D‐amino acids are being recognized as functionally important molecules in mammals. We recently identified endogenous D‐cysteine in mammalian brain. D‐cysteine is present in neonatal brain in substantial amounts (mM) and decreases with postnatal development. D‐cysteine binds to MARCKS and a host of proteins implicated in cell division and neurodevelopmental disorders. D‐cysteine decreases phosphorylation of MARCKS in neural progenitor cells (NPCs) affecting its translocation. D‐cysteine controls NPC proliferation by inhibiting AKT signaling. Exogenous D‐cysteine inhibits AKT phosphorylation at Thr 308 and Ser (...) 473 in NPCs. D‐cysteine treatment of NPCs led to 50% reduction in phosphorylation of Foxo1 at Ser 256 and Foxo3a at Ser 253. We hypothesize that in the developing brain endogenous D‐cysteine is as a physiologic regulator of NPC proliferation by inhibiting AKT signaling mediated by Foxo1 and Foxo3a. Endogenous D‐cysteine may regulate mammalian neurodevelopment with roles in schizophrenia and Alzheimer's disease (AD). (shrink)

Robin Downie has distinguished between two enduring cognitive and practical attitudes that have determined the way that doctors and societies thought about medicine. The Hippocratic tradition attached its faith to empirical observation and rational induction and deduction, while the Asklepian approach was holistic, intuitive and strongly spiritual. Hippocrates sought to generalize from individual observations, to generate rules and guidelines from pooled experience. Asklepian physicians believed that cure lay in understanding the personal experience of each patient, and in providing an (...) ambience of healing centered on temples and sacred ground. Hippocratic medicine emphasized the empirical.. (shrink)

This paper examines the concept of objectivity traceable in Francis Bacon's natural philosophy. After some historical background on this concept, it considers the question of whether it is not an anachronism to attribute such a concept to Bacon, since the word ‘objectivity’ is a later coinage and does not appear anywhere in his writings. The essay gives reasons for answering this question in the negative, and then criticizes the accounts given of Bacon's understanding of objectivity by Lorraine Daston and Julie (...) Robin Solomon. It argues that this understanding is most directly and fully expressed in his discussion of the idols of the mind. In this connection, the paper notes Bacon's critical attitude to sixteenth-century scepticism and its relevance to the idea of objectivity implicit in his comments on the idols. In conclusion, the paper argues that Bacon was not a pure empiricist and describes the place assigned to theories and hypotheses in his natural philosophy. (shrink)

Philosophy Compass, Volume 17, Issue 4, April 2022.

People disagree about the causes of social inequality and how to most effectively intervene in them. These may seem like empirical questions for social scientists, not philosophers. However, causal explanation itself depends on broadly normative commitments. From this it follows that (moral) philosophers have an important role to play in determining those causal explanations. I examine the case of causal explanations of poverty to demonstrate these claims. In short, philosophers who work to reshape our moral expectations also work, on the (...) back end, to restructure acceptable causal explanations—and hence solutions—for social inequality. Empirical and normative inquiry, then, are a two-way street. (shrink)

Robin McKenna argues that we need to make space for an approach to epistemology that avoids the idealizations typical of the field. He applies this approach to topics in applied and social epistemology, such as what to do about science denial, whether we should try to be intellectually autonomous, and what our obligations are to other inquirers.

them. Though Aristotle does not say so, presumably the questioner who conceals in this way must be prepared, when challenged, to show that the conclusion...

This article proposes an analytical approach to algorithms that stresses operations of folding. The aim of this approach is to broaden the common analytical focus on algorithms as biased and opaque black boxes, and to instead highlight the many relations that algorithms are interwoven with. Our proposed approach thus highlights how algorithms fold heterogeneous things: data, methods and objects with multiple ethical and political effects. We exemplify the utility of our approach by proposing three specific operations of folding—proximation, universalisation and (...) normalisation. The article develops these three operations through four empirical vignettes, drawn from different settings that deal with algorithms in relation to AIDS, Zika and stock markets. In proposing this analytical approach, we wish to highlight the many different attachments and relations that algorithms enfold. The approach thus aims to produce accounts that highlight how algorithms dynamically combine and reconfigure different social and material heterogeneities as well as the ethical, normative and political consequences of these reconfigurations. (shrink)

'Transgender’ is often described either as an identity, or else as the full spectrum of gender nonconformity. In this essay, I suggest that these descriptions do not align with the conceptual labor that we often ask ‘transgender’ to do: highlighting people who engage in forms of self-directed gender nonconformity that are heavily penalized.

