mRNA synthesis in all organisms is performed by RNA polymerases, which work as nanomachines on DNA templates. The rate at which their product is made is an important parameter in gene expression. Transcription rate encompasses two related, yet different, concepts: the nascent transcription rate, which measures the in situ mRNA production by RNA polymerase, and the rate of synthesis of mature mRNA, which measures the contribution of transcription to the mRNA concentration. Both parameters are useful for molecular biologists, but they (...) are not interchangeable and they are expressed in different units. It is important to distinguish when and where each one should be used. We propose that for functional genomics the use of nascent transcription rates should be restricted to the evaluation of the transcriptional process itself, whereas mature mRNA synthesis rates should be employed to address the transcriptional input to mRNA concentration balance leading to variation of gene expression. (shrink)

Utilising science and technology to maximize human performance is often an essential feature of military activity. This can often be focused on mission success rather than just the welfare of the individuals involved. This tension has the potential to threaten the autonomy of soldiers and military physicians around the taking or administering of enhancement neurotechnologies (e.g., pills, neural implants, and neuroprostheses). The Hybrid Framework was proposed by academic researchers working in the U.S. context and comprises “rules” for military neuroenhancement (e.g., (...) ensuring transparency and maintaining dignity of the warfighter). Integrating traditional bioethical perspectives with the unique requirements of the military environment, it has been referenced by military/government agencies tasked with writing official ethical frameworks. Our two-part investigation explored the ethical dimensions of military neuroenhancements with military officers – those most likely to be making decisions in this area in the future. In three workshops, structured around the Hybrid Framework, we explored what they thought about the ethical issues of enhancement neurotechnologies. From these findings, we conducted a survey (N = 332) to probe the extent of rule endorsement. Results show high levels of endorsement for a warfighter’s decision-making autonomy, but lower support for the view that enhanced warfighters would pose a danger to society after service. By examining the endorsement of concrete decision-making guidelines, we provide an overview of how military officers might, in practice, resolve tensions between competing values or higher-level principles. Our results suggest that the military context demands a recontextualisation of the relationship between military and civilian ethics. (shrink)

In the property listing task (PLT), participants are asked to list properties for a concept (e.g., for the concept dog, “barks,” and “is a pet” may be produced). In conceptual property norming (CPNs) studies, participants are asked to list properties for large sets of concepts. Here, we use a mathematical model of the property listing process to explore two longstanding issues: characterizing the difference between concrete and abstract concepts, and characterizing semantic knowledge in the blind versus sighted population. When we (...) apply our mathematical model to a large CPN reporting properties listed by sighted and blind participants, the model uncovers significant differences between concrete and abstract concepts. Though we also find that blind individuals show many of the same processing differences between abstract and concrete concepts found in sighted individuals, our model shows that those differences are noticeably less pronounced than in sighted individuals. We discuss our results vis‐a‐vis theories attempting to characterize abstract concepts. (shrink)

Psychological flexibility is a key concept of acceptation and commitment therapy. This factor has been linked with psychological wellbeing and associated factors, such as quality of life, in cancer patients. These and other positive results of acceptation and commitment therapy in cancer patients found in previous research could be enhanced by using mhealth tools. A three-arm randomized superiority clinical trial, with a pre-post-follow-up repeated measures intergroup design with a 1:1:1 allocation ratio is proposed. A hundred and twenty cancer patients will (...) be randomly assigned to one of the following interventions: face-to-face ACT + mobile application, face-to-face ACT, and Waitlist control group. The primary expected outcome is to observe significant improvements in psychological flexibility acceptance and action questionnaire- II in the face-to-face ACT + app group, after comparing baseline and post-treatment scores, and the scores will remain stable in the two assessment points, 3 and 6 months after the intervention. Secondary expected outcomes are significant increasing scores in quality of life and post-traumatic-growth, and significant decreasing scores in anxiety and depression, insomnia and fatigue at the same assessment points. Also, it is expected that the scores of this group will be higher than the scores of the face-to-face ACT group and the waitlist control group. This study aims to assess the efficacy of a combined intervention for psychological flexibility and associated symptoms in cancer patients. The results of this protocol may help to consider the use of acceptation and commitment therapy and mhealth applications in cancer settings as a valid therapeutic choice.Clinical Trial Registration[www.ClinicalTrials.gov], identifier [NCT05126823]. (shrink)

