mRNA synthesis in all organisms is performed by RNA polymerases, which work as nanomachines on DNA templates. The rate at which their product is made is an important parameter in gene expression. Transcription rate encompasses two related, yet different, concepts: the nascent transcription rate, which measures the in situ mRNA production by RNA polymerase, and the rate of synthesis of mature mRNA, which measures the contribution of transcription to the mRNA concentration. Both parameters are useful for molecular biologists, but they (...) are not interchangeable and they are expressed in different units. It is important to distinguish when and where each one should be used. We propose that for functional genomics the use of nascent transcription rates should be restricted to the evaluation of the transcriptional process itself, whereas mature mRNA synthesis rates should be employed to address the transcriptional input to mRNA concentration balance leading to variation of gene expression. (shrink)

Utilising science and technology to maximize human performance is often an essential feature of military activity. This can often be focused on mission success rather than just the welfare of the individuals involved. This tension has the potential to threaten the autonomy of soldiers and military physicians around the taking or administering of enhancement neurotechnologies (e.g., pills, neural implants, and neuroprostheses). The Hybrid Framework was proposed by academic researchers working in the U.S. context and comprises “rules” for military neuroenhancement (e.g., (...) ensuring transparency and maintaining dignity of the warfighter). Integrating traditional bioethical perspectives with the unique requirements of the military environment, it has been referenced by military/government agencies tasked with writing official ethical frameworks. Our two-part investigation explored the ethical dimensions of military neuroenhancements with military officers – those most likely to be making decisions in this area in the future. In three workshops, structured around the Hybrid Framework, we explored what they thought about the ethical issues of enhancement neurotechnologies. From these findings, we conducted a survey (N = 332) to probe the extent of rule endorsement. Results show high levels of endorsement for a warfighter’s decision-making autonomy, but lower support for the view that enhanced warfighters would pose a danger to society after service. By examining the endorsement of concrete decision-making guidelines, we provide an overview of how military officers might, in practice, resolve tensions between competing values or higher-level principles. Our results suggest that the military context demands a recontextualisation of the relationship between military and civilian ethics. (shrink)

In the property listing task (PLT), participants are asked to list properties for a concept (e.g., for the concept dog, “barks,” and “is a pet” may be produced). In conceptual property norming (CPNs) studies, participants are asked to list properties for large sets of concepts. Here, we use a mathematical model of the property listing process to explore two longstanding issues: characterizing the difference between concrete and abstract concepts, and characterizing semantic knowledge in the blind versus sighted population. When we (...) apply our mathematical model to a large CPN reporting properties listed by sighted and blind participants, the model uncovers significant differences between concrete and abstract concepts. Though we also find that blind individuals show many of the same processing differences between abstract and concrete concepts found in sighted individuals, our model shows that those differences are noticeably less pronounced than in sighted individuals. We discuss our results vis‐a‐vis theories attempting to characterize abstract concepts. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

This paper defends and develops the structuring account of conscious attention: attention is the conscious mental process of structuring one’s stream of consciousness so that some parts of it are more central than others. In the first part of the paper, I motivate the structuring account. Drawing on a variety of resources I argue that the phenomenology of attention cannot be fully captured in terms of how the world appears to the subject, as well as against an atomistic conception of (...) attention. In the second part of the paper, I show how the structuring account can be made precise: attention causes and causally sustains phenomenal relations to hold between the parts of the stream of consciousness; most importantly the relation of one part being peripheral to another. I end by pointing out consequences for both the scientific study of attention as well as for several areas of central philosophical interest. (shrink)

This book argues that we can only develop a proper grasp of Kant s practical philosophy if we appreciate the central role played in it by the notion of the interests of reason. While it is generally acknowledged that Kant does not regard reason as a purely instrumental faculty, this book is the first to show how his notion of reason as guided by its own interests offers the key to some of the most puzzling aspects of his practical philosophy.".

Sebastian Luft presents and defends the philosophy of culture championed by the Marburg School of Neo-Kantianism. Following a historical trajectory from Hermann Cohen to Paul Natorp and through to Ernst Cassirer, this book makes a systematic case for the viability and attractiveness of a philosophical culture in a transcendental vein, in the manner in which the Marburgers intended to broaden Kant's approach.