One of the most important students of Franz Brentano was Anton Marty, who made it his task to develop a philosophy of language on the basis of Brentano’s analysis of mind. It is most unfortunate that Marty does not receive the attention he deserves, primarily due to his detailed and distracting polemics. In the analysis presented here his philosophy of language and other aspects of his thought, such as his ontology , are examined first and foremost in their positive rather (...) than critical character. The analysis is moreover supplemented by translations of four important works by Marty, including his entire work On the Origin of Language. These are in fact the first English translations of any substantial writings by him. The resulting picture that emerges from the analysis and translations is that Marty has much to say that proves to be of enduring interest for the philosophy of language on a range of topics, especially the meanings of statements, of emotive expressions, and of names as regards both their communicative and their ontological aspects. The volume will be of interest not only to philosophers and historians of philosophy, but also to historians of linguistics and psychology. (shrink)

Despite striking similarities, the connection between Madhyamaka Buddhism and Richard Rorty’s philosophy has been almost entirely ignored. This article aims to correct this oversight by suggesting that much could be gained by exploring their connection. It does so, first, by establishing the similarities and differences between Rorty and Madhyamaka, and second, by demonstrating that Madhyamaka vocabulary can solve significant problems in Rorty’s thought. In particular, the article will argue that Madhyamaka can alleviate the tension between irony and liberalism, by showing (...) that internalisation of anti-essentialism induces liberal sentiments. This allows us to conceive of irony and solidarity as existing in harmony and mutual dependence, without attempting to reconcile them theoretically. In doing so, this article provides the basis for a cross-cultural conception of anti-essentialist ethics. (shrink)

Reviewed Works:Andrew Hodges, Rolf Herken, Alan Turing and the Turing Machine.Stephen C. Kleene, Turing's Analysis of Computability, and Major Applications of it.Robin Gandy, The Confluence of Ideas in 1936.Solomon Feferman, Turing in the Land of O.Martin Davis, Esther R. Phillips, Mathematical Logic and the Origin of Modern Computers.

Arrogance is traditionally regarded as among the worst of human vices. Kant’s discussion of one kind of arrogance as a violation of the categorical moral duty to respect other persons gives familiar support for this view. However, I argue that what Kant says about the ways in which another kind of arrogance is opposed to different kinds of self-respect reveals how profoundly vicious arrogance can be. As a failure of self-respect, arrogance is the Ur-Vice that corrupts moral agency and rational (...) judgment. As its contrary, self-respect is thus morally vital: it is the first condition of the possibility of genuine moral agency and judgment. There are also important gender dimensions to arrogance: although women are called haughty, supercilious, disdainful, even imperious or presumptuous, they are rarely called arrogant, perhaps because arrogance is an exercise of power. I consider, then, whether despite the Kantian condemnation of it, something that is properly called "arrogance" might be, in contexts of oppression, a liberatory virtue of self-respect that oppressed peoples ought to cultivate. (shrink)

In many cultures arrogance is regarded as a serious vice and a cause of numerous social ills. Although its badness is typically thought to lie in its harmful consequences for other persons and things, I draw on Kant to argue that what makes it a vice is first and foremost the failure to respect oneself. But arrogance is not only a problem inside individuals. Drawing on feminist insights I argue that it is a systemic problem constructed in and reinforcing unjust (...) distributions of social power. I identify ways in which arrogance is connected with social arrangements of domination and subordination, then discuss implications of a power-focused analysis Among the implications: (1) contrary to the widely-held view, humility is not the personal virtue opposing arrogance, self-respect is; (2) arrogance is not always a vice, for in circumstances of oppression a certain kind of arrogance is a virtue of self-respecting resistance to domination. (shrink)

The first principle of chemical composition is that elements are actually present in their compounds. It is a golden thread running through the history of compositional thinking in chemistry since before the chemical revolution. Opposed to this principle, which I call Actually Present Elements (APE), is the idea that elements are merely potentially present in their compounds: although not actually present, it is possible to recover them. In this paper I follow that golden thread, and then discuss the status of (...) APE itself: is it true? What arguments were there for it, and when? I argue that APE is a metaphysical principle, albeit at a lower level of generality and abstraction than the term ‘metaphysical’ usually suggests. I critically examine a range of different views on how metaphysical principles might be involved in research programmes in empirical science, and conclude by endorsing Elie Zahar’s view that metaphysical principles such as APE are to be found at the very heart of science. Moreover, they can be recipients of empirical support just like other parts of scientific theory. (shrink)

After the first wave of writings in environmental philosophy in the early 1970s, which were mostly critical of anthropocentrism, a new trend emerged which sought to humanise this subject, and to revive or vindicate anthropocentric stances. Only in this way, it was held, could environmental values become human values, and ecological movements manage to become social ecology. Later writers have detected tacit anthropocentrism lurking even in Deep Ecology, or have defended ‘perspectival anthropocentrism’, as the inevitable methodology of any system of (...) environmental ethics devised by and for the guidance of human beings. Human good, broadly enough conceptualised, is held to be the basis of ethics. Besides, it is sometimes added, non-anthropocentric considerations in any case add nothing to anthropocentric ones, when broadly construed. (shrink)

