schopenhauerian pessimism” may be a “legend.” The article examines the connection between Eminescu and one of Schopenhauer’s most influential followers, Eduard von Hartmann. (shrink)

The thesis that the probability of a conditional`if A, C' is the corresponding conditional probability of C, given A, enjoys wide currency among philosophers and growing empirical support in psychology. In this paper I ask how a probabilisitic account of conditionals along these lines could be extended to unconditional sentences, i.e., conditionals with interrogative antecedents. Such sentences are typically interpreted as equivalent to conjunctions of conditionals. This raises a number of challenges for a probabilistic account, chief among them the question (...) of what the probability of a conjunction of conditionals should be. I offer an analysis which addresses these issues by extending the interpretation of conditionals in Bernoulli models to the case of unconditionals. (shrink)

In my paper, I comment on Rainer Forst's paper in this issue. I raise doubts as to whether the justification of democracy emerges from a fundamental moral right to reciprocal and general justification, as Forst claims. His basic argument appears questionable because democracy is different from a “hypothetical‐consent‐conception” of moral legitimacy, which limits as well as enables democratic legitimacy. The former cannot, however, justify the latter through an argument centered on self‐government: Such an argument relies heavily on the possibility of (...) consensus, thus neglecting the crucial phenomenon of disagreement or dissent. As a result of not adequately dealing with this phenomenon, the argument is unable to account for the basic democratic principle of majority rule as the remedy at hand. (shrink)

This is the first volume of essays on Berkeley's Three Dialogues, a classic of early modern philosophy. Leading experts cover all the central issues in the text: the rejection of material substance, the nature of perception and reality, the limits of human knowledge, and the perceived threats of skepticism, atheism, and immorality.

This book argues that there is a complex logical and epistemological interplay between the concepts of metaphor, narrative, and emotions. They share a number of important similarities and connections. In the first place, all three are constituted by aspect-seeing, the seeing-as or perception of Gestalts. Secondly, all three are meaning-endowing devices, helping us to furnish our world with meaning. Thirdly, the threesome constitutes a trinity. Emotions have both a narrative and metaphoric structure, and we can analyse the concepts of metaphors (...) and narratives partly in each other's terms. Further, the concept of narratives can partly be analysed in the terms of emotions. And if emotions have both a narrative structure and a metaphoric one, then the concept of emotions must to some extent be analysable through the concepts of narratives and metaphors. But there is more. Metaphors (especially poetic ones) are important tools for the understanding of the tacit sides of emotions, perhaps because of the metaphoric structure of emotions. The notion that narrations can be tools for understanding emotions follows from two facts: narrations are devices for explanation and emotions have a narrative structure. Fourthly, the threesome has an impact on our rationality. It has become commonplace to say that emotions have a cognitive content, that narratives have an explanatory function, and that metaphors can perform cognitive functions. This book is the first attempt to articulate the implications that these new ways of seeing the three concepts entail for our concept of reason. The cognitive roles of the threesome suggest a richer notion of rationality than has traditionally been held, a rationality enlivened with metaphoric, narrative, and emotive qualities. Stefan Snaevarr (Reykjavik, 1953) studied philosophy and related subjects in Norway and Germany. Professor at Lillehammer University College in Norway, he is the author of several books of various kind in English, Norwegian and Icelandic. (shrink)

This chapter presents a survey of the most important features of the formal semantic analysis of modality and mood. It first focuses on modality as exemplified by the modal verbs, presenting the main concepts and introducing the most common basic formal apparatus used in its analysis, and surveying some of the issues that are currently central in the field. The chapter then turns to the treatment of mood, discussing formal semantic treatments of both “sentential mood” and “verbal mood”. The last (...) part of the chapter addresses the issue of modal subordination. The chapter aims to give a sense of the major phenomena and theoretical approaches, as well as introduce the primary literature. (shrink)

