Neurotrophins (NTs) are {?AUTHOR} a family of structurally related, secreted proteins that regulate the survival, differentiation and maintenance of function of different populations of peripheral and central neurons.1,2 Among these, BDNF (brain‐derived neurotrophic factor) has drawn considerable interest because both its synthesis and secretion are increased by physiological levels of activity, indicating a unique role of this neurotrophin in coupling neuronal activity to structural and functional properties of neuronal circuits. In addition to its classical neurotrophic effects, which are evident within (...) hours or days and which usually result from changes in cellular gene expression, BDNF exerts acute effects on synaptic transmission and is involved in the induction of long‐term potentiation. Many of these rapid effects of BDNF are mediated by its modulation of ion channel properties following TrkB‐mediated activation of intracellular second messenger cascades and protein phosphorylation. However, recent reports have shown that BDNF not only acts as a modulator of ion channels, but can also directly and rapidly gate a Na+ channel, thereby assigning BDNF the properties of a classical excitatory transmitter. Thus, BDNF, in addition its role as a potent neuromodulator, emerges as an excitatory transmitter‐like substance which acutely controls resting membrane potential, neuronal excitability, synaptic transmission and participates in the induction of synaptic plasticity. BioEssays 26:1185–1194, 2004. © 2004 Wiley Periodicals, Inc. (shrink)

The study of biodiversity spans many disciplines and includes data pertaining to species distributions and abundances, genetic sequences, trait measurements, and ecological niches, complemented by information on collection and measurement protocols. A review of the current landscape of metadata standards and ontologies in biodiversity science suggests that existing standards such as the Darwin Core terminology are inadequate for describing biodiversity data in a semantically meaningful and computationally useful way. Existing ontologies, such as the Gene Ontology and others in the Open (...) Biological and Biomedical Ontologies (OBO) Foundry library, provide a semantic structure but lack many of the necessary terms to describe biodiversity data in all its dimensions. In this paper, we describe the motivation for and ongoing development of a new Biological Collections Ontology, the Environment Ontology, and the Population and Community Ontology. These ontologies share the aim of improving data aggregation and integration across the biodiversity domain and can be used to describe physical samples and sampling processes (for example, collection, extraction, and preservation techniques), as well as biodiversity observations that involve no physical sampling. Together they encompass studies of: 1) individual organisms, including voucher specimens from ecological studies and museum specimens, 2) bulk or environmental samples (e.g., gut contents, soil, water) that include DNA, other molecules, and potentially many organisms, especially microbes, and 3) survey-based ecological observations. We discuss how these ontologies can be applied to biodiversity use cases that span genetic, organismal, and ecosystem levels of organization. We argue that if adopted as a standard and rigorously applied and enriched by the biodiversity community, these ontologies would significantly reduce barriers to data discovery, integration, and exchange among biodiversity resources and researchers. (shrink)

In this paper, I shall examine attempts to furnish formal models for deductive scientific explanation. All such attempts have had certain defects. The most serious of these defects is to be found in the fact that the extant models seem to be formally restrictive in ways that do not allow any obvious generalization of their conditions which will encompass the full range of all those scientific explanations which must be considered plausible candidates for translation into deductive models.

The fact that simplicity has been linked with induction by many philosophers of science, some of whom have proposed or supported criteria of “inductive simplicity,” means that the problem must be given some serious attention. I take “inductive simplicity” as a title, however, only by way of concession to these historical treatments, since it is precisely the burden of my paper to show that there is no such thing. So much for the conclusion. I shall spend the remainder of my (...) time arguing for it. (shrink)

Through close textual analysis, Ackermann (philosophy, U. of Massachusetts, Amherst) exposes the underlying unity and consistency in Nietzsche's thought. He challenges the common view that Nietzsche's work can best be understood as a collection of isolated insights and that each of several discrete periods of thought are based on a different set of values. Annotation copyrighted by Book News, Inc., Portland, OR.

