The focus of this study was to analyze the content, distribution, and comparative genome relationships of 996 chromosome bin-mapped expressed sequence tags accounting for 2266 restriction fragments on the homoeologous group 3 chromosomes of hexaploid wheat. Of these loci, 634, 884, and 748 were mapped on chromosomes 3A, 3B, and 3D, respectively. The individual chromosome bin maps revealed bins with a high density of mapped ESTs in the distal region and bins of low density in the proximal region of the (...) chromosome arms, with the exception of 3DS and 3DL. These distributions were more localized on the higher-resolution group 3 consensus map with intermediate regions of high-mapped-EST density on both chromosome arms. Gene ontology classification of mapped ESTs was not significantly different for homoeologous group 3 chromosomes compared to the other groups. A combined analysis of the individual bin maps using 537 of the mapped ESTs revealed rearrangements between the group 3 chromosomes. Approximately 232 of the consensus mapped ESTs matched sequences on rice chromosome 1 and revealed large- and small-scale differences in gene order. Of the group 3 mapped EST unigenes ∼21 and 32% matched the Arabidopsis coding regions and proteins, respectively, but no chromosome-level gene order conservation was detected. (shrink)

This report describes the rationale, approaches, organization, and resource development leading to a large-scale deletion bin map of the hexaploid wheat genome. Accompanying reports in this issue detail results from chromosome bin-mapping of expressed sequence tags representing genes onto the seven homoeologous chromosome groups and a global analysis of the entire mapped wheat EST data set. Among the resources developed were the first extensive public wheat EST collection. Described are protocols for sequencing, sequence processing, EST nomenclature, and the assembly of (...) ESTs into contigs. These contigs plus singletons were used for selection of distinct sequence motif unigenes. Selected ESTs were rearrayed, validated by 5′ and 3′ sequencing, and amplified for probing a series of wheat aneuploid and deletion stocks. Images and data for all Southern hybridizations were deposited in databases and were used by the coordinators for each of the seven homoeologous chromosome groups to validate the mapping results. Results from this project have established the foundation for future developments in wheat genomics. (shrink)

The history of comparative psychology is replete with proclamations of human uniqueness. Locke and Morgan denied animals relational thought; Darwin opened the door to that possibility. Penn et al. may be too quick to dismiss the cognitive competences of animals. The developmental precursors to relational thought in humans are not yet known; providing animals those prerequisite experiences may promote more advanced relational thought.

This was abstracted from a lengthier article titled "A Genuine Monotheism for Christians, Muslims, Jews, and All" originally published in the JOURNAL OF ECUMENICAL STUDIES, 52:575-586. Thanks to Paul Chase at Penn Press Journals for permission to use it here. This article proposes an understanding of the identity of God and Jesus that might be attractive and even plausible to persons of all monotheistic faiths. The basic thesis is that Jesus (as both "fully God and fully human") is best (...) understood to mean that Jesus fully identified with God experientially, psychologically, evaluationally, morally, and spiritually; and God fully identified with Jesus in similar ways. Read the article to get the full explanation of this. Might the founders and saints of non-Christian religions also have also thus identified with God, and God with them? (shrink)

Delves into the complexity of Paine's character as well as his efforts on behalf of popular causes in America, France, and England.

Dr Edwards' stimulating and provocative book advances the thesis that the appropriate axiomatic basis for inductive inference is not that of probability, with its addition axiom, but rather likelihood - the concept introduced by Fisher as a measure of relative support amongst different hypotheses. Starting from the simplest considerations and assuming no more than a modest acquaintance with probability theory, the author sets out to reconstruct nothing less than a consistent theory of statistical inference in science.

The practice of prenatal screening for disability is sometimes objected to because of the hurt and offence such practices may cause to people currently living with disabilities. This objection is commonly termed “the expressivist objection”. In response to the objection it is standardly claimed that disabilities are analogous to illnesses. And just as it would be implausible to suppose reduction of the incidence of illnesses such as flu sends a negative message to ill people, so it is not plausible to (...) suppose prevention of disability sends a negative message to disabled people. The expressivist objection hinges, however, upon a view of the relationship between disability and self identity which sees disability as part of the identity of the disabled person, in a way in which illnesses such as flu cannot be. This possibility is generally not considered in critiques of the expressivist objection. In this paper, an “identity claim” to the effect that disabilities can be identity constituting is accepted and the force of the expressivist argument is reconsidered in the light of its acceptance. It is concluded that even when such an identity claim is accepted, the expressivist objection is still not morally compelling. (shrink)

An almost unbelievable amount of false philosophy has arisen through not realizing what ‘existence’ means…. [It] rests upon the notion that existence is, so to speak, a property that you can attribute to things, and that the things that exist have the property of existence and the things that do not exist do not. That is rubbish . I have dared to puncture several metaphysical balloons and nothing came out of them but hot air.