In his paper “Wellbeing and Changing Attitudes Across Time”, Krister Bykvist investigates the challenge that changing attitudes pose for attitude-sensitive theories of well-being in determining temporal wellbeing. He offers both a useful tool to investigate the conceptual space of possible answers, namely an attitudinal matrix, as well as a seemingly plausible constraint on such an answer, which he terms ‘diagonalism’. This paper draws on his matrix to provide an argument against diagonalism and offer an error theory regarding its intuitive force. (...) Using his matrix, I sketch my own view of temporal well-being according to which it is not a single unified concept, but can rather be understood in two different ways (‘better for’ vs. ‘better off’), both of which are interesting in their own right. (shrink)

This paper defends and develops the structuring account of conscious attention: attention is the conscious mental process of structuring one’s stream of consciousness so that some parts of it are more central than others. In the first part of the paper, I motivate the structuring account. Drawing on a variety of resources I argue that the phenomenology of attention cannot be fully captured in terms of how the world appears to the subject, as well as against an atomistic conception of (...) attention. In the second part of the paper, I show how the structuring account can be made precise: attention causes and causally sustains phenomenal relations to hold between the parts of the stream of consciousness; most importantly the relation of one part being peripheral to another. I end by pointing out consequences for both the scientific study of attention as well as for several areas of central philosophical interest. (shrink)

El filósofo francés en su obra _Réduction et donation_ nos propone un nuevo principio –“_autant de réduction, autant de donation_”–, a partir del cual planteará una tercera reducción en el campo de la fenomenología. La pretensión de este artículo consiste en mostrar cómo este principio señala que la reducción, cada vez más radicalizada, no solo reduce en un sentido restrictivo, sino, más bien, abre o amplía el horizonte de la donación, puesto que permite penetrar cada vez más en el hecho (...) mismo de la donación como tal. De este modo, concluiremos que tras la reducción fenomenológica-transcendental y la reducción ontológicaexistencial se ejerce la reducción _a_ y _de_ la llamada, la cual subyace como el esquema fundamental de las dos reducciones anteriores. Esta será concebida como la estructura originaria de la donación. (shrink)

Cognitive scientists distinguish between automatic and controlled mental processes. Automatic processes are either innately involuntary or become automatized through extensive practice. For example, reading words is a purportedly automatic process for proficient readers and the Stroop effect is consequently considered the “gold standard” of automated performance. Although the question of whether it is possible to regain control over an automatic process is mostly unasked, we provide compelling data showing that posthypnotic suggestion reduced and even removed Stroop interference in highly hypnotizable (...) individuals. Drawing on a large sample of highly hypnotizable participants, we examined the effects of suggestion on Stroop performance both with and without a posthypnotic suggestion to perceive the input stream as meaningless symbols. We show that suggestion administered to highly hypnotizable persons significantly reduced Stroop interference and derailed a seemingly automatic process. (shrink)

This book argues that we can only develop a proper grasp of Kant s practical philosophy if we appreciate the central role played in it by the notion of the interests of reason. While it is generally acknowledged that Kant does not regard reason as a purely instrumental faculty, this book is the first to show how his notion of reason as guided by its own interests offers the key to some of the most puzzling aspects of his practical philosophy.".

The normative principle that every individual is equally entitled to continued life is a subject of debate in ethics, health economics and policy. We reconsider this principle in the context of setting priorities for healthcare interventions. When applied without restriction, the principle overlooks quality of life concerns entirely. However, we contend that it remains ethically relevant in certain situations, particularly when patients suffer from conditions unrelated to the therapeutic areas and treatments under consideration. Thus, we defend the principle while also (...) emphasizing the need for its application within tight limits. (shrink)

La pretensión de este artículo consiste en mostrar cómo el nihilismo que subyace bajo los diferentes modos en los que se presenta la secularización posmoderna no sólo conduce a la desnuclearización de lo religioso precisamente por el vaciamiento de sus contenidos específicos, sino, además, relega toda experiencia religiosa al ámbito privado de la conciencia individual. Este contexto nihilista propio de la posmodernidad impondría el tiempo de la religión sin religión, que consiste en vivir aparentemente como si fuésemos sujetos religiosos cuando, (...) en realidad, no lo somos. Sin duda, este nuevo horizonte posmoderno supone un reto para el cristianismo. Por ello, trataremos de indicar los tres mayores desafíos que debe afrontar el cristianismo, para que la lógica nihilista de la secularización posmoderna no termine contagiando también la lógica de lo religioso, y vislumbrar qué oportunidades prometedoras se le presentan hoy al cristianismo, para pensar su propia esencia y mostrar su praxis fundada en la caridad en este tiempo en el que nos toca vivir. (shrink)