Introduction: The many faces of human nature / Agustín Fuentes and Aku Visala Chapter 1. Off human nature / Jonathan Marks. Response I. On your marks... get set, we’re off human nature / James M. Calcagno ; Response II. Rethinking human nature : comments on Jonathan Marks’s anti-essentialism / Phillip R. Sloan ; Response III. Off human nature and on human culture : the importance of the concept of culture to science and society / Robert Sussman and Linda Sussman (...) Chapter 2. "To human" is a verb / Tim Ingold. Response I. Free and easy wandering : humans, humane education, and designing in harmony with the nature of the way / Susan D. Blum ; Response II. On human natures : anthropological and Jewish musings / Richard Sosis ; Response III. The humanifying adventure : a response to Tim Ingold / Markus Mühling ; Response IV. The ontogenesis of human moral becoming / Darcia Narvaez Chapter 3. Recognizing the complexity of personhood : complex emergent developmental linguistic relational neurophysiologicalism / Warren Brown and Brad D. Strawn. Response I. "Self-organizing personhood" and many loose ends / Lluis Oviedo ; Response II. A last hurrah for dualism? / Kelly James Clark ; Response III. Why the foundational question about human nature is open and empirical / Carl Gillett Chapter 4. Human origins and the emergence of a distinctively human imagination : theology and the archaeology of personhood / J. Wentzel van Huyssteen. Response I. Constructing the face, creating the collective : Neolithic mediation of personhood / Ian Kuijt ; Response II. Imago Dei and the glabrous ape / Douglas Hedley Chapter 5. What is human nature for? / Grant Ramsey. Response I. The difficulties of forsaking normativity / Neil Arner ; Response II. Some remarks on human nature and naturalism / Aku Visala Epilogues. Putting evolutionary theory to work in investigating human nature / Agustín Fuentes ; Moving us forward? / Celia Deane-Drummond. (shrink)

This book argues that the primary function of human thinking in language is to make judgments, which are logical-normative connections of concepts. Robert Abele points out that this presupposes cognitive conditions that cannot be accounted for by empirical-linguistic analyses of language content or social conditions alone. Judgments rather assume both reason and a unified subject, and this requires recognition of a Kantian-type of transcendental dimension to them. Judgments are related to perception in that both are syntheses, defined as the (...) unity of representations according to a rule/form. Perceptual syntheses are simultaneously pre-linguistic and proto-rational, and the understanding makes these syntheses conceptually and thus self-consciously explicit. Abele concludes with a transcendental critique of postmodernism and what its deflationary view of ontological categories—such as the unified and reasoning subject—has done to political thinking. He presents an alternative that calls for a return to normativity and a recognition of reason, objectivity, and the universality of principles. (shrink)

Franklin and Pickering agree that scientists in an experimental sequence, like the one to be discussed here, choose to accept certain experiments and their results as crucial, but disagree as to whether such choice can be justified in terms of an on-line estimate of evidential reliability. This paper suggests that it is possible to define a position between Franklin 's Bayesian objectivism and Pickering's social constructivism. This position depends on considering the sequence of improvement in material technique and instrumentation as (...) more important than any measure of reliability determined merely from such factors as evidential spread in relevant sequences, a factor that neither Franklin nor Pickering takes sufficiently into account. (shrink)

This book argues that the last eight years in particular have shown us that our democracy has largely evaporated, leaving behind only an exoskeleton that was once its original vertebrae of ends and principles. It is critical to our form of democracy in the U.S. that citizens become active participants.

In Howard Kahane's current reply to my previous discussion of Goodman's elimination rules, he suggests both that the notion of conflict required by the first elimination rule cannot be made clear, and that both proposed revisions of the second elimination rule are too strong [4]. These seem to me to be the points which require settlement, and I would like to discuss them in this paper.

In order to explain the behavior of a human organism, it is necessary to take its environment into consideration. Except for very severe psychotic withdrawal, this has been recognized as a near triviality since Aristotle. But although consideration of the environment may be necessary, it is not sufficient, and it is now generally conceded that a man's behavior cannot be explained solely from a consideration of his present environment and a history of his responses to past environments.

The philosopher Jorge J. E. Gracia engages fifteen prominent scholars on race, ethnicity, nationality, and Hispanic/Latino identity in the United States. Their discussion joins two distinct traditions: the philosophy of race begun by African Americans in the nineteenth century, and the search for an understanding of identity initiated by Latin American philosophers in the sixteenth century. Participants include Linda M. Alcoff, K. Anthony Appiah, Richard J. Bernstein, Lawrence Blum, Robert Gooding-Williams, Eduardo Mendieta, and Lucius T. Outlaw Jr., and (...) their dialogue reflects the analytic, Aristotelian, Continental, literary, Marxist, and pragmatic schools of thought. These intellectuals start with the philosophy of Hispanics/Latinos in the United States and then move to the philosophy of African Americans and Anglo Americans in the United States and the philosophy of Latin Americans in Latin America. Gracia and his interlocutors debate the nature of race and ethnicity and their relation to nationality, linguistic rights, matters of identity, and Affirmative Action, binding the concepts of race and ethnicity together in ways that open new paths of inquiry. Gracia's Familial-Historical View of ethnic and Hispanic/Latino identity operates at the center of each of these discussions, providing vivid access to the philosopher's provocative arguments while adding unique depth to issues that each of us struggles to understand. (shrink)