Discursive psychology approaches discourse not as the product or expression of thoughts or mental states lying behind or beneath it, but as a domain of public accountability in which psychological states are made relevant. DP draws heavily on conversation analysis in examining in close empirical detail how ostensibly psychological themes are handled and managed as part of talk’s everyday interactional business. A brief worked example is offered, in which the intentionality of a person’s actions is handled in the course of (...) police interrogation, in ways that perform police work. Degrees of intentionality are partialled out with regard to specific actions or components of actions, and with regard to how actions are described in ways that map onto how crime categories are defined in law. Cognitive states are generally relevant in discourse in the same manner, as participants’ concerns with regard to action categories and accountability on and for the occasions they are invoked. (shrink)

Alethic pluralism, on one version of the view , is the idea that truth is to be identified with different properties in different domains of discourse. 1 Whilst we operate with a univocal concept of truth, and a uniform truth predicate, the thought is that the truth property changes from one domain to the next. So the truth property for talk about the nature and state of the material world may be different from the truth property for moral discourse .Tappolet (...) challenged alethic pluralism by asking how it can account for the truth of mixed compounds, such as a mixed conjunction like ‘this cat is wet and funny’, where each of the conjuncts are from different domains of discourse, and thus assessable in terms of different truth properties. She argues that the alethic pluralist is left in a dilemma: either admit of a ‘generic’ truth property, which can be possessed by propositions from all domains, thus rendering the plural ways of being true obsolete, or deny the truth of mixed conjunctions.In Edwards 2008, I argued that there is route out of Tappolet's dilemma. Briefly, I suggested that we acknowledge that the truth of a mixed conjunction is dependent on the truth of its conjuncts, and we should explain the truth of the conjunction by saying that it is true just in case each of its conjuncts is true. This, I argued, gives us an account of the truth of the conjunction without needing to appeal to a troublesome ‘generic’ truth property.Aaron Cotnoir criticizes my solution to Tappolet's problem. Cotnoir argues that my solution to the problem admits of an unacceptable ‘proliferation’ of truth properties, and smuggles in a generic truth property. I …. (shrink)

We examine the asking and answering of `silly questions' in British police interviews with suspects, the courses of action SQs initiate, and the institutional contingencies they are designed to manage. We show how SQs are asked at an important juncture toward the ends of interviews, following police officers' formulations of suspects' testimony. These formulations are confirmed or even collaboratively produced by suspects. We then examine the design of SQs and show how they play a central role in the articulation of (...) suspects' reported `state of mind', and particularly attributing to them criminal intentions constitutive of the offence with which they may be charged. In cases where SQs do not produce unambiguous answers about `state of mind' or intentionality, police officers move toward direct questioning about suspects' intent, thus making explicit the project of SQs in such interviews. Following SQ—Answer sequences, police officers reformulate suspects' testimony, with subtle but crucial differences with regard to suspects' knowledge state and criminal intent. Suspects overwhelmingly align with police officers' formulations of their testimony, and such agreements have the interactional shape of affiliation. Yet SQs may work in ways that are institutionally adversarial with regard to criminal charges, relevant evidence and self-incriminating testimony. (shrink)

Using an ethnographic case study based in a UK state school for 11- to 18-year-olds, this paper explores the tensions that arose when the senior leadership team (SLT) introduced a justice-based ethic-of-care that prioritized good grades and equal treatment for all pupils over a feminist ethic-of-care (preferred by most teachers in non-leadership roles) that accentuated individual pupil need and placed greater emphasis on a broader social education. Through highlighting the tensions between a feminist ethic-of-care and a more ‘masculine’ style, justice-based (...) approach to care-ethics, the paper extends the organisational care-ethics literature. We emphasise that such tensions occurred whether the different ethics were enacted by men, women, or non-binary individuals. In order to better understand the tensions between these two ethical approaches, we draw upon the theoretical work of Donald Winnicott, which highlights the importance both of maternal and paternal roles during infancy. We update Winnicott’s ideas, noting how maternal and paternal caring roles can be undertaken by people of varied gender identities. Building on Winnicott’s theory, we propose a new ‘Parentalist’ ethic-of-care, which has the potential to balance and hold together ideas of both a feminist ethic-of-care, and a justice-based ethic. A Parentalist ethic-of-care could support teachers yet recognize the context of the contemporary neo-liberal environment, where most children need to attain formal qualifications in a marketized world, and where such measures of success are highly valued. (shrink)

What is truth? What role does truth play in the connections between language and the world? What is the relationship between truth and being? Douglas Edwards tackles these questions and develops a distinctive metaphysical worldview. He argues that in some domains language responds to the world, whereas in others language generates the world.