Georg Wilhelm Friedrich Hegel's 'Philosophy of Nature' has often been accused of promoting a view of nature fundamentally at odds with the modern scientific understanding of nature. I show this accusation to be false by pointing to two aspects of Hegel's treatment of nature: its rejection of the 'a priori/a posteriori' distinction, and its connection to Hegel's conception of autonomy as freedom from givenness. I give a reading of Hegel's treatment of the laws of motion along these lines, and I (...) close with some points connecting this reading of Hegel to contemporary philosophy (specifically John McDowell and Catherine Malabou). (shrink)

Resenha: MELO, Amarildo José de. Jansenismo no Brasil : traços de uma Moral rigorista. Santuário em Aparecida/SP. 2014, 343p.

The sheer multitude of criteria of empirical significance has been taken as evidence that the pre-analytic notion being explicated is too vague to be useful. I show instead that a significant number of these criteria—by Ayer, Popper, Przełęcki, Suppes, and David Lewis, among others—not only form a coherent whole, but also connect directly to the theory of definition, the notion of empirical content as explicated by Ramsey sentences, and the theory of measurement; two criteria by Carnap and Sober are trivial, (...) but can be saved and connected to the other criteria by slight modifications. A corollary is that the ordinary language defense of Lewis, the conceptual arguments by Ayer and Popper, the theoretical considerations by Przełęcki, and the practical considerations by Suppes all apply to the same criterion or closely related criteria. Furthermore, the equivalence of some criteria allows for their individual justifications to be taken cumulatively and, together with the entailment relations between nonequivalent criteria, suggest criteria for general auxiliary assumptions, comparative criteria, and more liberal conceptions of observation. (shrink)

In signaling games, a sender has private access to a state of affairs and uses a signal to inform a receiver about that state. If no common association of signals and states is initially available, sender and receiver must coordinate to develop one. How do players divide coordination labor? We show experimentally that, if players switch roles at each communication round, coordination labor is shared. However, in games with fixed roles, coordination labor is divided: Receivers adjust their mappings more frequently, (...) whereas senders maintain the initial code, which is transmitted to receivers and becomes the common code. In a series of computer simulations, player and role asymmetry as observed experimentally were accounted for by a model in which the receiver in the first signaling round has a higher chance of adjusting its code than its partner. From this basic division of labor among players, certain properties of role asymmetry, in particular correlations with game complexity, are seen to follow. (shrink)

The dominant assumption about the causal architecture of the mind is, that it is composed of a stable set of components that contribute independently to relevant observables that are employed to measure cognitive activity. This view has been called component-dominant dynamics. An alternative has been proposed, according to which the different components are not independent, but fundamentally interdependent, and are not stable basic properties of the mind, but rather an emergent feature of the mind given a particular task context. This (...) view has been called interaction-dominant dynamics. In this paper, we review evidence for interaction-dominant dynamics as the causal architecture of the mind. We point out, that such an architecture is consistent with problems of convergence in research on the level of results and theorizing. Moreover, we point out that if interaction-dominant dynamics as the causal architecture of the mind were to be true, this would naturally lead to problems with generalization and replicability in sciences of the mind and brain, and would probably warrant changes in the scientific practice with regard to study-design and data analysis. (shrink)

Diabetes contributes to COVID‐19 deaths in Colombia and Mexico, where the latter having the highest prevalence of diabetes among OECD countries. Some reports consider that advertising influences diabetes by confusing labels on ultra‐processed foods and soft drinks that lead to unhealthy food choices. Both countries are in the process of modifying their labeling legislation; however, governments and food industries have pushed to delay its implementation. Using a mixed research design, we interviewed 550 consumers in both countries during June–July 2020; a (...) high number of respondents misunderstand today's food labeling and are unaware of the new labeling legislation. Respondents strongly agree that the food industry should be in charge of changing the labels; otherwise, they would consider not buying their products. Using cluster analysis, we identified three groups that would help design public policies, nutritional and educational campaigns. Although changes in food labeling alone are not enough to reduce obesity and diabetes rates, food labels constitute public health tools due they assist consumers to make food and nutritional choices (considering that nutrition can help prevent and overcome COVID‐19). The costs of maintaining current labels could increase Colombians and Mexicans illnesss and poverty. These deceptive practices of the food industry would harm their brands. (shrink)

Se trata de una explicación del concepto de historicidad desarrollado por la hermenéutica filosófica y de las implicaciones de ese concepto para la historiografía, sobre todo en cuanto crítica de la concepción atemporal de la subjetividad en la que se basa el objetivismo historiográfico.