Jehuda ben Isaak Abrabanel, znany jako Leone Ebreo, XVI-wieczny sefardyjski intelektualista, definiuje tytułowe pojęcie w swoim dziele _Dialogi o miłości_ (_Dialoghi d’amore)_. Ten traktat filozoficzny z neoplatońskimi podtekstami, łączący wszystko, co wcześniejsi myśliciele napisali o tym szlachetnym uczuciu, był niezwykle popularny i stał się wzorem dla współczesnych mu pisarzy. Został przetłumaczony na język hiszpański m.in. przez Inkę Garcilaso de la Vega, a Miguel de Cervantes wspomina o nim w prologu do pierwszej części _Don Kichota_, sugerując, że opisana w nim miłość (...) daleka jest od rzeczywistości. Wizja wyidealizowanej miłości, którą kochanek Filon czuje do czystej Zofii, znajduje swoje odbicie w stworzonym przez Sefardyjczyka Eliasa Canettiego portrecie doktora Sonne, jednego z bohaterów _Gry oczu._ Przejawem mistycznej miłości jest miłość do boskiego intelektu, a tę osiągnąć można jedynie przez intelektualny wysiłek włożony w dialog filozoficzny. Leone Ebreo urodził się na Półwyspie Iberyjskim, wyemigrował do Włoch po 1492 r. i najprawdopodobniej (nie ma co do tego pewności) wybrał język nowej ojczyzny dla swojej ekspresji. Elias Canetti, Sefardyjczyk urodzony w Bułgarii (podówczas okupowanej przez Imperium Osmańskie), przed I wojną światową pisał po niemiecku. Postaci te, odległe od siebie w czasie i przestrzeni, łączy pochodzenie judeohiszpańskie i związany z nim bagaż hebrajskiej tradycji egzegetycznej, który prowadzi obu do bardzo podobnej pochwały intelektualnej miłości. Artykuł przedstawia pokrewieństwo myśli obu pisarzy ‒ których można uznać za Hiszpanów ze względu na ich sefardyjskie pochodzenie ‒ w odniesieniu do intelektualnego mistycyzmu wyrażonego poprzez miłość do Intelektu pisanego wielką literą. (shrink)

Georg Wilhelm Friedrich Hegel's 'Philosophy of Nature' has often been accused of promoting a view of nature fundamentally at odds with the modern scientific understanding of nature. I show this accusation to be false by pointing to two aspects of Hegel's treatment of nature: its rejection of the 'a priori/a posteriori' distinction, and its connection to Hegel's conception of autonomy as freedom from givenness. I give a reading of Hegel's treatment of the laws of motion along these lines, and I (...) close with some points connecting this reading of Hegel to contemporary philosophy (specifically John McDowell and Catherine Malabou). (shrink)

The sheer multitude of criteria of empirical significance has been taken as evidence that the pre-analytic notion being explicated is too vague to be useful. I show instead that a significant number of these criteria—by Ayer, Popper, Przełęcki, Suppes, and David Lewis, among others—not only form a coherent whole, but also connect directly to the theory of definition, the notion of empirical content as explicated by Ramsey sentences, and the theory of measurement; two criteria by Carnap and Sober are trivial, (...) but can be saved and connected to the other criteria by slight modifications. A corollary is that the ordinary language defense of Lewis, the conceptual arguments by Ayer and Popper, the theoretical considerations by Przełęcki, and the practical considerations by Suppes all apply to the same criterion or closely related criteria. Furthermore, the equivalence of some criteria allows for their individual justifications to be taken cumulatively and, together with the entailment relations between nonequivalent criteria, suggest criteria for general auxiliary assumptions, comparative criteria, and more liberal conceptions of observation. (shrink)

This article looks into mining in central Germany in the late eighteenth century as one area of highly charged exchange between (specific manifestations of early modern) science and the (early modern) state. It describes bureaucratic knowledge as socially distributed cognition by following the steps of a high-ranking official that led him to discover a rich silver ore deposit. Although this involved hybridization of practical/artisanal and theoretical/scientific knowledge, and knowers, the focus of this article is on purification or boundary work that (...) took place when actors in and around the mines consciously contributed to different circuits of knowledge production. For the sake of analysis, the article suggests a way of opposing bureaucratic versus scientific knowledge production, even when the sites, actors involved in, and practices of that knowledge production were the same or similar. Whereas the science of the time invoked consensus among equals to conflate competing knowledge claims, bureaucracies did so by applying a hierarchy among ranked individuals. (shrink)

