Responsible Research and Innovation provides a framework for judging the ethical qualities of innovation processes, however guidance for researchers on how to implement such practices is limited. Exploring RRI in the context of nanotechnology, this paper examines how the dispersed and interdisciplinary nature of the nanotechnology field somewhat hampers the abilities of individual researchers to control the innovation process. The ad-hoc nature of the field of nanotechnology, with its fluid boundaries and elusive membership, has thus far failed to establish a (...) strong collective agent, such as a professional organization, through which researchers could collectively steer technological development in light of social and environmental needs. In this case, individual researchers cannot innovate responsibly purely by themselves, but there is also no structural framework to ensure that responsible development of nanotechnologies takes place. We argue that, in such a case, individual researchers have a duty to collectivize. In short, researchers in situations where it is challenging for individual agents to achieve the goals of RRI are compelled to develop organizations to facilitate RRI. In this paper we establish and discuss the criteria under which individual researchers have this duty to collectivize. (shrink)

Volume 19, Issue 9, September 2019, Page 54-56.

The suggested citation for this white paper is: University of Waterloo Working Group on Bibliometrics, Winter 2016. White Paper: Measuring Research Outputs through Bibliometrics, Waterloo, Ontario: University of Waterloo.

BackgroundPeople with upper extremity amputations report receiving insufficient information about treatment options. Furthermore, patients commonly report not knowing what questions to ask providers. A question prompt sheet, or list of questions, can support patient-centered care by empowering patients to ask questions important to them, promoting patient-provider communication, and increasing patient knowledge. This study assessed information needs among people with UE amputations about UE vascularized composite allotransplantation and developed a UE VCA-QPS.MethodsThis multi-site, cross-sectional, mixed-methods study involved in-depth and semi-structured interviews with (...) people with UE amputations to assess information needs and develop a UE VCA-QPS. Qualitative data were analyzed by thematic analysis; quantitative data were analyzed by descriptive statistics. The initial UE VCA-QPS included 130 items across 18 topics.ResultsEighty-nine people with UE amputations participated. Most were male, had a mean age of 46 years, and had a unilateral and below-elbow amputation. Participants desired information about UE VCA eligibility, evaluation process, surgery, risks, rehabilitation, and functional outcomes. After refinement, the final UE VCA-QPS included 35 items, across 9 topics. All items were written at a ≤ 6th grade reading level. Most semi-structured interview participants reported being ‘completely’ or ‘very’ likely to use a UE VCA-QPS.ConclusionPeople with UE amputations have extensive information needs about UE VCA. The UE VCA-QPS aims to address patients’ information needs and foster patient-centered care. Future research should assess whether the UE VCA-QPS facilitates patient-provider discussion and informed decision-making for UE VCA. (shrink)

In <em>Phys. Rev. A</em> <strong>63</strong> 022113 (2001), Brukner and Zeilinger claim that the Shannon information is not well defined as a measure of information in quantum mechanics, adducing arguments that seek to show that it is inextricably tied to classical notions of measurement. It is shown here that these arguments do not succeed: the Shannon information does not have problematic ties to classical concepts. In a further argument, Brukner and Zeilinger compare the Shannon information unfavourably to their (...) preferred information measure, I(p), with regard to the definition of a notion of `total information content'. This argument is found unconvincing and the relationship betwen measures of information and notions of `total information content' investigated. (shrink)