Santayana the Philosopher: Philosophy as a Form of Life highlights the far-ranging nuances of Santayana’s philosophical system, while also discussing his ever-present concern for contemporary human affairs. Santayana understood the activity of philosophy in a Greek manner, as a form of life, but his interests always included the perennial philosophical questions and how they related to the present.

Through a close reading of the two definitions of evil in the Introduction to Responses to Thalassios, this article points out a circular, cognitive-affective-somatic, genetic mechanism that St. Maximos the Confessor considers responsible for the initiation and transmission of the fallness as a human condition and the specific manifestation of it in the form of passions. It elucidates the first definition as mainly phenomenological, by identifying the circular mechanism and its behavioural expressions, and the second definition as more aetiological, by (...) explaining why this mechanism emerges and reemerges with the fallen humanity despite its catastrophic results. CONTRIBUTION: This article highlights a double genetic mechanism that St. Maximos the Confessor grasped within the fallen human condition as a curse solvable only in Christ, a notion largely carved out by previous Maximian scholarship, but fully explained and valuated here. (shrink)

El mito platónico de Prometeo, con el robo del fuego a los dioses, simboliza el despegue del más apasionante reto de la Humanidad, la aventura del conocimiento. Dédalo con sus ingenios persiguió en vano la estela; y el rapto de Europa por Zeus, no en su vertiente ortodoxa, sino tal como lo representa Bayros, clausura un periplo en pos del bienestar que hoy se muestra tan esperanzador como amenazante. Cuando estamos a punto de realizar el imperativo de Francis Bacon dominando (...) el mundo natural, éste se resiste y rebela dejando al descubierto la fragilidad de la criatura humana. Piqueras como contrapunto esporádico es un testigo del pasado, un aldabonazo en la conciencia. El imperativo tecnológico resume este momento de inflexión en el que nos hallamos: un punto ¿de no retorno?, ante el que la conciencia moral zozobra y que puede marcar el sino de la humanidad doliente. Hasta aquí nos ha traído el apogeo de lo racional, hasta la crisis que todo lo impregna. Si esto es un cuento de Calleja, no acertamos a vislumbrar la moraleja. (shrink)

"En los últimos ocho años, hemos pasado de celebrar la posibilidad de una participación de la gente común en la política a casi dimitir de ella en favor de una visión anacrónicamente tecnócrata. ¿Cómo salir de la crisis de la democracia? Necesitamos distancia histórica para comprender que existen otras maneras de plantear el gobierno del pueblo. Necesitamos, también, claridad acerca de cuál es el mecanismo de la democracia que queremos poner en práctica. Sin esa claridad nos entregamos en brazos del (...) fetichismo, tomamos como evidentes e incuestionables las divisiones políticas."_ Editorial. (shrink)

This article studies how people leave eating disorders. The article is based on a study of how the labor market influences eating disorders. We present conflicts in which workers are involved. Finally, we propose policies to combat lines, in the labor market against the disease.

El análisis del registro fósil proporciona información sobre la historia evolutiva del aparato volador aviano y el origen y desarrollo del vuelo moderno. Existen dos hipótesis alternativas para explicar las complejas presiones de selección que configuraron la aparición del vuelo. La propuesta del corredor («desde el suelo hacia arriba») es la que mejor se ajusta a la evidencia disponible. El ave primitiva Archaeopteryx produciría, probablemente, algún tipo de vuelo batido, aunque su capacidad de maniobra, despegue y aterrizaje sería limitada. El (...) vuelo activo moderno comenzó, durante el Cretácico inferior, con las aves ornitotoraces basales, como Iberomesornis. No obstante, esta ave primitiva, cuya capacidad de vuelo estaba claramente incrementada con respecto a la condición ancestral presente en Archaeopteryx, tampoco parece tener las perfectas habilidades voladoras de las aves modernas. (shrink)

For years as an award-winning war reporter, Sebastian Junger traveled to many front lines and frequently put his life at risk. And yet the closest he ever came to death was the summer of 2020 while spending a quiet afternoon at the New England home he shared with his wife and two young children. Crippled by abdominal pain, Junger was rushed to the hospital by ambulance. Once there, he began slipping away. As blackness encroached, he was visited by his dead (...) father, inviting Junger to join him. "It's okay," his father said. "There's nothing to be scared of. I'll take care of you." That was the last thing Junger remembered until he came to the next day when he was told he had suffered a ruptured aneurysm that he should not have survived. This experience spurred Junger--a confirmed atheist raised by his physicist father to respect the empirical--to undertake a scientific, philosophical, and deeply personal examination of mortality and what happens after we die. How do we begin to process the brutal fact that any of us might perish unexpectedly on what begins as an ordinary day? How do we grapple with phenomena that science may be unable to explain? And what happens to a person, emotionally and spiritually, when forced to reckon with such existential questions? (shrink)

