Transcranial magnetic stimulation was used to test the functional role of parietal and prefrontal cortical regions activated during a playing card Guilty Knowledge Task. Single-pulse TMS was applied to 15 healthy volunteers at each of three target sites: left and right dorsolateral prefrontal cortex and midline parietal cortex. TMS pulses were applied at each of five latencies after the onset of a card stimulus. TMS applied to the parietal cortex exerted a latency-specific increase in inverse efficiency score and in reaction (...) time when subjects were instructed to lie relative to when asked to respond with the truth, and this effect was specific to when TMS was applied at 240 ms after stimulus onset. No effects of TMS were detected at left or right DLPFC sites. This manipulation with TMS of performance in a deception task appears to support a critical role for the parietal cortex in intentional false responding, particularly in stimulus selection processes needed to execute a deceptive response in the context of a GKT. However, this interpretation is only preliminary, as further experiments are needed to compare performance within and outside of a deceptive context to clarify the effects of deceptive intent. (shrink)

Aristotle connects modality and time in ways strange and perplexing to modern readers. In this book the author proposes a new solution to this exegetical problem. Although primarily expository, this work explores topics of central concern for current investigations into causality, time, and change.

The prospect of using genome technologies to modify the human germline has raised profound moral disagreement but also emphasizes the need for wide-ranging discussion and a well-informed policy response. The Hinxton Group brought together scientists, ethicists, policymakers, and journal editors for an international, interdisciplinary meeting on this subject. This consensus statement formulated by the group calls for support of genome editing research and the development of a scientific roadmap for safety and efficacy; recognizes the ethical challenges involved in clinical reproductive (...) applications of genome editing but, importantly, rejects the idea that human reproductive germline modification is necessarily morally unacceptable; and highlights the importance of meaningful engagement in discussions of genome editing and the development of regulation and oversight mechanisms to govern future uses of such technologies. (shrink)

As the usual regulatory framework did not fit well during the last Ebola outbreak, innovative thinking still needed. In the absence of an outbreak, randomised controlled trials of clinical efficacy in humans cannot be done, while during an outbreak such trials will continue to face significant practical, philosophical, and ethical challenges. This article argues that researchers should also test the safety and effectiveness of novel vaccines in wild apes by employing a pluralistic approach to evidence. There are three reasons to (...) test vaccines in wild populations of apes: i) protect apes; ii) reduce Ebola transmission from wild animals to humans; and iii) accelerate vaccine development and licensing for humans. Data obtained from studies of vaccines among wild apes and chimpanzees may even be considered sufficient for licensing new vaccines for humans. This strategy will serve to benefit both wild apes and humans. (shrink)

What is the best model of epistemic agency for virtue epistemology? Insofar as the intellectual and moral virtues are similar, it is desirable to develop models of agency that are similar across the two realms. Unlike Aristotle, the Stoics present a model of the virtues on which the moral and intellectual virtues are unified. The Stoics’ materialism and determinism also help to explain how we can be responsible for our beliefs even when we cannot believe otherwise. In this paper I (...) show how a neo-Stoic model of epistemic agency can address common objections to treating epistemic and moral agency similarly and allow a robust explanatory role for character in determining our actions and beliefs. The picture of epistemic responsibility that flows from this model also explains why we often deserve credit for our knowledge, while demonstrating that the truth of our beliefs is not something for which we are epistemically responsible. (shrink)

In Memory: A Self-Referential Account, Fernández offers a functionalist account of the metaphysics of memory, which is portrayed as presenting significant advantages over causal and narrative theories of memory. In this paper, I present a series of challenges for Fernández’s functionalism. There are issues with both the particulars of the account and the use of functionalism more generally. First, in characterizing the mnemonic role of episodic remembering, Fernández fails to make clear how the mental image type that plays this role (...) should be identified. Second, I argue that a functionalist approach, which appeals to the overall structure of the memory system and tendencies of mental state types, is ill-suited to the metaphysical question about episodic remembering that is of interest to the causal and narrative theorists with which Fernandez engages. Fernández’s self-referential account of memory has many other virtues, but functionalism is a poor fit for episodic remembering. (shrink)

