Mouse pre‐implantation development appears to be under the control of paracrine and autocrine growth factors. The epithelium of the oviduct and the uterus together, with the population of macrophages and lymphocytes present in the reproductive tract from the onset of pregnancy, are thought to be the major sources of paracrine growth factors targeted to the developing embryos. Some of the growth factors are synthesized by both uterine epithelial cells and activated lympho‐hematopoietic cells, suggesting a partial overlap of the regulatory signals (...) used by the reproductive and lympho‐hematopoietic systems. Such growth factors may be the long sought‐after mediators of the synchrony between the pre‐implantation embryo and the sex‐steroid hormone‐induced changes in the uterus. (shrink)

Various four- and three-valued modal propositional logics are studied. The basic systems are modal extensions BK and BS4 of Belnap and Dunn's four-valued logic of firstdegree entailment. Three-valued extensions of BK and BS4 are considered as well. These logics are introduced semantically by means of relational models with two distinct evaluation relations, one for verification and the other for falsification. Axiom systems are defined and shown to be sound and complete with respect to the relational semantics and with respect to (...) twist structures over modal algebras. Sound and complete tableau calculi are presented as well. Moreover, a number of constructive non-modal logics with strong negation are faithfully embedded into BS4, into its three-valued extension B3S4, or into temporal BS4, BtS4. These logics include David Nelson's three-valued logic N3, the four-valued logic N4 bottom, the connexive logic C, and several extensions of bi-intuitionistic logic by strong negation. (shrink)

While attention to research integrity has been growing over the past decades, the processes of signalling and denouncing cases of research misconduct remain largely unstudied. In this article, we develop a theoretically and empirically informed understanding of the causes and consequences of reporting research misconduct in terms of power relations. We study the reporting process based on a multinational survey at eight European universities. Using qualitative data that witnesses of research misconduct or of questionable research practices provided, we aim to (...) examine actors’ rationales for reporting and not reporting misconduct, how they report it and the perceived consequences of reporting. In particular we study how research seniority, the temporality of work appointments, and gender could impact the likelihood of cases being reported and of reporting leading to constructive organisational changes. Our findings suggest that these aspects of power relations play a role in the reporting of research misconduct. Our analysis contributes to a better understanding of research misconduct in an academic context. Specifically, we elucidate the processes that affect researchers’ ability and willingness to report research misconduct, and the likelihood of universities taking action. Based on our findings, we outline specific propositions that future research can test as well as provide recommendations for policy improvement. (shrink)

A far-reaching reinterpretation of Plato’s Timaeus and its engagement with time, eternity, body, and soul that in its original French edition profoundly influenced Derrida The Tomb of the Artisan God provides a radical rereading of Timaeus, Plato’s metaphysical text on time, eternity, and the relationship between soul and body. First published in French in 1995, the original edition of Serge Margel’s book included an extensive introductory essay by Jacques Derrida, who drew on Margel’s insights in developing his own concepts (...) of time, the promise, the world, and khōra. Now available in English with a new preface by Margel, this engagement with Platonic thought proceeds from two questions that span the history of philosophy: What is time? What is the body? Margel’s twinned interrogation centers around Plato’s concept of the demiurge (divine artisan or craftsman): its body, its anthropomorphic attributes, its productive capacities and regulatory functions in the ordering/organization/assembling of the world. He posits that this paradoxical figure is not merely a cosmological metaphor for the living body but also the site of its destruction, dissolution, and disappearance. Torn between the finite and the infinite, being and becoming, the concept of demiurge also poses metaphysical questions about time, time before time, and the end of time. The ontological status of the demiurge’s body, Margel argues, would become increasingly decisive in the history of philosophy, particularly in Christianity and the dogma of incarnation. (shrink)

According to Minstrumentalize” this framework to propose an evolutionary basis for the existence of a biological resilience to drug addiction in people.