Preview: /Review: Randall Auxier, Eli Kramer, and Krzysztof Piotr Skowroński, eds. Rorty and Beyond, 314 pages./ Richard Rorty became a highly controversial figure, both within and without the ranks of academic philosophy upon publication of his 1979 book, Philosophy and the Mirror of Nature. The controversy over Rorty intensified with his writings over the remaining years of his life and beyond. Co-edited by Randall Auxier, Eli Kramer, and Krzysztof Piotr Skowroński and including sixteen original essays, this new book, Beyond Rorty (...) studies Rorty’s work with the passage of the years following his death to re-assess his significance and to consider ways in which philosophers might both learn from and move beyond his work. The volume originated in a conference held on Rorty’s work in 2013 at Opole University, Poland. It includes both papers presented at the conference together with additional submissions. The essays offer many perspectives on Rorty while seeking to move beyond his work in areas including metaphysics and epistemology, social philosophy, axiology, philosophy of religion, and more. The following review of Beyond Rorty discusses each of the essays in the volume together with the introductory essays by Auxier and Kramer to explore directions which contemporary philosophy might take to move beyond Rorty. (shrink)

This article, which illustrates the practical effect of caste in employment practices in India, is the first in the series announced in the editorial of October-December 1984. The series will describe models of involvement which illustrate the relationship between evangelism and social responsibility.

For Kant and for feminists, self-respect is a morally central and morally powerful concern. In this paper I focus on some questions about the relation of self-respect to two other stances toward the self, humility and arrogance. Just as arrogance is usually treated as a serious vice, so humility is widely regarded as an important virtue. Indeed, it is supposed to be the virtue that opposes arrogance, keeping it in check or preventing it from developing in the first place. I’ve (...) argued elsewhere that, on Kant’s account, arrogance is a vice of disrespect for other people and for oneself. Humility is not, however, unproblematic from a Kantian perspective, and he is more concerned to identify bad forms of it than to praise it as a virtue or recommend it as a cure for arrogance. Feminist ethics draws our attention to the ways in which character traits, attitudes, beliefs, and stances take on differential moral valences in contexts of oppression, and what might be a virtue for members of dominant groups can be vices for members of subordinate groups. How, then, are we to understand and assess humility? The upshot of Kantian and feminist analyses is two-fold: First, humility is not the virtue opposing arrogance; rather, self-respect is. Second, humility is at best an ancillary, instrumental, contextual virtue and the servant of self-respect; but at worst, it is as serious a vice as arrogance, indeed, an aspect of it. (shrink)

Forty years after it first appeared, Sidney Shoemaker's much-read article, "Time without Change" , with its striking thought experiment, still dominates discussions of this intriguing topic. And rightly so: it is imaginative, subtle, and controversial. But times have changed, as they do, and in particular, the epistemological context in which Shoemaker was writing, overshadowed as it was by verificationism, no longer constrains our thinking as once it did. This is the age of bold and unashamedly realist metaphysical argument, in which (...) demands for evidential, as opposed to a priori, support for its theses are rarely made. (shrink)

It is widely held that moral obligations to non-human beings do not involve considerations of justice. For such a view, nonhuman interests are always prone to be trumped by human interests. Rawlsian contractarianism comprises an example of such a view. Through analysis of such theories, this essay highlights the problem of reconciling the claim that humans have obligations to non-humans with the claim that our treatment of the latter is not a matter of justice. We argue that if it is (...) granted that the basic interests of non-human beings sometimes count for more than the peripheral interests of humans, then our understandings of obligation and of justice must be aligned, so that what we say about obligation is not countered by assumptions about the invariable priority of humans in matters of justice. We further consider whether such a conclusion can be endorsed by those who adopt certain alternative theories to contractarianism. We conclude that adherents of a range of theories including sentientism and biocentrism must accept that human interests can sometimes be superseded by animal interests, and that this applies not least in matters of justice. (shrink)

In seeking to move beyond causal-reductivism, this book explores a variety of perspectives on the question of finding inherent meaning in madness and extreme states.

"Nietzsche in Context presents a comprehensive reinterpretation of Nietzsche's thought, placing Nietzsche in the context of the philosophers of his own time. Offering a survey of important philosophical themes, Robin Small identifies the writer or writers with whom Nietzsche most felt himself to be engaging in dialogue. This historical dimension is complemented by original analysis and interpretation of the ideas under discussion. Nietzsche in Context takes Nietzsche scholarship into new and fruitful directions. By locating his ideas within a broader (...) context, this book provides a comprehensive reinterpretation of Nietzsche's thought adding to the continuing interest of his contributions to philosophy."--Provided by publisher. (shrink)

In his impressive paper, John Nolt argues that the average American is harming future people. Yet people can only be harmed if they could have been unharmed. Nolt recognises this when...