One of our great behavioral scientists, the bestselling author of Behave, plumbs the depths of the science and philosophy of decision-making to mount a devastating case against free will, an argument with profound consequences Robert Sapolsky's Behave, his now classic account of why humans do good and why they do bad, pointed toward an unsettling conclusion: We may not grasp the precise marriage of nature and nurture that creates the physics and chemistry at the base of human behavior, but (...) that doesn't mean it doesn't exist. Now, in Determined, Sapolsky takes his argument all the way, mounting a brilliant (and in his inimitable way, delightful) full-frontal assault on the pleasant fantasy that there is some separate self telling our biology what to do. Determined offers a marvelous synthesis of what we know about how consciousness works-the tight weave between reason and emotion and between stimulus and response in the moment and over a life. One by one, Sapolsky tackles all the major arguments for free will and takes them out, cutting a path through the thickets of chaos and complexity science and quantum physics, as well as touching ground on some of the wilder shores of philosophy. He shows us that the history of medicine is in no small part the history of learning that fewer and fewer things are somebody's "fault"; for example, for centuries we thought seizures were a sign of demonic possession. Yet, as he acknowledges, it's very hard, and at times impossible, to uncouple from our zeal to judge others and to judge ourselves. Sapolsky applies the new understanding of life beyond free will to some of our most essential questions around punishment, morality, and living well together. By the end, Sapolsky argues that while living our daily lives recognizing that we have no free will is going to be monumentally difficult, doing so is not going to result in anarchy, pointlessness, and existential malaise. Instead, it will make for a much more humane world. (shrink)

Robert Merrihew Adams has been a leader in renewing philosophical respect for the idea that moral obligation may be founded on the commands of God. This collection of Adams' essays, two of which are previously unpublished, draws from his extensive writings on philosophical theology that discuss metaphysical, epistemological, and ethical issues surrounding the concept of God--whether God exists or not, what God is or would be like, and how we ought to relate ourselves to such a being. Adams studies (...) the relation between religion and ethics, delving into an analysis of moral arguments for theistic belief. In several essays, he applies contemporary studies in the metaphysics of individuality, possibility and necessity, and counterfactual conditionals to issues surrounding the existence of God and problems of evil. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Post-Traumatic Hermeneutics: Melancholia in the Wake of TraumaAngelika Rauch (bio)1Classical Analysis: Problems for Trauma TherapyAccording to the Journal of the American Psychoanalytical Association, American ego psychology has taken a leading role in debunking what it considers antiquated Freudian approaches to the study of trauma. As neutral observers and students of the facts, ego psychologists have purportedly reclaimed the study of trauma as the search for an objectifiable traumatic event (...) in the past, one that can be accessed as recovered memory, as a specimen of pathogenic development, or as cognitive and behavioral effects that point to an inaccessible implied memory buried in the psyche. Central to this revision of psychoanalytical trauma therapy is the dismissal of Nachträglichkeit as an antiquated and irrelevant concept. Harold P. Blum, for instance, writes in a recent article of JAPA that “‘deferred action’ is an ambiguous concept, a dubious, antiquated, theoretical legacy.” According to Blum, “deferred action overlooks the immediate and potentially powerful effects of preoedipal trauma and is dissociated from considerations of cumulative trauma and developmental disturbance.” [1155]. With respect to Freud’s case of the Wolf-Man, Blum states that “[d]eferred action emphasized traumatic events and memory rather than cumulative developmental effects of shock and strain trauma, and pathogenic object relationships.” Key to Blum’s view, then, is the assertion that “the concept of deferred action deterred consideration of real infantile experience and the complex overdetermination of pathogenesis through development” [1156]. Blum apparently takes the side of those who like to argue that trauma is more real than imagined. Whereas oedipal trauma is an imaginary or illusory trauma, preoedipal trauma is comprehensible as real shock and, as such, is empirically true. This is an idea that is very compatible with “recovered memory” therapy, a subject that has become controversial in recent debates about child abuse and recovered memory syndrome.In contrast, Arnold H. Modell in Other Times, Other Realities points out that “[t]he concept of Nachträglichkeit is virtually unknown among American psychoanalysts. This may be due in part to Strachey’s faulty translation; but this idea is also inconsistent with the belief in an orderly hierarchical psychic development such as that envisioned by ego psychologists.” [3]. In other words, Freudian Nachträglichkeit violates the principles of space and time assumed by empirical scientists whose conceptions are founded on the causality of such principles as stimulus/response. It is here, of course, that ego psychology’s treatment of trauma would come into conflict not only with Freudian analysis, including its French Freudian variants, but with the kind of trauma studies being conducted by the contributors to Cathy Caruth’s Trauma: Explorations in Memory. They include Bessel [End Page 111] van der Kolk, Onno van der Hart, Shoshana Felman, Dori Laub, Robert Lifton, and, of course, Cathy Caruth herself.Emphasis on the reality of traumatic shock (as abuse, stress, accident, and so on), however important it may be, loses sight of a hermeneutical dimension of psychoanalytic therapy that Caruth and her contributors emphasize: the question of how meanings are associated or bound to the understanding of life’s events. My own clinical approach to psychoanalysis favors the introduction of an even stronger hermeneutical perspective that is sensitive to the kinds of issues raised by philosophers like Dilthey, Heidegger, Benjamin, and Gadamer, for whom the question of experience is not reducible to restricted understandings of stimulus/response, nor—as in the case of Caruth (for example, in Unclaimed Experience)—to the privileging of language as a formal (that is, literary) construct. Rather, I am interested in emphasizing a hermeneutics of the therapeutic encounter within which questions of language, culture, history, and behavior are situated. With respect to trauma therapy, I will introduce a number of well-known analytical contributions even as I take the following statement of Arnold Modell’s as my point of departure:The analyst or therapist becomes an unwitting collaborator in the recreation of the past, while still retaining a proximity to present time. The therapist becomes the person with whom one can reexperience trauma within a new context or experience for the first time what has been absent in the past. Affects belonging to... (shrink)