Quantum Information Theory and the Foundations of Quantum Mechanics is a conceptual analysis of one of the most prominent and exciting new areas of physics, providing the first full-length philosophical treatment of quantum information theory and the questions it raises for our understanding of the quantum world. -/- Beginning from a careful, revisionary, analysis of the concepts of information in the everyday and classical information-theory settings, Christopher G. Timpson argues for an ontologically deflationary account of the nature of quantum information. (...) Against what many have supposed, quantum information can be clearly defined (it is not a primitive or vague notion) but it is not part of the material contents of the world. Timpson's account sheds light on the nature of nonlocality and information flow in the presence of entanglement and, in particular, dissolves puzzles surrounding the remarkable process of quantum teleportation. In addition it permits a clear view of what the ontological and methodological lessons provided by quantum information theory are; lessons which bear on the gripping question of what role a concept like information has to play in fundamental physics. Topics discussed include the slogan 'Information is Physical', the prospects for an informational immaterialism (the view that information rather than matter might fundamentally constitute the world), and the status of the Church-Turing hypothesis in light of quantum computation. -/- With a clear grasp of the concept of information in hand, Timpson turns his attention to the pressing question of whether advances in quantum information theory pave the way for the resolution of the traditional conceptual problems of quantum mechanics: the deep problems which loom over measurement, nonlocality and the general nature of quantum ontology. He marks out a number of common pitfalls to be avoided before analysing in detail some concrete proposals, including the radical quantum Bayesian programme of Caves, Fuchs, and Schack. One central moral which is drawn is that, for all the interest that the quantum information-inspired approaches hold, no cheap resolutions to the traditional problems of quantum mechanics are to be had. (shrink)

Brief survey of Charles Taylor's earlier books, followed by an extensive review of Taylor's A Secular Age, published 2007 by the Belknap Press of Harvard University Press.

The Safe-by-Design approach in synthetic biology holds the promise of designing the building blocks of life in an organism guided by the value of safety. This paves a new way for using biotechnologies safely. However, the Safe-by-Design approach moves the bulk of the responsibility for safety to the actors in the research and development phase. Also, it assumes that safety can be defined and understood by all stakeholders in the same way. These assumptions are problematic and might actually undermine safety. (...) This research explores these assumptions through the use of a Group Decision Room. In this set up, anonymous and non-anonymous deliberation methods are used for different stakeholders to exchange views. During the session, a potential synthetic biology application is used as a case for investigation: the Food Warden, a biosensor contained in meat packaging for indicating the freshness of meat. Participants discuss what potential issues might arise, how responsibilities should be distributed in a forward-looking way, who is to blame if something would go wrong. They are also asked what safety and responsibility mean at different phases, and for different stakeholders. The results of the session are not generalizable, but provide valuable insights. Issues of safety cannot all be taken care of in the R&D phase. Also, when things go wrong, there are proximal and distal causes to consider. In addition, capacities of actors play an important role in defining their responsibilities. Last but not least, this research provides a new perspective on the role of instruction manuals in achieving safety. (shrink)

Hedgehog (Hh) signaling is a widely studied signaling pathway because of its critical roles during development and in cell homeostasis. Vertebrate canonical and non‐canonical Hh signaling are typically assumed to be distinct and occur in different cellular compartments. While research has primarily focused on the canonical form of Hh signaling and its dependency on primary cilia – microtubule‐based signaling hubs – an extensive list of crucial functions mediated by non‐canonical Hh signaling has emerged. Moreover, amounting evidence indicates that canonical and (...) non‐canonical modes of Hh signaling are interlinked, and that they can overlap spatially, and in many cases interact functionally. Here, we discuss some of the many cellular effects of non‐canonical signaling and discuss new evidence indicating inter‐relationships with canonical signaling. We discuss how Smoothened (Smo), a key component of the Hh pathway, might coordinate such diverse downstream effects. Collectively, pursuit of questions such as those proposed here will aid in elucidating the full extent of Smo function in development and advance its use as a target for cancer therapeutics. (shrink)

The purpose of this paper is to elucidate, by means of concepts and theorems drawn from mathematical logic, the conditions under which the existence of a multiverse is a logical necessity in mathematical physics, and the implications of Gödel’s incompleteness theorem for theories of everything.Three conclusions are obtained in the final section: (i) the theory of the structure of our universe might be an undecidable theory, and this constitutes a potential epistemological limit for mathematical physics, but because such a theory (...) must be complete, there is no ontological barrier to the existence of a final theory of everything; (ii) in terms of mathematical logic, there are two different types of multiverse: classes of non-isomorphic but elementarily equivalent models, and classes of model which are both non-isomorphic and elementarily inequivalent; (iii) for a hypothetical theory of everything to have only one possible model, and to thereby negate the possible existence of a multiverse, that theory must be such that it admits only a finite model. (shrink)