In 1926, François Machon, a Swiss physician who lived for many years in Argentina, organised the restitution of a religious garment that had been stolen from the cathedral of Paraguay in the late 1860s and was kept in the Swiss Musée d'ethnographie de Neuchâtel (MEN) in exchange for a small part of his ethnographic collection. In the following decade, he donated more of his own collections to the MEN, but also negotiated as a go-between for the donation of his son (...) Roger's collections. On one occasion he managed, again, to arrange the exchange of a proto-historic Swiss lake-dweller axe for a small collection of Amerindian artefacts. The Machons' case sheds light on the logics of donations of a private collection holder, his tactics and strategies of persuasion, and his entangled web of affects, straddling two countries and two networks of fidelity in a context of migration. It also helps us understand the complex rationalities of acquisition and the polysemy of a peripheral municipal cultural institution. This case informs us about the rationales of a peripheral museum and on the criteria used to assess the quality of donators and their collections; it illustrates the asymmetry of the exchange values of European and South American, ancient and contemporary, artefacts, and the unequal vocality of the different actors. Similarly, it gives us a perspective on the rationales that were mobilised to justify giving away parts of its collections. The exchange of artefacts between the Machons and the MEN helps us understand museums not only as patrimonial of scientific institutions, but also as economic actors, whose agents convince, gamble, bargain, and negotiate, and try to make best use of their resources, symbolic and monetary, to increase their assets and social benefits. (shrink)

1Neurology Department and Cyclotron Research Center, University of Lie`ge, Sart Tilman B30, 4000 Liege, Belgium 2Neurorehabilitation Medicine, Hoˆpital Caremeau, CHU Nıˆmes, 30029 Nıˆmes Cedex, France 3Department of Speech Therapy, Hospital Pitie´ Salpe´trie`re, Paris and French Association Locked in Syndrome (ALIS), 225 Bd Jean-Jaures, MBE 182, 92100 Boulogne-Billancourt, France 4Neurosciences et Syste`mes Sensoriels Unite´ Mixte de Recherche 5020, Universite´ Claude Bernard Lyon 1 – CNRS, 69007 Lyon, France 5Intensive Care Medicine, Hoˆpital Erasme, Universite´ Libre de Bruxelles, Route de Lennik 808, 1070 (...) Brussels, Belgium 6Anesthesiology, Reanimation and Pain Clinic, CHU University Hospital, Sart Tilman B33, 4000 Liege, Belgium 7German Association Locked in Syndrome LIS e.V., Evangelischen Krankenhaus Ko¨ningin Elisabeth Herzberge gGmbh (Lehrkrankenhaus der Charite´), Haus 30, Herzbergstrasse 79, 10365 Berlin, Germany 8Intensive Care Medicine, Centre Hospitalier Re´gional de la Citadelle, Boulevard du 12e de Ligne 1, 4000 Liege, Belgium 9Biomedical PET Unit, Hoˆpital Erasme, Universite´ Libre de Bruxelles, Route de Lennik 808, 1070 Brussels, Belgium.. (shrink)

Peer review of journal submissions has become one of the most important pillars of quality management in academic publishing. Because of growing concerns with the quality and effectiveness of the system, a host of enthusiastic innovators has proposed and experimented with new procedures and technologies. However, little is known about whether these innovations manage to convince other journal editors. This paper will address open questions regarding the implementation of new review procedures, the occurrence rate of various peer review procedures and (...) their distribution over scientific disciplines or academic publishers, as well as the motivations for editors or publishers to engage in novel review procedures. It shows that in spite of enthusiastic innovation, the adoption of new peer review procedures is in fact very slow, with the exception of text similarity scanners. For now, peer review innovations appear to be restricted to specific niches in academic publishing. Analysing these niches, the article concludes with a reflection on the circumstances in which innovations might be more widely implemented. (shrink)