I use the psychological phenomenon of ‘attribute framing’ as a case study for exploring philosophical conceptions of semantics and the semantics-pragmatics divide. Attribute frames are pairs of sentences that use contradictory expressions to predicate the same property of an individual or object. Despite their equivalence, pairs of attribute frames have been observed to induce systematic variability in hearers’ responses. One explanation of such framing effects appeals to the distinct ‘reference point information’ conveyed by alternative frames. Although this information is taken (...) to be pragmatic, a live debate in the philosophy of language concerns the extent to which pragmatic information can really be held apart from semantics. Therefore, in this article I examine whether – and how – reference point information might be thought to intrude on the semantics of an attribute frame. I describe two ways in which the information might be considered broadly semantic, due to its being directly communicated or conventional. However, I argue that the framing data in fact support a narrower conception of semantics, and a semantics-pragmatics distinction that separates standing sentence meaning from enriched communicated meaning. (shrink)

Law contains many dualities, though most, if not all, of these dualities resolve into one complex puzzle: To what extent is law a matter of pure social facts, or moral value untethered to social facts? I argue that each concept of law reconciles this duality in a different way on the basis of certain beneficial consequences that might result. Instead of pitting concepts against one another universally, we should accept that the balance between law's social fact and moral value dimensions (...) is context-specific in relation to particular legal puzzles. This balance can be achieved only by considering both political theory and empirical data. (shrink)

Mit Ueber Wahrheit und Lüge im aussermoralischen Sinne (1873) versucht Nietzsche, ein Jahr nach Publikation der Geburt der Tragödie, eine Auseinandersetzung mit zentralen Fragen der Sprachphilosophie durch die Hinterfragung der Möglichkeitsbedingungen des Denkens. Zunächst als private Gedankensammlung angelegt, wird diese Schrift im 20. Jahrhundert zu einem der prominentesten Paradigmen der sprachphilosophisch-ästhetischen Reflexion.

Aristotle connects modality and time in ways strange and perplexing to modern readers. In this book the author proposes a new solution to this exegetical problem. Although primarily expository, this work explores topics of central concern for current investigations into causality, time, and change.

This paper describes, analyzes, and critiques the construction of separate “male” and “female” genomes in current human genome research. Comparative genomic work on human sex differences conceives of the sexes as like different species, with different genomes. I argue that this construct is empirically unsound, distortive to research, and ethically questionable. I propose a conceptual model of biological sex that clarifies the distinction between species and sexes as genetic classes. The dynamic interdependence of the sexes makes them “dyadic kinds” that (...) are not like species, which are “individual kinds.” The concept of sex as a “dyadic kind” may be fruitful as a remedy to the tendency to conceive of the sexes as distinct, binary classes in biological research on sex more generally. (shrink)

The current paper highlights a new, interactive Shiny App that can be used to aid in understanding and teaching the important task of conducting a prior sensitivity analysis when implementing Bayesian estimation methods. In this paper, we discuss the importance of examining prior distributions through a sensitivity analysis. We argue that conducting a prior sensitivity analysis is equally important when so-called diffuse priors are implemented as it is with subjective priors. As a proof of concept, we conducted a small simulation (...) study, which illustrates the impact of priors on final model estimates. The findings from the simulation study highlight the importance of conducting a sensitivity analysis of priors. This concept is further extended through an interactive Shiny App that we developed. The Shiny App allows users to explore the impact of various forms of priors using empirical data. We introduce this Shiny App and thoroughly detail an example using a simple multiple regression model that users at all levels can understand. In this paper, we highlight how to determine the different settings for a prior sensitivity analysis, how to visually and statistically compare results obtained in the sensitivity analysis, and how to display findings and write up disparate results obtained across the sensitivity analysis. The goal is that novice users can follow the process outlined here and work within the interactive Shiny App to gain a deeper understanding of the role of prior distributions and the importance of a sensitivity analysis when implementing Bayesian methods. The intended audience is broad and can include those with limited exposure to Bayesian methods or the specific model presented here. (shrink)