Like all previously published volumes of his lectures, the content of The Government of the Living defies brief summary. It shows us Foucault in 1980 mapping out a major new phase in his work in terms that complicate our existing understanding of his unfinished project. My review looks in turn at the two parts of the course: an unusually lengthy discussion of method and heuristics, followed by a tightly focused study of early Christian regimes of truth. I suggest that the (...) complex opening theoretical reflections in these lectures go well beyond mapping the course of the immediately following historical analysis. They need to be seen in coordination with other conceptual innovations introduced over the following years, putting a task that Foucault calls here a “history of the power of truth” on his agenda alongside, and in integral connection with the previously defined tasks of a history of governmentality and a history of the subject. A newly published discussion in Berkeley later in 1980 adds crucial context to these Paris lectures, spelling out the linkage of structures of subjectivation to governability and of penitential ascetics to pastoral power. Taken together, the later books and lectures can now be seen to establish a framework of what I suggest we can call “alethic” or “aletheological” analysis, analysing and mapping across the span of Western history the modes of engagement of life and truth, with a view to enabling a renewed analysis of the political present. (shrink)

The article explores the difference between something being merely extremely improbable but believable and something being literally incredible–unbelievably improbable without intervention of some sort. In the former case, a rational person would not expect a special explanation for the occurrence, but in the latter, she does. John Leslie and Peter van Inwagen have proposed principles that can be used to distinguish the two types of cases. The weaknesses of their principles are shown and a revised principle is proposed that is (...) more suited for the task. (shrink)

MAKING PUBLIC POLICY: A HOPEFUL VIEW OF AMERICAN GOVERNMENT by Steven Kelman New York: Basic Books, 1987.332 pp., $19.95.

The concept of collapse in history is one of the normative conceptions through which human past gets a shape. There is no necessary incompatibility between progress and decline, because the decline of some things can itself be interpreted as a mark of progress. This chapter provides an overview of philosophers like Alasdair MacIntyre, Friedrich Nietzsche, and Darwin on this issue. This chapter tries to illustrate through an example the differences between Christian morality and Nietzsche's concept of morality. Nietzsche claimed that (...) the cultural dominance of the Christian ascetic ideal in which self-negation is cultivated at the expense of the aristocratic virtue of self-assertion has come to an end. (shrink)

The study of history with the aim to understand the human past with some sense of detachment is a recent intellectual trend. In the past, a knowledge of history was aimed at ascertaining within history some hidden meaning: cosmic significance, general direction, or providential purpose. This chapter gives an overview of both the religious and secular philosophy of history including looking at Jewish, Christian, Hegelian, and Marxist ideas, and Idealism and Realism. The belief in historical development conceived as a philosophical (...) history provides substantial material for conceptual elaboration and examination. The chapter evaluates the attitude of continental and analytical philosophical traditions toward the concept of grand historical narrative. The combination of the continental and analytical techniques for the purpose of philosophical history is still rare. (shrink)

Walter Benjamin’s work shows evidence of a sustained engagement with Kant and neo-Kantianism, particularly his thoughts on history and experience. I read Benjamin’s “Theses” and “Theologico-Political Fragment” against Kant’s “Idea for a Cosmopolitan History” to suggest that actual experience becomes an impossibility in the Kantian system because historical events always outrun the efforts of the Kantian apparatus to contain them. That Kant ignores these excesses indicates the theological basis of his system. Benjamin’s “messianism” can then be read as a thoroughgoing (...) materialist critique of the Kantian position and its consequences. (shrink)