Ziel dieses Aufsatzes ist es, Robert Brandoms Begriff des Explizit-Machens explizit zu machen. Zu diesem Zweck werden zunächst verschiedene Formen des Explizit-Machens unterschieden. Dabei erweist sich allein der Begriff des logischen Explizit-Machens als haltbar. Anschließend wird gezeigt, dass diesem Begriff eine Schlüsselstellung im Rahmen von Brandoms Philosophie zukommt. Sowohl seine philosophische Methodologie als auch sein zentrales philosophisches Projekt einer Zurückführung von Semantik auf Pragmatik lassen sich höchstens soweit verständlich machen wie der Begriff des logischen Explizit-Machens. Dieser weist allerdings ein erhebliches (...) Defizit auf: Im Rahmen einer Inferentialistischen Semantik lässt sich die expressive Funktion wichtiger Teile des logischen Vokabulars nicht verständlich machen. Das Ergebnis ist, dass sich zwei der Grundpfeiler von Brandoms Sprachphilosophie, die Inferentialistische Semantik einerseits und deren Zurückführung auf eine normative Pragmatik andererseits, nicht gleichzeitig konsequent durchhalten lassen. (shrink)

We study satisfiability and infinite-state model checking in ICPDL, which extends Propositional Dynamic Logic (PDL) with intersection and converse operators on programs. The two main results of this paper are that (i) satisfiability is in 2EXPTIME, thus 2EXPTIME-complete by an existing lower bound, and (ii) infinite-state model checking of basic process algebras and pushdown systems is also 2EXPTIME-complete. Both upper bounds are obtained by polynomial time computable reductions to ω-regular tree satisfiability in ICPDL, a reasoning problem that we introduce specifically (...) for this purpose. This problem is then reduced to the emptiness problem for alternating two-way automata on infinite trees. Our approach to (i) also provides a shorter and more elegant proof of Danecki's difficult result that satisfiability in IPDL is in 2EXPTIME. We prove the lower bound(s) for infinite-state model checking using an encoding of alternating Turing machines. (shrink)

This paper examines how competition and competitive strategy influence companies’ propensity to engage in socially and environmentally responsible procurement processes (SERP). We interview 141 British procurement managers, on their perception of their company’s competitive strategy and the competitive environment in which they operating in. In addition, participants were asked how important responsible procurement was for their overall business and their strategy.Our results suggest that companies that produce a differentiated product engage in relatively proactive SERP process, compared to their counterparties, who (...) aimed to produce a product at the lowest price possible. (shrink)

“Narrativity and the Symbolic Vacuum” examines the descriptive and the prescriptive narrativity claim in the context of a claim that there are narratives in the biblical literature that resist both. The descriptive narrativity claim maintains that it is not an option for a person to conceive of their life without narrative coherence. The prescriptive claim holds that narrativity is a necessary condition for a good and successful human life. Phenomenological thought and Aristotelian virtue ethics, expressing a critical stance towards modernity (...) (modernity with its desire for objective, narrative-free criteria for truth), encourage narrativity claims. Biblical theology, despite its pervasive use of narrative strategies, offers a space in which narrativity claims are relativized. It is especially in confrontation with death where human life cannot be narratively managed. That is why it is in particular the cross in the New Testament which defies both descriptive and prescriptive narrativity claims. (shrink)

The remarks which follow deal with the ideas which I developed in more detail in my book: between Experience and Metaphysics. They are inspired principally by the vigorous polemic aroused by the publication several years ago of a work which caused a great uproar in epistemological circles; I am speaking of The Structure of Scientific Revolution by T.S. Kuhn. One could thus consider this essay, as well as my book, as an element to be added to that polemic's dossier. It (...) goes without saying that I am indebted to a great number of those who before me have given their points of view on the question, whether I agree with their opinions or not. (shrink)

We elucidate the conditions under which any hypothesis is explanatorily relevant by analyzing several tests of explanatory relevance and explanations based on those tests. A new causal criterion of explanatory relevance is developed and defended. We show how the causal criterion succeeds in establishing, at the very least, a very strong presumption against moral facts.

The author suggests that a synchronic reading of Bonhoeffer's major works yields a typology of the two main images around which Bonhoeffer's political ethics orbit: disciple and citizen. Concentrating on the latter, the author shows the centrality of the question of power for Bonhoeffer's political ethics, and how it relates to responsibility and vocation. He argues that Bonhoeffer's ethics follows a christological grammar which constitutes its specific realism and provides its focus on institutions and good works. The essay concludes that (...) the call to citizenship, the vocation of co-operative, representative and vicarious action, forms the central idea of Bonhoeffer's political ethics, which is still highly relevant for political ethics today. (shrink)