Governing nursing conduct: the rise of evidence‐based practice Drawing on the Foucauldian concept of ‘governmentality’ to analyse the evidence‐based movement in nursing, we argue that it is possible to identify the governance of nursing practice and hence nurses across two distinct axes; that of the political (governance through political and economic means) and the personal (governance of the self through the cultivation of the practices required by nurses to put evidence into practice). The evaluation of nursing work through evidence‐based reviews (...) provides detailed information that may enable governments to target and instruct nurses regarding their work in the interest of preserving the health of the population as a whole. Political governance of the nursing population becomes possible through centralised discursive mechanisms, such as evidence‐based reviews that present nursing practice as an intelligible field whose elements are connected in a more or less systematic manner. The identity of the evidence‐based nurse requires the modern nurse to develop new skills and attitudes. Evidence‐based nursing is an emerging technology of government that judges nursing research and knowledge and has the capacity to direct nursing practice at both the political and personal level. (shrink)

This article responds to two ethical conundrums associated with the practice of disability passing. One of these problems is the question of whether or not passing as abled is morally wrong in that it constitutes deception. The other, related difficulty arises from the tendency of the able-bodied in contemporary society to reinforce the activity of passing despite its frequent condemnation as a form of pretense or fraud. We draw upon recent scholarship on transgender and disability passing to criticize and explore (...) some alternatives to the problematic theory of personal identity that is presupposed by the claim that passing as abled always amounts to deceit. We additionally demonstrate the moral indefensibility of society’s reinforcement of disability passing by showing that it may derive, at least in part, from ablest assumptions concerning distributive justice as it relates to disabled individuals. (shrink)

Historically developed along gender lines and arguably the most sex segregated of institutions, U.S. prisons are organized around the assumption of a gender binary. In this context, the existence and increasing visibility of transgender prisoners raise questions about how gender is accomplished by transgender prisoners in prisons for men. This analysis draws on official data and original interview data from 315 transgender inmates in 27 California prisons for men to focus analytic attention on the pursuit of “the real deal”—a concept (...) we develop to reference a dynamic related to how gender is accomplished by transgender inmates. Specifically, among transgender inmates in prisons for men, there is competition for the attention and affection of “real men” in prisons: the demonstrable and well-articulated desire to secure standing as “the best girl” in sex segregated institutional environments. Our empirical examination sheds light on the gender order that underpins prison life, the lived experience of gender and sexuality for transgender inmates in prisons for men, and how that experience reveals new aspects of the workings of gender accountability. (shrink)

Volume 20, Issue 9, September 2020, Page 39-41.

Identifying links between human personality and attributed robot personality is a relatively new area of human–robot interaction. In this paper we report on an exploratory study that investigates human and robot personality traits as part of a human–robot interaction trial. The trials took place in a simulated living-room scenario involving 28 participants and a human-sized robot of mechanical appearance. Participants interacted with the robot in two task scenarios relevant to a ‘robot in the home’ context. It was found that participants’ (...) evaluations of their own personality traits are related to their evaluations of the robot’s personality traits. The statistical analysis of questionnaire data yields several statistically significant results: Participants do not tend to assign their personality traits to match the robots’, For individual personality traits, participants rated themselves as having stronger personality characteristics compared to the robot, Specific significant correlations were found between participants’ and robot personality traits, and Significant group differences for participant gender, age and technological background are highlighted. The results are discussed in light of developing personalized robot companions. (shrink)

This paper is a defence of Putnam's claim that the proposition expressed by the sentence 'I am a brain-in-a-vat' is necessarily false. In particular, the paper defends the anti-sceptical conclusion against an attack by Noonan.