Modern bioethics is clearly dominated by deontologists who believe that we have some way of identifying morally correct and incorrect acts or rules besides taking account of their consequences. Robert M. Veatch is one of the most outspoken of those numerous modern medical ethicists who agree in rejecting all forms of teleological, utilitarian, or consequentialist ethical theories. This paper examines his critique of utilitarianism and shows that the utilitarianism of John Stuart Mill is either not touched at all by his (...) critique or can be defended against it. This article argues that the dominant deontological majority is mistaken and that a utilitarian theory of moral action very much like Mill’s is precisely what is needed by modern medical ethics and by those medical practitioners who are resolved to practice medicine in a reasonable and morally acceptable manner. (shrink)

This article argues that process philosophy and Hartmanian formal axiology are natural allies that can contribute much to each other. Hartmanian axiology can bring much needed order and clarity to process thought about the definitions of “good,” “better,” and “best,” about what things are intrinsically good, and about the nature and value of unique, enduring, individual persons. Process thought can bring to axiology greater clarity about and emphasis on the relational and temporal features of human selfhood. The nature and significance (...) of personal endurance is emphasized throughout. (shrink)

Karl Marx (1818-1883) was trained as a philosopher and steeped in the thought of Hegel and German idealism, but turned away from philosophy in his mid-twenties towards politics, economics and history. It is for his these subjects Marx is best known and in which his work and ideas shaped the very nature of the nineteenth and twentieth centuries. However, Marx's engagement with philosophy runs through most of his work, especially in his philosophy of history and in moral and political philosophy. (...) In this outstanding introduction to Marx's philosophy Jaime Edwards and Brian Leiter begin with an overview of Marx's life and intellectual development, before examining and assessing the following important topics: Marx's theory of history: Hegel, dialectics, teleology, materialism functionalism and the causal explanation of historical change economics, history and the transition from communism to capitalism ideology, morality and religion human nature, alienation and the good life for human beings Marx's legacy and influence, including Western Marxism and the Frankfurt School. The addition of chapter summaries, annotated further reading and a glossary of technical terms make this an indispensable introduction to Marx's philosophy. It will also be useful to those in related disciplines such as politics, sociology, history and economics. (shrink)

The Metaphysics of Experience: Companion to Whitehead’s Process and Reality by Elizabeth M. Kraus develops very classical, Boethian, atemporal understanding of Whitehead’s God. Kraus contends that Whitehead intended “to infer that the divine actual world includes all actual worlds in unison of becoming” (p. 164). Her position is that even in his consequent nature, God coexists simultaneously and changelessly with the entire past, present, and future of every occasion in every world or cosmic epoch. Her rationale for this rests upon (...) 1. a highly questionable interpretation of one text in Process and Reality and the claims that 2. only such a view is compatible with human freedom, and 3. only such a view is compatible with human faith. This article argues that she is mistaken on all three counts. (shrink)

We examine the British newspapers' coverage of the death of Princess Diana and its immediate aftermath. Our main focus is on how the press dealt with the issue of their own potential culpability, as a feature of news reporting itself. The press deployed a series of descriptive categories and rhetorical oppositions, including regular press vs paparazzi; tabloid vs broadsheet; British vs foreign; supply vs demand ; and a number of general purpose devices such as a contrast between emotional reactions and (...) considered judgments. The study has two major aims: to analyse the textual workings of the press, as a medium of factual reportage operating within a range of normative requirements for factual objectivity, public concern, responsible journalism, meeting readers' demands, etc.; and to contribute to a generally applicable discourse analytic approach to how factual reports are assembled, used, and undermined, in an interplay of description and accountability. (shrink)

This article argues for the formal validity of and the truth of the premises and conclusion of a version of Aquinas' "Third Way" that says: If each of the parts of nature is contingent, the whole of nature is contingent. Each of the parts of nature is contingent. Therefore, the whole of nature is contingent--where "contingent" means having a cause and not existing self-sufficiently.