_A moving meditation on recent geopolitical crises, viewed through the lens of ancient and modern tragedy__ “Spare, elegant and poignant.... If there is a single contemporary book that should be pressed into the hands of those who decide issues of war and peace, this is it.”—John Gray, _New Statesman_ “It is tragic that Robert D. Kaplan’s luminous _The Tragic Mind_ is so urgently needed.”—George F. Will_ Some books emerge from a lifetime of hard-won knowledge. Robert D. Kaplan has (...) learned, from a career spent reporting on wars, revolutions, and international politics in Europe, the Middle East, and East Asia, that the essence of geopolitics is tragedy. In _The Tragic Mind_, he employs the works of ancient Greek dramatists, Shakespeare, German philosophers, and the modern classics to explore the central subjects of international politics: order, disorder, rebellion, ambition, loyalty to family and state, violence, and the mistakes of power. The great dilemmas of international politics, he argues, are not posed by good versus evil—a clear and easy choice—but by contests of good versus good, where the choices are often searing, incompatible, and fraught with consequences. A deeply learned and deeply felt meditation on the importance of lived experience in conducting international relations, this is a book for everyone who wants a profound understanding of the tragic politics of our time. (shrink)

Robert Cummins presents a series of essays motivated by the following question: Is the mind a collection of beliefs and desires that respond to and condition our feeling and perceptual experiences, or is this just a natural way to talk about it? What sort of conceptual framework do we need to understand what is really going on in our brains?

This book provides a comprehensive and critical account of Gadamer's hermeneutical philosophy. Robert J. Dostal shows that at the heart of Gadamer's enterprise is the thesis that "being that can be understood is language.".

이 책자는 형식 논리의 일종인 양상논리에 입문하고 싶으신 분들을 위한 짧은 교재입니다. “양상논리 맛보기” 라는 말마따나, 이 책자는 양상논리에 관심은 있지만 아직 본격적으로 공부를 시작하진 않은 분들께서 ‘맛보기’를 하기에 적합한 안내 책자입니다. 아무쪼록 이 책자가 양상논리를 공부해나가시는데 유용한 첫 발판이 될 수 있기를 바랍니다. / This booklet is a Korean adaptation and translation of Part VIII of forall x: Calgary (Fall 2021 edition), which is intended to be introductory material for modal logic. The original text is based on Robert (...) Trueman's A Modal Logic Primer, which is revised and expanded by Richard Zach and Aaron Thomas-Bolduc in forall x: Calgary. (forall x: Calgary is based on forall x: Cambridge by Tim Button, which is in turn based on forall x by P. D. Magnus, and also includes material from forall x: Lorain County Remix by Cathal Woods and J. Robert Loftis.) This booklet is licensed under a Creative Commons Attribution 4.0 license. (shrink)