The f-word -- Are you a spiritual rebel? -- A unicorn among sheep -- Taking out the sacred trash -- Redefining spirituality -- Spiritual moments -- Week 1: being -- Mindful Monday -- Talking Tuesday -- Wonder-filled Wednesday -- Trekking Thursday -- Fearless Friday -- Seva Saturday -- Sangha Sunday -- Week 2: deepening -- Week 3: expanding -- Rebel with (a lot of) clues -- Revealing higher purpose -- The rebel and the saint -- Reflections and ahas -- G-word (...) alternatives for sacred pondering -- Sacred shout-outs -- About the author. (shrink)

The United Kingdom is the first and so far only country to pass explicit legislation allowing for the licensed use of the new reproductive technology known as mitochondrial replacement therapy. The techniques used in this technology may prevent the transmission of mitochondrial DNA diseases, but they are controversial because they involve the manipulation of oocytes or embryos and the transfer of genetic material. Some commentators have even suggested that MRT constitutes germline genome modification. All eyes were on the United Kingdom (...) as the most likely location for the first MRT birth, so it was a shock when, on September 27, 2016, an announcement went out that the first baby to result from use of the intervention had already been born. In New York City, United States-based scientist John Zhang used maternal spindle transfer to generate five embryos for a woman carrying oocytes with deleterious mutations of the mitochondrial DNA. Zhang then shipped the only euploid embryo to Mexico, where it was transferred to the mother's uterus. Zhang's team's travel across international borders to carry out experimental procedures represents a form of scientific tourism that has not been properly ethically explored; it can, however, have seriously detrimental effects for developing countries. (shrink)

In this article I set out to trace some of the implications of recharging the political potency of nature in more-than-human terms. This shifts attention from a biopolitical focus on the inventiveness of the life sciences and what this means in terms of the emergence of ‘cyborg’ political subjects to an onto-political focus on the inventiveness of knowledge controversies and what these mean for techno-political practices. Specifically, the article examines the onto-politics of ‘natural’ hazard events and their capacity to force (...) thought in those affected by them, and so to place new demands on research practices in terms of rendering such events affective and amenable to political interrogation. I work these arguments through the demanding experimental ethos of the philosopher Isabelle Stengers, for whom scientific practices produce reliable knowledge claims only in so far as the questions they address are at risk of being redefined by the phenomena mobilized in them, and who extends this ethos to elaborate an understanding of, even a test for, an adequate political theory and practice. I do so with reference to a recent research experiment in which I collaborated with social and natural scientists and people affected by flooding in the UK. (shrink)

The paper spells out agency in a manner sympathetic to the approach in Helen Steward’s A Metaphysics for Freedom ; argues that agency so construed is compatible with determinism; then argues that this is a costly victory for compatibilism.

The slogan ‘anything goes’ first appears in Paul Feyerabend’s book Against Method at the end of the first chapter. Since that time, philosophical literature has been peppered with criticism and cries of outrage towards Feyerabend’s call for anarchy. Many have speculated on what exactly was meant by the slogan and even more philosophers and scientists have quickly discarded Feyerabend’s antidote as the obvious ramblings of a madman.In this essay, I will argue that Paul Feyerabend does not promote complete anarchy, contrary (...) to his critics. Upon closer examination, it becomes clear that Feyerabend promotes methodological and theoretical pluralism, and does not call for total chaos. First, I will briefly outline the overwhelmingly cynical yet popular reading of Feyerabend’s anarchical ideas. Unlike other contemporary perspectives, I willthen argue for what I believe to be a much more fair reading of his anarchy as a prescription for the scientific discipline. I will conclude with postulating an overarching and interesting possibility, namely that Feyerabend’s call for anarchy is an attempt to distance philosophy from the scientific domain. (shrink)

This is the fourth in a series of five papers on the role, remit and function of research ethics committees which are intended to provide for REC members a broad understanding of the most important issues in research ethics and governance. This paper explores the role of ethics committees in reviewing proposed conditions for recruiting human subjects and in checking the intended procedures for gaining consent. In so doing the paper will reiterate the conditions which are traditionally thought to make (...) consent valid, identify a number of limitations to meeting these conditions, and show when consent, however broadly construed or indeterminately focused, may be unnecessary. (shrink)

This is the second in a series of five papers on the role, remit and function of research ethics committees which are intended to provide for REC members a broad understanding of the most important issues in research ethics and governance. This paper examines the role of ethics committees in assessing the science of the research it reviews. While ethics committees are not specifically constituted to review the science of a project, they must nevertheless assess the social benefits of research (...) and, in this context, have an important role in checking that the science has been properly peer-reviewed. (shrink)