Author: Kołodziejczyk Sebastian Tomasz Title: ON THE MUTUAL RELATIONSHIP BETWEEN THE CONCEPT OF BEING AND THE PLURALITY OF METAPHYSICAL DISCOURSES (O związkach między wielością dyskursów metafizycznych a pojęciem bytu) Source: Filo-Sofija year: 2011, vol:.15, number: 2011/4, pages: 865-880 Keywords: METAPHYSICS, ARISTOTLE, BEING, CONCEPT OF BEING, CATEGORIES, UNIVERSALS, PARTICULARS, PARTICULARITY Discipline: PHILOSOPHY Language: POLISH Document type: ARTICLE Publication order reference (Primary author’s office address): E-mail: www:The aim of the paper is to argue that there is a mutual relationship between the concept (...) of being as it is conceived of in the classical Aristotelian metaphysics and the plurality of possible metaphysical discourses. That thesis is rooted in the inherent ambiguity of the concept of being and some consequences connected therewith. Three forms of metaphysical thinking are taken into account: the metaphysics of formal interpretation of the concept of being, metaphysics of existential determination of being, and metaphysics of the material content of every conceptual representation of being. (shrink)

The non-invasive stimulation techniques are already recognized as technology that allows neuroenhancement, specifically the Transcranial Magnetic Stimulation can be applied following potentiation protocols in order to enhance both cognitive and motor systems. Hand in hand with this capacity arises the ethical problem of its application. The objective of this contribution is to describe and discuss what ethical aspects have been established in relation to this current phenomenon. Thus, we will first describe the mechanisms and results of non-invasive technology in relation (...) to neuroenhancement, focusing on TMS enhancing protocols. Next, we will make a brief historical review of the ethical aspects established around the application of TMS and its ability to result in neuroenhancement. Finally, we will discuss the ethical aspects that have been described and new debates that arise from the previous ones, concluding in an expanded vision of addressing the discussion. (shrink)

El artículo es el análisis de algunos estudios realizados sobre el gaucho en los que se emiten juicios de valor acerca de la pertinencia o impertinencia de utilizar fuentes literarias o pictóricas para ayudarnos a comprender la historia argentina. Más aún, para indagar si pueden resultar útiles al estudiar los pasados subalternos que han quedado desplazados del relato nacional. Además de la discusión de posiciones teóricas, se presentan dos ejemplos a través de los cuales se intenta justificar la utilidad de (...) usar dichas fuentes para enriquecer los estudios históricos. Finalmente, se inicia un debate historiográfico acerca de la posibilidad o imposibilidad de hallar espacios de enunciación o huellas de las voces silenciadas de los sectores subalternos. (shrink)

Jairo Moreno adapts the methodologies and nomenclature of Foucault’s "archaeology of knowledge" and applies it through individual case studies to the theoretical writings of Zarlino, Descartes, Rameau, and Weber. His conclusion summarizes the conditions—musical, philosophical, and historical—that "make a certain form of thought about music necessary and possible at the time it emerges." Musical Meaning and Interpretation—Robert S. Hatten, editor.

El presente artículo fue escrito a escasos días de cumplirse los setenta y seis años de la célebre conferencia de Husserl sobre La filosofía en la crisis de la humanidad europea, dictada en el Círculo Cultural de Viena, el 7 y el 10 de mayo de 1935. Más que por lo casi redondo de las cifras, la necesidad de conmemorar ese acontecimiento filosófico tan importante fue motivada por el “Encuentro Regional de Filosofía y Pedagogía: Fenomenología y Aprendizaje Significativo”, con el (...) que la Universidad Autónoma de Baja California celebró, en su campus de Tijuana, el XXV aniversario de la fundación de su Facultad de Humanidades. En el contexto particular de México y América Latina, la conferencia interroga por la necesidad y vigencia de la filosofía en la actualidad. (shrink)