The postphenomenological framework of concepts—and especially the version utilized by the founder of this school of thought, Don Ihde—has proven useful for puncturing others’ totalizing or otherwise overgeneralizing claims about technology. However, does this specialization in deflating hype leave this perspective unable to identify the kinds of technological patterns necessary for contributing to activist interventions and political critique? Put differently, the postphenomenological perspective is committed to the study of concrete human-technology relations, and it eschews essentialist and fundamentalizing accounts of technology. (...) Do these commitments render it incapable of providing general assessments of our contemporary technological situation? It is my contention that this perspective can indeed be useful for these kinds of critical projects. To do so, we must go beyond Ihde’s personal tendency to utilize postphenomenology mostly for deflating others’ hype, and explore this perspective’s distinctive potential for identifying ways that technologies can become set within problematic patterns of usage and design. My suggestion is that the postphenomenological notion of “multistability” can play a helpful role in these efforts, especially when combined with a conception of local, rather than totalizing, stabilizations of human-technology relationships. (shrink)

Professor Kenneth Inada, State University of New York at Buffalo, writes: "There is no ordinary volume. It is a well crafted work containing brilliant reactions to traditional Chinese philosophical thought." -/- Ninian Smart, President, American Academy of Religion, Rowney Chair of Philosophy, The University of California, Santa Barbara, in a review of Understanding the Chinese Mind in Philosophy, East and West, writes: "This is an important book ... Robert E. Allinson is to be congratulated on putting together this thoughtful (...) and reflective volume." -/- Professor Mary Bockover, Humboldt State University, writes: "Understanding the Chinese Mind is an intriguing book that crosses linguistic and cultural boundaries to probe various issues in the Chinese philosophical tradition. In taking philosophy to be a kind of mirror of the mind, this book uses Western philosophical tools to provide an understanding of the Chinese mind through its philosophy." -/- Currently in its 11th impression, Understanding the Chinese Mind: The Philosophical Roots, was first published in 1989. Impressions of the work have been made in 2000, 1999, 1998, 1996, 1995, 1993, 1992, 1991, 1990, 1989: 1989, 1990, 1991, and 1989. These essays represent an attempt to understand the Chinese mind through its philosophy. The first volume of its kind, the collection demonstrates how Chinese philosophy can be understood in light of techniques and categories taken from Western philosophy. Eight philosophers, each of whom is a recognized authority in Western philosophy as well as in some area of Chinese philosophy, contribute chapters from perspectives that indicate the uniqueness of the Chinese way of thinking in categories adapted from Western philosophy. The book covers a wide range of topics including metaphysics, ethics, aesthetics, logic, the history of philosophy, philosophy of religion, philosophy of mind, and western parallels and non-parallels of philosophical development. (shrink)

This collection of 21 essays explores the creative interaction among the cognitive neurosciences, philosophy, and theology. It is the result of an international research conference co-sponsored by the Vatican Observatory, Rome, and the Center for Theology and the Natural Sciences, Berkeley.

Martin Heidegger and Michel Foucault are two of the most important and influential thinkers of the twentieth century. Each has spawned volumes of secondary literature and sparked fierce, polarizing debates, particularly about the relationship between philosophy and politics. And yet, to date there exists almost no work that presents a systematic and comprehensive engagement of the two in relation to one another. _The World of Freedom_ addresses this lacuna. Neither apology nor polemic, the book demonstrates that it is not merely (...) interesting but necessary to read Heidegger and Foucault alongside one another if we are to properly understand the shape of twentieth-century Continental thought. Through close, scholarly engagement with primary texts, Robert Nichols develops original and demanding insights into the relationship between fundamental and historical ontology, modes of objectification and subjectification, and an ethopoetic conception of freedom. In the process, his book also reveals the role that Heidegger's reception in France played in Foucault's intellectual development—the first major work to do so while taking full advantage of the recent publication of Foucault's last Collège de France lectures of the 1980s, which mark a return to classical Greek and Roman philosophy, and thus to familiar Heideggerian loci of concern. (shrink)

Religion is the third and final volume in Robert Cummings Neville's systematic development of a new philosophical theology. Unfolding through his earlier volumes, Ultimates and Existence, and now in Religion, philosophical theology considers first-order questions generally treated by religious traditions through philosophical methods while reflecting Neville's long engagement with philosophy, theology, and Eastern and Western religious traditions. In this capstone to the trilogy, Neville provides a theory of religion and presents a sacred worldview to guide religious participation. His philosophical (...) theory of value enlightens religions' approaches to ethics, spirituality, and religious institutional living and collaboration. With a detailed examination of plausibility conditions for sacred worldviews, the book concludes with an exploration of "religionless religion" for which institutions of religion are of penultimate value. Through the development of philosophical theology, Neville has built a unique, multidisciplinary, comparative, nonconfessional theological system, one that addresses concerns and provides tools for scientific and humanistic scholars of religion, postmodern thinkers, intellectuals from both secular and religious backgrounds, and those interested in the global state of religion today. (shrink)