In the years 2020–2021, journalists, lawyers, scholars, and civil society actors noticed an unusual spike in the refusal of francophone African immigrants in Québec, Canada. While Immigration, refugee and citizenship Canada’s systemic racism problem were already documented, the novelty appeared to be how standardized and sometimes, “nonsensical” the reasons given to many of the applicants were. This eventually prompted a lawsuit against IRCC in which it was revealed that a new piece of software called “Chinook” had been deployed since 2018, (...) approximately at the same time application refusal started spiking. Online and media-fueled speculations culminated in a broad debate about whether Chinook was an artificial intelligence-based technology. Such controversy, for instance, unfolded during parliamentary consultations in which it was finally disclosed that Chinook was not AI per se., but more of a half-baked automated interface. The present article aims to understand how the performative ambiguity of Chinook informs on the progressive becoming of the Canadian Federal state and its immigration control practices in the current Machine Learning hype. Furthermore, it seeks to understand how the interlacing of public–private partnership, in which the private sector is mobilized to produce AI-driven technology, recursively transforms the exercise of governance and governmentality. We argue, through the Chinook controversy and its unfolding, that there is a shift occurring where AI becomes ever more central in statecraft “anarchitecture” and cybernetic adaptability. (shrink)

This paper aims to show that Sartre’s later work represents a valuable resource for feminist scholarship that remains relatively untapped. It analyses Sartre’s discussions of women’s attitude towards their situation from the 1940s, 1960s, and 1970s, alongside Beauvoir’s account of women’s situation in The Second Sex, to trace the development of Sartre’s thought on the structure of gendered experience. It argues that Sartre transitions from reducing psychological oppression to self-deception in Being and Nothingness to construing women as ‘survivors’ of it (...) in The Family Idiot. Then, it underlines the potential for Sartre’s mature existentialism to contribute to current debates in feminist philosophy by illuminating the role of the imagination in women’s psychological oppression. (shrink)

Released mid-November 2022, Galactica is a set of six large language models (LLMs) of different sizes (from 125 M to 120B parameters) designed by Meta AI to achieve the ultimate ambition of “a single neural network for powering scientific tasks”, according to its accompanying whitepaper. It aims to carry out knowledge-intensive tasks, such as publication summarization, information ordering and protein annotation. However, just a few days after the release, Meta had to pull back the demo due to the strong hallucinatory (...) tendencies or underwhelming performances of the model. This article aims to study, through a critical threefold argument, the potential impacts of LLMs once deployed in the scientific value chain. Our first argument is a technical one. By examining the technicity of Galactica, it is possible to explain the descripancies between its promotional corporate discourse and abysmal outputs. Second, by going back to debates in both computer science and computational philosophy on the automation of abduction, we argue from the epistemological front that LLMs indeed cannot produce strong abductions and, therefore, claims about the automation of hypothesis generation remains chambering. Finally, our third argument is a sociological one. By conceptualizing the scientific field through Nancy Katherine Hayles’ cognitive assemblage theory, we aim to outline the potential steering of science by LLMs, mainly through information ordering. The core of our argument rests on the assertion that excessive control on information risks contravening a certain serendipitous aspect inherent to scientific discoveries. (shrink)

Background: Alexithymia is a personality trait which is characterized by an inability to identify and describe conscious emotions of oneself and others.Aim: The present study aimed to determine whether various measures of mental health, interoception, psychological flexibility, and self-as-context, predicted through linear associations alexithymia as an outcome. This also included relevant mediators and non-linear predictors identified for particular sub-groups of participants through cluster analyses of an Artificial Neural Network output.Methodology: Two hundred and thirty participants completed an online survey which included (...) the following questionnaires: Toronto alexithymia scale; Acceptance and Action Questionnaire 2 ; Positive and Negative Affect Scale, Depression, Anxiety, and Stress Scale 21 ; Multidimensional Assessment of Interoceptive Awareness ; and the Self-as-Context scale. A stepwise backwards linear regression and mediation analysis were performed, as well as a cluster analysis of the non-linear ANN upper hidden layer output.Results: Higher levels of alexithymia were associated with increased psychological inflexibility, lower positive affect scores, and lower interoception for the subscales of “not distracting” and “attention regulation.” SAC mediated the relation between emotional regulation and total alexithymia. The ANNs accounted for more of the variance than the linear regressions, and were able to identify complex and varied patterns within the participant subgroupings.Conclusion: The findings were discussed within the context of developing a SAC processed-based therapeutic model for alexithymia, where it is suggested that alexithymia is a complex and multi-faceted condition, which requires a similarly complex, and process-based approach to accurately diagnose and treat this condition. (shrink)