Cet article propose une hypothèse au sujet des Oracles Chaldaïques en les abordant sous l’angle de l’histoire de leur réception. L’objectif de l’A. est de replacer l’origine de ces oracles dans le contexte immédiat de la spiritualité néoplatonicienne. L’hypothèse proposée est illustrée par quelques vers de Proclus qui nous sont rapportés par son disciple Marinus dans son traité Proclus ou sur le bonheur ainsi que par quelques témoignages littéraires sur la conception de la prière chez les néoplatoniciens. L’article se termine (...) sur un exemple de réception moderne des Oracles Chaldaïques. This paper proposes a hypothesis on the Chaldean Oracles by an approach under the angle of the history of their reception. The objective of the A. is to replace the origin of these oracles in the immediate context of Neoplatonician’s spirituality. The hypothesis suggested is illustrated by some verses of Proclus which are brought back to us by his disciple Marinus in his Proclus or on happiness as well as by some literary testimonies on the conception of prayer among Neoplatonicians. The paper finishes on a modern example of reception of the Chaldean Oracles. (shrink)

La crise écologique actuelle prend ses racines dans une histoire faite de possibles, parfois aboutis, d'échecs et de renoncements. Près de deux siècles de politiques environnementales que Serge Audier synthétise ici à la lumière des entraves et des infléchissements qui les ont forgées, les empêchant encore aujourd'hui de répondre efficacement à l'urgence toujours plus criante. Depuis la fin du XXe siècle, des signaux d'alarme écologiques ne cessent de retentir : réchauffement climatique toujours plus incontrôlable, destruction exponentielle et dramatique de (...) la biodiversité, déforestations accélérées, pollutions diverses, " plastification " des mers, etc. Pourtant, les défenseurs de la cause écologique peinent à véritablement convaincre l'ensemble de la société ainsi que les décideurs économiques et politiques de la nécessité d'un changement urgent de modèle. Pourquoi les forces politiques, de droite mais aussi de gauche, n'ont-elles pas su ou voulu prendre en charge le défi écologique? C'est à cette question que s'intéresse ce livre de Serge Audier, qui offre une ample fresque inédite sur les racines philosophiques, idéologiques et politiques de la crise actuelle. Au croisement de l'histoire et de la philosophie, cette généalogie intellectuelle examine les logiques doctrinales et politiques qui, depuis près de deux siècles, ont présidé aux prises de position et aux programmes en matière environnementale, à leurs réussites comme à leurs nombreux échecs. L'auteur montre notamment pourquoi, dans de nombreuses régions du monde, la logique socio-économique, politique et culturelle dominante est allée dans le sens d'un modèle productiviste qui a provoqué une destruction accélérée et sans précédent du milieu naturel. Parallèlement, il soulève la question des " possibles " non aboutis ou non réalisés, et invite à (re)découvrir des voies alternatives - entre anarchisme et socialisme - qui ont cherché à articuler critique sociale et critique écologique du capitalisme, dans l'horizon d'une " cité écologique " à venir. (shrink)

This first book in English by Serge-Christophe Kolm provides an overview of his far-reaching vision of distributive justice. Kolm derives justice from considerations of rationality.

Reciprocity is the basis of social relations. It permits a peaceful and free society in which people and rights are respected. The essence of families and communities, it also enables the working of markets and organisations, while correcting their main failures. Reciprocity is also a basis of politics, and it justifies social policies. Although the importance of reciprocity has been widely recognised in other social sciences, it has, until recently, been somewhat ignored in economic analysis. Over the past three decades, (...) economic theorist and moral philosopher Serge-Christophe Kolm has been at the forefront of research into the economics of the deepest aspects of societies. In Reciprocity, he provides a unique in-depth analysis of the motives, conducts, and effects of reciprocal relationships. In doing this, he explains crucial functionings of society and its economy, and the ways in which they can be improved. This book should be read by economists, sociologists, philosophers, and anyone concerned with understanding the economy of social relationships and its far-reaching consequences. (shrink)

The unified framework for addiction (UFA) formulated by Redish et al. is a tour de force. It uniquely predicts that there should be multiple addiction syndromes and pathways – a diversity that would reflect the complexity of the mammalian brain decision system. Here I explore some of the evolutionary and developmental ramifications of UFA and derive several new avenues for research.