Refugee migration leads to increased diversity in host societies and refugees have to face many stereotyped attitudes in the host society. However, there has been little research on minority group stereotypes toward host society members and how these stereotypes relate to the acculturation-relevant attitudes of refugees in their first phase of acculturation. This study surveyed 783 refugees in Germany who had migrated mostly in the so-called “refugee crisis” between 2015 and 2016. At the time of the survey in 2018, they (...) had been in Germany for an average of 27 months. These refugees reported their positive and negative sociability stereotypes toward German host society members, acculturation-related orientations, shared reality values, and perceived discrimination. Results showed that positive sociability stereotypes toward host society members were associated with increased cultural adoption and shared reality. In contrast, negative sociability stereotypes negatively affected cultural adoption and shared reality. However, stereotypes showed no association at all with cultural maintenance. Interactions between sociability stereotypes and discrimination experiences highlighted a disillusion effect, in the sense that discrimination reduced the motivation to adopt the host culture more strongly among refugees who held strongly positive sociability stereotypes. The study extends knowledge on the significance of minority group stereotypes in the context of refugee migration and reveals the maladaptive consequences of discriminatory behavior against refugees by host society members. (shrink)

The 'late' Foucault and his purported 'return to the subject' is a much discussed issue. Over the past twenty years, various suggestions have been made as to how to integrate Foucault's ethics into his oeuvre as a whole. This paper holds that there is a 'conceptual continuity', rather than a break, between Foucault's earlier works on normalizing power, and his later works on ethical self-constitution. On the basis of a conceptual framework, which is developed in Section II, a reading of (...) two themes concerning certain practices of the self is offered in the following sections (namely, dietetics and spiritual guidance). The material, drawn from the recently published lecture series L'herméneutique du sujet as well as from other published works, is related back to Foucault's ideas on the process of 'subjectivation', in order to support the claim that 'fabrication' and 'self-constitution' are but two aspects of subjectivation. Keywords: late Foucault, ethics, practices of the self, self-constitution, discipline, power, surveillance, spiritual guidance, meditation, parrhesia, dietetics, art of living, aesthetics of existence, return of the subject, subjectivation, relation to self. (shrink)

When Caja de Pensiones para la Vejez y de Ahorros, "la Caixa," was created in 1905, it was not only the transient response to a serious social, political, and economical problem, but also provided a permanent solution by creating a long-lasting social welfare institution. In addition, its founder understood the responsibility of social welfare institutions not as an isolated responsibility for each institution, but as part of a harmonious whole that is a real moral entity with a socio-economic character, with (...) autonomy and unity of nature, purpose, and form. The purpose of this article is to show how the corporate social responsibility conception of Francesc Moragas, the founder of "la Caixa," informed the activities of the new institution in a variety of dimensions, including its service to the customers, its economic strengths, the social work, and its participation in the creation of the public system of social security in Spain. (shrink)

Although Bohr’s Correspondence Principle (CP) played a central role in the first days of quantum mechanics, its original version seems to have no present-day relevance. The purpose of this article is to show that the CP, with no need of being interpreted in terms of the quantum-to-classical limit, still plays a relevant role in the understanding of the relationships between the classical and the quantum domains. In particular, it will be argued that a generic version of the CP is very (...) helpful in elucidating the physical meaning of the phenomenon of quantum decoherence. (shrink)

Nietzsches Ausnahmestatus als Philosoph gründet nicht zuletzt in seinem künstlerischen Verhältnis zur Sprache. Der Grenzen sprengende Denker erweist sich zugleich als ein Grenzen sprengender Sprachartist, der den traditionellen Unterschied zwischen Philosophie und Dichtung zum Verschwimmen bringt. Während die Forschung meist den Hauptakzent auf den Denker Nietzsche legt, widmet sich der vorliegende Band dem Dichter Nietzsche. Untersucht wird ein großes, von der Forschung bislang erst ansatzweise erschlossenes Korpus von Gedichten und Gedichtfragmenten. Betrachtet werden darüber hinaus auch weitere literarische Ausdrucksformen Nietzsches sowie (...) ausgewählte Stationen seiner Rezeption als Dichter. (shrink)

What does it mean to be a community and to be in a community? Can this social phenomenon be analogized to an individual person with her interwoven opinions, wants, and desires? Or is a community a phenomenon sui generis that requires its own methods and tools for research? Concretely: What does it mean that a community may achieve certain acts? And what about the intentional object of such an act, which has also been referred to as “social act”? These questions (...) raise the methodological ones: how is it even possible to characterize a community, such that it can be said to issue social acts? And how can such an inquiry be carried out, does it require an outside perspective or one from within a community, or can it be done by both? (shrink)