The present article aims to analyze, from literary studies, the aspects of the life of Tomás Carrasquilla that, reflected in his historical novel La marquesa de Yolombó, contributed to the creation of Yolombó as a literary universe that exposes the tensions of creation identity of the Colombian nation. This purpose is achieved through three moments: the first, the identification of bibliographic sources that within literary criticism have addressed the biographical aspects of the author; the second, the exploration of the mining (...) route that led the first Spanish settlers, established in the municipality of Cancán, to migrate to neighboring municipalities such as Yolombó and Santo Domingo and, thirdly, the review of the influences of the oral accounts of the Carrasquilla family in the composition of the novel. It is concluded that the tragic fate that the character of Bárbara Caballero faces in the work may represent a rejection of the author towards the realistic spirit and submission to the Spanish crown of the legendary Marchioness. This hypothesis is based on the fact that the historical Bárbara, the writer's great-great-great aunt, was out of tune in the middle of a family that was favorable to the independence cause, such is the case of José María Córdova, distinguished hero of independence, related to Carrasquilla in the same degree of consanguinity as Bárbara Caballero. Finally, in methodological terms, this work is developed as a documentary investigation whose level is interpretive. (shrink)

Review of A Companion to Ricœur’s Freedom and Nature, Ed. Scott Davidson, New York, Lexington Press, 2018.

During the COVID-19 epidemic, draconian countermeasures forbidding nonessential human activities have been adopted in several countries worldwide, providing an unprecedented setup for testing and quantifying the current impact of humankind on climate and for driving potential sustainability policies in the postpandemic era from a perspective of complex systems. In this study, we consider heterogeneous sources of environmental and human activity observables, considered as components of a complex socioenvironmental system, and apply information theory, network science, and Bayesian inference to analyze their (...) structural relations and nonlinear dynamics between January 2019 and August 2020 in northern Italy, i.e., before, during, and after the national lockdown. The topological structure of a complex system strongly impacts its collective behavior; therefore, mapping this structure is essential to fully understand the functions of the system as a whole and its fragility to unexpected disruptions or shocks. To this aim, we unravel the causal relationships between the 16 environmental conditions and human activity variables, mapping the backbone of the complex interplay between intervening physical observables—such as NO2 emissions, energy consumption, intervening climate variables, and different flavors of human mobility flows—to a causal network model. To identify a tipping point during the period of observation, denoting the presence of a regime shift between distinct network states, we introduce a novel information-theoretic method based on statistical divergence widely used in statistical physics. We find that despite a measurable decrease in NO2 concentration, due to an overall decrease in human activities, locking down a region as a climate change mitigation is an insufficient remedy to reduce emissions. Our results provide a functional characterization of socioenvironmental interdependent systems, and our analytical framework can be used, more generally, to characterize environmental changes and their interdependencies using statistical physics. (shrink)

First it is argued that the linkage of natural theology to epistemology is invalid historically, epistemologically and metaphysically. Second it is argued that knowledge claims about the ultimate cause of everything should be evaluated not in terms of justified true belief but in terms of the intellectual virtue of wisdom.

This paper considers Aristotle’s distinction between the cause of being and the cause of coming to be. It is intended to show that Aristotle is able to unify both kinds of causes on the basis of the idea that a thing’s substance is its end. He is not confused about the cause of being and of coming to be, as it might seem in several passages. The paper’s focus is on Metaphysics Zeta 17. In contrast to David Charles’ interpretation, my (...) reading of this chapter puts weight on the fact that the end is said to explain both coming to be and being. According to this reading, Zeta 17 is a clue to understanding the unification of both causes in Aristotle. (shrink)

Die Erfindungen von Athanasius Kircher und Johann Philipp Kirnberger markieren die zeitlichen Eckpunkte des Zeitraumes, in dem Komponierkastchen, musikalische Automaten, Wurfelspiele zur Erzeugung von Menuetten und Polonaisen, musikalische Farbenklaviere, Fantasiermaschinen u. a. Projekte entwickelt wurden. Sebastian Klotz analysiert diese Automaten, Tabellen, Kompositionshilfen und Wurfelspiele und verdichtet seine Ergebnisse zu einer Geschichte der Formalisierung des Musikalischen. Indem Klotz das Operativwerden musikalischer Zeichen und die Auslagerung des musikalischen Denkakts in technische Medien aufeinander bezieht und durch eine Vielzahl von Abbildungen dokumentiert, kann er (...) den vielfaltigen Experimentierraum fur die Musikgeschichte in grundlegender Weise erschliessen.". (shrink)