This volume surveys 150 law books of fundamental importance in the history of Western legal literature and culture. The entries are organized in three sections: the first dealing with the transitional period of fifteenth-century editions of medieval authorities, the second spanning the early modern period from the sixteenth to the eighteenth century, and the third focusing on the nineteenth and twentieth centuries. The contributors are scholars from all over the world. Each 'old book' is analyzed by a recognized specialist in (...) the specific field of interest. Individual entries give a short biography of the author and discuss the significance of the works in the time and setting of their publication, and in their broader influence on the development of law worldwide. Introductory essays explore the development of Western legal traditions, especially the influence of the English common law, and of Roman and canon law on legal writers, and the borrowings and interaction between them. The book goes beyond the study of institutions and traditions of individual countries to chart a broader perspective on the transmission of legal concepts across legal, political, and geographical boundaries. Examining the branches of this genealogical tree of books makes clear their pervasive influence on modern legal systems, including attempts at rationalizing custom or creating new hybrid systems by transplanting Western legal concepts into other jurisdictions. (shrink)

L’accueil familial de la protection de l’enfant traverse une crise importante. Comprendre cette crise passe par l’analyse critique du dispositif d’Aide sociale à l’enfance dans lequel s’inscrit l’accueil familial. Les évolutions du métier d’assistant familial ont déstabilisé le dispositif lorsqu’elles n’ont pas été accompagnées par des transformations des organisations et des pratiques. La loi de 2016 qui réoriente la protection de l’enfance sur les besoins de l’enfant est une opportunité pour l’accueil familial. À partir de l’analyse critique des pratiques en (...) protection de l’enfance, cet article propose les concepts de pourvoyance des besoins de l’enfant, de parentalité empêchée et de développement du pouvoir être parent pour penser les pratiques de l’accueil familial d’enfant. (shrink)

Le rapport entre culture et politique est l'un des plus débattu sous l'angle des sciences sociales, opposant notamment culture légitime et culture anthropologique ; et ceci selon deux points de vue complémentaires : d'abord quant aux vicissitudes subies par les politiques culturelles des États-nations, à l'exemple de la France du fait de l'échec de l'objectif de démocratisation culturelle, ensuite quant à leur remise en cause frontale par les processus de la mondialisation libérale. C'est dans ce contexte que s'inscrit la diversité (...) culturelle substituée à l'exception culturelle, et comportant la diversité linguistique, défendue par la FrancophonieThe relation between culture and politics represents one of the most discussed topics from the social sciences perspective, particularly the opposition between high culture and popular culture. The question is viewed from two complementary standpoints: firstly, one related to difficulties faced by the cultural politics of Nation States, for example France’s difficulties because of the fact that the objective of cultural democratization has not been achieved; and secondly bringing cultural politics into question by the process of liberal globalisation. It is in this context that cultural exception is replaced by cultural diversity including linguistic diversity as defended by Francophony. (shrink)

En 1517, il y a cinq cents ans, la réforme de Luther fracture l'Europe. La même année, les conquistadores espagnols s'en prennent au Mexique, qu'ils colonisent et christianisent. Ils y introduisent aussi notre façon d'écrire l'histoire. Les vainqueurs ignorent tout des sociétés indigènes. Or pour imposer leur loi, ils doivent impérativement connaître les coutumes et donc le passé des vaincus. Mais que sont l'histoire et le temps dans l'esprit des Indiens? Le temps n'est pas encore une valeur universelle. Comment les (...) Espagnols formatés dans une Europe chrétienne où l'histoire est chronologique et orientée auraient-ils pu concevoir et accepter la cosmologie méso-américaine? Civilisés contre barbares? En quelques décennies, la machine à remonter le temps des envahisseurs s'emploie à capturer les mémoires des sociétés amérindiennes pour leur fabriquer un passé qui puisse être rattaché au patrimoine antique de la chrétienté. Du côté des Indiens, le souvenir de leur monde au sein duquel les êtres, les choses et les dieux étaient liés se dilue avec le passage des générations même si, dans les codex ou dans les mystérieux cantares, subsistent quelques pans secrets de leur mémoire. Serge Gruzinski propose ici une exploration inédite des débuts de l'expansion coloniale et nous explique comment, sur le terrain, religieux et Indiens se mettent à écrire l'histoire du monde. (shrink)