In her foreword to Science Next, Elizabeth Edwards wrote of science as a tool for social progress: "Innovation is not simply the abstract victory of knowledge [or] the research that gave me years to live; the next science can advance human flourishing and serve the common good. That's the kind of world I want to leave for my children, and for yours." With these words, she joined a tradition that goes back to America's founders, who saw America itself as a (...) "great experiment." Yet while no one can deny that science undergirds the American Dream, it has long been fertile terrain for the "culture wars." Along with arguing the pros and cons of abortion and healthcare, policymakers must now grapple with advancements that raise questions about what it means to be human: we've decoded the genome, but should we modify it to enhance certain "desirable" traits? If we can, should we prolong life at any cost? Will we soon be counting robots, cyborgs, and chimeras among our friends and family?The first book to unpack our love/hate relationship with science from our country's origins to today, The Body Politic is essential reading for science buffs and concerned citizens alike.Jonathan D. Moreno is editor of the Center for American Progress' online magazine Science Progress and professor of bioethics at the University of Pennsylvania. Author and editor of many seminal books and articles on science and science policy, he divides his time between Philadelphia, PA, and Washington, DC. (shrink)

El objetivo de las presentes páginas consiste en analizar el concepto de libertad en las Disertaciones de Epicteto, centrándonos sobre la posibilidad de la libertad y su articulación con el concepto de proaíresis. Demostraremos que la libertad no puede ser comprendida en la obra de Epicteto simplemente como un proceso negativo de liberación respecto de determinaciones (externas e internas), sino que exige un momento complementario de sustitución de las determinaciones erróneas por determinaciones racionales/virtuosas. Tal conclusión exigirá precisar que la proaíresis (...) no es en absoluto una facultad naturalmente indeterminada y libre, sino que su libertad opera como un horizonte regulativo al que sólo se puede acceder mediante el correcto cuidado (epiméleia) del alma. (shrink)

The non-invasive stimulation techniques are already recognized as technology that allows neuroenhancement, specifically the Transcranial Magnetic Stimulation can be applied following potentiation protocols in order to enhance both cognitive and motor systems. Hand in hand with this capacity arises the ethical problem of its application. The objective of this contribution is to describe and discuss what ethical aspects have been established in relation to this current phenomenon. Thus, we will first describe the mechanisms and results of non-invasive technology in relation (...) to neuroenhancement, focusing on TMS enhancing protocols. Next, we will make a brief historical review of the ethical aspects established around the application of TMS and its ability to result in neuroenhancement. Finally, we will discuss the ethical aspects that have been described and new debates that arise from the previous ones, concluding in an expanded vision of addressing the discussion. (shrink)

El mito platónico de Prometeo, con el robo del fuego a los dioses, simboliza el despegue del más apasionante reto de la Humanidad, la aventura del conocimiento. Dédalo con sus ingenios persiguió en vano la estela; y el rapto de Europa por Zeus, no en su vertiente ortodoxa, sino tal como lo representa Bayros, clausura un periplo en pos del bienestar que hoy se muestra tan esperanzador como amenazante. Cuando estamos a punto de realizar el imperativo de Francis Bacon dominando (...) el mundo natural, éste se resiste y rebela dejando al descubierto la fragilidad de la criatura humana. Piqueras como contrapunto esporádico es un testigo del pasado, un aldabonazo en la conciencia. El imperativo tecnológico resume este momento de inflexión en el que nos hallamos: un punto ¿de no retorno?, ante el que la conciencia moral zozobra y que puede marcar el sino de la humanidad doliente. Hasta aquí nos ha traído el apogeo de lo racional, hasta la crisis que todo lo impregna. Si esto es un cuento de Calleja, no acertamos a vislumbrar la moraleja. (shrink)

"En los últimos ocho años, hemos pasado de celebrar la posibilidad de una participación de la gente común en la política a casi dimitir de ella en favor de una visión anacrónicamente tecnócrata. ¿Cómo salir de la crisis de la democracia? Necesitamos distancia histórica para comprender que existen otras maneras de plantear el gobierno del pueblo. Necesitamos, también, claridad acerca de cuál es el mecanismo de la democracia que queremos poner en práctica. Sin esa claridad nos entregamos en brazos del (...) fetichismo, tomamos como evidentes e incuestionables las divisiones políticas."_ Editorial. (shrink)

This article studies how people leave eating disorders. The article is based on a study of how the labor market influences eating disorders. We present conflicts in which workers are involved. Finally, we propose policies to combat lines, in the labor market against the disease.