Much work has been done, recently, on the harms and benefits of shaming. One may argue, for example, that feeling shamed inherently alienates and forecloses, and thus quite harmful to a compulsorily social and futurally oriented creature. This does not, however, preclude the argument that shame is ethically useful, providing, at a very basic, felt level, the absolute prohibitions such a social, futural, creature requires. This paper does not claim to finally evaluate shame itself. Instead I look to Merleau-Ponty, seeking (...) the fleshly and felt structures of the social world – of our innate proximity and intimacy, as well as our isolation and alienation – within the embodied phenomenon of being ashamed. From the contours of this spontaneous, yet admittedly dangerous, corporeo-social phenomenon, there is comes an intimation of an ethics of the flesh: one which compels us to at least attempt to heed the often opaque, even mysterious powers of our bodies, not only for the good of our intimate others, but for the good of entire peoples. (shrink)

As the number of people affected by dementia increases rapidly, dementia has been transformed into an epidemic which endangers global health and wealth, and many populations are now living in what Jain terms a time of prognosis, in fear of the disease. Through its strong association with ageing and memory loss, dementia is conceived of as a linear decline into loss of self and death, and those with dementia as other. More significantly, imagined as a threat that signifies both a (...) loss of able-bodied workforce and a large population dependent on care and support, dementia inevitably feeds into the ‘crisis-of-care’ narrative that is prominent in many ageing societies. With one of the fastest ageing populations in the world, and an extremely low birth rate, the dementia prognosis is particularly acute in Japan and dementia is strongly linked to the idea of a ‘care crisis’. This situation has produced an increasing number of cultural representations of dementia and care and this paper considers three of these cultural texts, all rooted in the historical and cultural contexts in which they were produced: the novel The Twilight Years; the film Memories of Tomorrow; and the comic book Pecoross’ Mother and Her Days. The analysis concentrates upon their representations of care, seeing this as a space where the ethical relationship between self and other can be negotiated and where time with dementia can be imagined and re-imagined. The analysis of these texts from a feminist ethics perspective demonstrates the potential of popular and creative representations to interrogate and potentially expand the meanings of dementia, ageing and living in prognosis. (shrink)

There are various motives for refining the notion of cause. Aristotle's was an interest in providing the most informative and illuminating method of explaining the central natural phenomena of his universe. A different sort of motive is created by problems of free will and responsibility, of which readers may have been reminded by the reference to indeterminism. The thought that our free and responsible behaviour is caused by factors over which we have no control has often seemed impossible to accept (...) and impossible to reject. The challenge then is to refine the notion of cause either so that the thought becomes more acceptable or so that it becomes more rejectable. (shrink)

In this paper, I defend the compatibility of externalism and privileged access and argue that the warrant transmission succeeds in cases of armchair knowledge, but that it does not have the anti-sceptical consequences that it is typically thought to have.

The recent expansion of online genetic-genealogical networks has been hailed as a development that could break racial taboos in the United States by providing irrefutable evidence of the myriad historical and genetic links—many originating in slavery—connecting white and black families. These predictions are countered, however, by a scholarly literature on “white ignorance,” defined as an active historical project that works to prevent privileged groups from apprehending their links to, and positionality within, systems of racial oppression. This paper mobilizes concepts from (...) the fields of agnotology and epistemic ethics to assess how far genetic-genealogical technologies can contribute to redressing racialized epistemic inequities between slave and slaveholder descendants, by inducing the latter to respond to the former’s kinship claims and give access to data that could help reconstruct their linked family histories. Drawing on ethnographic and interview data that foreground the experiences of African American genealogists, the study outlines the structural and affective dimensions that have converged to enable white ignorance regarding genealogies of slavery and discusses ethical and technical solutions proposed by genealogical practitioners to redress the racialized power dynamics that continue to condition access to, and public acceptance of, family history knowledge relating to slavery. (shrink)