This full-color title is designed to be a classic reference for the millions of photographers going to digital, from enthusiasts shooting family events and vacations with their SLRs, to professionals creating journalistic prints and fine art. It?s the only book on the market with a focus on complete, end-to-end workflow from shoot to print. It?s tied to Adobe?s latest version of Photoshop, which boasts an installed base of 4 million! Serge Timacheff is a professional photographer living in Pacific Northwest. (...) He is the official photographer for the International Fencing Federation, based in Lausanne, Switzerland, and he photographs fencing at World Championships and the Summer Olympics. His 100-percent digital studio provides portraiture, event, commercial, and boudoir photography, and his fine art photographs appear in galleries and individual collections worldwide. David Karlins is a digital imaging expert, Web designer, teacher, consultant and author of numerous books and magazine articles. (shrink)

Active ending of the life of a newborn baby is a crime. Yet its clandestine practise is a reality in several European countries. In this paper, we defend the necessity to institute a proper legal frame for what we define as active neonatal euthanasia. The only legal attempt so far, the Dutch Groningen protocol, is not satisfactory. We critically analyse this protocol, as well as several other clinical practises and philosophical stances. Furthermore, we have tried to integrate our opinions as (...) clinicians into a law project, with the purpose of pinpointing several issues, specific of perinatality that should be addressed by such a law. In conclusion, we argue that the legalisation of neonatal euthanasia under exceptional circumstances is the only way to avoid all the “well-intentioned” malpractices associated with ending life at the very dawn of it. (shrink)

Serge Mboukou. – Votre collaboration et votre travail au long cours semblent croiser avec force les fils souvent tendus et tragiques d’une actualité qui ne cesse, s’il en était besoin, de confirmer vos analyses et, en tout cas, d’en souligner la pertinence. Ils en appellent, au fond, à une analyse et une réflexion conséquentes. Si le texte que vous présentez aujourd’hui au public semble fonctionner comme un précipité lié aux accélérations et aux explosions de l’actualité,...

Ronald Dworkin, né en 1931, est actuellement Professor of Jurisprudence à l’Université d’Oxford et Professor of Law à l’Université de New York. Après des études à Harvard College, à l’Université d’Oxford et à la Harvard Law School, il occupe le poste d’assistant auprès du juge Learned Hand, puis se..

Journal of Political Philosophy, EarlyView.

I shall tell you the story, propose an overview, and show the structure, goal, and peculiarities of this monstrous edition that I undertook forty-four years ago: the Heraclitea, of which ten volumes have appeared since 1999. One volume was published in November 2011 and a few others are still in preparation. While telling you this story, I shall strive to show the radical differences between my approaches and the standard ones taught worldwide in the departments of classics and ancient philosophy (...) in universities. (shrink)

Veteran professional photographer Serge Timacheff walks you through the features of the Canon EOS DSLR camera; selecting, understanding, and using lenses and accessories; and caring for your equipment. You'll also get professional insight into protecting your gear and building your skill set. Once you understand how to build a photography system that meets your needs and discover which filters and accessories are best for you, you can begin to embrace all the Canon EOS camera system has to offer. Note: (...) CD-ROM/DVD and other supplementary materials are not included as part of eBook file. (shrink)