Legal scholars, privacy advocates and major tech corporations all coalesce around one single idea. Data should be considered property. Legal analysts point to the ability of governments to regulate property, privacy advocates argue that personal rights would be better protected through a property model, and large tech companies want to claim ownership over data as a proprietary trade secret. I argue that the tendency to view data as property is a result of the long legacy of enlightenment philosophy surrounding property. (...) In particular, John Locke has a special hold on the public imaginary, and his twin concepts of self-ownership and the labor theory of accumulation lead us to conceptualize data as a special form of property. However, the property model of data has significant drawbacks. By commodifying data, we commodify ourselves and allow for colonial theories of enclosure to dominate the discourse. Instead, I propose an alternative framing of data, drawn from the work of Judith Butler, whose ideas allow us to see data as an extension of the performance of identity. Drawing on both Gender Trouble and Bodies that Matter I argue that viewing data as part of the performance of identity allows us to mitigate the harms of a property model and reconsider our relationship with our data. (shrink)

Visual neglect has been associated with an imbalance in the level of activity in the saccadic system: activity in the contralesional field is suppressed, which makes target selection unlikely. We recorded eye movements of a patient with hemispatial neglect and a group of healthy participants during an oculomotor distractor paradigm. Results showed that the interfering effects of a distractor were very strong when presented in her ipsilesional visual field. However, when the distractor was presented in her contralesional field, there were (...) no interfering effects when the target was presented in her ipsilesional field. These findings could not be explained by the presence of a visual field defect as revealed by the results of two hemianopic patients. Our results are in line with an imbalance in the level of activity in the saccadic system in visual neglect because visual elements presented in the contralesional field did not compete for saccadic selection. (shrink)

In ?155 of his New Theory of Vision Berkeley explains that a hypothetical ?unbodied spirit? ?cannot comprehend the manner wherein geometers describe a right line or circle?.1The reason for this, Berkeley continues, is that ?the rule and compass with their use being things of which it is impossible he should have any notion.? This reference to geometrical tools has led virtually all commentators to conclude that at least one reason why the unbodied spirit cannot have knowledge of plane geometry is (...) because it cannot manipulate a ruler or a compass. In this article I will show that such an interpretation is flawed. I will instead argue that Berkeley's understanding of Euclidian geometry was based on Isaac Barrow's account of the foundations of geometry. On this view geometrical objects are conceived in terms of the idealized motion that generates the objects of geometry. Consequently, that what the unbodied spirit cannot do in this context is to form an idea of motion rather than being unable to handle geometrical tools. 1All references to Berkeley are from, A. A. Luce and T. E. Jessop (eds.), The Works of George Berkeley, Bishop of Cloyne (London: Thomas Nelson and Sons, Ltd., 1948) The following abbreviations are used: An Essay Towards A New Theory of Vision, section x = New Theory x; Philosophical Commentaries, entry x = Commentaries x; Part I of A Treatise concerning the Principles of Knowledge, section x = Principles x. All other references to Berkeley's works are of the form The Works of George Berkeley, Bishop of Cloyne, volume x, page y = Works, x, y. (shrink)

I question here the differentiation of kinds as substantive universals in Lowe and Ellis’ metaphysics, by taking up, for the argument’s sake, two extreme approaches on kind differentiation and kind change, a Heraclitan and a Spinozan approach. I show that, as things currently stand, Heraclitanism or Spinozism about kinds is consistent with the broad tenets of Lowe and Ellis’ metaphysics of kinds.

Die Fähigkeiten, nachzudenken und sich denkend auf Wirkliches zu beziehen, werden in der heutigen Philosophie des Geistes unter dem Begriff "Intentionalität" zusammengefasst. Wie können diese Fähigkeiten im Rahmen unseres naturwissenschaftlich geprägten Weltbildes erklärt werden? Stefan Kappner beantwortet diese Frage, indem er auf die Zeichentheorie von Charles Sanders Peirce zurückgreift.

In this article I attempt to find out the appropriate understanding of “liberal education”. Firstly, I distinguish the two most important meanings of the notion “freedom” which I call momentary and lifelong freedom. Momentary freedom is a type of negative freedom, and lifelong freedom a type of positive freedom. Secondly, I show the consequences, which these two meanings of “freedom” have on the practice of a “liberal education”. Finally, I analyse which type of liberal education is the best.